| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dana Savulescu, Jiajun Feng, Yueh Shyang Ping, Oliver Mai, Ulrich Boehm, Bin He, Bert W O'Malley, Philippa Melame. Gonadotropin-releasing hormone-regulated prohibitin mediates apoptosis of the gonadotrope cells. Molecular endocrinology (Baltimore, Md.). vol 27. issue 11. 2014-06-17. PMID:24085822. |
phb is required for mitochondrial import of the proapoptotic bax, whose expression is also induced by gnrh-activated c-jun nh2-terminal kinase, as is expression of the bh3-only protein, hrk, and this too plays a role in gnrh-induced apoptosis. |
2014-06-17 |
2023-08-12 |
mouse |
| Xue Zhu, Ke Wang, Kai Zhang, Ling Zhu, Fanfan Zho. Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS/JNK pathway in human breast cancer cells. Toxicology letters. vol 227. issue 1. 2014-06-17. PMID:24680927. |
further knockdown of jnk by sirna could inhibit ziyuglycoside ii-mediated apoptosis with attenuating the up-regulation of bax and fas/fasl as well as the down-regulation of bcl-2. |
2014-06-17 |
2023-08-12 |
human |
| Yi-Ran Huang, Ying-Li Jin, Na Li, Lin-Dan Lei, Fei Yu, Yu-Bo Li, Lin Tao, Qian Zhang, Chang-Qing Gu. [Effects of acupotomy, electroacupuncture or round-sharp acupuncture needle interventions on expression of Bcl-2, Bax, Caspase-3 proteins of rectus femoris in rabbits with knee ostarthritis]. Zhen ci yan jiu = Acupuncture research. vol 39. issue 2. 2014-06-17. PMID:24818492. |
to observe the effect of acupotomy, electroacupuncture (ea) or round-sharp acupuncture needle intervention on the expression of bcl-2,bax and caspase-3 proteins in the rectus femoris in rabbits with knee ostarthritis (koa), so as to explore their mechanisms underlying improvement of braking-induced joint damage from the cellular apoptosis. |
2014-06-17 |
2023-08-13 |
Not clear |
| Minjun Wu, Hua Zhang, Jiehua Hu, Zhiyong Weng, Chenyuan Li, Hong Li, Yan Zhao, Xifan Mei, Fu Ren, Lihua L. Isoalantolactone inhibits UM-SCC-10A cell growth via cell cycle arrest and apoptosis induction. PloS one. vol 8. issue 9. 2014-06-16. PMID:24098753. |
to explain the molecular mechanisms underlying its effects, flow cytometry and western blot analysis showed that the apoptosis was associated with cell cycle arrest during the g1 phase, up-regulation of p53 and p21, and down-regulation of cyclin d. furthermore, our results revealed that induction of apoptosis through a mitochondrial pathway led to up-regulation of pro-apoptotic protein expression (bax), down-regulation of anti-apoptotic protein expression (bcl-2), mitochondrial release of cytochrome c (cyto c), reduction of mitochondrial membrane potential (mmp) and activation of caspase-3 (casp-3). |
2014-06-16 |
2023-08-12 |
Not clear |
| Lamia Hamdan, Zoheir Arrar, Yacoub Al Muataz, Lutfi Suleiman, Claude Négrier, Joseph Kajima Mulengi, Habib Boukerch. Alpha cyano-4-hydroxy-3-methoxycinnamic acid inhibits proliferation and induces apoptosis in human breast cancer cells. PloS one. vol 8. issue 9. 2014-06-15. PMID:24039831. |
induction of apoptosis correlated with an increase in bax protein, an established inducer of programmed cell death, and the ratio of bax to bcl-2, an established inhibitor of apoptosis. |
2014-06-15 |
2023-08-12 |
human |
| M Salmanidis, G Brumatti, N Narayan, B D Green, J A van den Bergen, J J Sandow, A G Bert, N Silke, R Sladic, H Puthalakath, L Rohrbeck, T Okamoto, P Bouillet, M J Herold, G J Goodall, A M Jabbour, P G Eker. Hoxb8 regulates expression of microRNAs to control cell death and differentiation. Cell death and differentiation. vol 20. issue 10. 2014-06-12. PMID:23872792. |
apoptosis was dependant on bax and bak and, in part, on bim, which was repressed by hoxb8. |
2014-06-12 |
2023-08-12 |
Not clear |
| Michelle Hanthequeste Bittencourt dos Santos, Andréia Ferreira Eduardo da Costa, Beatriz Jandre Ferreira, Simone Lima Souza, Pamella da Silva Lannes, Gabriela Silva Santos, Ana Luiza Mattos-Guaraldi, Prescilla Emy Naga. A phosphoramidon-sensitive metalloprotease induces apoptosis of human endothelial cells by Group B Streptococcus. Antonie van Leeuwenhoek. vol 104. issue 6. 2014-06-12. PMID:24052367. |
gbs and cs induced huvec death by apoptosis (76.5 and 32 %, respectively) with an increasing pro-apoptotic bax expression and decreasing anti-apoptotic bcl-2 expression. |
2014-06-12 |
2023-08-12 |
human |
| M Kvansakul, M G Hind. Structural biology of the Bcl-2 family and its mimicry by viral proteins. Cell death & disease. vol 4. 2014-06-12. PMID:24201808. |
in contrast, our understanding of the mode of action of bax and bak, the two necessary proteins for apoptosis is incomplete. |
2014-06-12 |
2023-08-12 |
Not clear |
| P M Vidal, E Lemmens, A Avila, T Vangansewinkel, A Chalaris, S Rose-John, S Hendri. ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice. Cell death & disease. vol 4. 2014-06-12. PMID:24336074. |
surprisingly, although blocking adam17 in vivo does not substantially change the ratio between membrane-bound and soluble tnf-α, it increases expression of the pro-apoptotic marker bax and microglial apoptosis while impairing functional recovery after sci. |
2014-06-12 |
2023-08-12 |
mouse |
| Yuehui Hong, Yuting Zhou, Ying Wang, Shunhua Xiao, D Joshua Liao, Qing Zha. PPARγ mediates the effects of WIN55,212-2, an synthetic cannabinoid, on the proliferation and apoptosis of the BEL-7402 hepatocarcinoma cells. Molecular biology reports. vol 40. issue 11. 2014-06-11. PMID:24062073. |
moreover, win could cause apoptosis of the cells via up-regulation of bax expression, down-regulation of bcl-2 expression, induction of the mitochondrial membrane potential, increase of caspase-3, -8 and -9 activities, and induction of the cleavage of caspase-3 and poly-adp-ribose polymerase (parp). |
2014-06-11 |
2023-08-12 |
human |
| Wen-Jing Li, Shan-Liang Zhong, Yuan-Jian Wu, Wei-Dong Xu, Jin-Jin Xu, Jin-Hai Tang, Jian-Hua Zha. Systematic expression analysis of genes related to multidrug-resistance in isogenic docetaxel- and adriamycin-resistant breast cancer cell lines. Molecular biology reports. vol 40. issue 11. 2014-06-11. PMID:24078162. |
some key genes on the pathways related to drug resistance (including drug-transporters: mdr1, mrp1 and bcrp; drug metabolizing-enzymes: cyp3a4 and glutathione s-transferases (gst) pi; target genes: topoisomerase ii (topoiiα) and tubb3; apoptosis genes: bcl-2 and bax) were analyzed at rna and protein expression levels by real time rt-qpcr and western blot, respectively. |
2014-06-11 |
2023-08-12 |
human |
| Jing J Wang, Wei Zhang, Barbara J S Sanderso. Altered mRNA expression related to the apoptotic effect of three xanthones on human melanoma SK-MEL-28 cell line. BioMed research international. vol 2013. 2014-06-11. PMID:24175297. |
the molecular mechanisms were investigated by qrt-pcr for mrna related to cell cycle arrest in g1 phase (p21(waf1) and cyclin d1), apoptosis (cytochrome c, bcl-2, and bax), and survival pathways (akt1, nfκb, and iκbα). |
2014-06-11 |
2023-08-12 |
human |
| Wei Lv, Yan Zhang, Guangju Guan, Peng Li, Jianping Wang, Dong Q. Mycophenolate mofetil and valsartan inhibit podocyte apoptosis in streptozotocin-induced diabetic rats. Pharmacology. vol 92. issue 3-4. 2014-06-10. PMID:24158161. |
to investigate the effects of mycophenolate mofetil on apoptosis and the expression of bax and bcl-2 of podocytes in rats with diabetic nephropathy. |
2014-06-10 |
2023-08-12 |
rat |
| Mothanna Sadiq Al-Qubaisi, Abdullah Rasedee, Moayad Husein Flaifel, Sahrim Hj Ahmad, Samer Hussein-Al-Ali, Mohd Zobir Hussein, Zulkarnain Zainal, Fatah H Alhassan, Yun H Taufiq-Yap, Eltayeb E M Eid, Ismail Adam Arbab, Bandar A Al-Asbahi, Thomas J Webster, Mohamed Ezzat El Zowalat. Induction of apoptosis in cancer cells by NiZn ferrite nanoparticles through mitochondrial cytochrome C release. International journal of nanomedicine. vol 8. 2014-06-09. PMID:24204141. |
our results indicate that nizn ferrite nanoparticles promote apoptosis in cancer cells via caspase-3 and caspase-9, downregulation of bcl-2, and upregulation of bax and p53, with cytochrome c translocation. |
2014-06-09 |
2023-08-12 |
Not clear |
| Shixiong Ding, Airong Hu, Yaoren Hu, Jianbo Ma, Pengjian Weng, Jinhua Da. Anti-hepatoma cells function of luteolin through inducing apoptosis and cell cycle arrest. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 4. 2014-06-09. PMID:24287949. |
and the mechanism maybe through arresting cell cycle at phase g1/s, enhancing bax level, reducing anti-apoptotic protein bcl-2 level, resulting in activating caspase-3 enzyme and decrease of mitochondrial membrane potential, and finally leading to cell apoptosis. |
2014-06-09 |
2023-08-12 |
Not clear |
| Ylermi Soini, M Eskelinen, P Juvonen, V Kärjä, K M Haapasaari, A Saarela, P Karihtal. Strong claudin 5 expression is a poor prognostic sign in pancreatic adenocarcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 4. 2014-06-09. PMID:24519061. |
the results were correlated with patient prognosis, with claudin 5 expression in blood vessels, with the expression level of bcl2 and bax and with apoptosis. |
2014-06-09 |
2023-08-12 |
Not clear |
| Ylermi Soini, M Eskelinen, P Juvonen, V Kärjä, K M Haapasaari, A Saarela, P Karihtal. Strong claudin 5 expression is a poor prognostic sign in pancreatic adenocarcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 4. 2014-06-09. PMID:24519061. |
claudin 5 also associated with a higher extent of apoptosis and greater expression of bax protein. |
2014-06-09 |
2023-08-12 |
Not clear |
| Ylermi Soini, M Eskelinen, P Juvonen, V Kärjä, K M Haapasaari, A Saarela, P Karihtal. Strong claudin 5 expression is a poor prognostic sign in pancreatic adenocarcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 4. 2014-06-09. PMID:24519061. |
the association of claudin 5 with apoptosis and bax might be due to stronger cellular kinetics found in such tumours. |
2014-06-09 |
2023-08-12 |
Not clear |
| Hao Li, Xin Xiang Li, Qing Ma, Jia Cu. The variability of oxLDL-induced cytotoxicity on different types of cell lines. Cell biochemistry and biophysics. vol 67. issue 2. 2014-06-07. PMID:23479334. |
cells apoptosis is mediated by reducing bcl-2 and increasing bax and caspase-3 mrna and protein expression. |
2014-06-07 |
2023-08-12 |
human |
| Jitender Monga, Saurabh Pandit, Chetan Singh Chauhan, Manu Sharm. Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 7-8. 2014-06-07. PMID:23706674. |
the induction of apoptosis is correlated with the increased mrna expressions of p53, bax, and caspase-3, -7, -8 and -9 and decreased mrna expressions of bcl-2. |
2014-06-07 |
2023-08-12 |
human |