| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shouying Li, Shumin Yang, Geng Chen, Xiaodong Li, Jia Chen, Yuguang Ma, Yuguang M. Mechanism of cellular uptake, localization and cytotoxicity of organic nanoparticles. Journal of nanoscience and nanotechnology. vol 14. issue 5. 2014-05-13. PMID:24734543. |
our results demonstrated that the cells treated with dpa-tsb nps showed an increase in apoptosis accompanied by the increased expression of bax protein, decreased expression of bcl-2 protein and caspase-3 protein, the decreased mitochondrial membrane potential and the release of ros. |
2014-05-13 |
2023-08-13 |
Not clear |
| Kazim Husain, Barbara A Centeno, Dung-Tsa Chen, Sunil R Hingorani, Said M Sebti, Mokenge P Malaf. Vitamin E δ-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer. Cancer prevention research (Philadelphia, Pa.). vol 6. issue 10. 2014-05-12. PMID:23963802. |
biomarkers of apoptosis (plasma ck18), parp1 cleavage, and bax expression were more greatly induced in tumors subjected to combined treatment versus individual treatment. |
2014-05-12 |
2023-08-12 |
mouse |
| Kuppusamy Tamilselvam, Nady Braidy, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Nagarajan Rajendra Prasad, Subburayan Karthikeyan, Arokyasamy Justin Thenmozhi, Subash Selvaraju, Gilles J Guillemi. Neuroprotective effects of hesperidin, a plant flavanone, on rotenone-induced oxidative stress and apoptosis in a cellular model for Parkinson's disease. Oxidative medicine and cellular longevity. vol 2013. 2014-05-12. PMID:24205431. |
apoptosis was determined in normal, rotenone, and hesperidin treated cells, by measuring the protein expression of cytochrome c (cyt c), caspases 3 and 9, bax, and bcl-2 using the standard western blotting technique. |
2014-05-12 |
2023-08-12 |
human |
| Kuppusamy Tamilselvam, Nady Braidy, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Nagarajan Rajendra Prasad, Subburayan Karthikeyan, Arokyasamy Justin Thenmozhi, Subash Selvaraju, Gilles J Guillemi. Neuroprotective effects of hesperidin, a plant flavanone, on rotenone-induced oxidative stress and apoptosis in a cellular model for Parkinson's disease. Oxidative medicine and cellular longevity. vol 2013. 2014-05-12. PMID:24205431. |
the apoptosis in rotenone-induced sk-n-sh cells was accompanied by the loss of mitochondrial membrane potential, increased ros generation, the depletion of gsh, enhanced activities of enzymatic antioxidants, upregulation of bax, cyt c, and caspases 3 and 9, and downregulation of bcl-2, which were attenuated in the presence of hesperidin. |
2014-05-12 |
2023-08-12 |
human |
| Haitao Liu, Feng Hou, Haiying Liang, Guocheng Liu, Yunfei L. Effects of diagnostic ultrasound on HSP70 expression in chorionic villi in rats during early pregnancy and the role of HSP70 in apoptosis in chorionic villi. International journal of molecular medicine. vol 32. issue 5. 2014-05-09. PMID:24026294. |
using tunel, rt-pcr, western blot analysis and immunohistochemistry, the extent of apoptosis and the gene/protein expression of hsp70, bcl-2 and bax was determined in the samples of the chorionic villus from the rats during early pregnancy. |
2014-05-09 |
2023-08-12 |
rat |
| Yuangang Wang, Haifeng Tang, Yun Zhang, Juan Li, Bo Li, Zhenhui Gao, Xiaoyang Wang, Guang Cheng, Zhou Fe. Saponin B, a novel cytostatic compound purified from Anemone taipaiensis, induces apoptosis in a human glioblastoma cell line. International journal of molecular medicine. vol 32. issue 5. 2014-05-09. PMID:24048272. |
treatment with saponin b activated the receptor-mediated pathway of apoptosis, as western blot analysis revealed the activation of fas-l. saponin b increased the bax and caspase-3 ratio and decreased the protein expression of bcl-2. |
2014-05-09 |
2023-08-12 |
human |
| Saeed Esmaeili-Mahani, Farzaneh Falahi, Mohammad Mehdi Yaghoob. Proapoptotic and Antiproliferative Effects of Thymus caramanicus on Human Breast Cancer Cell Line (MCF-7) and Its Interaction with Anticancer Drug Vincristine. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-05-09. PMID:24812569. |
biochemical markers of apoptosis (caspase 3, bax, and bcl-2) and cell proliferation (cyclin d1) were evaluated by immunoblotting. |
2014-05-09 |
2023-08-13 |
human |
| Maidong Li, Shuwen Han, Gang Zhang, Ying Wang, Zhaoning J. Antiproliferative activity and apoptosis-inducing mechanism of L-securinine on human breast cancer MCF-7 cells. Die Pharmazie. vol 69. issue 3. 2014-05-08. PMID:24716413. |
real-time quantitative pcr was conducted to evaluate expression levels of apoptosis related genes p53, bax, bcl-2, mtor, p70s6k. |
2014-05-08 |
2023-08-13 |
human |
| Yanzhe Xia, Jie Chen, Yuan Cao, Chenshu Xu, Ruiming Li, Yuhua Pan, Xiao Che. Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX-2. European journal of pharmacology. vol 714. issue 1-3. 2014-05-06. PMID:23791612. |
the apoptosis of lx-2 cells was induced by wedelolactone accompanied with the decreasing expression of anti-apoptotic bcl-2 and increasing expression of pro-apoptotic bax. |
2014-05-06 |
2023-08-12 |
human |
| Kun Yao, Ying Yang, Rong Hu, Miao Miao, Ai-Jun Liao, Wei Yang, Zhuo-Gang Li. [Influence of TIEG1 on apoptosis of HL-60 cells and expression of Bcl-2/Bax]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 3. 2014-05-05. PMID:23815903. |
during the course of cell apoptosis, bax expression increased, but bcl-2 expression decreased (p < 0.05). |
2014-05-05 |
2023-08-12 |
Not clear |
| Xueting Wang, Yu Chen, Xintong Zuo, Naiqing Ding, Huijuan Zeng, Xiang Zou, Xiaodong Ha. Microcystin (-LR) induced testicular cell apoptosis via up-regulating apoptosis-related genes in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 60. 2014-05-05. PMID:23891578. |
in conclusion, p53, bcl-2, bax, caspase 3 and caspase 8 are involved in the regulation of mc-lr-induced apoptosis of testicular cells. |
2014-05-05 |
2023-08-12 |
mouse |
| Liping Ma, Cuili Qin, Mingchun Wang, Dan Gan, Lin Cao, Hong Ye, Xiaoxiong Zen. Preparation, preliminary characterization and inhibitory effect on human colon cancer HT-29 cells of an acidic polysaccharide fraction from Stachys floridana Schuttl. ex Benth. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 60. 2014-05-05. PMID:23911803. |
these results indicated that sfpsa might induce apoptosis of ht-29 cells through regulation of apoptosis-associated gene expressions such as bcl-2, bax and p53 and the activation of caspase-3. |
2014-05-05 |
2023-08-12 |
human |
| Kyung-No Son, Zhiguo Liang, Howard L Lipto. Mutation of the Theiler's virus leader protein zinc-finger domain impairs apoptotic activity in murine macrophages. Virus research. vol 177. issue 2. 2014-05-05. PMID:24036175. |
a functional l zinc-finger domain was also required for activation of p38 mapk that results in phosphorylation and activation of p53, and in turn, alteration of the conformation of the anti-apoptotic proteins puma and mcl-1, leading to the release of pro-apoptotic bax and apoptosis through the intrinsic pathway. |
2014-05-05 |
2023-08-12 |
Not clear |
| Nguyen Phuong Thao, Nguyen Xuan Cuong, Bui Thi Thuy Luyen, Nguyen Hoai Nam, Pham Van Cuong, Nguyen Van Thanh, Nguyen Xuan Nhiem, Tran Thi Hong Hanh, Eun-Ji Kim, Hee-Kyoung Kang, Phan Van Kiem, Chau Van Minh, Young Ho Ki. Steroidal constituents from the starfish Astropecten polyacanthus and their anticancer effects. Chemical & pharmaceutical bulletin. vol 61. issue 10. 2014-05-02. PMID:24088696. |
investigations for the possible mechanism underlying the induction of apoptosis showed that ch₂cl₂ fraction or compound 7 induced apoptosis through down-regulation of bcl-2, up-regulation of bax, cleavage of caspase-9, cleavage of caspase-3 and cleavage of poly(adp-ribose) polymerase (parp) in hl-60 cells. |
2014-05-02 |
2023-08-12 |
human |
| Eun-Seok Park, Jae-Myung Yoo, Hwan-Soo Yoo, Do-Young Yoon, Yeo-Pyo Yun, Jintae Hon. IL-32γ enhances TNF-α-induced cell death in colon cancer. Molecular carcinogenesis. vol 53 Suppl 1. 2014-05-01. PMID:23255489. |
the il-32γ-overexpressing colon cancer cells further increased tnf-α-mediated expression of p38 mapk as well as that of bax, cleaved caspase-3 and -9, but decreased that of antiapoptotic proteins such as bcl-2, cellular inhibitor of apoptosis protein (iap) and x chromosome iap. |
2014-05-01 |
2023-08-12 |
mouse |
| Yu-Ping Wei, Hai Bai, Yan-Qing Sun, Shen Bao, Rui Xi, Lin Li. [Effect of salidroside on apoptosis of bone marrow mesenchymal stem cells induced by ara-C]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 6. 2014-05-01. PMID:24370051. |
the apoptosis of hbmmsc treated with salidroside were significantly higher as compared with control group (p < 0.05); rt-pcr results demonstrated that the bcl-2 expression was significantly down regulated but bax mrna expressions was up-regulated in ara- c group as compared with those in the control group. |
2014-05-01 |
2023-08-12 |
human |
| Yu-Ping Wei, Hai Bai, Yan-Qing Sun, Shen Bao, Rui Xi, Lin Li. [Effect of salidroside on apoptosis of bone marrow mesenchymal stem cells induced by ara-C]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 6. 2014-05-01. PMID:24370051. |
salidroside significantly inhibited the apoptosis of msc and reversed the mrna expression of bcl-2 and bax. |
2014-05-01 |
2023-08-12 |
human |
| Feng Wang, Lin Chen, Hongbin Ni, Guihua Wang, Weifeng Ding, Hui Cong, Shaoqing Ju, Shumei Yang, Huimin Wan. APRIL depletion induces cell cycle arrest and apoptosis through blocking TGF-β1/ERK signaling pathway in human colorectal cancer cells. Molecular and cellular biochemistry. vol 383. issue 1-2. 2014-04-29. PMID:23867993. |
herein, we demonstrated that april depletion by using rna interference in human colorectal cancer (crc) colo 205 and sw480 cells resulted in cell proliferation inhibition and evoked cell cycle arrest in g0/g1 phase and apoptosis, coupled with decrease in cdk2, cyclin d1, bcl-2 expression and an increase of p21 and bax expression. |
2014-04-29 |
2023-08-12 |
human |
| Hongda Lu, Zhang Lei, Zhongxin Lu, Qianming Lu, Chi Lu, Weiqun Chen, Chun Wang, Qiu Tang, Qingzhi Kon. Silencing tankyrase and telomerase promotes A549 human lung adenocarcinoma cell apoptosis and inhibits proliferation. Oncology reports. vol 30. issue 4. 2014-04-29. PMID:23933993. |
further studies showed that ashtert and astanks-promoted a549 apoptosis was not mediated by downregulation of the expression of the anti-apoptotic gene bcl-2 or upregulation of the expression of the pro-apoptotic gene bax, but by adjusting the two isoforms proportion of myeloid cell leukemia-1 (mcl-1) which can interact with tankyrase directly. |
2014-04-29 |
2023-08-12 |
mouse |
| Yu-ting Chen, Xiang-chen Song, Fu-ping Zhang, Min Lian. [Expression of Bim, Bax and Bak in the process of gingipain-induced osteoblast apoptosis]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. vol 48. issue 5. 2014-04-28. PMID:24004622. |
[expression of bim, bax and bak in the process of gingipain-induced osteoblast apoptosis]. |
2014-04-28 |
2023-08-12 |
Not clear |