| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anupam Bishayee, Animesh Mandal, Roslin J Thoppil, Altaf S Darvesh, Deepak Bhati. Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. International journal of cancer. vol 133. issue 5. 2013-10-23. PMID:23404339. |
amr-me dose-dependently suppressed abnormal cell proliferation, induced apoptosis, up-regulated pro-apoptotic protein bax and down-regulated antiapoptotic protein bcl-2 in mammary tumors. |
2013-10-23 |
2023-08-12 |
human |
| M Ruscica, M Arvigo, L Steffani, D Ferone, P Magn. Somatostatin, somatostatin analogs and somatostatin receptor dynamics in the biology of cancer progression. Current molecular medicine. vol 13. issue 4. 2013-10-22. PMID:22934849. |
these compounds may control tumor development, cell proliferation and metastatization by direct actions, including cell division arrest in g0/g1 phase (i.e., induction of cyclin-dependent kinase inhibitor p27(kip1) or p21(cip1)), induction of apoptosis (i.e., induction of p53 and bax) and suppression of cell invasion. |
2013-10-22 |
2023-08-12 |
Not clear |
| Junjun Zhou, Yi Sun, Xin Zhao, Zheng Deng, Xiaoping P. 3-O-demethylswertipunicoside inhibits MPP⁺-induced oxidative stress and apoptosis in PC12 cells. Brain research. vol 1508. 2013-10-22. PMID:23499562. |
moreover, 3-ods also attenuated mpp(+)-induced apoptosis by inhibiting bax and bcl-2 expressions, activating caspase-9, caspase-3, poly (adp-ribose) polymerase-1 (parp-1) cleavage, apoptosis-inducing factor (aif) translocation and α-synuclein expression. |
2013-10-22 |
2023-08-12 |
Not clear |
| Anna V Miller, Mark A Hicks, Wataru Nakajima, Amanda C Richardson, Jolene J Windle, Hisashi Harad. Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor. PloS one. vol 8. issue 4. 2013-10-22. PMID:23577147. |
paclitaxel-induced apoptosis is bak-dependent, but bax and bim-independent in breast tumor. |
2013-10-22 |
2023-08-12 |
mouse |
| Anna V Miller, Mark A Hicks, Wataru Nakajima, Amanda C Richardson, Jolene J Windle, Hisashi Harad. Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor. PloS one. vol 8. issue 4. 2013-10-22. PMID:23577147. |
however, paclitaxel sensitivity was not affected in bax(-/-) mefs or in human breast cancer cells in which bax was down-regulated, suggesting that paclitaxel-induced apoptosis is bak-dependent, but bax-independent. |
2013-10-22 |
2023-08-12 |
mouse |
| Praveen K Sobhan, Mahendra Seervi, Lokesh Deb, Saneesh Varghese, Anjana Soman, Jeena Joseph, Krupa Ann Mathew, Godi Raghu, George Thomas, Sreekumar E, Manjula S, Santosh Kumar T . Calpain and reactive oxygen species targets Bax for mitochondrial permeabilisation and caspase activation in zerumbone induced apoptosis. PloS one. vol 8. issue 4. 2013-10-22. PMID:23593137. |
calpain and reactive oxygen species targets bax for mitochondrial permeabilisation and caspase activation in zerumbone induced apoptosis. |
2013-10-22 |
2023-08-12 |
Not clear |
| Praveen K Sobhan, Mahendra Seervi, Lokesh Deb, Saneesh Varghese, Anjana Soman, Jeena Joseph, Krupa Ann Mathew, Godi Raghu, George Thomas, Sreekumar E, Manjula S, Santosh Kumar T . Calpain and reactive oxygen species targets Bax for mitochondrial permeabilisation and caspase activation in zerumbone induced apoptosis. PloS one. vol 8. issue 4. 2013-10-22. PMID:23593137. |
zerumbone failed to induce apoptosis or mitochondrial permeabilisation in bax knockout cells and over-expression of bax enhanced cell death induced by zerumbone confirming the essential role of bax for mitochondrial permeabilsation. |
2013-10-22 |
2023-08-12 |
Not clear |
| Hua-Sheng Ding, Jun Yang, Ping Chen, Jian Yang, Sun-Qing Bo, Jia-Wang Ding, Qin-Qin Y. The HMGB1-TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis. Gene. vol 527. issue 1. 2013-10-22. PMID:23727604. |
the myocardial infarct size, hmgb1 levels, apoptosis index, bax, bcl-2 and tnf-α mrna levels were assessed. |
2013-10-22 |
2023-08-12 |
mouse |
| Minjing Zhang, Zhuangwei Qiu, Yinyu Li, Yan Yang, Qihao Zhang, Qi Xiang, Zhijian Su, Yadong Huan. Construction and characterization of a recombinant human beta defensin 2 fusion protein targeting the epidermal growth factor receptor: in vitro study. Applied microbiology and biotechnology. vol 97. issue 9. 2013-10-21. PMID:22903275. |
moreover, hbd2-4d5 could also mediate apoptosis of skbr-3 cells by up-regulating the ratio of bax to bcl-2. |
2013-10-21 |
2023-08-12 |
human |
| Muneeb U Rehman, Mir Tahir, Abdul Quaiyoom Khan, Rehan Khan, Abdul Lateef, Oday O Hamiza, Farrah Ali, Sarwat Sultan. Diosmin protects against trichloroethylene-induced renal injury in Wistar rats: plausible role of p53, Bax and caspases. The British journal of nutrition. vol 110. issue 4. 2013-10-21. PMID:23402272. |
the animals in groups ii and iii received an oral treatment of dm at doses of 20 and 40 mg/kg body weight, respectively, for twenty consecutive days, while groups i and v were given maize oil (5 ml/kg body weight and dm 40 mg/kg body weight, respectively) for 20 d. the protective effects of dm on tce-induced oxidative stress and caspase-dependent apoptosis were investigated by assaying oxidative stress biomarkers, lipid peroxidation (lpo), serum toxicity markers, alkaline unwinding assay, caspase-3, -7 and -9, bax and p53 expression. |
2013-10-21 |
2023-08-12 |
rat |
| Gary D Stone. Ginger: is it ready for prime time? Cancer prevention research (Philadelphia, Pa.). vol 6. issue 4. 2013-10-21. PMID:23559451. |
on the basis of substantial preclinical data showing the preventive efficacy of ginger and its constituents in vitro and in animal models, as well as a phase i pilot trial indicating that ginger extract is well tolerated in humans, citronberg and colleagues conducted a pilot trial of ginger extract (2 g/day for 28 days) on biomarkers of cell proliferation [human telomerase reverse transcriptase (htert), mib-1], differentiation (p21waf1/cip1), and apoptosis (bax, bcl-2) in colonic mucosa from individuals at high-risk for colorectal cancer. |
2013-10-21 |
2023-08-12 |
human |
| Y Jia, Y-H Lue, R Swerdloff, K-W Lee, L J Cobb, P Cohen, C Wan. The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis. Andrology. vol 1. issue 4. 2013-10-21. PMID:23686888. |
gnrh-a increased germ cell apoptosis and bax in the testicular mitochondrial fractions. |
2013-10-21 |
2023-08-12 |
rat |
| Y Jia, Y-H Lue, R Swerdloff, K-W Lee, L J Cobb, P Cohen, C Wan. The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis. Andrology. vol 1. issue 4. 2013-10-21. PMID:23686888. |
synthetic hn decreased germ cell apoptosis induced by gnrh-a and bax in the mitochondria. |
2013-10-21 |
2023-08-12 |
rat |
| Mi Hee Park, Miran Jo, Dohee Won, Ho Sueb Song, Min Jong Song, Jin Tae Hon. Snake venom toxin from Vipera lebetina turanica sensitizes cancer cells to TRAIL through ROS- and JNK-mediated upregulation of death receptors and downregulation of survival proteins. Apoptosis : an international journal on programmed cell death. vol 17. issue 12. 2013-10-18. PMID:23007278. |
consistent with cell growth inhibition, the expression of trail receptors; dr4 and dr5 was significantly increased as well as apoptosis related proteins such as cleaved caspase-3, -8, -9 and bax. |
2013-10-18 |
2023-08-12 |
Not clear |
| Anju Thoppil Raveendran, Paulose Cheramadatikudiyil Skari. Learning and cognitive deficits in hypoxic neonatal rats intensified by BAX mediated apoptosis: protective role of glucose, oxygen, and epinephrine. The International journal of neuroscience. vol 123. issue 2. 2013-10-17. PMID:22998365. |
learning and cognitive deficits in hypoxic neonatal rats intensified by bax mediated apoptosis: protective role of glucose, oxygen, and epinephrine. |
2013-10-17 |
2023-08-12 |
rat |
| Anju Thoppil Raveendran, Paulose Cheramadatikudiyil Skari. Learning and cognitive deficits in hypoxic neonatal rats intensified by BAX mediated apoptosis: protective role of glucose, oxygen, and epinephrine. The International journal of neuroscience. vol 123. issue 2. 2013-10-17. PMID:22998365. |
topro-3 staining was used to visualize cell loss and real-time polymerase chain reaction (pcr) analysis of bax mrna was used to evaluate the level of apoptosis in the cerebral cortex, cerebellum, brain stem, and striatum of hypoxic neonatal rats and hypoxic rats resuscitated with glucose, oxygen, and epinephrine. |
2013-10-17 |
2023-08-12 |
rat |
| Hu Peng, Huanhai Liu, Shuwei Zhao, Jian Wu, Jingping Fan, Jianchun Lia. Silencing of RASSF3 by DNA hypermethylation is associated with tumorigenesis in somatotroph adenomas. PloS one. vol 8. issue 3. 2013-10-17. PMID:23555615. |
rassf3 overexpression in gh3 and gt1.1 cells inhibited proliferation, induced apoptosis accompanied by increased bax, p53, and caspase-3 protein and decreased bcl-2 protein expression. |
2013-10-17 |
2023-08-12 |
mouse |
| Yun Jeong Kim, Eun Byul Jung, Seong Jun Seo, Kwan Hee Park, Min Won Lee, Chung Soo Le. Quercetin-3-O-(2"-galloyl)-α-l-rhamnopyranoside prevents TRAIL-induced apoptosis in human keratinocytes by suppressing the caspase-8- and Bid-pathways and the mitochondrial pathway. Chemico-biological interactions. vol 204. issue 3. 2013-10-17. PMID:23711929. |
trail triggers apoptosis by inducing a decrease in bid, bcl-2, bcl-xl and survivin protein levels, increase in bax and vdac1 levels, loss of the mitochondrial transmembrane potential, release of cytochrome c, activation of caspases (-8, -9 and -3), cleavage of parp-1, and an increase in the tumor suppressor p53 levels. |
2013-10-17 |
2023-08-12 |
human |
| Shang-ze Li, Hui-hui Zhang, Jia-nong Zhang, Ze-yan Zhang, Xiao-fei Zhang, Xiao-dong Zhang, Run-lei D. ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochemical and biophysical research communications. vol 437. issue 2. 2013-10-17. PMID:23831472. |
in addition, the alln-induced apoptosis response was through bax translocation from cytosol to mitochondria. |
2013-10-17 |
2023-08-12 |
mouse |
| Shang-ze Li, Hui-hui Zhang, Jia-nong Zhang, Ze-yan Zhang, Xiao-fei Zhang, Xiao-dong Zhang, Run-lei D. ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochemical and biophysical research communications. vol 437. issue 2. 2013-10-17. PMID:23831472. |
in this study we showed intraperitoneally injected alln to inhibit colon tumor formation in nude mice, and found alln to inhibit tumor growth in colon cancer cells, mainly through apoptosis that depends on translocation of bax to a mitochondrial endogenous pathway; this implies a molecular mechanism for alln against human colon cancer. |
2013-10-17 |
2023-08-12 |
mouse |