| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanta Kar, Shreyasi Palit, Writoban Basu Ball, Pijush K Da. Carnosic acid modulates Akt/IKK/NF-κB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells. Apoptosis : an international journal on programmed cell death. vol 17. issue 7. 2012-12-21. PMID:22453599. |
apoptosis was associated with the activation of caspase-8, -9, -3 and -7, increase in bax:bcl-2 ratio, release of cytochrome-c and decrease in expression of inhibitor of apoptosis (iap) family of proteins. |
2012-12-21 |
2023-08-12 |
human |
| Susanta Kar, Shreyasi Palit, Writoban Basu Ball, Pijush K Da. Carnosic acid modulates Akt/IKK/NF-κB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells. Apoptosis : an international journal on programmed cell death. vol 17. issue 7. 2012-12-21. PMID:22453599. |
in addition, ca induced apoptosis in another androgen refractory prostate cancer du145 cells via intrinsic pathway as evidenced from the activation of caspase 3, cleavage of parp, increase in bax:bcl-2 ratio and cytochrome-c release. |
2012-12-21 |
2023-08-12 |
human |
| Ling Liu, Junjie Fu, Tingting Li, Ran Cui, Jingjing Ling, Xing Yu, Hui Ji, Yihua Zhan. NG, a novel PABA/NO-based oleanolic acid derivative, induces human hepatoma cell apoptosis via a ROS/MAPK-dependent mitochondrial pathway. European journal of pharmacology. vol 691. issue 1-3. 2012-12-21. PMID:22824464. |
moreover, it was found that antioxidant n-acetylcysteine (nac) blocked the induction of apoptosis and partly reversed the activation of jnk and p38, up-regulation of bax, down-regulation of bcl-2 and the activation of caspase-3 in ng-treated cells. |
2012-12-21 |
2023-08-12 |
mouse |
| Muhammad Khan, Fei Yi, Azhar Rasul, Ting Li, Nan Wang, Hongwen Gao, Rong Gao, Tonghui M. Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB life. vol 64. issue 9. 2012-12-21. PMID:22837216. |
the alantolactone-induced apoptosis was found to be associated with glutathione (gsh) depletion, reactive oxygen species (ros) generation, mitochondrial transmembrane potential dissipation, cardiolipin oxidation, upregulation of p53 and bax, downregulation of bcl-2, cytochrome c release, activation of caspases (caspase 9 and 3), and cleavage of poly (adp-ribose) polymerase. |
2012-12-21 |
2023-08-12 |
mouse |
| Sang-Won Hong, Hee-Seung Lee, Kyung Hee Jung, Hyunseung Lee, Soon-Sun Hon. Protective effect of fucoidan against acetaminophen-induced liver injury. Archives of pharmacal research. vol 35. issue 6. 2012-12-21. PMID:22870820. |
fucoidan also reduced the hepatic apoptosis induced by acetaminophen exposure as shown in the protein expression of bax, bcl-2, and cleaved caspase-3. |
2012-12-21 |
2023-08-12 |
rat |
| Hong-Mei Liu, Guo-Hua Zhen, Zhen-Xiang Zhang, Hui-Lan Zhang, Yong Cao, Tao Wang, Nai-Bing Gu, Yong-Jian X. [Effects of bone marrow mesenchymal stem cells transplantation on the apoptosis of alveolar wall cells in papain and Co60-induced pulmonary emphysema rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 24. issue 2. 2012-12-20. PMID:21141529. |
to study the effects of bone marrow mscs transplantation on the apoptosis of alveolar wall cells and the expression of bcl-2 and bax of lung tissue in papain and co60-induced pulmonary emphysema rats. |
2012-12-20 |
2023-08-12 |
rat |
| Mohanad Mossalam, Karina J Matissek, Abood Okal, Jonathan E Constance, Carol S Li. Direct induction of apoptosis using an optimal mitochondrially targeted p53. Molecular pharmaceutics. vol 9. issue 5. 2012-12-20. PMID:22380534. |
(1, 2) p53 forms a complex with the antiapoptotic bcl-xl, which leads to bak and bax oligomerization resulting in apoptosis via mitochondrial outer membrane permeabilization. |
2012-12-20 |
2023-08-12 |
Not clear |
| Juan Chen, Ying-Hao Y. [Inhibitory effects of sporoderm-broken Ganoderma lucidum spores on growth of lymphoma implanted in nude mouse]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 2. 2012-12-20. PMID:22541088. |
the cellular apoptosis of tumor tissues in nude mice were observed by transmission electron microscopy (tem), the mrna expression of bax, bcl-2, bcl-xl was determined by rt-pcr. |
2012-12-20 |
2023-08-12 |
mouse |
| Juan Chen, Ying-Hao Y. [Inhibitory effects of sporoderm-broken Ganoderma lucidum spores on growth of lymphoma implanted in nude mouse]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 2. 2012-12-20. PMID:22541088. |
it is concluded that gls can inhibit proliferation of lymphoma cells and induce the lymphoma cell apoptosis, the mechanism of which may be related with up-regulating the expression of bax and down-regulating the expression of bcl-2 and bcl-xl. |
2012-12-20 |
2023-08-12 |
mouse |
| Zhao-Xia Wang, Zhi-Min Yang, Ya-Wei Zou, Min-Min Li, Fu-Xiong Chen, Guo-Yu Zhong, Jing-Ming Guan, Feng-Gui Wei, Shang-Zhi Wu, Zheng-Tao He, Zi-Liang W. [Effects of acute lymphoblastic leukemia children bone marrow mesenchymal stem cells on drug resistance of K562/A02 cell line]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 1. 2012-12-17. PMID:21362214. |
the co-culture of msc and k562/a02 and the culture of k562/a02 cell suspension alone was performed, of which 2 kinds of cells were treated with same concentration of adriamycin (adm), and the rate of apoptosis was detected by flow cytometry, bcl-2 and bax of k562/a02 were detected by rt-pcr, while mdr1 gene level was detected by fq-pcr. |
2012-12-17 |
2023-08-12 |
Not clear |
| Monica Pallis, Amina Abdul-Aziz, Francis Burrows, Claire Seedhouse, Martin Grundy, Nigel Russel. The multi-kinase inhibitor TG02 overcomes signalling activation by survival factors to deplete MCL1 and XIAP and induce cell death in primary acute myeloid leukaemia cells. British journal of haematology. vol 159. issue 2. 2012-12-17. PMID:22934750. |
this antitumour activity is most likely mediated by dephosphorylation of rna polymerase ii leading to depletion of survival molecules such as mcl1 and xiap, with subsequent bax activation and apoptosis. |
2012-12-17 |
2023-08-12 |
Not clear |
| Wei Gu, ChunSheng Li, Wenpeng Yin, Zhijun Guo, Xiaomin Hou, Da Zhan. Shen-fu injection reduces postresuscitation myocardial dysfunction in a porcine model of cardiac arrest by modulating apoptosis. Shock (Augusta, Ga.). vol 38. issue 3. 2012-12-14. PMID:22683733. |
shen-fu injection was associated with a reduction in (i) bcl-2, bax, and caspase 3 protein expression (p < 0.05); (ii) caspase 3 mrna upregulation; and (iii) apoptosis, compared with the ep and sa groups. |
2012-12-14 |
2023-08-12 |
Not clear |
| Wei Gu, ChunSheng Li, Wenpeng Yin, Zhijun Guo, Xiaomin Hou, Da Zhan. Shen-fu injection reduces postresuscitation myocardial dysfunction in a porcine model of cardiac arrest by modulating apoptosis. Shock (Augusta, Ga.). vol 38. issue 3. 2012-12-14. PMID:22683733. |
shen-fu injection decreased myocardial injury; improved myocardial ultrastructure; inhibited bcl-2, bax, and caspase 3 expression; and reduced myocardial apoptosis. |
2012-12-14 |
2023-08-12 |
Not clear |
| Sebastián Zamorano, Diego Rojas-Rivera, Fernanda Lisbona, Valentina Parra, Felipe A Court, Rosario Villegas, Emily H Cheng, Stanley J Korsmeyer, Sergio Lavandero, Claudio Het. A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway. PloS one. vol 7. issue 6. 2012-12-13. PMID:22719850. |
chronic endoplasmic reticulum (er) stress leads to apoptosis through the upregulation of a subset of pro-apoptotic bh3-only proteins, activating bax and bak at the mitochondria. |
2012-12-13 |
2023-08-12 |
Not clear |
| Michael S Dittmar, Walter Petermichl, Felix Schlachetzki, Bernhard M Graf, Michael Grube. Isoflurane induces endothelial apoptosis of the post-hypoxic blood-brain barrier in a transdifferentiated human umbilical vein endothelial cell model. PloS one. vol 7. issue 6. 2012-12-12. PMID:22723852. |
apoptosis of ac-huvecs was investigated using light microscopy of the native culture for morphological changes, western blot (wb) analysis of bax and bcl-2, and a tunel assay. |
2012-12-12 |
2023-08-12 |
human |
| Stéphanie Pellegrin, Kate J Heesom, Timothy J Satchwell, Bethan R Hawley, Geoff Daniels, Emile van den Akker, Ashley M Toy. Differential proteomic analysis of human erythroblasts undergoing apoptosis induced by epo-withdrawal. PloS one. vol 7. issue 6. 2012-12-12. PMID:22723854. |
other classical hallmarks of apoptosis were also observed, including cytochrome c release into the cytosol, loss of mitochondrial membrane potential, bax translocation to the mitochondria and caspase activation. |
2012-12-12 |
2023-08-12 |
human |
| Sandra-Annika Quast, Anja Berger, Nicole Buttstädt, Kristin Friebel, Roland Schönherr, Jürgen Eberl. General Sensitization of melanoma cells for TRAIL-induced apoptosis by the potassium channel inhibitor TRAM-34 depends on release of SMAC. PloS one. vol 7. issue 6. 2012-12-12. PMID:22723988. |
bax knockdown and bcl-2 overexpression abolished apoptosis. |
2012-12-12 |
2023-08-12 |
Not clear |
| Haiyang Li, Xiaoping Wang, Tongsheng Chen, Junle Q. p38 inhibitor SB203580 sensitizes the resveratrol-induced apoptosis in human lung adenocarcinoma (A549) cells. Journal of biochemical and molecular toxicology. vol 26. issue 7. 2012-12-11. PMID:22644961. |
we found that pretreatment with sb203580 enhanced the resveratrol-induced apoptosis by accelerating the intrinsic apoptotic pathway including bax activation, loss of mitochondrial membrane potential, and activation of both caspase-9 and -3. |
2012-12-11 |
2023-08-12 |
human |
| Lihua Sun, Wensheng Wang, Weidong Xiao, Hongyin Liang, Yang Yang, Hua Yan. Angiotensin II induces apoptosis in intestinal epithelial cells through the AT2 receptor, GATA-6 and the Bax pathway. Biochemical and biophysical research communications. vol 424. issue 4. 2012-12-10. PMID:22776205. |
angiotensin ii induces apoptosis in intestinal epithelial cells through the at2 receptor, gata-6 and the bax pathway. |
2012-12-10 |
2023-08-12 |
Not clear |
| Lihua Sun, Wensheng Wang, Weidong Xiao, Hongyin Liang, Yang Yang, Hua Yan. Angiotensin II induces apoptosis in intestinal epithelial cells through the AT2 receptor, GATA-6 and the Bax pathway. Biochemical and biophysical research communications. vol 424. issue 4. 2012-12-10. PMID:22776205. |
pretreatment with angiotensin type 2 (at2) receptor antagonist, pd123319, significantly reduced the expression of bax and prevented the caco-2 cells apoptosis induced by ang ii. |
2012-12-10 |
2023-08-12 |
Not clear |