| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia Zhou, Wei-Yu Zhao, Xu Ma, Rui-Jun Ju, Xiu-Ying Li, Nan Li, Meng-Ge Sun, Ji-Feng Shi, Cheng-Xiang Zhang, Wan-Liang L. The anticancer efficacy of paclitaxel liposomes modified with mitochondrial targeting conjugate in resistant lung cancer. Biomaterials. vol 34. issue 14. 2013-09-04. PMID:23422592. |
the targeting paclitaxel liposomes could significantly enhance the cellular uptake, be selectively accumulated into the mitochondria, and cause the release of cytochrome c. this targeting delivery of drug initiated a cascade of caspase 9 and 3 reactions, activated the pro-apoptotic bax and bid proteins and suppressed the anti-apoptotic bcl-2 protein, thereby enhancing the apoptosis by acting on the mitochondrial signaling pathways. |
2013-09-04 |
2023-08-12 |
mouse |
| Xin Li, Juan Zhang, Zhiheng Chen, Li Yang, Xiaowei Xing, Xing Ma, Zuocheng Yan. Both PI3K- and mTOR-signaling pathways take part in CVB3-induced apoptosis of Hela cells. DNA and cell biology. vol 32. issue 7. 2013-09-04. PMID:23705975. |
in summary, our results demonstrated that the mtor-signaling pathway plays an important role in cvb3-induced cpe and apoptosis, which is indispensable in vmc, via regulating bim, bax, caspase-9, caspase-3, and viral replication. |
2013-09-04 |
2023-08-12 |
Not clear |
| Zhao-Lin Que, Wen-Jiang Zhou, Jun Chang, Xin-Hua Liu, Jian-Ming Yu, Xun Su. Neuroprotective effects of mercaptoethylleonurine and mercaptoethylguanidine analogs on hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells. Bioorganic & medicinal chemistry letters. vol 23. issue 6. 2013-09-03. PMID:23403085. |
further investigation demonstrated that 8k reduced h2o2-induced activation of mitochondrial apoptosis by inhibiting the expression of bax and elevating the expression of bcl-2. |
2013-09-03 |
2023-08-12 |
human |
| Yao Sun, Fansong Mu, Chunying Li, Wei Wang, Meng Luo, Yujie Fu, Yuangang Z. Aspidin BB, a phloroglucinol derivative, induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells. Chemico-biological interactions. vol 204. issue 2. 2013-09-03. PMID:23628508. |
western blot analysis showed that aspidin bb suppressed bcl-2 expression and enhanced bax expression to desintegrate the outer mitochondrial membrane, then caused cytochrome c release which led to the activation of effector caspase-3, and further cleaved the poly adp-ribose polymerase (parp) in the nucleus, finally induced cell apoptosis. |
2013-09-03 |
2023-08-12 |
human |
| Nansong Liu, Jiadong Wang, Jifeng Wang, Rukai Wang, Zhongle Liu, Yao Yu, Hong L. ING5 is a Tip60 cofactor that acetylates p53 in response to DNA damage. Cancer research. vol 73. issue 12. 2013-08-30. PMID:23576563. |
ing5 was required for acetylation of p53 at k120, and p53 acetylated at k120 subsequently bound to the promoters of its target apoptotic genes, bax and gadd45, to promote their expression and lead to apoptosis. |
2013-08-30 |
2023-08-12 |
Not clear |
| Rick Sai-Chuen Wu, Kuo-Ching Liu, Nou-Ying Tang, Hsiung-Kwang Chung, Siu-Wan Ip, Jai-Sing Yang, Jing-Gung Chun. cDNA microarray analysis of the gene expression of murine leukemia RAW 264.7 cells after exposure to propofol. Environmental toxicology. vol 28. issue 8. 2013-08-29. PMID:21786383. |
western blot analysis demonstrated that propofol promoted fas, cytochrome c, caspase-9 and -3 active form and bax levels, but inhibited bcl-xl protein level which led to cell apoptosis. |
2013-08-29 |
2023-08-12 |
mouse |
| Yang-yang Chen, Sen Cui, Zhan-quan L. [Studies on Bcl-xl, Bax and Bid expressions and erythroblasts apoptosis in chronic altitude sickness]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. vol 33. issue 4. 2013-08-29. PMID:22781732. |
[studies on bcl-xl, bax and bid expressions and erythroblasts apoptosis in chronic altitude sickness]. |
2013-08-29 |
2023-08-12 |
Not clear |
| Juan Liu, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Hesong Wang, Bangyuan Wu, Yuanxin Deng, Kangping Wan. Dietary high fluorine induces apoptosis and alters Bcl-2, Bax, and caspase-3 protein expression in the cecal tonsil lymphocytes of broilers. Biological trace element research. vol 152. issue 1. 2013-08-29. PMID:23296903. |
dietary high fluorine induces apoptosis and alters bcl-2, bax, and caspase-3 protein expression in the cecal tonsil lymphocytes of broilers. |
2013-08-29 |
2023-08-12 |
Not clear |
| Juan Liu, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Hesong Wang, Bangyuan Wu, Yuanxin Deng, Kangping Wan. Dietary high fluorine induces apoptosis and alters Bcl-2, Bax, and caspase-3 protein expression in the cecal tonsil lymphocytes of broilers. Biological trace element research. vol 152. issue 1. 2013-08-29. PMID:23296903. |
the aims of this study were to investigate the effects of high dietary fluorine on apoptosis and the expression of the bcl-2, bax, and caspase-3 in the cecal tonsil lymphocytes of broilers. |
2013-08-29 |
2023-08-12 |
Not clear |
| Juan Liu, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Hesong Wang, Bangyuan Wu, Yuanxin Deng, Kangping Wan. Dietary high fluorine induces apoptosis and alters Bcl-2, Bax, and caspase-3 protein expression in the cecal tonsil lymphocytes of broilers. Biological trace element research. vol 152. issue 1. 2013-08-29. PMID:23296903. |
in conclusion, dietary fluorine in the range of 800-1,200 mg/kg increased lymphocyte apoptosis in the cecal tonsil of broilers, suggesting that the lymphocyte apoptosis in the cecal tonsil was mediated by direct effects of fluoride on the expression of bcl-2, bax, and caspase-3. |
2013-08-29 |
2023-08-12 |
Not clear |
| Jie Wu, Jinghua Yang, Qiufang Liu, Shengwen Wu, Honglin Ma, Yuan Ca. Lanthanum induced primary neuronal apoptosis through mitochondrial dysfunction modulated by Ca²⁺ and Bcl-2 family. Biological trace element research. vol 152. issue 1. 2013-08-29. PMID:23338853. |
(3) lacl3 elevated intracellular ca(2+) concentration, promoted reactive oxygen species generation, and upregulated pro-apoptotic bax, whereas it downregulated anti-apoptotic bcl-2 expression and consequently altered bax/bcl-2 ratio, which ultimately lead to neuronal mitochondrial apoptosis. |
2013-08-29 |
2023-08-12 |
human |
| Shoba Amarnath, Francis A Flomerfelt, Carliann M Costanzo, Jason E Foley, Jacopo Mariotti, Daniel M Konecki, Anu Gangopadhyay, Michael Eckhaus, Susan Wong, Bruce L Levine, Carl H June, Daniel H Fowle. Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD. Autophagy. vol 6. issue 4. 2013-08-27. PMID:20404486. |
such rapamycin-resistant human th1/tc1 cells: (1) were generated through autophagy (increased lc3bii expression; phenotype reversion by autophagy inhibition via 3-ma or sirna for beclin1); (2) expressed anti-apoptotic bcl-2 family members (reduced bax, bak; increased phospho-bad); (3) maintained mitochondrial membrane potentials; and (4) displayed reduced apoptosis. |
2013-08-27 |
2023-08-12 |
human |
| Shuyao Tang, Jing Hu, Qingfeng Meng, Xuesong Dong, Kaifu Wang, Yuebin Qi, Chao Chu, Xiaochuan Zhang, Limin Ho. Daidzein induced apoptosis via down-regulation of Bcl-2/Bax and triggering of the mitochondrial pathway in BGC-823 cells. Cell biochemistry and biophysics. vol 65. issue 2. 2013-08-27. PMID:22926545. |
furthermore, it was found that an insult of daidzein to bgc-823 cells caused them to die by disruption of mitochondrial transmembrane potential, demonstrated not only by staining dead cells for phosphatidylserine but also by the up-regulation (cleaved parp, cleaved caspase-9, cleaved caspase-3, bax) and down-regulation (bcl-2) of proteins associated with apoptosis and survival; whereas, the pan-caspase inhibitor z-vad-fmk could partially rescue cells against damage of daidzein. |
2013-08-27 |
2023-08-12 |
human |
| Sung Taek Park, Hyun-Jung Byun, Boh-Ram Kim, Seung Myung Dong, Sung Ho Park, Pong Rheem Jang, Seung Bae Rh. Tumor suppressor BLU promotes paclitaxel antitumor activity by inducing apoptosis through the down-regulation of Bcl-2 expression in tumorigenesis. Biochemical and biophysical research communications. vol 435. issue 1. 2013-08-27. PMID:23628417. |
in addition, both blu and paclitaxel enhanced the expression of the pro-apoptotic protein bax together with the suppression of anti-apoptotic protein bcl-2, a protein which is well-known for its function as a regulator in protecting cells from apoptosis. |
2013-08-27 |
2023-08-12 |
Not clear |
| Yi Zhang, Lu Song, Lin Cai, Renxiong Wei, Hao Hu, Wei Ji. Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 53. 2013-08-26. PMID:23266503. |
we also showed that the down-regulation of bcl-2 and concurrent increase in bax and bim levels contribute to the apoptosis induced by baicalein. |
2013-08-26 |
2023-08-12 |
Not clear |
| H L Gao, C Li, H Nabeka, T Shimokawa, S Saito, Z Y Wang, Y M Cao, S Matsud. Attenuation of MPTP/MPP(+) toxicity in vivo and in vitro by an 18-mer peptide derived from prosaposin. Neuroscience. vol 236. 2013-08-26. PMID:23321539. |
in addition, ps18 showed protection from mpp(+)/mptp-induced apoptosis in the sh-sy5y cells and dopaminergic neurons in the pd model mice via suppression of the c-jun n-terminal kinase/c-jun pathway; upregulation of bcl-2; downregulation of bax, attenuating mitochondrial damage; and inhibition of caspase-3. |
2013-08-26 |
2023-08-12 |
mouse |
| J Guadagno, X Xu, M Karajgikar, A Brown, S P Crega. Microglia-derived TNFα induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma. Cell death & disease. vol 4. 2013-08-23. PMID:23492769. |
furthermore, we demonstrate that microglia-derived tnfα induces npc apoptosis via a mitochondrial pathway regulated by the bcl-2 family protein bax. |
2013-08-23 |
2023-08-12 |
mouse |
| T C Izidoro-Toledo, A C Borges, D D Araújo, D P S Leitão Mazzi, F O Nascimento Júnior, J F Sousa, C P Alves, A P B Paiva, D M Trindade, E V Patussi, P M Peixoto, K W Kinnally, E M Espreafic. A myosin-Va tail fragment sequesters dynein light chains leading to apoptosis in melanoma cells. Cell death & disease. vol 4. 2013-08-23. PMID:23519116. |
murine embryonic fibroblasts (mefs) lacking bim and bmf or bax and bak were less sensitive to apoptosis caused by mvaf expression than wild-type mefs, strengthening the putative role of the intrinsic apoptotic pathway in this response. |
2013-08-23 |
2023-08-12 |
mouse |
| S Tripathi, J Batra, W Cao, K Sharma, J R Patel, P Ranjan, A Kumar, J M Katz, N J Cox, R B Lal, S Sambhara, S K La. Influenza A virus nucleoprotein induces apoptosis in human airway epithelial cells: implications of a novel interaction between nucleoprotein and host protein Clusterin. Cell death & disease. vol 4. 2013-08-23. PMID:23538443. |
clu prevents induction of the intrinsic apoptosis pathway by binding to bax and inhibiting its movement into the mitochondria. |
2013-08-23 |
2023-08-12 |
human |
| Roman Kireev, Samuel Bitoun, Sara Cuesta, Alejandro Tejerina, Carolina Ibarrola, Enrique Moreno, Elena Vara, Jesus A F Tresguerre. Melatonin treatment protects liver of Zucker rats after ischemia/reperfusion by diminishing oxidative stress and apoptosis. European journal of pharmacology. vol 701. issue 1-3. 2013-08-22. PMID:23220161. |
the expression of inos, enos, bcl2, bax, bad and aif were determined by rt-pcr melatonin was effective at decreasing liver injury by both ways as assessed by liver transaminases, markers of apoptosis, of oxidative stress and improved liver atp content. |
2013-08-22 |
2023-08-12 |
rat |