| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-Qing Wang, Rong Li, Qing-Xian Bai, Wei-Ping Zhang, Juan-Hong Wang, Zhe Wang, Xie-Qun Chen, Gao-Sheng Huan. [Apoptosis of multiple myeloma cells induced by gossypol acetic acid in vitro and its mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 17. issue 6. 2011-08-23. PMID:20030926. |
meanwhile, western-blot assay was used to detect the changes of several key cell apoptosis regulatory proteins such as bax, caspase-3 and caspase-8 in these cells before and after treatment. |
2011-08-23 |
2023-08-12 |
human |
| Bin Li, Li-Jun Zhang, Zhou-Liang Zhang, Min Long, Ji-Hong Ren, Fang Lin, Xi Wang, Jun-Xia Wei, Ke Dong, Hui-Zhong Zhan. Synergistic tumor growth-inhibitory effect of the prostate-specific antigen-activated fusion peptide BSD352 for prostate cancer therapy. Anti-cancer drugs. vol 22. issue 3. 2011-08-23. PMID:21150773. |
furthermore, the bsd352 fusion peptide was efficiently transduced into tumor cells both in vitro and in vivo, and the bh3 domain was found to induce tumor cell apoptosis by elevating the expression of bax, cytochrome c release, and caspase-9 cleavage. |
2011-08-23 |
2023-08-12 |
mouse |
| Eui-Man Jung, Kyung-Chul Choi, Eui-Bae Jeun. Expression of calbindin-D28k is inversely correlated with proapototic gene expression in hydrogen peroxide-induced cell death in endometrial cancer cells. International journal of oncology. vol 38. issue 4. 2011-08-23. PMID:21258766. |
interestingly, overexpression of cabp-28k inhibited cell death and caused a decrease in bax, p53 and caspase 3 expression during h2o2-induced apoptosis, suggesting that cabp-28k blocks the up-regulation of apoptosis-related gene expression. |
2011-08-23 |
2023-08-12 |
human |
| Yuhua Li, Yinbo Niu, Huanjie Wu, Yang Sun, Qian Li, Xianghe Kong, Li Liu, Qibing Me. Modified apple polysaccharides could induce apoptosis in colorectal cancer cells. Journal of food science. vol 75. issue 8. 2011-08-23. PMID:21535499. |
it increased the expression of caspase 3, 8, 9, and bax, while decreased of bcl-2, which denoted that map may induce apoptosis through both the mitochondrial-mediated and death receptor-mediated apoptotic ways. |
2011-08-23 |
2023-08-12 |
human |
| Wei Ge, We Ge, Yingmei Zhang, Xuefeng Han, Jun Re. Cardiac-specific overexpression of catalase attenuates paraquat-induced myocardial geometric and contractile alteration: role of ER stress. Free radical biology & medicine. vol 49. issue 12. 2011-08-18. PMID:20937379. |
paraquat promoted overt apoptosis and er stress as evidenced by increased caspase-3 activity, apoptosis, and er stress markers including bax, bcl-2, gadd153, calregulin, and phosphorylated jnk, ire1α, and eif2α; all were ablated by the catalase transgene. |
2011-08-18 |
2023-08-12 |
mouse |
| Ling Zhang, Yuan-yuan Li, Huai-cai Zeng, Miao Li, Yan-Jian Wan, Hermann J Schluesener, Zhi-yuan Zhang, Shun-qing X. Perfluorooctane sulfonate induces apoptosis in N9 microglial cell line. International journal of toxicology. vol 30. issue 2. 2011-08-18. PMID:21115943. |
the results showed that pfos could reduce the cell viability significantly, and the cellular apoptosis induced by pfos was closely accompanied with dissipation of mitochondria membrane potential, upregulation messenger rnas (mrnas) of p53, bax, caspase 9, and caspase 3, and decreased expression of bcl-2 mrna. |
2011-08-18 |
2023-08-12 |
human |
| Deepika Jain, Neelam Pathak, Saba Khan, Gorantla Venkata Raghuram, Arpit Bhargava, Ravindra Samarth, Pradyumna Kumar Mishr. Evaluation of cytotoxicity and anticarcinogenic potential of Mentha leaf extracts. International journal of toxicology. vol 30. issue 2. 2011-08-18. PMID:21300767. |
of all the extracts tested, chloroform and ethyl acetate extracts of m piperita showed significant dose- and time-dependent anticarcinogenic activity leading to g1 cell cycle arrest and mitochondrial-mediated apoptosis, perturbation of oxidative balance, upregulation of bax gene, elevated expression of p53 and p21 in the treated cells, acquisition of senescence phenotype, while inducing pro-inflammatory cytokines response. |
2011-08-18 |
2023-08-12 |
human |
| Liang Feng, Wai Au-Yeung, You-Hua Xu, Shan-Shan Wang, Quan Zhu, Ping Xian. Oleanolic acid from Prunella Vulgaris L. induces SPC-A-1 cell line apoptosis via regulation of Bax, Bad and Bcl-2 expression. Asian Pacific journal of cancer prevention : APJCP. vol 12. issue 2. 2011-08-18. PMID:21545203. |
oleanolic acid from prunella vulgaris l. induces spc-a-1 cell line apoptosis via regulation of bax, bad and bcl-2 expression. |
2011-08-18 |
2023-08-12 |
Not clear |
| Liang Feng, Wai Au-Yeung, You-Hua Xu, Shan-Shan Wang, Quan Zhu, Ping Xian. Oleanolic acid from Prunella Vulgaris L. induces SPC-A-1 cell line apoptosis via regulation of Bax, Bad and Bcl-2 expression. Asian Pacific journal of cancer prevention : APJCP. vol 12. issue 2. 2011-08-18. PMID:21545203. |
the results suggest oa induced apoptosis of lung adenocarcinoma cells through down-regulating bcl-2 expression, and up-regulating bax and bad expression. |
2011-08-18 |
2023-08-12 |
Not clear |
| Takeshi Kanno, Tomoyuki Nishizak. Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c. Journal of cellular physiology. vol 226. issue 9. 2011-08-17. PMID:21660956. |
taken together, the results of the present study indicate that sphingosine activates sdk, produced through proteolytic processing of an active form of pkc-δ, to phosphorylate 14-3-3 protein and transform into a monomeric structure, causing bax dissociation from 14-3-3 protein and accumulation in the mitochondria, which perturbs mitochondrial membrane potentials allowing cytochrome c release into the cytosol, to activate caspase-9 and the effector caspase-3, responsible for apoptosis in hippocampal neurons and astrocytes. |
2011-08-17 |
2023-08-12 |
rat |
| A P Morales, A C P Carvalho, P T Monteforte, H Hirata, S W Han, Y-T Hsu, S S Smail. Endoplasmic reticulum calcium release engages Bax translocation in cortical astrocytes. Neurochemical research. vol 36. issue 5. 2011-08-16. PMID:21347840. |
taken together, our results show that in bax overexpressing cortical astrocytes, endoplasmic reticulum-ca(2+) release may induce bax transactivation and specifically control apoptosis. |
2011-08-16 |
2023-08-12 |
rat |
| Jiajie Zou, Qian Chen, Xi Jin, Shusheng Tang, Kaipao Chen, Ting Zhang, Xilong Xia. Olaquindox induces apoptosis through the mitochondrial pathway in HepG2 cells. Toxicology. vol 285. issue 3. 2011-08-16. PMID:21549799. |
meanwhile, the data showed that olaquindox triggered ros-mediated apoptosis in hepg2 cells correlated with both the mitochondrial dna damage and nuclear dna damage, collapse of Δψ(m), opening of mptp, down-regulation of bcl-2 and up-regulation of bax. |
2011-08-16 |
2023-08-12 |
Not clear |
| Song Jiao, Zheng L. Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission. Neuron. vol 70. issue 4. 2011-08-16. PMID:21609830. |
in contrast to apoptosis, however, bad is activated only moderately and transiently and bax is not translocated to mitochondria, resulting in only modest caspase-3 activation. |
2011-08-16 |
2023-08-12 |
Not clear |
| Ahmed Malki, Amal Yousse. Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling. Oncology research. vol 19. issue 6. 2011-08-16. PMID:21776823. |
metformin induced apoptosis by arresting cells in g1 phase and reducing cyclin d level and increasing the expression of p21 and cyclin e. molecular and cellular studies indicated that metformin significantly elevated p53 and bax levels and reduced stat3 and bcl-2. |
2011-08-16 |
2023-08-12 |
human |
| Ahmed Malki, Amal Yousse. Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling. Oncology research. vol 19. issue 6. 2011-08-16. PMID:21776823. |
all these results suggested that metformin activated p53, bax, and induced tumor cell apoptosis through the erk signaling pathway. |
2011-08-16 |
2023-08-12 |
human |
| Ahmed Malki, Amal Yousse. Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling. Oncology research. vol 19. issue 6. 2011-08-16. PMID:21776823. |
this pathway has not been previously described for ir, p53, bax activation, or apoptosis. |
2011-08-16 |
2023-08-12 |
human |
| Zhen-min Sun, Yan Xiao, Li-li Ren, Xiao-bo Lei, Jian-wei Wan. [Enterovirus 71 induces apoptosis in a Bax dependent manner]. Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology. vol 25. issue 1. 2011-08-16. PMID:21789855. |
[enterovirus 71 induces apoptosis in a bax dependent manner]. |
2011-08-16 |
2023-08-12 |
Not clear |
| Tao Meng, Jun Li, Hai-ying Chen, Tao Shan. [Relationship between the expressions of lectin-like oxidized low-density lipoprotein receptor-1 and apoptosis associated genes in placenta tissues and the pathogenesis of preeclampsia]. Zhonghua fu chan ke za zhi. vol 43. issue 6. 2011-08-15. PMID:19035131. |
to explore the expressions of lectin-like oxidized low-density lipoprotein receptor-1 (lox-1) and apoptosis related genes caspase-3, bax and bcl-2 in placenta, and their associations with the pathogenesis of preeclampsia. |
2011-08-15 |
2023-08-12 |
Not clear |
| Xin Wang, Li-xin Shang, Nan Wu, Jing Wang, Li-mei Wan. [Effects of di-(2-ethylexyl) phthalate on apoptosis of cytotrophoblasts in early pregnancy]. Zhonghua fu chan ke za zhi. vol 45. issue 6. 2011-08-15. PMID:21029589. |
to investigate the influence of di-(2-ethylexyl) phthalate (dehp) on cell apoptosis and expression of bcl-2 and bax in cultured human first trimester cytotrophoblasts. |
2011-08-15 |
2023-08-12 |
human |
| Junyan An, Libo Zheng, Shurui Xie, Zhina Dun, Lisen Hao, Dongmei Yao, David Q Shih, Xiaolan Zhan. Down-regulation of focal adhesion kinase by short hairpin RNA increased apoptosis of rat hepatic stellate cells. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 119. issue 6. 2011-08-15. PMID:21569089. |
tunel also confirmed the increase in the rate of apoptosis (19.00 ± 0.92% vs 7.63 ± 0.70%, p < 0.01), and studies showed that the caspase-3 expression was increased while the ratio of bcl-2 to bax was decreased. |
2011-08-15 |
2023-08-12 |
rat |