| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bandana Chakravarti, Jawed A Siddiqui, Shailendra K Dhar Dwivedi, Shreekant Deshpande, Krishnanda Samanta, Rabi S Bhatta, Gautam Panda, Yenamandra S Prabhakar, Rituraj Konwar, Sabaysachi Sanyal, Naibedya Chattopadhya. Specific targeting of insulin-like growth factor 1 receptor signaling in human estrogen dependent breast cancer cell by a novel tyrosine-based benzoxazepine derivative. Molecular and cellular endocrinology. vol 338. issue 1-2. 2011-10-31. PMID:21457754. |
further, thbp increased pro-apoptotic protein, bax; decreased anti-apoptotic protein, bcl-2; and decreased mitochondrial membrane potential in mcf-7 cells, indicating involvement of an intrinsic pathway of apoptosis following caspase 8 activation. |
2011-10-31 |
2023-08-12 |
mouse |
| Megha Agrawal, Vivek Kumar, Mahendra P Kashyap, Vinay K Khanna, Gursharn S Randhawa, Aditya B Pan. Ischemic insult induced apoptotic changes in PC12 cells: protection by trans resveratrol. European journal of pharmacology. vol 666. issue 1-3. 2011-10-25. PMID:21620820. |
these results indicate that trans resveratrol administration attenuates free radical formation and mitochondria mediated apoptosis perhaps by regulating the expressions of bax, bcl(2,) and caspase-3 in pc12 cells receiving ogd and re-oxygenation insult. |
2011-10-25 |
2023-08-12 |
Not clear |
| Tricia Nardiello, Achim A Jungbluth, Anna Mei, Maurizio Diliberto, Xiangao Huang, Ania Dabrowski, Valéria C C Andrade, Rebecca Wasserstrum, Scott Ely, Ruben Niesvizky, Roger Pearse, Morton Coleman, David S Jayabalan, Nina Bhardwaj, Lloyd J Old, Selina Chen-Kiang, Hearn Jay Ch. MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of Bax and maintenance of survivin. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 17. issue 13. 2011-10-24. PMID:21565982. |
mage-a inhibits apoptosis in proliferating myeloma cells through repression of bax and maintenance of survivin. |
2011-10-24 |
2023-08-12 |
Not clear |
| Xianbiao Xie, Junqiang Yin, Qiang Jia, Jin Wang, Changye Zou, Kari J Brewer, Chiara Colombo, Yaofei Wang, Gang Huang, Jingnan She. Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. Oncology reports. vol 26. issue 3. 2011-10-24. PMID:21617882. |
quercetin-induced apoptosis was accompanied by a significant reduction of mitochondrial membrane potential, release of mitochondrial cytochrome c to the cytosol, activation of caspase-3, down-regulation of bcl-2, p-bad and up-regulation of bax. |
2011-10-24 |
2023-08-12 |
Not clear |
| Rita Rani, Vinod Kumar Kansal, Deepti Kaushal, Sachinandan D. Dietary intervention of cow ghee and soybean oil on expression of cell cycle and apoptosis related genes in normal and carcinogen treated rat mammary gland. Molecular biology reports. vol 38. issue 5. 2011-10-21. PMID:21088903. |
the present study investigated the effect of cow ghee (clarified butter fat) versus soybean oil on the expression of cyclins a and d1, and apoptosis regulating bax, bcl-2 and pkc-α genes in mammary gland of normal and 7,12-dimethylbenz(a)anthracene (dmba) treated rats. |
2011-10-21 |
2023-08-12 |
rat |
| Hong Yu Xue, Dong Yan Niu, Gui Zhen Gao, Qiu Ye Lin, Li Ji Jin, Yong Ping X. Aucubin modulates Bcl-2 family proteins expression and inhibits caspases cascade in H₂O₂-induced PC12 cells. Molecular biology reports. vol 38. issue 5. 2011-10-21. PMID:21120620. |
we have analyzed the apoptosis of h(2)o(2)-induced pc12 cells, h(2)o(2)-induced apoptosis appeared to correlate with lower bcl-2 expression, higher bax expression and sequential activation of caspase-3 leading to cleavage of poly-adp-ribose polymerase (parp). |
2011-10-21 |
2023-08-12 |
rat |
| Hong Yu Xue, Dong Yan Niu, Gui Zhen Gao, Qiu Ye Lin, Li Ji Jin, Yong Ping X. Aucubin modulates Bcl-2 family proteins expression and inhibits caspases cascade in H₂O₂-induced PC12 cells. Molecular biology reports. vol 38. issue 5. 2011-10-21. PMID:21120620. |
aucubin not only inhibited lower bcl-2 expression, high bax expression, but also modulated caspase-3 activation, parp cleavage, and eventually protected against h(2)o(2)-induced apoptosis. |
2011-10-21 |
2023-08-12 |
rat |
| Hong Yu Xue, Dong Yan Niu, Gui Zhen Gao, Qiu Ye Lin, Li Ji Jin, Yong Ping X. Aucubin modulates Bcl-2 family proteins expression and inhibits caspases cascade in H₂O₂-induced PC12 cells. Molecular biology reports. vol 38. issue 5. 2011-10-21. PMID:21120620. |
these results indicated that aucubin can obstruct h(2)o(2)-induced apoptosis by regulating of the expression of bcl-2 and bax, as well as suppression of caspases cascade activation. |
2011-10-21 |
2023-08-12 |
rat |
| Eduardo C Filippi-Chiela, Emilly Schlee Villodre, Lauren L Zamin, Guido Len. Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cells. PloS one. vol 6. issue 6. 2011-10-21. PMID:21695150. |
inhibition of rsv-induced autophagy triggered apoptosis, with an increase in bax and cleavage of caspase-3. |
2011-10-21 |
2023-08-12 |
human |
| Raghu Gogada, Varun Prabhu, Michael Amadori, Rachael Scott, Sana Hashmi, Dhyan Chandr. Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation. The Journal of biological chemistry. vol 286. issue 33. 2011-10-19. PMID:21712378. |
resveratrol induces p53-independent, x-linked inhibitor of apoptosis protein (xiap)-mediated bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation. |
2011-10-19 |
2023-08-12 |
Not clear |
| Raghu Gogada, Varun Prabhu, Michael Amadori, Rachael Scott, Sana Hashmi, Dhyan Chandr. Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation. The Journal of biological chemistry. vol 286. issue 33. 2011-10-19. PMID:21712378. |
here, we show that resveratrol induced p53-independent, x-linked inhibitor of apoptosis protein (xiap)-mediated translocation of bax to mitochondria where it underwent oligomerization to initiate apoptosis. |
2011-10-19 |
2023-08-12 |
Not clear |
| Rick Sai-Chuen Wu, King-Chuen Wu, Jai-Sing Yang, Shang-Ming Chiou, Chun-Shu Yu, Shu-Jen Chang, Fu-Shin Chueh, Jing-Gung Chun. Etomidate induces cytotoxic effects and gene expression in a murine leukemia macrophage cell line (RAW264.7). Anticancer research. vol 31. issue 6. 2011-10-19. PMID:21737642. |
results from western blotting indicated that etomidate enhanced the levels of cytochrome c, apoptosis-inducing factor (aif), endonuclease g (endo g), caspase-9, caspase-3 active form and bax proteins, but it inhibited the expression of bcl-xl, leading to apoptosis. |
2011-10-19 |
2023-08-12 |
Not clear |
| Shaun Rosebeck, Kuladeep Sudini, Tiannan Chen, Douglas W Leama. Involvement of Noxa in mediating cellular ER stress responses to lytic virus infection. Virology. vol 417. issue 2. 2011-10-18. PMID:21742363. |
noxa mrna and protein were synergistically upregulated by ifn or dsrna when combined with er stress inducers, leading to noxa/mcl-1 interaction, activation of bax and pro-apoptotic caspases, degradation of mcl-1, loss of mitochondrial membrane potential and initiation of apoptosis. |
2011-10-18 |
2023-08-12 |
mouse |
| Ben A Croker, Joanne A O'Donnell, Cameron J Nowell, Donald Metcalf, Grant Dewson, Kirsteen J Campbell, Kelly L Rogers, Yifang Hu, Gordon K Smyth, Jian-Guo Zhang, Michael White, Kurt Lackovic, Louise H Cengia, Lorraine A O'Reilly, Philippe Bouillet, Suzanne Cory, Andreas Strasser, Andrew W Robert. Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 32. 2011-10-18. PMID:21768356. |
fas-mediated neutrophil apoptosis is accelerated by bid, bak, and bax and inhibited by bcl-2 and mcl-1. |
2011-10-18 |
2023-08-12 |
Not clear |
| Ben A Croker, Joanne A O'Donnell, Cameron J Nowell, Donald Metcalf, Grant Dewson, Kirsteen J Campbell, Kelly L Rogers, Yifang Hu, Gordon K Smyth, Jian-Guo Zhang, Michael White, Kurt Lackovic, Louise H Cengia, Lorraine A O'Reilly, Philippe Bouillet, Suzanne Cory, Andreas Strasser, Andrew W Robert. Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 32. 2011-10-18. PMID:21768356. |
by monitoring the rate of change in neutrophil viability associated with activation of the fas-triggered death receptor pathway using real-time cell imaging, we show that the bcl-2-related proteins bid, bax, and bak accelerate neutrophil apoptosis but are not essential for cell death. |
2011-10-18 |
2023-08-12 |
Not clear |
| Ru-Duan Yeh, Jung-Chou Chen, Tung-Yuan Lai, Jai-Sing Yang, Chun-Shu Yu, Jo-Hua Chiang, Chi-Cheng Lu, Su-Tso Yang, Chien-Chih Yu, Shu-Jen Chang, Hui-Yi Lin, Jing-Gung Chun. Gallic acid induces G₀/G₁ phase arrest and apoptosis in human leukemia HL-60 cells through inhibiting cyclin D and E, and activating mitochondria-dependent pathway. Anticancer research. vol 31. issue 9. 2011-10-18. PMID:21868525. |
the results indicated that ga-mediated apoptosis of hl-60 cells mainly depended on mitochondrial pathway, by promoting the release of cytochrome c, apoptosis-inducing factor (aif) and endonuclease g (endo g) and by up-regulating the protein expression of bcl-2-associated x protein (bax), caspase-4, caspase-9 and caspase-3. |
2011-10-18 |
2023-08-12 |
human |
| Bonsu Ku, Chengyu Liang, Jae U Jung, Byung-Ha O. Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX. Cell research. vol 21. issue 4. 2011-10-17. PMID:21060336. |
collectively, the data show that due to the high affinity of bax for bcl-2, bcl-w and a1, and of bak for bcl-x(l), mcl-1 and a1, only a subset of bh3-only proteins, commonly including bim, bid and puma, could be expected to free bax or bak from the antiapoptotic bcl-2 proteins to elicit apoptosis. |
2011-10-17 |
2023-08-12 |
Not clear |
| Tatsuya Hayama, Keiichi Tabata, Taketo Uchiyama, Yasuo Fujimoto, Takashi Suzuk. Ferrearin C induces apoptosis via heme oxygenase-1 (HO-1) induction in neuroblastoma. Journal of natural medicines. vol 65. issue 3-4. 2011-10-14. PMID:21327520. |
in a western blot analysis, ferrearin c (1) increased the level of bax and reduced the level of survivin, indicating the activation of the mitochondrial pathway of apoptosis. |
2011-10-14 |
2023-08-12 |
human |
| Cláudia Trindade Nunes, Kelly L Miners, Garry Dolton, Chris Pepper, Chris Fegan, Malcolm D Mason, Stephen Ma. A novel tumor antigen derived from enhanced degradation of bax protein in human cancers. Cancer research. vol 71. issue 16. 2011-10-13. PMID:21697278. |
for example, genetic mutations or abnormal proteasomal degradation can reduce expression of bax which limits apoptosis. |
2011-10-13 |
2023-08-12 |
human |
| Gloria M Palomo, Toñi Cerrato, Ricardo Gargini, Javier Diaz-Nid. Silencing of frataxin gene expression triggers p53-dependent apoptosis in human neuron-like cells. Human molecular genetics. vol 20. issue 14. 2011-10-11. PMID:21531789. |
frataxin-deficient neuron-like cells appear to die through apoptosis that is accompanied by up-regulation of p53, puma and bax and activation of caspase-3. |
2011-10-11 |
2023-08-12 |
human |