| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yudong Jia, Jinxing Lin, Yuling Mi, Caiqiao Zhan. Quercetin attenuates cadmium-induced oxidative damage and apoptosis in granulosa cells from chicken ovarian follicles. Reproductive toxicology (Elmsford, N.Y.). vol 31. issue 4. 2011-09-20. PMID:21262342. |
however, simultaneous supplementation with 1 μg/ml quercetin protected granulosa cells against cadmium-induced cytotoxicity through attenuating lipid peroxidation, renewing antioxidant enzymes activities and alleviating apoptosis by modulating xiap, bax and bcl2 expression, and inhibiting caspase-3 activity. |
2011-09-20 |
2023-08-12 |
chicken |
| Yan Chen, Meizeng Zhang, Qin Li, Yunliang Guo, Wei Ding, Lihua Wang, Zhen Zhou, Xiping Che. Interfering effect and mechanism of neuregulin on experimental dementia model in rats. Behavioural brain research. vol 222. issue 2. 2011-09-20. PMID:21473886. |
to investigate the effect of neuregulin 1β (nrg1β) on the neuronal apoptosis and the expressions of bcl-2 and bax proteins in experimental dementia model rats. |
2011-09-20 |
2023-08-12 |
rat |
| Q Gao, Y Xiang, Z Chen, L Zeng, X Ma, Y Zhan. βγ-CAT, a non-lens betagamma-crystallin and trefoil factor complex, induces calcium-dependent platelet apoptosis. Thrombosis and haemostasis. vol 105. issue 5. 2011-09-16. PMID:21359407. |
we found that βγ-cat induced several apoptosis events in human platelets, including caspase-3 activation, phosphatidylserine (ps) exposure, depolarisation of mitochondrial inner transmembrane potential (ΔΨm), cytochrome c release and strong expression of pro-apoptotic bax and bak proteins. |
2011-09-16 |
2023-08-12 |
human |
| Irene Paterniti, Emanuela Esposito, Emanuela Mazzon, Placido Bramanti, Salvatore Cuzzocre. Evidence for the role of PI(3) -kinase-AKT-eNOS signalling pathway in secondary inflammatory process after spinal cord compression injury in mice. The European journal of neuroscience. vol 33. issue 8. 2011-09-16. PMID:21496122. |
in this study we clearly demonstrated that pre-treatment with ly294002 reversed the increased activation of enos and akt observed following sci, and developed a severe trauma characterized by oedema, tissue damage and apoptosis (measured by tunel staining, bax, bcl-2 and fas-l expression). |
2011-09-16 |
2023-08-12 |
mouse |
| M Karlberg, M Ekoff, V Labi, A Strasser, D Huang, G Nilsso. Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis. Cell death & disease. vol 1. 2011-09-15. PMID:21364649. |
pro-apoptotic bax is the major and bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis. |
2011-09-15 |
2023-08-12 |
mouse |
| M Karlberg, M Ekoff, V Labi, A Strasser, D Huang, G Nilsso. Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis. Cell death & disease. vol 1. 2011-09-15. PMID:21364649. |
the intrinsic pathway of apoptosis is ultimately controlled by the pro-apoptotic bcl-2 family members bax and bak, which upon activation oligomerize to cause increased permeabilization of the mitochondria outer membrane leading to cell death. |
2011-09-15 |
2023-08-12 |
mouse |
| M Karlberg, M Ekoff, V Labi, A Strasser, D Huang, G Nilsso. Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis. Cell death & disease. vol 1. 2011-09-15. PMID:21364649. |
we examined the role of bax and bak in cytokine deprivation-induced apoptosis in mast cells using connective tissue-like mast cells and mucosal-like mast cells derived from bax(-/-), bak(-/-) and bax(-/-)bak(-/-) mice. |
2011-09-15 |
2023-08-12 |
mouse |
| M Karlberg, M Ekoff, V Labi, A Strasser, D Huang, G Nilsso. Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis. Cell death & disease. vol 1. 2011-09-15. PMID:21364649. |
although both bax and bak were expressed at readily detectable protein levels, we found a major role for bax in mediating mast cell apoptosis induced by cytokine deprivation. |
2011-09-15 |
2023-08-12 |
mouse |
| M Karlberg, M Ekoff, V Labi, A Strasser, D Huang, G Nilsso. Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis. Cell death & disease. vol 1. 2011-09-15. PMID:21364649. |
upon cytokine withdrawal, bak(-/-) mast cells died at a similar rate as wild type, whereas bax(-/-) and bax(-/-)bak(-/-) mast cells were partially or completely resistant to apoptosis, respectively. |
2011-09-15 |
2023-08-12 |
mouse |
| M Karlberg, M Ekoff, V Labi, A Strasser, D Huang, G Nilsso. Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis. Cell death & disease. vol 1. 2011-09-15. PMID:21364649. |
these results show that bax has a predominant and bak a minor role in cytokine deprivation-induced apoptosis in both connective tissue-like and mucosal-like mast cells. |
2011-09-15 |
2023-08-12 |
mouse |
| Jinyang Lin, Zhuoying Zhang, Ying Sha. Effect of Achyranthes bidentata polysaccharides on the expression of BCL-2 and bax in hepatic tissues after exhaustive exercise in rats. African journal of traditional, complementary, and alternative medicines : AJTCAM. vol 7. issue 4. 2011-09-15. PMID:21731162. |
the result indicated that bax and bcl-2 co-regulated the exercise-induced hepatocyte apoptosis. |
2011-09-15 |
2023-08-12 |
rat |
| Ashok Kumar, Hoe-Sup Byun, Robert Bittman, Julie D Sab. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cellular signalling. vol 23. issue 7. 2011-09-14. PMID:21385609. |
trans-2-hexadecenal-induced apoptosis was accompanied by activation of downstream targets of jnk including c-jun phosphorylation, cytochrome c release, bax activation, bid cleavage and increased translocation of bim into mitochondria. |
2011-09-14 |
2023-08-12 |
human |
| Jonathan M Gall, Vincent Wong, David R Pimental, Andrea Havasi, Zhiyong Wang, John G Pastorino, Ramon G B Bonegio, John H Schwartz, Steven C Borka. Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress. Kidney international. vol 79. issue 11. 2011-09-13. PMID:21430642. |
we exposed renal epithelial cells to metabolic stress causing atp depletion in the absence of glucose and found that this activated glycogen synthase kinase 3β (gsk3β) and bax caused mitochondrial membrane injury and apoptosis. |
2011-09-13 |
2023-08-12 |
Not clear |
| L Sun, C Guo, D Liu, Y Zhao, Y Zhang, Z Song, H Han, D Chen, Y Zha. Protective effects of bone morphogenetic protein 7 against amyloid-beta induced neurotoxicity in PC12 cells. Neuroscience. vol 184. 2011-09-13. PMID:21496477. |
our results suggest that bmp7 has neuroprotective effects against aβ, which may be mediated through inhibition of bax gene expression during cell apoptosis and elevation of sod activities during the oxidative stress response. |
2011-09-13 |
2023-08-12 |
rat |
| M Saygin, S Caliskan, N Karahan, A Koyu, N Gumral, Ac Ugu. Testicular apoptosis and histopathological changes induced by a 2.45 GHz electromagnetic field. Toxicology and industrial health. vol 27. issue 5. 2011-09-12. PMID:21310776. |
when bax apoptosis genes and caspase-8 apoptosis enzyme were compared, there were significant differences between the groups (p < 0.05). |
2011-09-12 |
2023-08-12 |
human |
| Wei Guo, Ying-Bo Zou, Yao-Guang Jiang, Ru-Wen Wang, Yun-Ping Zhao, Zheng M. Zinc induces cell cycle arrest and apoptosis by upregulation of WIG-1 in esophageal squamous cancer cell line EC109. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 4. 2011-09-12. PMID:21559779. |
we found that zinc could suppress cell proliferation and induce g0/g1 cell cycle arrest and apoptosis of ec109, and this efficacy might result from the expression altering of several apoptosis-related genes, such as bax, p21 ( waf ), and cyclin d1. |
2011-09-12 |
2023-08-12 |
human |
| Wei Guo, Ying-Bo Zou, Yao-Guang Jiang, Ru-Wen Wang, Yun-Ping Zhao, Zheng M. Zinc induces cell cycle arrest and apoptosis by upregulation of WIG-1 in esophageal squamous cancer cell line EC109. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 4. 2011-09-12. PMID:21559779. |
in particular, upregulation of wig-1 was observed after zinc supplementation, indicating that wig-1 might be involved in the zinc-induced cell cycle arrest and apoptosis of ec109 cells by regulating the expression of bax, p21 ( waf ), and cyclin d1. |
2011-09-12 |
2023-08-12 |
human |
| Xiu-hua Wang, Song-min Jiang, Qing-wen Su. Effects of berberine on human rheumatoid arthritis fibroblast-like synoviocytes. Experimental biology and medicine (Maywood, N.J.). vol 236. issue 7. 2011-09-12. PMID:21676922. |
the inhibitory effects of berberine correlated with an induction of cyclin-dependent kinase (cdk) inhibitors cip1/p21 and kip1/p27 and a reduction of cdk2, cdk4 and cdk6, and cyclins d1, d2 and e. furthermore, an apoptosis assay showed that berberine treatment increased apoptotic death of raflss, which was associated with an increased expression of proapoptotic protein bax and decreased expression of antiapoptotic proteins bcl-2 and bcl-xl, disruption of mitochondrial membrane potential, and activation of caspase-3, caspase-9 and poly (adp-ribose) polymerase. |
2011-09-12 |
2023-08-12 |
human |
| Chin-Chung Lin, Chao-Lin Kuo, Mau-Hwa Lee, Kuang-Chi Lai, Jing-Pin Lin, Jai-Sing Yang, Chun-Shu Yu, Chi-Cheng Lu, Jo-Hua Chiang, Fu-Shin Chueh, Jing-Gung Chun. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. International journal of oncology. vol 39. issue 1. 2011-09-09. PMID:21573491. |
also, results from western blotting indicated that wogonin increased the levels of bad, bax, cytochrome c, cleaved caspase-9, cleaved caspase-3, aif, endo g, fas/cd95, caspase-8, gadd153, grp78, atf-6α, calpain 1, calpain 2 and caspase-4 then leading to cell apoptosis. |
2011-09-09 |
2023-08-12 |
human |
| Ian Paul, Kienan I Savage, Jaine K Blayney, Elisabeth Lamers, Kathy Gately, Keith Kerr, Michael Sheaff, Kenneth Arthur, Derek J Richard, Peter W Hamilton, Jacqueline A James, Kenneth J O'Byrne, D Paul Harkin, Jennifer E Quinn, Dean A Fennel. PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer. The Journal of pathology. vol 224. issue 4. 2011-09-09. PMID:21706479. |
the pro-apoptotic bcl-2 family proteins bax and bak are critical regulators of mitochondrial apoptosis. |
2011-09-09 |
2023-08-12 |
Not clear |