| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Le Yang, Xu-Bo Li, Qi Yang, Kun Zhang, Nan Zhang, Yan-Yan Guo, Bin Feng, Ming-Gao Zhao, Yu-Mei W. The neuroprotective effect of praeruptorin C against NMDA-induced apoptosis through down-regulating of GluN2B-containing NMDA receptors. Toxicology in vitro : an international journal published in association with BIBRA. vol 27. issue 2. 2013-08-20. PMID:23313464. |
pra-c also significantly inhibited neuronal apoptosis induced by nmda exposure by reversing intracellular ca(2+) overload and balancing bcl-2 and bax expression. |
2013-08-20 |
2023-08-12 |
Not clear |
| Zhang Yiran, Jiang Chenyang, Wang Jiajing, Yuan Yan, Gu Jianhong, Bian Jianchun, Liu Xuezhong, Liu Zongpin. Oxidative stress and mitogen-activated protein kinase pathways involved in cadmium-induced BRL 3A cell apoptosis. Oxidative medicine and cellular longevity. vol 2013. 2013-08-20. PMID:23577223. |
these results suggest that oxidative stress and mapk pathways participate in cd-induced apoptosis and that the balance between pro- and antiapoptotic genes (bax and bcl-2) is important in cd-induced apoptosis. |
2013-08-20 |
2023-08-12 |
Not clear |
| Hao He, Ling-He Zang, Yong-Sheng Feng, Jian Wang, Wei-Wei Liu, Li-Xia Chen, Ning Kang, Shin-ichi Tashiro, Satoshi Onodera, Feng Qiu, Takashi Ikejim. Physalin A induces apoptotic cell death and protective autophagy in HT1080 human fibrosarcoma cells. Journal of natural products. vol 76. issue 5. 2013-08-20. PMID:23647462. |
however, there were no significant changes in caspase-9, bid, bax, and bcl-2 expression, indicating that 1-induced apoptosis in ht1080 cells occurs mainly through activation of the death receptor-associated extrinsic apoptotic pathways. |
2013-08-20 |
2023-08-12 |
human |
| Navin Kumar Tailor, Hong Boon Lee, Manu Sharm. Effective melanoma inhibition by synthetic pentacyclic triterpenoid 2-(3-phenylprop-2-en-1-ylidene)-22β-hydroxy-3-oxoolean-12-en-28-oic acid: an in vitro and in vivo study. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 32. issue 1. 2013-08-20. PMID:23758153. |
compound 3 induced sub-g1 cell cycle arrest and apoptosis in b16f10 cells by down-regulating nf-κb, c-jun, bcl-2, and by activating caspase-3 and bax expression. |
2013-08-20 |
2023-08-12 |
mouse |
| Alessio Papi, Fulvia Farabegoli, Renato Iori, Marina Orlandi, Gina R De Nicola, Manuela Bagatta, Donato Angelino, Lorenzo Gennari, Paolino Ninfal. Vitexin-2-O-xyloside, raphasatin and (-)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells. Food chemistry. vol 138. issue 2-3. 2013-08-16. PMID:23411276. |
further analysis revealed a g0/g1 arrest of the phase cell progression and apoptosis, linked to modulation of bax, bcl2, caspase-9 and poly(adp-ribose) polymerase as well as reactive oxygen species (ros) generation in both colon cancer cells, whereas apoptosis and ros were not significantly detected in normal human lymphocytes. |
2013-08-16 |
2023-08-12 |
human |
| Yu Jiang, Jingbo Yang, Chunhui Yang, Fanmin Meng, Yongfeng Zhou, Bo Yu, Muhammad Khan, Hong Yan. Vitamin K4 induces tumor cytotoxicity in human prostate carcinoma PC-3 cells via the mitochondria-related apoptotic pathway. Die Pharmazie. vol 68. issue 6. 2013-08-16. PMID:23875252. |
further mechanistic studies revealed that vk4-mediated induction of apoptosis in pc-3 cell is associated with disruption of mitochondrial membrane potential, down-regulation of bcl-2, and up-regulation of bax, release of cytochrome c from mitochondria, and activation of caspase-3 and parr thus, vk4 might be useful in prostate cancer chemotherapy. |
2013-08-16 |
2023-08-12 |
human |
| H-Y Lin, R-H Lai, S-T Lin, R-C Lin, M-J Wang, C-C Lin, H-C Lee, F-F Wang, J-Y Che. Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation. Cell death and differentiation. vol 20. issue 1. 2013-08-15. PMID:22955947. |
socs6 promotes intrinsic apoptosis, with increased bax conformational change, mitochondrial targeting, and oligomerization. |
2013-08-15 |
2023-08-12 |
human |
| Yongxing Song, Zhongyou Zeng, Caiyi Jin, Jianqiao Zhang, Baoyue Ding, Feng Zhan. Protective effect of ginkgolide B against acute spinal cord injury in rats and its correlation with the Jak/STAT signaling pathway. Neurochemical research. vol 38. issue 3. 2013-08-15. PMID:23274522. |
it significantly increased the ratio of b cell cll/lymphoma-2 (bcl-2)/bcl-2-associated x protein (bax) protein expression at 24 h, led to an obvious down-regulation of caspase-3 gene and protein expression at 3 days, and significantly decreased the cell apoptosis index at each time point after sci. |
2013-08-15 |
2023-08-12 |
rat |
| Nada Al-Ajmi, May Al-Maghrebi, Waleed Mohammed Renn. (-)-Epigallocatechin-3-gallate Modulates the Differential Expression of Survivin Splice Variants and Protects Spermatogenesis During Testicular Torsion. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 17. issue 4. 2013-08-15. PMID:23946684. |
the expression of the survivin variants (140 and 40) and other apoptosis genes (p53, bax and bcl-2) was measured with semi-quantitative rt-pcr. |
2013-08-15 |
2023-08-12 |
mouse |
| Nada Al-Ajmi, May Al-Maghrebi, Waleed Mohammed Renn. (-)-Epigallocatechin-3-gallate Modulates the Differential Expression of Survivin Splice Variants and Protects Spermatogenesis During Testicular Torsion. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 17. issue 4. 2013-08-15. PMID:23946684. |
in parallel, there was an increase in the mrna level of p53 and the bax to bcl-2 ratio in support of apoptosis induction. |
2013-08-15 |
2023-08-12 |
mouse |
| Juliana Noguti, Tathiana Aparecida Alvarenga, Mônica Levy Andersen, Sergio Tufik, Celina Tijuko Fujiyama Oshima, Daniel Araki Ribeir. The influence of sleep deprivation on expression of apoptosis regulatory proteins p53, bcl-2 and bax following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. Dental research journal. vol 10. issue 2. 2013-08-15. PMID:23946744. |
the influence of sleep deprivation on expression of apoptosis regulatory proteins p53, bcl-2 and bax following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. |
2013-08-15 |
2023-08-12 |
rat |
| Alexis Díaz-García, Luis Morier-Díaz, Yahima Frión-Herrera, Hermis Rodríguez-Sánchez, Yamira Caballero-Lorenzo, Dianeya Mendoza-Llanes, Yanelis Riquenes-Garlobo, José A Fraga-Castr. In vitro anticancer effect of venom from Cuban scorpion Rhopalurus junceus against a panel of human cancer cell lines. Journal of venom research. vol 4. 2013-08-15. PMID:23946884. |
scorpion venom demonstrated to induce apoptosis in less sensitive tumor cells (hela) as evidenced by chromatin condensation, over expression of p53 and bax mrna, down expression of bcl-2 mrna and increase of activated caspases 3, 8, 9. |
2013-08-15 |
2023-08-12 |
human |
| Cagri Bodur, Ozgur Kutuk, Gizem Karsli-Uzunbas, Tayirjan T Isimjan, Paul Harrison, Huveyda Basag. Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling. PloS one. vol 8. issue 2. 2013-08-13. PMID:23441183. |
resistance of bax -/- cells and the protective nature of caspase-9 inhibition indicate that mitochondria play a central role in pmc-a induced apoptosis. |
2013-08-13 |
2023-08-12 |
human |
| Peng Li, Yunpeng Xue, Wenbin Zhang, Fei Teng, Yong Sun, Tiejun Qu, Xingxing Chen, Xiaogang Cheng, Bing Song, Wenjing Luo, Qing Y. Sodium fluoride induces apoptosis in odontoblasts via a JNK-dependent mechanism. Toxicology. vol 308. 2013-08-13. PMID:23578390. |
exposure of cells to 4mm naf for 24h induced caspase-3 activation, ultrastructural alterations, and resulted in the translocation of bax to the mitochondria and the release of cytochrome c from the mitochondrial inter-membrane space into the cytosol, indicating that fluoride-mediated apoptosis is mitochondria-dependent. |
2013-08-13 |
2023-08-12 |
Not clear |
| Jing Sun, Guibo Sun, Xiangbao Meng, Hongwei Wang, Min Wang, Meng Qin, Bo Ma, Yun Luo, Yingli Yu, Rongchang Chen, Qidi Ai, Xiaobo Su. Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-08-12. PMID:23935671. |
moreover, rk3 pretreatment inhibited cell apoptosis, as evidenced by decreased caspase-3 activity, tunel-positive cells, and bax expression, as well as increased bcl-2 level. |
2013-08-12 |
2023-08-12 |
Not clear |
| Kyoung-Hee Lee, Chul-Gyu Yo. Simultaneous inactivation of GSK-3β suppresses quercetin-induced apoptosis by inhibiting the JNK pathway. American journal of physiology. Lung cellular and molecular physiology. vol 304. issue 11. 2013-08-09. PMID:23564507. |
blockade of jnk activation by overexpression of dominant negative jnk1 suppressed apoptosis by quercetin via inhibition of caspase-3 activation and reduction of p53 and bax expression. |
2013-08-09 |
2023-08-12 |
Not clear |
| Romina Scian, Paula Barrionuevo, Ana María Rodriguez, Paula Constanza Arriola Benitez, Clara García Samartino, Carlos Alberto Fossati, Guillermo Hernán Giambartolomei, María Victoria Delpin. Brucella abortus invasion of synoviocytes inhibits apoptosis and induces bone resorption through RANKL expression. Infection and immunity. vol 81. issue 6. 2013-08-08. PMID:23509146. |
in contrast, infection did not change the expression of proteins that have been involved in apoptosis induction such as bad, bax, cleaved procaspase 3, cytc, and trail, among others; or their expression was reduced, as occurs in the case of p-p53(s15). |
2013-08-08 |
2023-08-12 |
human |
| Delu Zhang, Chunxiang Hu, Gaohong Wang, Dunhai Li, Genbao Li, Yongding Li. Zebrafish neurotoxicity from aphantoxins--cyanobacterial paralytic shellfish poisons (PSPs) from Aphanizomenon flos-aquae DC-1. Environmental toxicology. vol 28. issue 5. 2013-08-07. PMID:21710505. |
rt-pcr revealed that mrna levels of the apoptosis-related genes encoding p53, bax, caspase-3, and c-jun were upregulated after aphantoxin exposure, but there was no evidence of dna laddering; apoptosis could take place by pathways independent of dna fragmentation. |
2013-08-07 |
2023-08-12 |
human |
| Stephanie Bleicken, Corinna Wagner, Ana J García-Sáe. Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis. Biophysical journal. vol 104. issue 2. 2013-08-06. PMID:23442864. |
mechanistic differences in the membrane activity of bax and bcl-xl correlate with their opposing roles in apoptosis. |
2013-08-06 |
2023-08-12 |
Not clear |
| Stephanie Bleicken, Corinna Wagner, Ana J García-Sáe. Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis. Biophysical journal. vol 104. issue 2. 2013-08-06. PMID:23442864. |
based on our findings, we propose new models for the mechanisms of action of bax and bcl-xl that relate their membrane activity to their opposing roles in apoptosis and beyond. |
2013-08-06 |
2023-08-12 |
Not clear |