| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenjuan Zhou, Wenliang Pan, Xiao Ping Wang, Tong Sheng Che. Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells. Journal of cellular physiology. vol 227. issue 12. 2012-11-06. PMID:22378505. |
of the utmost importance, art treatment induced the activation of bak but not bax, and silencing bak but not bax remarkably inhibited art-induced apoptosis and aif release. |
2012-11-06 |
2023-08-12 |
human |
| Ying Zhang, Meng Luo, Yuangang Zu, Yujie Fu, Chengbo Gu, Wei Wang, Liping Yao, Thomas Effert. Dryofragin, a phloroglucinol derivative, induces apoptosis in human breast cancer MCF-7 cells through ROS-mediated mitochondrial pathway. Chemico-biological interactions. vol 199. issue 2. 2012-11-06. PMID:22796323. |
western blot results showed that dryofragin inhibited bcl-2 and induced bax expression which led to an activation of caspases-9 and -3 in the cytosol, and further cleavage of poly adp-ribose polymerase (parp) in the nucleus, then induced cell apoptosis. |
2012-11-06 |
2023-08-12 |
human |
| Susmita Mondal, Kaushik Bhattacharya, Asish Mallick, Rajender Sangwan, Chitra Manda. Bak compensated for Bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during Withanolide D-induced apoptosis. PloS one. vol 7. issue 3. 2012-11-05. PMID:22479585. |
bak compensated for bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during withanolide d-induced apoptosis. |
2012-11-05 |
2023-08-12 |
Not clear |
| Susmita Mondal, Kaushik Bhattacharya, Asish Mallick, Rajender Sangwan, Chitra Manda. Bak compensated for Bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during Withanolide D-induced apoptosis. PloS one. vol 7. issue 3. 2012-11-05. PMID:22479585. |
additionally, in hct116p53+/+ cells, combined loss of bax and bak (hct116bax-bak-) reduced withad-induced apoptosis and completely blocked cytochrome c release whereas single loss of bax or bak (hct116bax-bak+/hct116bax+bak-) was only marginally effective after withad treatment. |
2012-11-05 |
2023-08-12 |
Not clear |
| Susmita Mondal, Kaushik Bhattacharya, Asish Mallick, Rajender Sangwan, Chitra Manda. Bak compensated for Bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during Withanolide D-induced apoptosis. PloS one. vol 7. issue 3. 2012-11-05. PMID:22479585. |
taken together, withad elicited apoptosis in malignant cells through bax/bak dependent pathway in p53-wild type cells, whereas bak compensated against loss of bax in p53-null cells. |
2012-11-05 |
2023-08-12 |
Not clear |
| Li-Ching Lin, Chi-Tai Yeh, Chia-Chun Kuo, Chi-Ming Lee, Gow-Chin Yen, Liang-Shun Wang, Chih-Hsiung Wu, Wei-Chung Vivian Yang, Alexander T H W. Sulforaphane potentiates the efficacy of imatinib against chronic leukemia cancer stem cells through enhanced abrogation of Wnt/β-catenin function. Journal of agricultural and food chemistry. vol 60. issue 28. 2012-11-02. PMID:22708678. |
im and sfn combined treatment sensitized cd34(+)/cd38(-) lscs and induced apoptosis, shown by increased caspase 3, parp, and bax while decreased bcl-2 expression. |
2012-11-02 |
2023-08-12 |
human |
| Guangzhi Chen, Renfan Xu, Yinna Wang, Peihua Wang, Gang Zhao, Xizhen Xu, Artiom Gruzdev, Darryl C Zeldin, Dao Wen Wan. Genetic disruption of soluble epoxide hydrolase is protective against streptozotocin-induced diabetic nephropathy. American journal of physiology. Endocrinology and metabolism. vol 303. issue 5. 2012-11-02. PMID:22739108. |
the seh-deficient diabetic mice also had decreased renal tubular apoptosis that coincided with increased levels of antiapoptotic bcl-2 and bcl-xl, and decreased levels of the proapoptotic bax. |
2012-11-02 |
2023-08-12 |
mouse |
| Zhaohai Wang, Xuelian Tang, Yilu Zhang, Ruizhao Qi, Zhiwei Li, Keming Zhang, Zhenwen Liu, Xinying Yan. Lobaplatin induces apoptosis and arrests cell cycle progression in human cholangiocarcinoma cell line RBE. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 66. issue 3. 2012-10-31. PMID:22425181. |
in addition, lobaplatin increased p53, bax expression, caspase-3 and poly (adp-ribose) polymerase (parp) cleavage, and reduced bcl-2 expression, which contributed to the apoptosis of cca cells. |
2012-10-31 |
2023-08-12 |
human |
| Angie Yeung, Rishi K Bhargava, Raphael Ahn, Sarra Bahna, Na Hyea Kang, Ayush Lacoul, Lennard P Nile. HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 66. issue 3. 2012-10-31. PMID:22436652. |
similar treatment with m344 also induced expression of the pro-apoptotic genes, puma and bax, together with the morphological features of apoptosis, in mcf-7 cells. |
2012-10-31 |
2023-08-12 |
Not clear |
| Linlin Zeng, Ting Li, Derek C Xu, Jennifer Liu, Guozhang Mao, Mei-Zhen Cui, Xueqi Fu, Xuemin X. Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein. The Journal of biological chemistry. vol 287. issue 34. 2012-10-31. PMID:22761420. |
death receptor 6 induces apoptosis not through type i or type ii pathways, but via a unique mitochondria-dependent pathway by interacting with bax protein. |
2012-10-31 |
2023-08-12 |
Not clear |
| Linlin Zeng, Ting Li, Derek C Xu, Jennifer Liu, Guozhang Mao, Mei-Zhen Cui, Xueqi Fu, Xuemin X. Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein. The Journal of biological chemistry. vol 287. issue 34. 2012-10-31. PMID:22761420. |
our data demonstrated that bax translocation is absolutely required for dr6-induced apoptosis. |
2012-10-31 |
2023-08-12 |
Not clear |
| Linlin Zeng, Ting Li, Derek C Xu, Jennifer Liu, Guozhang Mao, Mei-Zhen Cui, Xueqi Fu, Xuemin X. Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein. The Journal of biological chemistry. vol 287. issue 34. 2012-10-31. PMID:22761420. |
our results strongly suggest that dr6-induced apoptosis occurs through a new pathway that is different from the type i and type ii pathways through interacting with bax. |
2012-10-31 |
2023-08-12 |
Not clear |
| Zhiyong Cheng, Ning Yang, Wentong Liang, Xiaoyan Yan, Lin Li, Ling Pa. Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells. Leukemia & lymphoma. vol 53. issue 7. 2012-10-30. PMID:22185283. |
pten, nuclear factor-κb (nf-κb), i-κb, p53, multidrug resistance genes mdr1 and mrp, and apoptosis related genes bcl-2, bcl-xl and bax mrna levels were detected by real-time fluorescence relative-quantification reverse transcription polymerase chain reaction (fq-pcr). |
2012-10-30 |
2023-08-12 |
human |
| Hsiao-Chi Wang, Shu-Chen Hsieh, Jen-Hung Yang, Shuw-Yuan Lin, Lee-Yan Shee. Diallyl trisulfide induces apoptosis of human basal cell carcinoma cells via endoplasmic reticulum stress and the mitochondrial pathway. Nutrition and cancer. vol 64. issue 5. 2012-10-30. PMID:22519436. |
western analysis demonstrated concordant expression of molecules involved in mitochondrial apoptosis, including dats-associated increases in phospho-p53, proapoptotic bax, and decreases in antiapoptotic bcl-2 and bcl-xl in bcc cells. |
2012-10-30 |
2023-08-12 |
human |
| Weihong Kong, Xiaoshan Jiang, W Edward Merce. Downregulation of Wip-1 phosphatase expression in MCF-7 breast cancer cells enhances doxorubicin-induced apoptosis through p53-mediated transcriptional activation of Bax. Cancer biology & therapy. vol 8. issue 6. 2012-10-26. PMID:19242108. |
downregulation of wip-1 phosphatase expression in mcf-7 breast cancer cells enhances doxorubicin-induced apoptosis through p53-mediated transcriptional activation of bax. |
2012-10-26 |
2023-08-12 |
human |
| Manika Das, Somak Das, Istvan Lekli, Dipak K Da. Caveolin induces cardioprotection through epigenetic regulation. Journal of cellular and molecular medicine. vol 16. issue 4. 2012-10-26. PMID:21707918. |
cardioprotective property of cav-1 was further confirmed by reduced ventricular function, increased cardiomyocyte apoptosis, increased expression of junas kinase (jnk) and bax and decreased expression of phospho-adenosine monophosphate-activated protein kinase (ampk), phospho-akt and b cell lymphoma-2 (bcl-2) in cav-1 ko preconditioned heart. |
2012-10-26 |
2023-08-12 |
mouse |
| Crina-Maria Ionescu, Radka Svobodová Vařeková, Jochen H M Prehn, Heinrich J Huber, Jaroslav Koč. Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation. PLoS computational biology. vol 8. issue 6. 2012-10-25. PMID:22719244. |
the pro-apoptotic proteins bax and bak are essential for executing programmed cell death (apoptosis), yet the mechanism of their activation is not properly understood at the structural level. |
2012-10-25 |
2023-08-12 |
Not clear |
| b' Luigi Leanza, Brian Henry, Nicola Sassi, Mario Zoratti, K George Chandy, Erich Gulbins, Ildik\\xc3\\xb2 Szab\\xc3\\xb. Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO molecular medicine. vol 4. issue 7. 2012-10-24. PMID:22496117.' |
it is therefore important to identify novel apoptosis inducers that bypass bax and bak. |
2012-10-24 |
2023-08-12 |
mouse |
| Zengning Li, Xianghong Zhang, Jinfeng Cui, Weijun Kan. Assessment on pollution of Ochratoxin A in grain in China and its apoptosis effect on vitro-cultured human tubular kidney cells. Journal of biochemical and molecular toxicology. vol 26. issue 4. 2012-10-24. PMID:22511400. |
the effects of ota on cell apoptosis, caspase-3, bax, and bcl-2 expression, and phosphorylation of c-jun nh(2) terminal kinase (jnk) were detected in cultured hkcs via flow cytometry (fcm), hoechst 33258 staining, and western blot. |
2012-10-24 |
2023-08-12 |
human |
| Zengning Li, Xianghong Zhang, Jinfeng Cui, Weijun Kan. Assessment on pollution of Ochratoxin A in grain in China and its apoptosis effect on vitro-cultured human tubular kidney cells. Journal of biochemical and molecular toxicology. vol 26. issue 4. 2012-10-24. PMID:22511400. |
ota could affect caspase-3, bax, and bcl-2 expression and increased cell apoptosis in cultured hkcs. |
2012-10-24 |
2023-08-12 |
human |