| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lihua Sun, Wensheng Wang, Weidong Xiao, Hongyin Liang, Yang Yang, Hua Yan. Angiotensin II induces apoptosis in intestinal epithelial cells through the AT2 receptor, GATA-6 and the Bax pathway. Biochemical and biophysical research communications. vol 424. issue 4. 2012-12-10. PMID:22776205. |
interestingly, gata-6 short hairpin rna prevented ang ii-induced intestinal epithelial cells apoptosis and reduced the expression of bax, but not bcl-2. |
2012-12-10 |
2023-08-12 |
Not clear |
| Lihua Sun, Wensheng Wang, Weidong Xiao, Hongyin Liang, Yang Yang, Hua Yan. Angiotensin II induces apoptosis in intestinal epithelial cells through the AT2 receptor, GATA-6 and the Bax pathway. Biochemical and biophysical research communications. vol 424. issue 4. 2012-12-10. PMID:22776205. |
taken together, the present study suggests that angiotensin ii promotes apoptosis in intestinal epithelial cells through gata-6 and the bax pathway in an at2 receptor-dependent manner. |
2012-12-10 |
2023-08-12 |
Not clear |
| Brahma N Singh, Dhruv Kumar, Sharmila Shankar, Rakesh K Srivastav. Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. Biochemical pharmacology. vol 84. issue 9. 2012-12-10. PMID:22902833. |
prolonged exposure of cscs to rot eventually caused apoptosis which was associated with the suppression of phosphorylated akt (ser473) and mtor (ser2448), downregulation of xiap, ciap-1, bcl-2 and bcl-x(l), induction of bax, activation of caspase-3 and -9, and concomitant degradation of parp. |
2012-12-10 |
2023-08-12 |
human |
| Yang Liu, Wenlong Lu. Betulinic acid induces Bax/Bak-independent cytochrome c release in human nasopharyngeal carcinoma cells. Molecules and cells. vol 33. issue 5. 2012-12-07. PMID:22526391. |
moreover, bax was not activated during the induction of apoptosis. |
2012-12-07 |
2023-08-12 |
human |
| Shwetha K Shetty, Yashodhar P Bhandary, Amarnath S Marudamuthu, Daniel Abernathy, Thirunavukkarasu Velusamy, Barry Starcher, Sreerama Shett. Regulation of airway and alveolar epithelial cell apoptosis by p53-Induced plasminogen activator inhibitor-1 during cigarette smoke exposure injury. American journal of respiratory cell and molecular biology. vol 47. issue 4. 2012-12-07. PMID:22592924. |
the protection against atii cell apoptosis by csp involves inhibition of passive cs-induced proapoptotic bax and bak expression and restoration of the prosurvival proteins bcl-x(l). |
2012-12-07 |
2023-08-12 |
mouse |
| Soon Young Shin, Ji Ho Kim, Jung Ho Lee, Yoongho Lim, Young Han Le. 2'-Hydroxyflavanone induces apoptosis through Egr-1 involving expression of Bax, p21, and NAG-1 in colon cancer cells. Molecular nutrition & food research. vol 56. issue 5. 2012-12-07. PMID:22648623. |
2'-hydroxyflavanone induces apoptosis through egr-1 involving expression of bax, p21, and nag-1 in colon cancer cells. |
2012-12-07 |
2023-08-12 |
Not clear |
| Jing Pan, Hui Li, Jian-Fang Ma, Yu-Yan Tan, Qin Xiao, Jian-Qing Ding, Sheng-Di Che. Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease through suppressing mitochondria dysfunction. Translational neurodegeneration. vol 1. issue 1. 2012-12-06. PMID:23210631. |
jnks phosphorylation can cause translocation of bax to mitochondria and the release of cytochrome c which both ultimately contribute to mitochondria-mediated apoptosis. |
2012-12-06 |
2023-08-12 |
mouse |
| Jee Eun Kim, Jae Seung Kang, Wang Jae Le. Vitamin C Induces Apoptosis in Human Colon Cancer Cell Line, HCT-8 Via the Modulation of Calcium Influx in Endoplasmic Reticulum and the Dissociation of Bad from 14-3-3β. Immune network. vol 12. issue 5. 2012-12-06. PMID:23213312. |
taken together, vitamin c induces apoptosis of colon cancer cell line, hct-8 through the increase of 1) the calcium influx in endoplasmic reticulum (er), 2) the translocation of bad to mitochondria, and 3) the expression of bax. |
2012-12-06 |
2023-08-12 |
human |
| De Cheng, Zhenzhen Li, Yajun Liu, Yi Gao, Huayan Wan. Kinetic analysis of porcine fibroblast reprogramming toward pluripotency by defined factors. Cellular reprogramming. vol 14. issue 4. 2012-12-05. PMID:22775330. |
bax gene expression, a proapoptotic member of the bcl-2 family, was also increased at day 5, suggesting that c-myc might trigger cell apoptosis. |
2012-12-05 |
2023-08-12 |
mouse |
| Guang-Hui Dong, Jing Wang, Ying-Hua Zhang, Miao-Miao Liu, Da Wang, Li Zheng, Yi-He Ji. Induction of p53-mediated apoptosis in splenocytes and thymocytes of C57BL/6 mice exposed to perfluorooctane sulfonate (PFOS). Toxicology and applied pharmacology. vol 264. issue 2. 2012-12-04. PMID:22959464. |
we also observed that pfos induced p53-dependent apoptosis through the cooperation between the bcl-xl down regulation without changing the bcl-2 and bax expression. |
2012-12-04 |
2023-08-12 |
mouse |
| Ahmed Kamal, Jaki R Tamboli, M Janaki Ramaiah, S F Adil, G Koteswara Rao, A Viswanath, Adla Mallareddy, S N C V L Pushpavalli, Manika Pal-Bhadr. Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells. ChemMedChem. vol 7. issue 8. 2012-12-03. PMID:22700474. |
immunoblot and rt-pcr analyses proved the presence of mitochondria-mediated apoptosis with involvement p53 target genes such as bax, bcl2, and p21 (cdki). |
2012-12-03 |
2023-08-12 |
Not clear |
| Juan García Valero, Aurélie Cornut-Thibaut, Romain Jugé, Anne-Laure Debaud, Diana Giménez, Germain Gillet, Nathalie Bonnefoy-Bérard, Jesús Salgado, Gilles Salles, Abdel Aouacheria, Jérôme Kucharcza. µ-Calpain conversion of antiapoptotic Bfl-1 (BCL2A1) into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-mediated apoptosis. PloS one. vol 7. issue 6. 2012-11-30. PMID:22745672. |
anti-apoptotic bfl-1 and pro-apoptotic bax, two members of the bcl-2 family sharing a similar structural fold, are classically viewed as antagonist regulators of apoptosis. |
2012-11-30 |
2023-08-12 |
Not clear |
| Juan García Valero, Aurélie Cornut-Thibaut, Romain Jugé, Anne-Laure Debaud, Diana Giménez, Germain Gillet, Nathalie Bonnefoy-Bérard, Jesús Salgado, Gilles Salles, Abdel Aouacheria, Jérôme Kucharcza. µ-Calpain conversion of antiapoptotic Bfl-1 (BCL2A1) into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-mediated apoptosis. PloS one. vol 7. issue 6. 2012-11-30. PMID:22745672. |
hence, despite a common 3d-structure, c-terminal toxic domains present on bfl-1 and bax function in a dissimilar manner to permeabilize mitochondria and induce apoptosis. |
2012-11-30 |
2023-08-12 |
Not clear |
| Huafei Zou, Daniela Volonte, Ferruccio Galbiat. Interaction of caveolin-1 with Ku70 inhibits Bax-mediated apoptosis. PloS one. vol 7. issue 6. 2012-11-30. PMID:22745744. |
mechanistically, we found that binding of caveolin-1 to ku70 inhibits the chemotherapeutic drug-induced release of bax from ku70, activation of bax, translocation of bax to mitochondria and apoptosis. |
2012-11-30 |
2023-08-12 |
Not clear |
| Huafei Zou, Daniela Volonte, Ferruccio Galbiat. Interaction of caveolin-1 with Ku70 inhibits Bax-mediated apoptosis. PloS one. vol 7. issue 6. 2012-11-30. PMID:22745744. |
potentiation of apoptosis by knockdown of caveolin-1 protein expression is greatly reduced in the absence of bax expression. |
2012-11-30 |
2023-08-12 |
Not clear |
| Dingkun Gui, Yongping Guo, Feng Wang, Wei Liu, Jianguo Chen, Yifang Chen, Jianhua Huang, Niansong Wan. Astragaloside IV, a novel antioxidant, prevents glucose-induced podocyte apoptosis in vitro and in vivo. PloS one. vol 7. issue 6. 2012-11-30. PMID:22745830. |
apoptosis, albuminuria, ros generation, caspase-3 activity and cleavage, as well as bax and bcl-2 mrna and protein expression were measured in vitro and in vivo. |
2012-11-30 |
2023-08-12 |
rat |
| Dingkun Gui, Yongping Guo, Feng Wang, Wei Liu, Jianguo Chen, Yifang Chen, Jianhua Huang, Niansong Wan. Astragaloside IV, a novel antioxidant, prevents glucose-induced podocyte apoptosis in vitro and in vivo. PloS one. vol 7. issue 6. 2012-11-30. PMID:22745830. |
increased apoptosis, bax expression, caspase-3 activity and cleavage while decreased bcl-2 expression were detected in diabetic rats. |
2012-11-30 |
2023-08-12 |
rat |
| Dingkun Gui, Yongping Guo, Feng Wang, Wei Liu, Jianguo Chen, Yifang Chen, Jianhua Huang, Niansong Wan. Astragaloside IV, a novel antioxidant, prevents glucose-induced podocyte apoptosis in vitro and in vivo. PloS one. vol 7. issue 6. 2012-11-30. PMID:22745830. |
these findings suggested as-iv, a novel antioxidant, to prevent glucose-induced podocyte apoptosis partly through restoring the balance of bax and bcl-2 expression and inhibiting caspase-3 activation. |
2012-11-30 |
2023-08-12 |
rat |
| Shun-Quan Wu, Zhen-Zhen Xu, Hao-Bo Huang, Jun Lin, Rong Zha. [Mechanism associated to enhancing the sensitivity of myeloma cells U266 to bortezomib by 2-methoxyestradiol]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 6. 2012-11-29. PMID:22169296. |
the cell viability and proliferative curve were detected by cck8, the cell apoptosis was detected by caspase 3/7 activity test, cell cycle status was analyzed by flow cytometry, and real-time pcr was used to detect the mrna expression of p21, bax and bcl-2. |
2012-11-29 |
2023-08-12 |
Not clear |
| Shun-Quan Wu, Zhen-Zhen Xu, Hao-Bo Huang, Jun Lin, Rong Zha. [Mechanism associated to enhancing the sensitivity of myeloma cells U266 to bortezomib by 2-methoxyestradiol]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 6. 2012-11-29. PMID:22169296. |
the results showed that compared with cells treated with 2-me2 or bor alone, the proliferative potential of cells in combination group was significantly inhibited (p < 0.05), and apoptosis rate markedly increased (p < 0.05), cell cycle was arrested at g(1)-s phase, the mrna expressive level of p21 and bax increased, while the expression of bcl-2 decreased. |
2012-11-29 |
2023-08-12 |
Not clear |