| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin-Li Li, Jiu-Hong Xu, Ji-Hua Nie, Sai-Jun Fa. Exogenous expression of UHRF1 promotes proliferation and metastasis of breast cancer cells. Oncology reports. vol 28. issue 1. 2012-09-04. PMID:22552622. |
our results demonstrated that uhrf1 transfection conferred serum independence to mda-mb-231 cells, g1 phase shortage and apoptosis suppression, accompanied with an increased expression of cyclin d1 and decreased expression of bax. |
2012-09-04 |
2023-08-12 |
Not clear |
| Jin Meng, Hai-Hua Zhang, Chun-Xiang Zhou, Chen Li, Feng Zhang, Qi-Bing Me. The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. Oncology reports. vol 28. issue 1. 2012-09-04. PMID:22552631. |
bax knockdown by sirna significantly impaired tsa-induced apoptosis in both cell lines. |
2012-09-04 |
2023-08-12 |
human |
| Leonard P Rybak, Debashree Mukherjea, Sarvesh Jajoo, Tejbeer Kaur, Vickram Ramkuma. siRNA-mediated knock-down of NOX3: therapy for hearing loss? Cellular and molecular life sciences : CMLS. vol 69. issue 14. 2012-09-04. PMID:22562580. |
in addition, sirna against nox3 reduced apoptosis as demonstrated by tunel staining, and prevented the increased expression of bax and abrogated the decrease in bcl2 expression following cisplatin administration. |
2012-09-04 |
2023-08-12 |
Not clear |
| Savita Lochab, Pooja Pal, Jitendra K Kanaujiya, Shashi B Tripathi, Isha Kapoor, Madan L B Bhatt, Sabyasachi Sanyal, Gerhard Behre, Arun K Trived. Proteomic identification of E6AP as a molecular target of tamoxifen in MCF7 cells. Proteomics. vol 12. issue 9. 2012-09-04. PMID:22589186. |
furthermore, we show that tam- and sie6ap-mediated inhibition of e6ap leads to enhanced g0-g1 growth arrest and apoptosis, which is also evident from significant upregulation of cytochrome-c, bax, p21, and parp cleavage. |
2012-09-04 |
2023-08-12 |
Not clear |
| Carmine Spampanato, Salvatore De Maria, Maddalena Sarnataro, Elisabetta Giordano, Mario Zanfardino, Salvatore Baiano, Maridela Cartenì, Franco Morell. Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expression. International journal of oncology. vol 40. issue 4. 2012-08-31. PMID:22134829. |
simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of bax and down-regulation of bcl-2 gene expression. |
2012-08-31 |
2023-08-12 |
Not clear |
| Carmine Spampanato, Salvatore De Maria, Maddalena Sarnataro, Elisabetta Giordano, Mario Zanfardino, Salvatore Baiano, Maridela Cartenì, Franco Morell. Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expression. International journal of oncology. vol 40. issue 4. 2012-08-31. PMID:22134829. |
in this study, we have demonstrated that simvastatin, at a dose of 20 µm for 24-72 h, induced in cancer cells but not in normal cells precise features of apoptosis including increased dna fragmentation while, at the molecular level simvastatin induced overexpression of the pro-apoptotic gene bax together with an inhibition of bcl-2, the gene that has the well-known function of protecting cells from apoptosis. |
2012-08-31 |
2023-08-12 |
Not clear |
| Dian-Lei Liu, Heqi Bu, Hong Li, Hui Chen, Hong-Chun Guo, Zhao-Hong Wang, Hong-Fei Tong, Zhong-Lin Ni, Hai-Bin Liu, Sheng-Zhang Li. Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro. International journal of oncology. vol 40. issue 4. 2012-08-31. PMID:22159556. |
emodin monotherapy or combination with gemcitabine both decreased the gene and protein expression levels of mdr-1 (p-gp), nf-κb and bcl-2 and inhibited the function of p-gp, but increased the expression levels of bax, cytochrome-c (cytosol), caspase-9 and -3, and promoted cell apoptosis. |
2012-08-31 |
2023-08-12 |
Not clear |
| Vijay S Thakur, Karishma Gupta, Sanjay Gupt. Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases. International journal of oncology. vol 41. issue 1. 2012-08-31. PMID:22552582. |
the increased gtp/egcg-mediated p53 acetylation enhanced its binding on the promoters of p21/waf1 and bax, which was associated with increased accumulation of cells in the g0/g1 phase of the cell cycle and induction of apoptosis. |
2012-08-31 |
2023-08-12 |
human |
| Raluca Dumitru, Vivian Gama, B Matthew Fagan, Jacquelyn J Bower, Vijay Swahari, Larysa H Pevny, Mohanish Deshmuk. Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis. Molecular cell. vol 46. issue 5. 2012-08-30. PMID:22560721. |
human embryonic stem cells have constitutively active bax at the golgi and are primed to undergo rapid apoptosis. |
2012-08-30 |
2023-08-12 |
human |
| Raluca Dumitru, Vivian Gama, B Matthew Fagan, Jacquelyn J Bower, Vijay Swahari, Larysa H Pevny, Mohanish Deshmuk. Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis. Molecular cell. vol 46. issue 5. 2012-08-30. PMID:22560721. |
a critical mediator of apoptosis is bax, which is reported to become active and translocate to the mitochondria only after apoptotic stimuli. |
2012-08-30 |
2023-08-12 |
human |
| Soghra Mehri, Khalil Abnous, Seyed Hadi Mousavi, Vahideh Motamed Shariaty, Hossein Hosseinzade. Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cellular and molecular neurobiology. vol 32. issue 2. 2012-08-29. PMID:21901509. |
crocin inhibited the downregulation of bcl-2 and the upregulation of bax and decreased apoptosis in treated cells. |
2012-08-29 |
2023-08-12 |
human |
| Raghu Gogada, Michael Amadori, Honghao Zhang, Anthony Jones, Alissa Verone, Jason Pitarresi, Sirisha Jandhyam, Varun Prabhu, Jennifer D Black, Dhyan Chandr. Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis. Cell cycle (Georgetown, Tex.). vol 10. issue 23. 2012-08-29. PMID:22101335. |
crosslinking experiments demonstrated bax oligomerization during curcumin-induced apoptosis, suggesting that induced expression of bax, bid, and bim causes bax-channel formation on the mitochondrial membrane. |
2012-08-29 |
2023-08-12 |
Not clear |
| Virginie Ory, Qingfeng Fan, Nabila Hamdaoui, Shao-yu Zhang, Dominique Desvaux, Vincent Audard, Marina Candelier, Laure-Helene Noel, Philippe Lang, Georges Guellaën, Andre Pawlak, Djillali Sahal. c-mip down-regulates NF-κB activity and promotes apoptosis in podocytes. The American journal of pathology. vol 180. issue 6. 2012-08-28. PMID:22507836. |
overexpression of c-mip in differentiated podocytes promotes apoptosis by inducing caspase-3 activity and up-regulating the proapoptotic protein bax, whereas the overall levels of the antiapoptotic protein bcl-2 was concomitantly decreased. |
2012-08-28 |
2023-08-12 |
Not clear |
| Rong Tian, Yali She, Yuxin Jia, Yu Wang, Xiaoli Cheng, Baolong M. [Effect of pingxian granules on protein expression of apoptosis regulatory genes in hippocampus of pentylenetetrazol-induced epileptic model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 37. issue 9. 2012-08-28. PMID:22803381. |
to observe the effect of pingxian granules on the protein expression of apoptosis regulatory genes bcl-2 and bax in the hippocampus of epileptic model rats and study the molecular biological mechanism of the anti-epileptic effect of pingxian granules. |
2012-08-28 |
2023-08-12 |
rat |
| David R Abbott, Robert T Abbott, Stephen D Jenson, G Chris Fillmore, Kojo S J Elenitoba-Johnson, Megan S Li. Apoptosis of t(14;18)-positive lymphoma cells by a Bcl-2 interacting small molecule. Journal of hematopathology. vol 2. issue 2. 2012-08-27. PMID:19669197. |
the results show down-regulation of mcl-1 but up-regulation of p27(kip1), bad, bcl-xl, and bcl-2 proteins, without change in bax levels during ha14-1-mediated apoptosis. |
2012-08-27 |
2023-08-12 |
Not clear |
| Y Ye, R Hou, J Chen, L Mo, J Zhang, Y Huang, Z M. Formononetin-induced apoptosis of human prostate cancer cells through ERK1/2 mitogen-activated protein kinase inactivation. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 44. issue 4. 2012-08-27. PMID:22328166. |
we further found that formononetin inactivated extracellular signal-regulated kinase1/2 (erk1/2) mitogen-activated protein kinase (mapk) signaling pathway in a dose-dependent manner, which resulted in increased the expression levels of bcl2-associated x (bax) mrna and protein, and induced apoptosis in lncap cells. |
2012-08-27 |
2023-08-12 |
human |
| Yali Xu, Xiaoxia Liu, Fenghua Guo, Yanxia Ning, Xiuling Zhi, Xinhong Wang, Sifeng Chen, Lianhua Yin, Xiaobo L. Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers. Cancer science. vol 103. issue 6. 2012-08-27. PMID:22380844. |
by real-time reverse transcription-polymerase chain reaction and western-blot assays, overexpression of sult1e1 and papss1 suppressed cell growth and triggered apoptosis by downregulating the levels of c-myc, cyclin d1 and bcl-2, meanwhile, upregulating bax expression. |
2012-08-27 |
2023-08-12 |
Not clear |
| Ghassan M Sulaiman, Ali H Ad'hiah, Khulood W Al-Sammarrae, Renzo Bagnati, Roberta Frapolli, Ezia Bello, Sarah Uboldi, Michela Romano, Nicolò Panini, Eugenio Scanziani, Marzia Pezzolato, Eugenio Erba, Maurizio D'Incalc. Assessing the anti-tumour properties of Iraqi propolis in vitro and in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 5. 2012-08-24. PMID:22306915. |
the apoptosis in hl-60 cells was associated with down-regulation of bcl-2 and activation of bax, while in hct-116 cells, necrotic features were observed; size of cells was dramatically increased by swelling of cytoplasm and loss of membrane integrity, cell rupture and release of cellular contents. |
2012-08-24 |
2023-08-12 |
mouse |
| Md Motarab Hossain, Naren L Banik, Swapan K Ra. Survivin knockdown increased anti-cancer effects of (-)-epigallocatechin-3-gallate in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells. Experimental cell research. vol 318. issue 13. 2012-08-24. PMID:22507272. |
apoptosis occurred with activation of caspase-8 and cleavage of bid to tbid, increase in bax:bcl-2 ratio, mitochondrial release of cytochrome c, and increases in the expression and activity of calpain and caspase-3. |
2012-08-24 |
2023-08-12 |
human |
| Po-Yuan Chen, Kai-Chun Lin, Jing-Pin Lin, Nou-Ying Tang, Jai-Sing Yang, Kung-Wen Lu, Jing-Gung Chun. Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G(0)/G(1) Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-24. PMID:22919418. |
peitc induced g(0)/g(1) phase arrest through the effects of associated protein such as p53, p21, p17, cdk2 and cyclin e, and it triggered apoptosis through promotion of bax and bid expression and reduction of bcl-2, leading to decrease the levels of mitochondrial membrane potential (ΔΨ(m)), and followed the releases of cytochrome c, aif and endo g then for causing apoptosis in hsc-3 cells. |
2012-08-24 |
2023-08-12 |
human |