| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zengning Li, Xianghong Zhang, Jinfeng Cui, Weijun Kan. Assessment on pollution of Ochratoxin A in grain in China and its apoptosis effect on vitro-cultured human tubular kidney cells. Journal of biochemical and molecular toxicology. vol 26. issue 4. 2012-10-24. PMID:22511400. |
the effects of ota on cell apoptosis, caspase-3, bax, and bcl-2 expression, and phosphorylation of c-jun nh(2) terminal kinase (jnk) were detected in cultured hkcs via flow cytometry (fcm), hoechst 33258 staining, and western blot. |
2012-10-24 |
2023-08-12 |
human |
| Zengning Li, Xianghong Zhang, Jinfeng Cui, Weijun Kan. Assessment on pollution of Ochratoxin A in grain in China and its apoptosis effect on vitro-cultured human tubular kidney cells. Journal of biochemical and molecular toxicology. vol 26. issue 4. 2012-10-24. PMID:22511400. |
ota could affect caspase-3, bax, and bcl-2 expression and increased cell apoptosis in cultured hkcs. |
2012-10-24 |
2023-08-12 |
human |
| Marcus Wallgren, Martin Lidman, Quoc Dat Pham, Konrad Cyprych, Gerhard Gröbne. The oxidized phospholipid PazePC modulates interactions between Bax and mitochondrial membranes. Biochimica et biophysica acta. vol 1818. issue 11. 2012-10-24. PMID:22705638. |
in addition to triggering the onset of apoptosis, oxidative stress generates oxidized lipids whose impact on mitochondrial membrane integrity and the activity of membrane-associated bax is unclear. |
2012-10-24 |
2023-08-12 |
Not clear |
| Yuehai Wang, Ziyang Huang, Huixia Lu, Huili Lin, Zhenhua Wang, Xiaoqing Chen, Qiufang Ouyang, Mengxiong Tang, Panpan Hao, Jingqin Ni, Dongming Xu, Mingxiang Zhang, Qunye Zhang, Ling Lin, Yun Zhan. Apolipoprotein E-knockout mice show increased titers of serum anti-nuclear and anti-dsDNA antibodies. Biochemical and biophysical research communications. vol 423. issue 4. 2012-10-22. PMID:22713470. |
we also survey the changes of serum autoantibodies, spleen weight, splenocyte apoptosis and the expressions of tlr4, myd88, pp38, irf3 and bax in spleen tissue in male apoe(-/-) mice after 4weeks of lipopolysaccharide (lps), toll-like receptor 4 ligand, administration. |
2012-10-22 |
2023-08-12 |
mouse |
| Yuehai Wang, Ziyang Huang, Huixia Lu, Huili Lin, Zhenhua Wang, Xiaoqing Chen, Qiufang Ouyang, Mengxiong Tang, Panpan Hao, Jingqin Ni, Dongming Xu, Mingxiang Zhang, Qunye Zhang, Ling Lin, Yun Zhan. Apolipoprotein E-knockout mice show increased titers of serum anti-nuclear and anti-dsDNA antibodies. Biochemical and biophysical research communications. vol 423. issue 4. 2012-10-22. PMID:22713470. |
splenocyte apoptosis and the expression of tlr4, myd88, pp38, irf3 and bax in spleen tissue were significantly lower in apoe(-/-) than b6 mice. |
2012-10-22 |
2023-08-12 |
mouse |
| S Carreau, H Bouraima-Lelong, C Delaland. Estrogen, a female hormone involved in spermatogenesis. Advances in medical sciences. vol 57. issue 1. 2012-10-19. PMID:22440937. |
thus estrogens through both gpr30 and genomic effects are able to activate the rapid signaling cascade, which in turn triggers an apoptotic mitochondrial pathway (via an increase in bax expression) and a concomitant decrease of cyclin a1 and b1 gene levels as well as in controlling apoptosis and maturation/differentiation of round spermatids. |
2012-10-19 |
2023-08-12 |
rat |
| M Gryko, A Pryczynicz, K Guzińska-Ustymowicz, Z Kamocki, K Zaręba, A Kemona, B Kędr. Immunohistochemical assessment of apoptosis-associated proteins: p53, Bcl-xL, Bax and Bak in gastric cancer cells in correlation with clinical and pathomorphological factors. Advances in medical sciences. vol 57. issue 1. 2012-10-19. PMID:22440942. |
the p53 protein as well as bcl-2 family proteins such as bax, bak and bcl-xl regulate apoptosis. |
2012-10-19 |
2023-08-12 |
Not clear |
| Fan-Ji Meng, Su-Min Jiao, Bo Y. Picroside II protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis by activating the PI3K/Akt and CREB pathways. International journal of molecular medicine. vol 30. issue 2. 2012-10-19. PMID:22581361. |
in addition, we found that picroside ii not only increased the expression of bcl-2, while decreasing bax expression, but also augmented akt and camp response element-binding protein (creb) phosphorylation and ultimately inhibited hypoxia/reoxygenation-induced apoptosis. |
2012-10-19 |
2023-08-12 |
Not clear |
| Fan-Ji Meng, Su-Min Jiao, Bo Y. Picroside II protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis by activating the PI3K/Akt and CREB pathways. International journal of molecular medicine. vol 30. issue 2. 2012-10-19. PMID:22581361. |
the present study suggests that picroside ii inhibits hypoxia/reoxygenation-induced apoptosis in cardiomyocytes by activating the pi3k/akt and creb pathways and modulating expression of bcl-2 and bax. |
2012-10-19 |
2023-08-12 |
Not clear |
| Maddalena Frau, Maria L Tomasi, Maria M Simile, Maria I Demartis, Fabiana Salis, Gavinella Latte, Diego F Calvisi, Maria A Seddaiu, Lucia Daino, Claudio F Feo, Stefania Brozzetti, Giuliana Solinas, Satoshi Yamashita, Toshikazu Ushijima, Francesco Feo, Rosa M Pascal. Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression. Hepatology (Baltimore, Md.). vol 56. issue 1. 2012-10-17. PMID:22318685. |
forced mat1a overexpression in hepg2 and huh7 cells led to a rise in the sam level, decreased cell proliferation, increased apoptosis, down-regulation of cyclin d1, e2f1, ikk, nf-κb, and antiapoptotic bcl2 and xiap genes, and up-regulation of bax and bak proapoptotic genes. |
2012-10-17 |
2023-08-12 |
human |
| Michael Plötz, Amir M Hossini, Bernhard Gillissen, Peter T Daniel, Eggert Stockfleth, Jürgen Eberl. Mutual regulation of Bcl-2 proteins independent of the BH3 domain as shown by the BH3-lacking protein Bcl-x(AK). PloS one. vol 7. issue 4. 2012-10-17. PMID:22506026. |
bcl-x(ak) was critically dependent on either bax or bak, and apoptosis was abrogated in bax/bak double knockout conditions as well by overexpression of bcl-2 or bcl-x(l). |
2012-10-17 |
2023-08-12 |
Not clear |
| Xianwei Wang, Jingjun Lu, Magomed Khaidakov, Sona Mitra, Zufeng Ding, Tanu Goyal, Jawahar L Meht. Delineation of the effects of angiotensin type 1 and 2 receptors on HL-1 cardiomyocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 17. issue 8. 2012-10-17. PMID:22527949. |
caspase-3 staining indicated that overexpression of at1r as well as at2r resulted in cardiomyocyte apoptosis with appropriate alterations in annexin v, bax and bcl2 expression. |
2012-10-17 |
2023-08-12 |
Not clear |
| Ramovatar Meena, Madhu Rani, Ruchita Pal, Paulraj Rajaman. Nano-TiO2-induced apoptosis by oxidative stress-mediated DNA damage and activation of p53 in human embryonic kidney cells. Applied biochemistry and biotechnology. vol 167. issue 4. 2012-10-17. PMID:22614867. |
in conclusion, ros-mediated oxidative stress, the activation of p53, bax, caspase-3 and oxidative dna damage are involved in the mechanistic pathways of nano-tio(2)-induced apoptosis in hek-293 cells. |
2012-10-17 |
2023-08-12 |
human |
| Yuntao Zhang, Yong Wang, Jianlin Yuan, Weijun Qin, Fei Liu, Fuli Wang, Geng Zhang, Xiaojian Yan. Toll-like receptor 4 ligation confers chemoresistance to docetaxel on PC-3 human prostate cancer cells. Cell biology and toxicology. vol 28. issue 4. 2012-10-17. PMID:22648782. |
downregulation of tlr4 using small-interference rna sensitized pc-3 cells to docetaxel-induced apoptosis as determined by annexin v staining and poly (adp-ribose) polymerase cleavage, which was coupled with increased bax expression and decreased bcl-2. |
2012-10-17 |
2023-08-12 |
human |
| Hye-Jin Boo, Jae-Hee Hyun, Sang-Cheol Kim, Jung-Il Kang, Min-Kyoung Kim, Sun-Yeou Kim, Heeyeong Cho, Eun-Sook Yoo, Hee-Kyoung Kan. Fucoidan from Undaria pinnatifida induces apoptosis in A549 human lung carcinoma cells. Phytotherapy research : PTR. vol 25. issue 7. 2012-10-16. PMID:21452391. |
with respect to the mechanism underlying the induction of apoptosis, fucoidan reduced bcl-2 expression, but the expression of bax was increased in a dose-dependent manner compared with the controls. |
2012-10-16 |
2023-08-12 |
human |
| R D V S Morais, R G Thomé, F S Lemos, N Bazzoli, E Rizz. Autophagy and apoptosis interplay during follicular atresia in fish ovary: a morphological and immunocytochemical study. Cell and tissue research. vol 347. issue 2. 2012-10-16. PMID:22314847. |
the interplay of apoptosis and autophagy was analysed by tunel in situ and by immunocytochemistry for caspase-3, bax, bcl-2, beclin-1 and cathepsin-d. during early and advanced stages of follicular regression, the actin cytoskeleton was well developed and labelling for bcl-2 and cathepsin-d were pronounced in the follicular cells at a stage when they were intensively involved in yolk phagocytosis. |
2012-10-16 |
2023-08-12 |
Not clear |
| R D V S Morais, R G Thomé, F S Lemos, N Bazzoli, E Rizz. Autophagy and apoptosis interplay during follicular atresia in fish ovary: a morphological and immunocytochemical study. Cell and tissue research. vol 347. issue 2. 2012-10-16. PMID:22314847. |
tunel-positive reaction and immunostaining for bax and caspase-3 demonstrated the participation of apoptosis in late follicular regression. |
2012-10-16 |
2023-08-12 |
Not clear |
| Xiao-hui Liao, Guo-tao Chen, Ying Li, Ling Zhang, Qi Liu, Hang Sun, Hui Gu. Augmenter of liver regeneration attenuates tubular cell apoptosis in acute kidney injury in rats: the possible mechanisms. Renal failure. vol 34. issue 5. 2012-10-16. PMID:22417144. |
rhalr inhibits apoptosis by increasing the ratio of bcl-2 to bax and by decreasing the activity of caspase-3. |
2012-10-16 |
2023-08-12 |
human |
| Hanna Piotrowska, Krzysztof Myszkowski, Alicja Ziółkowska, Katarzyna Kulcenty, Marcin Wierzchowski, Mariusz Kaczmarek, Marek Murias, Eliza Kwiatkowska-Borowczyk, Jadwiga Jodynis-Lieber. Resveratrol analogue 3,4,4',5-tetramethoxystilbene inhibits growth, arrests cell cycle and induces apoptosis in ovarian SKOV-3 and A-2780 cancer cells. Toxicology and applied pharmacology. vol 263. issue 1. 2012-10-16. PMID:22687606. |
in skov-3 cells dmu-212 caused up-regulation of pro-apoptotic bax, apaf-1 and p53 genes, specific to intrinsic pathway of apoptosis, and a decrease in bcl-2 and bcl 2110 mrna expressions. |
2012-10-16 |
2023-08-12 |
human |
| Tian Chen, Ling Zhang, Jun-Qiu Yue, Zi-Quan Lv, Wei Xia, Yan-Jian Wan, Yuan-Yuan Li, Shun-Qing X. Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring. Reproductive toxicology (Elmsford, N.Y.). vol 33. issue 4. 2012-10-15. PMID:21440054. |
the results showed that maternal exposure to 2.0mg/kgd pfos caused severe histopathological changes along with marked oxidative injuries and cell apoptosis in offspring lungs; at the same time, the ratio of bax to bcl-2, release of cytochrome c (cyt c) from mitochondria to cytoplasm, expressions of fas and fas-l, and activities of caspase-3, -8 and -9 were up-regulated correspondingly. |
2012-10-15 |
2023-08-12 |
rat |