| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenli Mao, Zhenquan Song, Gang Li, Wei Lv, Xu Zhao, Bin Li, Xinli Feng, Youli Che. 8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury. Neural regeneration research. vol 8. issue 2. 2014-09-10. PMID:25206483. |
these results suggest that 8-oh-dpat inhibits bax and caspase-3 expression, increases bcl-2 expression, and reduces neural cell apoptosis, resulting in neuroprotection against diffuse axonal injury. |
2014-09-10 |
2023-08-13 |
rat |
| Liping Chen, Zhigao Sun, Fawei Wang, Chengyong Xu, Miao Geng, Hongyan Chen, Dongmei Dua. Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment. Neural regeneration research. vol 8. issue 22. 2014-09-10. PMID:25206514. |
results revealed that shuyusan-containing serum elevated the survival rate of sh-sy5y cells, reduced bax expression, increased bcl-2 expression, markedly elevated brain-derived neurotrophic factor mrna expression, and blocked cell apoptosis. |
2014-09-10 |
2023-08-13 |
Not clear |
| Hai Gu, Zequn Jiang, Mingyan Wang, Haiying Jiang, Fengming Zhao, Xia Ding, Baochang Cai, Zhen Zha. 5-Hydroxymethylfurfural from wine-processed Fructus corni inhibits hippocampal neuron apoptosis. Neural regeneration research. vol 8. issue 28. 2014-09-10. PMID:25206571. |
these results suggested that 5-hydroxymethylfurfural could inhibit apoptosis of cultured rat hippocampal neurons injured by h2o2 via increase in bcl-2 levels and decrease in p53, bax and caspase-3 protein expression levels. |
2014-09-10 |
2023-08-13 |
rat |
| Shumin Zhao, Wei Kong, Shufeng Zhang, Meng Chen, Xiaoying Zheng, Xiangyu Kon. Pretreatment with scutellaria baicalensis stem-leaf total flavonoid prevents cerebral ischemia-reperfusion injury. Neural regeneration research. vol 8. issue 34. 2014-09-10. PMID:25206639. |
results showed that neurological deficit scores increased, infarct volumes enlarged, apoptosis increased and bcl-2 and bax protein expression were upregulated at 24 hours after reperfusion. |
2014-09-10 |
2023-08-13 |
rat |
| Shumin Zhao, Wei Kong, Shufeng Zhang, Meng Chen, Xiaoying Zheng, Xiangyu Kon. Pretreatment with scutellaria baicalensis stem-leaf total flavonoid prevents cerebral ischemia-reperfusion injury. Neural regeneration research. vol 8. issue 34. 2014-09-10. PMID:25206639. |
pretreatment with scutellaria baicalensis stem-leaf total flavonoid at any dose lowered the neurological deficit scores, reduced the infarct volume, prevented apoptosis in hippocampal cells, attenuated neuronal and blood-brain barrier damage and upregulated bcl-2 protein expression but inhibited bax protein expression. |
2014-09-10 |
2023-08-13 |
rat |
| Ziyi Wang, Zhi Wan. Effects of rapamycin on expression of Bcl-2 and Bax in human lens epithelial cells and cell cycle in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 31. issue 4. 2014-09-09. PMID:21823021. |
rfq-pcr indicated that rapamycin could down-regulate the expression of bcl-2 mrna, but up-regulate the expression of bax mrna, suggesting it could induce apoptosis of lecs. |
2014-09-09 |
2023-08-12 |
human |
| Shu Guo, Jin Zhou, Xuemei Chen, Yunjiang Yu, Mingzhong Ren, Guocheng Hu, Yun Liu, Fei Zo. Bystander effects of PC12 cells treated with Pb²⁺ depend on ROS-mitochondria-dependent apoptotic signaling via gap-junctional intercellular communication. Toxicology letters. vol 229. issue 1. 2014-09-08. PMID:24960054. |
here we show that 10 μm lead acetate, the optimum concentration for inducing apoptosis confirmed by the expression levels of bax and bcl-2, can also induce rat pheochromocytoma (pc12) cells to exert bystander effects to neighboring cells. |
2014-09-08 |
2023-08-13 |
human |
| Samak Sutjarit, Shota M M Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Wijit Banlunara, Worawut Rerkamnuaychoke, Susumu Kumagai, Amnart Poapolathe. Apoptosis and gene expression in the developing mouse brain of fusarenon-X-treated pregnant mice. Toxicology letters. vol 229. issue 1. 2014-09-08. PMID:24983900. |
moreover, the genetic regulatory mechanisms of fx-induced apoptosis are regulated by bax, bcl2, trp53 and casp9 or can be defined via an intrinsic apoptotic pathway. |
2014-09-08 |
2023-08-13 |
mouse |
| Ulrike Heinicke, Simone Fuld. Chemosensitization of rhabdomyosarcoma cells by the histone deacetylase inhibitor SAHA. Cancer letters. vol 351. issue 1. 2014-09-05. PMID:24814395. |
consistently, saha and doxorubicin cooperate to stimulate activation of bax and bak, caspase activation and caspase-dependent apoptosis. |
2014-09-05 |
2023-08-13 |
Not clear |
| Aik Kia Khaw, M Pradeepa Hande, Guruprasad Kalthur, M Prakash Hand. Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells. Journal of cellular biochemistry. vol 114. issue 6. 2014-09-04. PMID:23192708. |
curcumin-induced apoptosis is found to be associated with increased caspase-3/7 activity and overexpression of bax. |
2014-09-04 |
2023-08-12 |
Not clear |
| Fangfang Zheng, Kaiwen He, Xin Li, Dan Zhao, Fei Sun, Yu Zhang, Dan Nie, Xingda Li, Wenfeng Chu, Yan Sun, Yanjie L. Transient overexpression of TGFBR3 induces apoptosis in human nasopharyngeal carcinoma CNE-2Z cells. Bioscience reports. vol 33. issue 2. 2014-09-04. PMID:23387308. |
the expression of apoptosis-related proteins, p-bad, bad, xiap (x-linked inhibitor of apoptosis), aif (apoptosis-inducing factor), bax and bcl-2, was determined by western blot or immunofluorescence analysis. |
2014-09-04 |
2023-08-12 |
human |
| Yong Jiang, Shan-shan Chang, Jin-yan Li, Xin Wang, Feng-jie Tian, Wen-ping Zhang, Jin-ping Zhen. [The modification of apoptosis correlated gene, protein and protein activity in rat hippocampus induced by benzo[a] pyrene sub-chronic exposure]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 31. issue 3. 2014-09-04. PMID:23510837. |
to observe the effects of subchronic exposure to benzo[a]pyrene (b[a]p) on the mrna and protein expression levels of apoptosis-related genes (bax, bcl-2, caspase-3, caspase-6, and caspase-9) and the activities of caspase-3, caspase-6, and caspase-9 in the hippocampal neurons of rats and to investigate the neurotoxic mechanism by which b[a]p induces the apoptosis of neurons. |
2014-09-04 |
2023-08-12 |
rat |
| Ga Bin Park, Yunock Choi, Yeong Seok Kim, Hyun-Kyung Lee, Daejin Kim, Dae Young Hu. ROS-mediated JNK/p38-MAPK activation regulates Bax translocation in Sorafenib-induced apoptosis of EBV-transformed B cells. International journal of oncology. vol 44. issue 3. 2014-09-04. PMID:24402682. |
ros-mediated jnk/p38-mapk activation regulates bax translocation in sorafenib-induced apoptosis of ebv-transformed b cells. |
2014-09-04 |
2023-08-12 |
Not clear |
| Ga Bin Park, Yunock Choi, Yeong Seok Kim, Hyun-Kyung Lee, Daejin Kim, Dae Young Hu. ROS-mediated JNK/p38-MAPK activation regulates Bax translocation in Sorafenib-induced apoptosis of EBV-transformed B cells. International journal of oncology. vol 44. issue 3. 2014-09-04. PMID:24402682. |
srf triggered the generation of reactive oxygen species (ros), translocation of bax into the mitochondria, disruption of mitochondrial membrane potential, activation of caspase-9, caspase-3 and parp, and subsequent apoptosis. |
2014-09-04 |
2023-08-12 |
Not clear |
| Vicente Fresquet, Melissa Rieger, Carlo Carolis, Maria J García-Barchino, Jose A Martinez-Climen. Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma. Blood. vol 123. issue 26. 2014-09-04. PMID:24786774. |
in resistant human lymphoma cells, a missense mutation in the c-terminal transmembrane domain of proapoptotic bax (g179e) was found, which abrogated bax anchoring to mitochondria and blocked abt-199-induced apoptosis both in vitro and in vivo. |
2014-09-04 |
2023-08-13 |
mouse |
| Lídia Cedó, Anna Castell-Auví, Victor Pallarès, Alba Macià, Mayte Blay, Anna Ardévol, Maria-José Motilva, Montserrat Pinen. Gallic acid is an active component for the anticarcinogenic action of grape seed procyanidins in pancreatic cancer cells. Nutrition and cancer. vol 66. issue 1. 2014-09-03. PMID:24325191. |
the effects of the extract were analyzed on the proliferation and apoptosis processes in mia paca-2 cells, as well as in the levels of the apoptosis markers bcl-2 and bax, the mitochondrial membrane potential, and reactive oxygen species levels. |
2014-09-03 |
2023-08-12 |
Not clear |
| Yan Zhang, Qihong Wang, Susheng Niu, Junning Liu, Li Zhan. Pien Tze Huang induces apoptosis in multidrug‑resistant U2OS/ADM cells via downregulation of Bcl‑2, survivin and P-gp and upregulation of Bax. Oncology reports. vol 31. issue 2. 2014-09-03. PMID:24337940. |
pien tze huang induces apoptosis in multidrug‑resistant u2os/adm cells via downregulation of bcl‑2, survivin and p-gp and upregulation of bax. |
2014-09-03 |
2023-08-12 |
human |
| Yan Zhang, Qihong Wang, Susheng Niu, Junning Liu, Li Zhan. Pien Tze Huang induces apoptosis in multidrug‑resistant U2OS/ADM cells via downregulation of Bcl‑2, survivin and P-gp and upregulation of Bax. Oncology reports. vol 31. issue 2. 2014-09-03. PMID:24337940. |
further experiments demonstrated that apoptosis induction by pzh was accompanied by downregulation of bcl-2 and survivin and upregulation of bax. |
2014-09-03 |
2023-08-12 |
human |
| Christian Schöneich, Elena Dremina, Nadezhda Galeva, Victor Sharo. Apoptosis in differentiating C2C12 muscle cells selectively targets Bcl-2-deficient myotubes. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24129924. |
in the current study we characterize apoptotic phenotypes of different types of c2c12 cells at all stages of differentiation, and report here that myotubes of differentiated c2c12 cells with low levels of anti-apoptotic bcl-2 expression are particularly vulnerable to apoptosis even though they are displaying low levels of pro-apoptotic proteins bax, bak and bad. |
2014-09-02 |
2023-08-12 |
Not clear |
| Christian Schöneich, Elena Dremina, Nadezhda Galeva, Victor Sharo. Apoptosis in differentiating C2C12 muscle cells selectively targets Bcl-2-deficient myotubes. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24129924. |
apoptosis in differentiating myoblasts and myotubes is regulated not through interaction of bcl-2 with pro-apoptotic bcl-2 family proteins such as bax, bak, and bad. |
2014-09-02 |
2023-08-12 |
Not clear |