| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paulraj Raja Singh, Ramachandran Arunkumar, Velayutham Sivakamasundari, Govindaraj Sharmila, Perumal Elumalai, Elayapillai Suganthapriya, Amalanathan Brindha Mercy, Kalimuthu Senthilkumar, Jegadeesan Arunakara. Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line. Cell biochemistry and function. vol 32. issue 3. 2014-12-01. PMID:23963693. |
the mrna expression of fas ligand, fas-associated death domain receptor (faddr), bcl-2-associated x protein (bax), bcl-2-associated death promoter (bad), phosphatidylinositide 3-kinases (pi3k), akt, igf1, igf1 receptor (igf1r) and igf binding protein 3 were quantified by reverse transcription polymerase chain reaction and protein expression of bax, cytochrome c, x-linked inhibitor of apoptosis protein (xiap), b-cell lymphoma 2 (bcl-2), caspases -8, -9, -10 and -3, poly(adp-ribose) polymerase (parp), cleaved parp, igf1r, pi3k, akt, p-akt was determined by western blot analysis, in nimbolide-treated pc-3 cell line. |
2014-12-01 |
2023-08-12 |
Not clear |
| A Dwivedi, S F Mujtaba, N Yadav, H N Kushwaha, S K Amar, S K Singh, M C Pant, R S Ra. Cellular and molecular mechanism of ofloxacin induced apoptotic cell death under ambient UV-A and sunlight exposure. Free radical research. vol 48. issue 3. 2014-12-01. PMID:24286391. |
in conclusion, the study revealed that photosensitized oflx induced apoptosis via ros-mediated dna damage, destabilization of lysosomal and mitochondrial membrane, and upregulation of p21, bax, and caspase-3 genes. |
2014-12-01 |
2023-08-12 |
Not clear |
| De-Yong Zhang, Xiu-Ying Shen, Qin Ruan, Xiao-Lu Xu, San-Ping Yang, Yin Lu, Hui-Ying Xu, Fei-Lin Ha. Effects of subchronic samarium exposure on the histopathological structure and apoptosis regulation in mouse testis. Environmental toxicology and pharmacology. vol 37. issue 2. 2014-12-01. PMID:24561534. |
and expression up-regulation of p53 and bax, and down-regulation of bcl-2 were observed (p<0.05), indicating the apoptosis is related to p53 mediated pathway. |
2014-12-01 |
2023-08-12 |
mouse |
| Nur Diyana Md Zamri, Mustapha Umar Imam, Siti Aisyah Abd Ghafar, Maznah Ismai. Antioxidative Effects of Germinated Brown Rice-Derived Extracts on H2O2-Induced Oxidative Stress in HepG2 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-11-28. PMID:25431609. |
in addition, h2o2 produced transcriptional changes in p53, jnk, p38 mapk, akt, bax, and cdk4 that were inclined towards apoptosis, while gbr-extracts showed some transcriptional changes (upregulation of bax and p53) that suggested an inclination for apoptosis although other changes (upregulation of antioxidant genes, akt, jnk, and p38 mapk) suggested that gbr-extracts favored survival of the hepg2 cells. |
2014-11-28 |
2023-08-13 |
Not clear |
| Anyu Bao, Yan Li, Yongqing Tong, Hongyun Zheng, Wei Wu, Chuandong We. 1,25-Dihydroxyvitamin D₃ and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells. International journal of molecular medicine. vol 33. issue 5. 2014-11-26. PMID:24573222. |
our results revealed that co-treatment with 1,25(oh)2d3 enhanced cisplatin-induced apoptosis and upregulated the expression of bax, and promoted the cleavage of parp and caspase-3. |
2014-11-26 |
2023-08-12 |
human |
| Anyu Bao, Yan Li, Yongqing Tong, Hongyun Zheng, Wei Wu, Chuandong We. 1,25-Dihydroxyvitamin D₃ and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells. International journal of molecular medicine. vol 33. issue 5. 2014-11-26. PMID:24573222. |
the results of this study suggest that 1,25(oh)2d3 potentiates cisplatin-mediated cell growth inhibition and cell apoptosis, which involves the upregulation of bax, a decrease in erk and akt phosphorylation levels, and increased p21 and p27 levels. |
2014-11-26 |
2023-08-12 |
human |
| Lin Sun, Qi Li, Qing Li, Yuzhe Zhang, Dexiang Liu, Hong Jiang, Fang Pan, David T Ye. Chronic ketamine exposure induces permanent impairment of brain functions in adolescent cynomolgus monkeys. Addiction biology. vol 19. issue 2. 2014-11-25. PMID:23145560. |
the current study examined the abnormalities in behavior (move, walk, jump and climb) and apoptosis of the prefrontal cortex using terminal deoxynucleotidyl transferase-mediated biotinylated dutp nick end labeling (tunel) and apoptotic markers, including bax, bcl-2 and caspase-3 in adolescent male cynomolgus monkeys (macaca fascicularis) after 1 or 6 months of sub-anesthetic ketamine administration (1 mg/kg, i.v.). |
2014-11-25 |
2023-08-12 |
human |
| Robert F Gahl, Ephrem Tekle, Nico Tjandr. Single color FRET based measurements of conformational changes of proteins resulting from translocation inside cells. Methods (San Diego, Calif.). vol 66. issue 2. 2014-11-25. PMID:23872323. |
live-cell fret imaging has been applied to identify conformational changes between two native cysteines in bax, a member of the bcl-2 family of proteins that regulates apoptosis. |
2014-11-25 |
2023-08-12 |
Not clear |
| Robert F Gahl, Ephrem Tekle, Nico Tjandr. Single color FRET based measurements of conformational changes of proteins resulting from translocation inside cells. Methods (San Diego, Calif.). vol 66. issue 2. 2014-11-25. PMID:23872323. |
bax exists in the cytosol and translocates to the mitochondria outer membrane upon apoptosis induction. |
2014-11-25 |
2023-08-12 |
Not clear |
| Magdalena Nowakowska, Elżbieta Płuciennik, Wioletta I Wujcicka, Anna Sitkiewicz, Bernarda Kazanowska, Elżbieta Zielińska, Andrzej K Bednare. The correlation analysis of WWOX expression and cancer related genes in neuroblastoma- a real time RT-PCR study. Acta biochimica Polonica. vol 61. issue 1. 2014-11-25. PMID:24455756. |
we performed real-time rt-pcr to analyse levels of wwox expression in 22 neuroblastic tumour samples in correlation with genes involved in cell cycle regulation (ccne1, ccnd1), proliferation (mki67), apoptosis (bcl2, birc5, bax) and signal transduction (egfr, erbb4). |
2014-11-25 |
2023-08-12 |
Not clear |
| Basil Smith, Diandra Randle, Roman Mezencev, LeeShawn Thomas, Cimona Hinton, Valerie Odero-Mara. Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D. Molecules (Basel, Switzerland). vol 19. issue 4. 2014-11-25. PMID:24699144. |
immunocytochemical analysis revealed cd relocalization from the lysosome to the cytosol subsequent to camalexin treatments, which was associated with increased protein expression of mature cd; p53, a transcriptional activator of cd; bax, a downstream effector of cd, and cleaved parp, a hallmark for apoptosis. |
2014-11-25 |
2023-08-13 |
Not clear |
| Nan Wu, Wenna Li, Wenqi Shu, Dalin Ji. Protective effect of picroside II on myocardial ischemia reperfusion injury in rats. Drug design, development and therapy. vol 8. 2014-11-24. PMID:24868147. |
the cardiac function, myocardial infarct size, apoptosis, myocardial nitric oxide content, the expressions of bcl-2 and bax, and the activation of the phosphoinositide 3-kinase/akt/endothelial nos pathway were evaluated. |
2014-11-24 |
2023-08-13 |
rat |
| Nan Wu, Wenna Li, Wenqi Shu, Dalin Ji. Protective effect of picroside II on myocardial ischemia reperfusion injury in rats. Drug design, development and therapy. vol 8. 2014-11-24. PMID:24868147. |
treatment with 10 μm and 100 μm picroside ii significantly improved postischemic myocardial function, reduced myocardial infarct size, inhibited apoptosis, increased myocardial no content, upregulated bcl-2, downregulated bax, and increased the phosphorylation of akt and endothelial nos, but cardioprotection was not shown in the 1 μm picroside ii treatment group and was abrogated by wortmannin and l-n(g)-nitroarginine methyl ester. |
2014-11-24 |
2023-08-13 |
rat |
| Nan Wu, Wenna Li, Wenqi Shu, Dalin Ji. Protective effect of picroside II on myocardial ischemia reperfusion injury in rats. Drug design, development and therapy. vol 8. 2014-11-24. PMID:24868147. |
in conclusion, the data reveals that picroside ii has a significant protective effect on myocardial ischemia reperfusion injury in a dose-dependent manner, which was mediated by upregulating the phosphoinositide 3-kinase/akt/endothelial nos pathway to increase nitric oxide production and regulating the expressions of bcl-2 and bax to inhibit apoptosis. |
2014-11-24 |
2023-08-13 |
rat |
| Qi Shi, Qin-Qin Song, Peng Sun, Jin Zhang, Juan Song, Li-Na Chen, Kang Xiao, Shao-Bin Wang, Ya-Zhou Zhang, Gong-Qi Li, Lin-Jun Sheng, Bao-Dong Wang, Ming-Zhi Lu, Jun Han, Xiao-Ping Don. Infection of prions and treatment of PrP106-126 alter the endogenous status of protein 14-3-3 and trigger the mitochondrial apoptosis possibly via activating Bax pathway. Molecular neurobiology. vol 49. issue 2. 2014-11-21. PMID:24135906. |
infection of prions and treatment of prp106-126 alter the endogenous status of protein 14-3-3 and trigger the mitochondrial apoptosis possibly via activating bax pathway. |
2014-11-21 |
2023-08-12 |
Not clear |
| Junzhe Jin, Guofu Lin, Hong Huang, Dong Xu, Hao Yu, Xu Ma, Lisi Zhu, Dongyan Ma, Honglei Jian. Capsaicin mediates cell cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53. International journal of biological sciences. vol 10. issue 3. 2014-11-21. PMID:24643130. |
here, we reported that capsaicin had a profound anti-proliferative effect on human colon cancer cells via inducing cell cycle g0/g1 phase arrest and apoptosis, which was associated with an increase of p21, bax and cleaved parp. |
2014-11-21 |
2023-08-12 |
human |
| Saroj Nepal, Pil-Hoon Par. Regulatory role of autophagy in globular adiponectin-induced apoptosis in cancer cells. Biomolecules & therapeutics. vol 22. issue 5. 2014-11-21. PMID:25414767. |
in the present study, we demonstrated that globular adiponectin (gacrp) induces both apoptosis and autophagy in human hepatoma cell line (hepg2 cells) and breast cancer cells (mcf-7), as evidenced by increase in caspase-3 activity, bax, microtubule-associated protein light chain 3-ii (lc3 ii) protein levels, and autophagosome formation. |
2014-11-21 |
2023-08-13 |
human |
| Yonju Ha, Arul K Shanmugam, Shanu Markand, Eric Zorrilla, Vadivel Ganapathy, Sylvia B Smit. Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. Cell and tissue research. vol 356. issue 1. 2014-11-18. PMID:24469320. |
we therefore used σr1(-/-) mice to investigate the expression of er stress genes (bip/grp78, atf6, atf4, ire1α) and proteins involved in apoptosis (bcl2, bax) and to examine the retinal transcriptome at young ages. |
2014-11-18 |
2023-08-12 |
mouse |
| Xin-Yan Huang, Song-Zhao Zhang, Wen-Xi Wan. Enhanced antitumor efficacy with combined administration of astragalus and pterostilbene for melanoma. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 3. 2014-11-18. PMID:24606435. |
in vivo, ai inhibited melanoma tumor growth, with inhibition rates ranging from 36.5 to 62.3%, by inducing apoptosis via up-regulation bax expression and the bax/bcl-2 ratio and down-regulating bcl-2 expression. |
2014-11-18 |
2023-08-12 |
Not clear |
| Thamaraiselvan Rengarajan, Natarajan Nandakumar, Peramaiyan Rajendran, Lingaiah Haribabu, Ikuo Nishigaki, Maruthaiveeran Periyasamy Balasubramania. D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-κB. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 4. 2014-11-18. PMID:24641404. |
d-pinitol promotes apoptosis in mcf-7 cells via induction of p53 and bax and inhibition of bcl-2 and nf-κb. |
2014-11-18 |
2023-08-12 |
human |