| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thamaraiselvan Rengarajan, Natarajan Nandakumar, Peramaiyan Rajendran, Lingaiah Haribabu, Ikuo Nishigaki, Maruthaiveeran Periyasamy Balasubramania. D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-κB. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 4. 2014-11-18. PMID:24641404. |
the mechanism of apoptosis was studied with reference to expression of p53, bcl-2, bax and nf-kb proteins. |
2014-11-18 |
2023-08-12 |
human |
| Dae-Eun Kim, Bokyung Kim, Hwa-Sup Shin, Ho Jeong Kwon, Eun-Seok Par. The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway. Experimental cell research. vol 327. issue 2. 2014-11-18. PMID:25128810. |
while the treatment of h9c2 cardiomyoblast cells with hydrogen peroxide caused a loss of cell viability and an increase in the number of apoptotic cells, hispidin significantly protected the cells against hydrogen peroxide-induced cell death without any cytotoxicity as determined by xtt assay, ldh release assay, hoechst 33342 assay, and western blotting of apoptosis proteins such as caspase-3, bax, and bcl-2. |
2014-11-18 |
2023-08-13 |
rat |
| Dae-Eun Kim, Bokyung Kim, Hwa-Sup Shin, Ho Jeong Kwon, Eun-Seok Par. The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway. Experimental cell research. vol 327. issue 2. 2014-11-18. PMID:25128810. |
furthermore, inhibiting the akt/gsk-3β and erk1/2 pathway by these inhibitors significantly reversed the hispidin-induced bax and bcl-2 expression, apoptosis induction, and ros production. |
2014-11-18 |
2023-08-13 |
rat |
| Gbenga Anthony Adefolaju, Kathrine Elizabeth Theron, Margot Jill Hosi. Effects of HIV protease, nucleoside/non-nucleoside reverse transcriptase inhibitors on Bax, Bcl-2 and apoptosis in two cervical cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 68. issue 2. 2014-11-17. PMID:24011602. |
effects of hiv protease, nucleoside/non-nucleoside reverse transcriptase inhibitors on bax, bcl-2 and apoptosis in two cervical cell lines. |
2014-11-17 |
2023-08-12 |
human |
| Ching-Lung Liao, Shu-Chun Hsu, Chien-Chih Yu, Jai-Sing Yang, Nou-Ying Tang, Wellington Gibson Wood, Jaung-Geng Lin, Jing-Gung Chun. The crude extract of Corni Fructus induces apoptotic cell death through reactive oxygen species-modulated pathways in U-2 OS human osteosarcoma cells. Environmental toxicology. vol 29. issue 9. 2014-11-14. PMID:23239598. |
cecf increased protein levels of caspase-3, caspase-9, bax, cytochrome c, grp78, aif, atf-6α, fas, trail, p21, p27, and p16 which were associated with cell-cycle arrest and apoptosis. |
2014-11-14 |
2023-08-12 |
human |
| Mei Ling Jin, Sun Young Park, Young Hun Kim, Jeong-Il Oh, Sang Joon Lee, Geuntae Par. The neuroprotective effects of cordycepin inhibit glutamate-induced oxidative and ER stress-associated apoptosis in hippocampal HT22 cells. Neurotoxicology. vol 41. 2014-11-14. PMID:24486958. |
cordycepin inhibits chop and bax expressions, as well as p-erk, p-jnk, and p-p38, all of which are involved in oxidative or er stress-induced apoptosis. |
2014-11-14 |
2023-08-12 |
Not clear |
| Jie Zhao, Jing-xia Wu, Wei Yan. [Expression of caspase-3, Bcl-2, and Bax in pentavalent vanadium-induced neuronal apoptosis]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 31. issue 8. 2014-11-13. PMID:24053958. |
[expression of caspase-3, bcl-2, and bax in pentavalent vanadium-induced neuronal apoptosis]. |
2014-11-13 |
2023-08-12 |
rat |
| Jie Zhao, Jing-xia Wu, Wei Yan. [Expression of caspase-3, Bcl-2, and Bax in pentavalent vanadium-induced neuronal apoptosis]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 31. issue 8. 2014-11-13. PMID:24053958. |
to investigate the expression of caspase-3, bcl-2, and bax in pentavalent vanadium-induced neuronal apoptosis and the neurotoxicity of pentavalent vanadium to in vitro cultured rat neurons. |
2014-11-13 |
2023-08-12 |
rat |
| Jian-Guo Sun, Hua Li, Xia Li, Xueli Zeng, Ping Wu, Kwok-Pui Fung, Fei-Yan Li. Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo. Apoptosis : an international journal on programmed cell death. vol 19. issue 5. 2014-11-12. PMID:24563182. |
biochemical analysis revealed that clitocine-induced tumor growth inhibition is associated with activation of caspases 3, 8 and 9, parp cleavage, cytochrome c release and bax, bak activation, suggesting that clitocine inhibits drug-resistant cancer cell growth through induction of apoptosis. |
2014-11-12 |
2023-08-12 |
human |
| Jian-Guo Sun, Hua Li, Xia Li, Xueli Zeng, Ping Wu, Kwok-Pui Fung, Fei-Yan Li. Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo. Apoptosis : an international journal on programmed cell death. vol 19. issue 5. 2014-11-12. PMID:24563182. |
over-expression of mcl-1 reversed the activation of bax and attenuated clitocine-induced apoptosis, suggesting that clitocine-induced apoptosis was at least partially by inducing mcl-1 degradation to release bax and bak. |
2014-11-12 |
2023-08-12 |
human |
| Sanjeev Shukla, Pingfu Fu, Sanjay Gupt. Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70-Bax interaction in prostate cancer. Apoptosis : an international journal on programmed cell death. vol 19. issue 5. 2014-11-12. PMID:24563225. |
apigenin treatment resulted in the inhibition of class i histone deacetylases and hdac1 protein expression, thereby increasing the acetylation of ku70 and the dissociation of bax resulting in apoptosis of cancer cells. |
2014-11-12 |
2023-08-12 |
mouse |
| Chang-Dong Wang, Cheng-Fu Yuan, You-Quan Bu, Xiang-Mei Wu, Jin-Yuan Wan, Li Zhang, Ning Hu, Xian-Jun Liu, Yong Zu, Ge-Li Liu, Fang-Zhou Son. Fangchinoline inhibits cell proliferation via Akt/GSK-3beta/ cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 2. 2014-11-12. PMID:24568493. |
furthermore, fan induced apoptosis by increasing the expression of bax (relative to bcl-2), active caspase 3 and cytochrome-c. |
2014-11-12 |
2023-08-12 |
Not clear |
| Yong Ling, Zhiqiang Wang, Hongyan Zhu, Xuemin Wang, Wei Zhang, Xinyang Wang, Li Chen, Zhangjian Huang, Yihua Zhan. Synthesis and biological evaluation of farnesylthiosalicylamides as potential anti-tumor agents. Bioorganic & medicinal chemistry. vol 22. issue 1. 2014-11-06. PMID:24300920. |
in addition, 10f induced smmc-7721 cell apoptosis, down-regulated the expression of bcl-2 and up-regulated bax and caspase-3. |
2014-11-06 |
2023-08-12 |
human |
| Katharina Korpis, Frauke Weber, Stefanie Brune, Bernhard Wünsch, Patrick J Bednarsk. Involvement of apoptosis and autophagy in the death of RPMI 8226 multiple myeloma cells by two enantiomeric sigma receptor ligands. Bioorganic & medicinal chemistry. vol 22. issue 1. 2014-11-06. PMID:24331758. |
both compounds induced apoptosis, which was evidenced by nuclear condensation, binding of annexin-v to phosphatidylserine in the outer leaf of the cell membrane, cleavage products of poly(adp-ribose) polymerase-1 (parp-1) and caspase-8 as well as the expression of bcl₂ family members bax, bad and bid. |
2014-11-06 |
2023-08-12 |
human |
| Qian Han, Sze C Yeung, Mary S M Ip, Judith C W Ma. Cellular mechanisms in intermittent hypoxia-induced cardiac damage in vivo. Journal of physiology and biochemistry. vol 70. issue 1. 2014-11-04. PMID:24122132. |
in parallel, there was an increase in apoptosis in the heart of ih-exposed rats, demonstrated by elevations of bax and cleaved caspase-3 protein and tunel staining. |
2014-11-04 |
2023-08-12 |
rat |
| Jianxin Shi, Qingqi Han, Heng Zhao, Chenxi Zhong, Feng Ya. Downregulation of MED23 promoted the tumorigenecity of esophageal squamous cell carcinoma. Molecular carcinogenesis. vol 53. issue 10. 2014-11-03. PMID:23625751. |
mechanistically, knockdown the expression of med23 inhibited cell apoptosis by downregulation of bax, activated caspase 3, activated caspase 9 and upregulation of cyclind1 and bcl2. |
2014-11-03 |
2023-08-12 |
Not clear |
| Lin Chen, Xinbing Wei, Yunfeng Hou, Xiaoqian Liu, Senpeng Li, Baozhu Sun, Xinyong Liu, Huiqing Li. Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats. Neurochemistry international. vol 66. 2014-10-31. PMID:24462584. |
the results showed that administration of cxc195 at the doses of 3mg/kg and 10mg/kg significantly inhibited the apoptosis by decreasing the number of apoptotic cells, decreasing the level of cleaved caspase-3 and bax, and increasing the level of bcl-2 in rats subjected to i/r injury. |
2014-10-31 |
2023-08-12 |
rat |
| Yanyan Du, Hong Zhu, Dongye Li, Lele Wang, Lin Zhang, Yuanyuan Luo, Defeng Pan, Manman Huan. Lentiviral-mediated overexpression of Akt1 reduces anoxia-reoxygenation injury in cardiomyocytes. Cell biology international. vol 38. issue 4. 2014-10-30. PMID:24375547. |
akt1 transfection increased the levels of intracellular p-akt, enhanced the expression of the anti-apoptosis protein bcl-2, and reduced that of the apoptosis protein bax (thereby increasing the bcl-2/bax ratio), and caused some increase in hypoxia-inducible factor1α (hif-1α) and vascular endothelial growth factor (vegf) expression after a/r. |
2014-10-30 |
2023-08-12 |
rat |
| Dan-Ju Luo, Qiong Feng, Zhi-Hao Wang, Dong-Sheng Sun, Qun Wang, Jian-Zhi Wang, Gong-Ping Li. Knockdown of phosphotyrosyl phosphatase activator induces apoptosis via mitochondrial pathway and the attenuation by simultaneous tau hyperphosphorylation. Journal of neurochemistry. vol 130. issue 6. 2014-10-30. PMID:24821282. |
we found that ptpa located in the integral membrane of mitochondria, and knockdown of ptpa induced cell apoptosis in hek293 and n2a cell lines by decreasing mitochondrial membrane potential, which leads to translocation of bax and a simultaneous release of cyt c. in the cells with tau over-expression, ptpa knockdown inactivated pp2a to phosphorylate tau to avoid cell apoptosis which induced by ptpa knockdown. |
2014-10-30 |
2023-08-13 |
mouse |
| b' Robert Domitrovi\\xc4\\x87, Olga Cvijanovi\\xc4\\x87, Vesna \\xc5\\xa0u\\xc5\\xa1ni\\xc4\\x87, Nata\\xc5\\xa1a Katalini\\xc4\\x8. Renoprotective mechanisms of chlorogenic acid in cisplatin-induced kidney injury. Toxicology. vol 324. 2014-10-30. PMID:25043994.' |
additionally, ca significantly suppressed p53, bax active caspase-3, cyclin d1 and microtubule-associated protein 1 light chain 3 isoform b (lc3b) expression, suggesting the inhibition of both apoptosis and autophagy. |
2014-10-30 |
2023-08-13 |
mouse |