| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel Morales-Cano, Eva Calviño, Virginia Rubio, Angel Herráez, Pilar Sancho, M Cristina Tejedor, José C Die. Apoptosis induced by paclitaxel via Bcl-2, Bax and caspases 3 and 9 activation in NB4 human leukaemia cells is not modulated by ERK inhibition. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 7-8. 2014-06-07. PMID:23735541. |
apoptosis induced by paclitaxel via bcl-2, bax and caspases 3 and 9 activation in nb4 human leukaemia cells is not modulated by erk inhibition. |
2014-06-07 |
2023-08-12 |
human |
| S Zahra Bathaie, Reyhane Hoshyar, Hamidreza Miri, Majid Sadeghizade. Anticancer effects of crocetin in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 91. issue 6. 2014-06-06. PMID:24219281. |
flow cytometry and caspases activity assays revealed apoptosis had been induced in these cells; rt-pcr and western blot analyses revealed the suppression of bcl-2 and up-regulation of bax expression in ags cells treated with crocetin. |
2014-06-06 |
2023-08-12 |
human |
| Xiongxiong Liu, Chao Sun, Xiaodong Jin, Ping Li, Fei Ye, Ting Zhao, Li Gong, Qiang L. Genistein enhances the radiosensitivity of breast cancer cells via G₂/M cell cycle arrest and apoptosis. Molecules (Basel, Switzerland). vol 18. issue 11. 2014-06-06. PMID:24284485. |
the combined treatment obviously up-regulated the phosphorylation of atm, chk2, cdc25c and cdc2, leading to permanent g₂/m phase arrest, and up-regulated bax and p73, down-regulated bcl-2, finally induced mitochondria-mediated apoptosis in both cell lines. |
2014-06-06 |
2023-08-12 |
human |
| Cam Ngoc Nguyen, Hye-Eun Kim, Seong-Gene Le. Caffeoylserotonin protects human keratinocyte HaCaT cells against H2 O2 -induced oxidative stress and apoptosis through upregulation of HO-1 expression via activation of the PI3K/Akt/Nrf2 pathway. Phytotherapy research : PTR. vol 27. issue 12. 2014-06-05. PMID:23418094. |
h2 o2 induced apoptosis in the cells through activation of pro-apoptotic p21, bax, and caspase-3. |
2014-06-05 |
2023-08-12 |
human |
| Chibo Liu, Lihui Yin, Jiaqi Chen, Jiayu Che. The apoptotic effect of shikonin on human papillary thyroid carcinoma cells through mitochondrial pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 3. 2014-06-03. PMID:24081676. |
shikonin can inhibit k1 and w3 cell proliferation in a dose- and time-dependent manner, enhance bax levels, reduce anti-apoptotic protein bcl-2 levels, result in decreasing mitochondrial membrane potential and activating caspase-3 enzyme, and finally lead to apoptosis. |
2014-06-03 |
2023-08-12 |
human |
| Li Ding, Yong Huang, Qian Du, Feng Dong, Xiaomin Zhao, Wenlong Zhang, Xingang Xu, Dewen Ton. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochemical and biophysical research communications. vol 445. issue 2. 2014-06-03. PMID:24548406. |
moreover, the expression of tgev n gene promoted translocation of bax to mitochondria, which in turn caused the release of cytochrome c, followed by activation of caspase-3, resulting in cell apoptosis in the transfected pk-15 cells following cell cycle arrest. |
2014-06-03 |
2023-08-12 |
Not clear |
| Li Ding, Yong Huang, Qian Du, Feng Dong, Xiaomin Zhao, Wenlong Zhang, Xingang Xu, Dewen Ton. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochemical and biophysical research communications. vol 445. issue 2. 2014-06-03. PMID:24548406. |
further studies showed that p53 inhibitor attenuated tgev n protein induced cell cycle arrest at s and g2/m phases and apoptosis through reversing the expression changes of cdc2, cdk2 and cyclin b1 and the translocation changes of bax and cytochrome c induced by tgev n protein. |
2014-06-03 |
2023-08-12 |
Not clear |
| Fan Chen, Yong-gang Cao, Han-ping Qi, Lei Li, Wei Huang, Ye Wang, Hong-li Su. Involvement of cardiomyocyte apoptosis in myocardial injury of hereditary epileptic rats. Canadian journal of physiology and pharmacology. vol 91. issue 10. 2014-06-02. PMID:24144051. |
further investigation revealed that apoptosis was mediated by reducing bcl-2, upregulating bax, and activating caspase-3. |
2014-06-02 |
2023-08-12 |
rat |
| Vijayalakshmi Sridharan, Nukhet Aykin-Burns, Preeti Tripathi, Kimberly J Krager, Sunil K Sharma, Eduardo G Moros, Peter M Corry, Grazyna Nowak, Martin Hauer-Jensen, Marjan Boerm. Radiation-induced alterations in mitochondria of the rat heart. Radiation research. vol 181. issue 3. 2014-06-02. PMID:24568130. |
at time points from 6 h to 9 months after a cardiac dose of 21 gy, the following analyses were performed: left ventricular bax and bcl-2 protein levels; apoptosis; mitochondrial inner membrane potential and mptp opening; mitochondrial mass and expression of mitophagy mediators parkin and pten induced putative kinase-1 (pink-1); mitochondrial respiration and protein levels of succinate dehydrogenase a (sdha); and the 70 kda subunit of complex ii. |
2014-06-02 |
2023-08-12 |
rat |
| Nan Wang, Lei Wu, Yanjun Cao, Yuanji Wang, Yanmin Zhan. The protective activity of imperatorin in cultured neural cells exposed to hypoxia re-oxygenation injury via anti-apoptosis. Fitoterapia. vol 90. 2014-05-29. PMID:23856091. |
our data had shown that imperatorin reduced the number of apoptosis cells after ogd-r, this effect was associated with the inhibition of the apoptosis factors bax and caspase-3, and the upregulation of anti-apoptosis factor bcl-2. |
2014-05-29 |
2023-08-12 |
Not clear |
| Chang-Qing Guo, Fu-Shui Liu, Hui-Fang Ma, Yan Guo, Chu-Xi Lian. [Effect of acupotomy intervention on cervicomuscular apoptosis in cervical spondylosis rabbits]. Zhen ci yan jiu = Acupuncture research. vol 39. issue 1. 2014-05-29. PMID:24684115. |
to observe the effect of acupotomy therapy on cervicomuscular apoptosis and apoptosis regulator bax protein expression in cervical spondylosis (cs) rabbits so as to investigate its mechanisms underlying improvement of cs. |
2014-05-29 |
2023-08-12 |
Not clear |
| Yu-Jin Ko, Jin-Woo Jeong, Yung-Hyun Choi, Chung-Ho Ry. Soy soluble polysaccharide induces apoptosis in HCT‑116 human colon cancer cells via reactive oxygen species generation. Molecular medicine reports. vol 8. issue 6. 2014-05-28. PMID:24126443. |
induction of apoptotic cell death of hct‑116 cells by ssps showed a correlation with the downregulation of members of the inhibitor of apoptosis protein family, including x‑linked inhibitor of apoptosis protein and antiapoptotic bcl‑2, and upregulation of bax and bad. |
2014-05-28 |
2023-08-12 |
human |
| Lei Lei, Jiao Wang, Zhen Zhang, Hua Zhang, Hong Chen, Dehong Ca. Lipopolysaccharide-induced apoptosis in a murine intestinal endocrine cell line by modulation of Bcl-2, Bax and caspase-3. Molecular medicine reports. vol 8. issue 6. 2014-05-28. PMID:24145669. |
lipopolysaccharide-induced apoptosis in a murine intestinal endocrine cell line by modulation of bcl-2, bax and caspase-3. |
2014-05-28 |
2023-08-12 |
Not clear |
| Elżbieta Płuciennik, Katarzyna Kośla, Katarzyna Wójcik-Krowiranda, Andrzej Bieńkiewicz, Andrzej K Bednare. The WWOX tumor suppressor gene in endometrial adenocarcinoma. International journal of molecular medicine. vol 32. issue 6. 2014-05-27. PMID:24126431. |
quantitative pcr was used to assess the correlation between the expression levels of wwox and the genes involved in the proliferation (mki67), apoptosis (bax, bcl2), signal transduction (egfr), cell cycle (ccne1, ccnd1), cell adhesion (cdh1) and transcription regulation (tp73, ncor1). |
2014-05-27 |
2023-08-12 |
Not clear |
| Junlian Gu, Bo Wang, Yanan Liu, Lingzhi Zhong, Yufeng Tang, Hua Guo, Tao Jiang, Liwei Wang, Yang Li, Lu Ca. Murine double minute 2 siRNA and wild-type p53 gene therapy interact positively with zinc on prostate tumours in vitro and in vivo. European journal of cancer (Oxford, England : 1990). vol 50. issue 6. 2014-05-27. PMID:24447832. |
combined treatments significantly inhibited tumour xenograft growth, retaining wild-type p53 conformation and enhancing its transcriptional regulation of p21 and bax gene expression, leading to the decreased proliferation and increased apoptosis. |
2014-05-27 |
2023-08-12 |
mouse |
| Shang H Lin, Nuval Cherian, Benjamin Wu, Hyo Phee, Christy Cho, Marco Colombin. Bax channel triplet: co-operativity and voltage gating. The Biochemical journal. vol 459. issue 2. 2014-05-27. PMID:24498874. |
bax, despite being a cytosolic protein, has the distinct ability to form channels in the mitochondrial outer membrane, which are capable of releasing proteins that initiate the execution phase of apoptosis. |
2014-05-27 |
2023-08-12 |
Not clear |
| Hasan Riaz, Ping Dong, Muhammad Shahzad, Liguo Yan. Constitutive and follicle-stimulating hormone-induced action of somatostatin receptor-2 on regulation of apoptosis and steroidogenesis in bovine granulosa cells. The Journal of steroid biochemistry and molecular biology. vol 141. 2014-05-27. PMID:24530462. |
furthermore, silencing of sstr2 reduced gcs apoptosis (52.5%, p<0.05) and increased cell proliferation, which was further corroborated by up-regulation in protein expressions of b-cell leukemia/lymphoma 2 (bcl-2), inhibition of caspase3 and mrna level of bcl2-associated-x protein (bax). |
2014-05-27 |
2023-08-12 |
cattle |
| Xin Zhao, Jia-Le Song, Jong-Deog Kim, Jong-Suk Lee, Kun-Young Par. Fermented Pu-erh tea increases in vitro anticancer activities in HT-29 cells and has antiangiogenetic effects on HUVECs. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 32. issue 4. 2014-05-27. PMID:24579782. |
fermented pu-erh tea x induced apoptosis indicated by increased expression of bax, caspase-9, and caspase-3 messenger rna and decreased expression of bcl-2. |
2014-05-27 |
2023-08-12 |
human |
| Wei Song, Wenyong Liu, Xufeng Niu, Qingchun Wang, Lianwen Sun, Meili Liu, Yubo Fa. Three-dimensional morphometric comparison of normal and apoptotic endothelial cells based on laser scanning confocal microscopy observation. Microscopy research and technique. vol 76. issue 11. 2014-05-26. PMID:23955846. |
the results reveal that h2 o2 can induce apoptosis effectively by regulating the activity of apoptosis-related biomolecules, including pro-apoptotic factors p53 and bax, and anti-apoptotic factor bcl-2. |
2014-05-26 |
2023-08-12 |
human |
| Giorgia Gioacchini, Luisa Dalla Valle, Francesca Benato, Gian Maria Fimia, Roberta Nardacci, Fabiola Ciccosanti, Mauro Piacentini, Andrea Borini, Oliana Carneval. Interplay between autophagy and apoptosis in the development of Danio rerio follicles and the effects of a probiotic. Reproduction, fertility, and development. vol 25. issue 8. 2014-05-22. PMID:23195281. |
the increased autophagy in preovulatory follicles from females fed the probiotic was concomitant with a decrease in the apoptotic process in the ovary, as evidenced by terminal deoxyribonucleotidyl transferase-mediated dutp-digoxigenin nick end-labelling analysis and confirmed by lower expression of genes involved in apoptosis (i.e., p53, bax, apaf and cas3) and higher expression as igfii and igf1r. |
2014-05-22 |
2023-08-12 |
zebrafish |