| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joachim Rasso. Helicobacter pylori vacuolating toxin A and apoptosis. Cell communication and signaling : CCS. vol 9. 2012-10-02. PMID:22044628. |
apoptosis is triggered by loss of the mitochondrial membrane potential, recruitment of bax and bak, and release of cytochrome c. |
2012-10-02 |
2023-08-12 |
Not clear |
| Zhiping Zhang, Xuefeng Wang, Wenguang Wu, Jianwei Wang, Yong Wang, Xiangsong Wu, Xiaozhou Fei, Songgang Li, Jie Zhang, Ping Dong, Jun Gu, Yingbin Li. Effects of matrine on proliferation and apoptosis in gallbladder carcinoma cells (GBC-SD). Phytotherapy research : PTR. vol 26. issue 6. 2012-10-02. PMID:22162124. |
overall, the results indicate that matrine perturbs gallbladder cancer cell progression during the g1 phase by down-regulating cycline and induces apoptosis by decreasing the expression of the antiapoptotic protein bcl-2 and increasing expression of the proapoptotic protein bax. |
2012-10-02 |
2023-08-12 |
human |
| Tuhina Prasad, Joshua A Weine. Direct and Indirect Regulation of Spinal Cord Ia Afferent Terminal Formation by the γ-Protocadherins. Frontiers in molecular neuroscience. vol 4. 2012-10-02. PMID:22275881. |
the ia afferent phenotype is ameliorated, though not entirely rescued, when apoptosis is blocked in pcdh-γ null mice by introduction of a bax null allele. |
2012-10-02 |
2023-08-12 |
mouse |
| Xue-mei Chen, Jun Liu, Tao Wang, Jing Shan. Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 5. 2012-10-02. PMID:22342440. |
the colchicine-induced loss of mitochondrial membrane potential, activation of caspase-3 and 9, up-regulation of bax and down-regulation of bcl-2 showed an evidence for the colchicine activity on apoptosis, at least, by acting via the intrinsic apoptotic pathway. |
2012-10-02 |
2023-08-12 |
human |
| Almudena Valenciano, Luis Alberto Henríquez-Hernández, Mercedes Moreno, Marta Lloret, Pedro Carlos Lar. Role of IGF-1 receptor in radiation response. Translational oncology. vol 5. issue 1. 2012-10-02. PMID:22348170. |
recently, igf-1r has been associated to new partners as major vault proteins, bcl-2, bax, or ku70/80, related to radiochemotherapy resistance, regulation of apoptosis, and nonhomologous end-joining dna repair. |
2012-10-02 |
2023-08-12 |
Not clear |
| Y T An, Z Zhao, Y C Sheng, Y Min, Y Y Xi. Therapeutic time window of YGY-E neuroprotection of cerebral ischemic injury in rats. Drug discoveries & therapeutics. vol 5. issue 2. 2012-10-02. PMID:22466144. |
furthermore, we evaluated effects of this compound on neuronal apoptosis and synthesis of bcl-2 and bax in ischemic brain tissue with in situ dna end labeling (tunel), immunohistochemistry assay, and western blot analysis. |
2012-10-02 |
2023-08-12 |
rat |
| Filippo Pietrantonio, Pamela Biondani, Filippo de Braud, Alessandro Pellegrinelli, Giampaolo Bianchini, Federica Perrone, Barbara Formisano, Maria Di Bartolome. Bax expression is predictive of favorable clinical outcome in chemonaive advanced gastric cancer patients treated with capecitabine, oxaliplatin, and irinotecan regimen. Translational oncology. vol 5. issue 3. 2012-10-02. PMID:22741034. |
bax protein is a key mediator of apoptosis, and it might be related to chemosensitivity. |
2012-10-02 |
2023-08-12 |
Not clear |
| Nguyen Xuan Nhiem, Vu Kim Thu, Phan Van Kiem, Chau Van Minh, Bui Huu Tai, Tran Hong Quang, Nguyen Xuan Cuong, Pham Hai Yen, Hye-Jin Boo, Jung-Il Kang, Hee-Kyoung Kang, Young Ho Ki. Cytotoxic oleane-type triterpene saponins from Glochidion eriocarpum. Archives of pharmacal research. vol 35. issue 1. 2012-09-28. PMID:22297739. |
in the mechanism of apoptosis induction, compounds 1-4 reduced bcl-2 expression, whereas the expression of bax was increased compared to controls in hct-116 cells. |
2012-09-28 |
2023-08-12 |
human |
| Kyung-Ae Lee, Yong-Jin Lee, Jung Ok Ban, Yoon-Jin Lee, Sang-Han Lee, Moon-Kyun Cho, Hae-Seon Nam, Jin Tae Hong, Jung-Hyun Shi. The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1. International journal of molecular medicine. vol 30. issue 1. 2012-09-28. PMID:22552784. |
after treatment with res, apoptosis signaling cascades were activated by the activation of bid, bim, caspase-3 and parp, upregulation of bax and downregulation of bcl-xl. |
2012-09-28 |
2023-08-12 |
mouse |
| Astrid Rohrbeck, Tanja Kolbe, Sandra Hagemann, Harald Genth, Ingo Jus. Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174Q. The FEBS journal. vol 279. issue 15. 2012-09-26. PMID:22621765. |
serum starvation induced apoptosis in ht22 cells, as determined on the basis of increased expression of caspase-9 and bax. |
2012-09-26 |
2023-08-12 |
Not clear |
| Nathan W Werneburg, Steve F Bronk, Maria Eugenia Guicciardi, Laurel Thomas, Jimmy D Dikeakos, Gary Thomas, Gregory J Gore. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2). The Journal of biological chemistry. vol 287. issue 29. 2012-09-26. PMID:22645134. |
despite the requirement for lysosome membrane permeabilization during trail-induced apoptosis, little is known about the mechanism that controls recruitment of bim and bax to lysosomal membranes. |
2012-09-26 |
2023-08-12 |
Not clear |
| Nathan W Werneburg, Steve F Bronk, Maria Eugenia Guicciardi, Laurel Thomas, Jimmy D Dikeakos, Gary Thomas, Gregory J Gore. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2). The Journal of biological chemistry. vol 287. issue 29. 2012-09-26. PMID:22645134. |
the determination that recombinant pacs-2 bound bim but not bax in vitro and that shrna knockdown of bim blocked bax recruitment to lysosomes suggests that trail/dr5 triggers endosomal pacs-2 to recruit bim and bax to lysosomes to release cathepsin b and induce apoptosis. |
2012-09-26 |
2023-08-12 |
Not clear |
| Yuanyuan Gao, Hirotaka Kazama, Shin Yonehar. Bim regulates B-cell receptor-mediated apoptosis in the presence of CD40 signaling in CD40-pre-activated splenic B cells differentiating into plasma cells. International immunology. vol 24. issue 5. 2012-09-24. PMID:22301689. |
we detected up-regulation of bim expression followed by bax activation in this apoptotic process and cessation of the apoptosis in bim-deficient b cells, indicating that bim is a key regulator of the bcr-mediated apoptosis in the presence of cd40 signaling in cd40-pre-activated b cells. |
2012-09-24 |
2023-08-12 |
Not clear |
| Daniel R Premkumar, Esther P Jane, Joseph D DiDomenico, Natalie A Vukmer, Naomi R Agostino, Ian F Pollac. ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines. The Journal of pharmacology and experimental therapeutics. vol 341. issue 3. 2012-09-24. PMID:22393246. |
abt-737 synergizes with bortezomib to induce apoptosis, mediated by bid cleavage, bax activation, and mitochondrial dysfunction in an akt-dependent context in malignant human glioma cell lines. |
2012-09-24 |
2023-08-12 |
human |
| Daniel R Premkumar, Esther P Jane, Joseph D DiDomenico, Natalie A Vukmer, Naomi R Agostino, Ian F Pollac. ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines. The Journal of pharmacology and experimental therapeutics. vol 341. issue 3. 2012-09-24. PMID:22393246. |
genetic and pharmacological inhibition of pi3k inhibition sensitized pten-deficient glioma cells to bortezomib- and abt-737-induced apoptosis by increasing cleavage of bid protein, activation and oligomerization of bax, and loss of mitochondrial membrane potential. |
2012-09-24 |
2023-08-12 |
human |
| Xu Wang, Qin Liu, Awais Ihsan, Lingli Huang, Menghong Dai, Haihong Hao, Guyue Cheng, Zhenli Liu, Yulian Wang, Zonghui Yua. JAK/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin. Toxicological sciences : an official journal of the Society of Toxicology. vol 127. issue 2. 2012-09-24. PMID:22454431. |
with the intervention of ag490 and stattic, don and t-2 toxin induced apoptosis in a strengthened way, with the loss of mitochondrial membrane potential and the decrease ratios of the b-cell leukemia/lymphoma 2 (bcl-2)/bcl-2-associated x (bax) and b-cell lymphoma-extra large (bcl-xl)/bax. |
2012-09-24 |
2023-08-12 |
Not clear |
| Anastasia R Goloudina, Sharlyn J Mazur, Ettore Appella, Carmen Garrido, Oleg N Demido. Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio. Cell cycle (Georgetown, Tex.). vol 11. issue 10. 2012-09-24. PMID:22544321. |
the increased sensitivity resulted from activation of the intrinsic pathway of apoptosis through increased levels of the pro-apoptotic protein bax and decreased levels of the anti-apoptotic protein bcl-xl. |
2012-09-24 |
2023-08-12 |
human |
| Kwang Hwa Jung, Ji Heon Noh, Jeong Kyu Kim, Jung Woo Eun, Hyun Jin Bae, Hong Jian Xie, Young Gyoon Chang, Min Gyu Kim, Hanna Park, Jung Young Lee, Suk Woo Na. HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins. Journal of cellular biochemistry. vol 113. issue 6. 2012-09-21. PMID:22492270. |
hdac2 inactivation resulted in regression of tumor cell growth and activation of cellular apoptosis via p53 and bax activation and bcl2 suppression. |
2012-09-21 |
2023-08-12 |
mouse |
| Xiao-Yu Zhang, Zhong-Qiang Guo, Shi-Qi Ji, Min Zhang, Ning Jiang, Xue-Song Li, Li-Qun Zho. Small interfering RNA targeting HMGN5 induces apoptosis via modulation of a mitochondrial pathway and Bcl-2 family proteins in prostate cancer cells. Asian journal of andrology. vol 14. issue 3. 2012-09-20. PMID:22504871. |
the induction of cell apoptosis was accompanied by the upregulation of bax, the bax/bcl-2 ratio and the activation of caspase3. |
2012-09-20 |
2023-08-12 |
human |
| Yong Jiang, Dian-Wei Liu, Xiang-Yang Han, Ya-Nan Dong, Jun Gao, Bin Du, Lei Meng, Jian-Guo Sh. Neuroprotective effects of anti-tumor necrosis factor-alpha antibody on apoptosis following subarachnoid hemorrhage in a rat model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 19. issue 6. 2012-09-20. PMID:22516550. |
interestingly, we found increased expression of bax, but not caspase-3, in the prefrontal cortex, which indicates different molecular mechanisms of apoptosis in distinct brain regions. |
2012-09-20 |
2023-08-12 |
rat |