| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun-Feng Zhang, Jia-Jun Liu, Pei-Qing Liu, Dong-Jun Lin, Xu-Dong Li, Gui-Hua Che. Oridonin inhibits cell growth by induction of apoptosis on human hepatocelluar carcinoma BEL-7402 cells. Hepatology research : the official journal of the Japan Society of Hepatology. vol 35. issue 2. 2011-07-14. PMID:16638644. |
marked morphological changes of cell apoptosis were observed very clearly by hoechst 33258 staining as well as dna fragmentation analysis after the cells exposed to oridonin for 60h; western blotting showed cleavage of the caspase-3 zymogen protein (32-kda) with the appearance of its 20-kda subunit; along with the apoptotic process bcl-2 expression was down-regulated and bax expression up-regulated concurrently observed by western blotting. |
2011-07-14 |
2023-08-12 |
human |
| Jun-Feng Zhang, Jia-Jun Liu, Pei-Qing Liu, Dong-Jun Lin, Xu-Dong Li, Gui-Hua Che. Oridonin inhibits cell growth by induction of apoptosis on human hepatocelluar carcinoma BEL-7402 cells. Hepatology research : the official journal of the Japan Society of Hepatology. vol 35. issue 2. 2011-07-14. PMID:16638644. |
we therefore conclude that oridonin can inhibit cell growth by induction of apoptosis in bel-7402 cells via activation of caspase-3 as well as down-regulation of bcl-2 and up-regulation of bax expression. |
2011-07-14 |
2023-08-12 |
human |
| K Nishida, T Kunisada, Z N Shen, Y Kadota, K Hashizume, T Ozak. Chondrosarcoma and peroxisome proliferator-activated receptor. PPAR research. vol 2008. 2011-07-14. PMID:18725985. |
the treatment of oums-27 by 15d-pgj(2), the most potent endogenous ligand for ppargamma, downregulated expression of bcl-xl and induced transient upregulation of proapoptotic bax, which could accelerate cytochrome c release from mitochondria to the cytosol, followed by induction of caspase-dependent apoptosis. |
2011-07-14 |
2023-08-12 |
human |
| Hsien W Chan, Tianbing Liu, Giuseppe Verdile, Glenda Bishop, Ryan J Haasl, Mark A Smith, George Perry, Ralph N Martins, Craig S Atwoo. Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the tx Mouse is a Better Model of Hepatic than Brain Cu Toxicity. International journal of clinical and experimental medicine. vol 1. issue 1. 2011-07-14. PMID:19079689. |
to test whether the induction of apoptosis in neuroblastoma cells was via post-translational mechanisms, we measured the protein expression of these apoptotic markers in m17 neuroblastoma cells treated with cu-glycine(2) (0-100 mum) for 24-48 h. compared with glycine treated cells, cu-glycine(2) reduced bcl-2 expression by 50 %, but increased bax and bak expression by 130% and 400 %, respectively. |
2011-07-14 |
2023-08-12 |
mouse |
| Minaxi Jhawer, David Kelsen, Manish Sha. Incorporation of biologic therapies in the management of gastroesophageal cancers. Gastrointestinal cancer research : GCR. vol 1. issue 2 Suppl. 2011-07-14. PMID:19343157. |
such targets include cell growth regulators (human epidermal growth factor like receptor, ki-67), vascular modulators (vascular endothelial growth factor), cell cycle checkpoint modulators (p16, p21, cyclin d1, cyclindependent kinases), apoptosis promoters (p53, bax, bcl-2), and cell proliferators, tissue invasion and metastasis potentiators (matrix metalloproteinase, e-cadherin, gastrin 17). |
2011-07-14 |
2023-08-12 |
human |
| Satoru Sakuma, Hiromi Sumi, Tetsuya Kohda, Yukio Arakawa, Yohko Fujimot. Effects of Lipid Peroxidation-Derived Products on the Growth of Human Colorectal Cancer Cell Line HT-29. Journal of clinical biochemistry and nutrition. vol 45. issue 2. 2011-07-14. PMID:19794925. |
further experiments concerning dna fragmentation, expression levels of bax and bcl-2 mrna, expression levels of pro-caspase-3 and caspase-3 proteins, and activity of caspase-3 suggested that 4-oxononenal may increase the sensitivity of ht-29 cells to apoptosis through a decreased expression level of bcl-2 and then increased formation of caspase-3 from pro-caspase-3. |
2011-07-14 |
2023-08-12 |
human |
| Young Sun Kim, Hong Joon Lee, Chorong Jang, Ho-Shik Kim, Young-Jin Ch. Knockdown of RCAN1.4 Increases Susceptibility to FAS-mediated and DNA-damage-induced Apoptosis by Upregulation of p53 Expression. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 13. issue 6. 2011-07-14. PMID:20054496. |
transfection of sirnas against rcan1.4 resulted in enhanced fas- and etoposide-induced apoptosis, which was associated with increased expression and translocation of bax to mitochondria. |
2011-07-14 |
2023-08-12 |
human |
| Young Sun Kim, Hong Joon Lee, Chorong Jang, Ho-Shik Kim, Young-Jin Ch. Knockdown of RCAN1.4 Increases Susceptibility to FAS-mediated and DNA-damage-induced Apoptosis by Upregulation of p53 Expression. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 13. issue 6. 2011-07-14. PMID:20054496. |
our results suggest that enhanced expression and activation of p53 was responsible for the upregulation of bax and the increased sensitivity to apoptosis, which could be reversed by p53 knockdown. |
2011-07-14 |
2023-08-12 |
human |
| Ahmed Shalaby, Timo Rinne, Otso Järvinen, Juha Latva-Hirvelä, Kristiina Nuutila, Antti Saraste, Jari Laurikka, Helena Porkkala, Pekka Saukko, Matti Tarkk. The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2. Cardiology research and practice. vol 2009. 2011-07-14. PMID:20069048. |
open heart surgery is associated with rapid reduction in the expression of apoptosis regulating genes bax and bcl-2. |
2011-07-14 |
2023-08-12 |
Not clear |
| Hiroyasu Takita, Shin Yoneya, Peter L Gehlbach, Lisa L Wei, Keisuke Mor. An empty E1, E3, E4 adenovirus vector protects photoreceptors from light-induced degeneration. Journal of ocular biology, diseases, and informatics. vol 1. issue 1. 2011-07-14. PMID:20072633. |
semiquantitative assessment of messenger ribonucleic acid (mrna) for the apoptosis related genes: p50, p65, ikba, caspase-1, caspase-3, bad, c-jun, bax, bak, bcl-2, c-fos, and p53 using quantitative reverse transcriptase polymerase chain reaction was performed on eyes following 12 h of light exposure. |
2011-07-14 |
2023-08-12 |
mouse |
| Nadia Gabellini, Valentina Masol. Expression of LGI1 Impairs Proliferation and Survival of HeLa Cells. International journal of cell biology. vol 2009. 2011-07-14. PMID:20111625. |
expression of lgi1 increased the activity of apoptosis effectors caspase-3/7; furthermore it downregulated the antiapoptotic bcl2 gene and upregulated the proapoptotic bax gene expression, suggesting that the cause of hela cells death might be an increased susceptibility to apoptosis induced by lgi1. |
2011-07-14 |
2023-08-12 |
Not clear |
| Hung-Jen Lin, Ching-Ping Tseng, Chia-Fan Lin, Mei-Huei Liao, Chuan-Mu Chen, Shung-Te Kao, Ju-Chien Chen. A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2011-07-14. PMID:20976079. |
in this study, we found that mygj induced hepatic stellate cells (hscs) apoptosis concomitant with the downregulation of bcl-2 expression and slight elevation of bax level. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ai Gao, Xin Zuo, Shanshan Song, Wei Guo, Lin Tia. Epigenetic modification involved in benzene-induced apoptosis through regulating apoptosis-related genes expression. Cell biology international. vol 35. issue 4. 2011-07-14. PMID:21143203. |
results showed that benzene caused cell apoptosis accompanied with bcl-2 mrna decrease, caspase-3 and bax mrna increase. |
2011-07-14 |
2023-08-12 |
rat |
| Ai Gao, Xin Zuo, Shanshan Song, Wei Guo, Lin Tia. Epigenetic modification involved in benzene-induced apoptosis through regulating apoptosis-related genes expression. Cell biology international. vol 35. issue 4. 2011-07-14. PMID:21143203. |
in conclusion, 5-aza inhibited benzene-induced apoptosis through down-regulating of caspase-3 and bax and up-regulating bcl-2 mrna expression, whereas the effect of tsa on apoptosis dominatingly affected bcl-2 mrna expression, and 5-aza together with tsa had no synergic effect on benzene-induced apoptosis. |
2011-07-14 |
2023-08-12 |
rat |
| Siddig Ibrahim Abdelwahab, Syam Mohan, Manal Mohamed Elhassan, Nabil Al-Mekhlafi, Abdelbasit Adam Mariod, Ahmad Bustamam Abdul, Mahmood Ameen Abdulla, Khalid M Alkharf. Antiapoptotic and Antioxidant Properties of Orthosiphon stamineus Benth (Cat's Whiskers): Intervention in the Bcl-2-Mediated Apoptotic Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2011-07-14. PMID:21234328. |
this plant not only increased the expression of bcl-2, but also decreased bax expression, and ultimately reduced h(2)o(2)-induced apoptosis. |
2011-07-14 |
2023-08-12 |
cat |
| Sun-Young Lee, Kyoung-Won Ko, Won-Kyung Kang, Yun-Jeong Choe, Yoon-Hyoung Kim, In-Kyung Kim, Jin Kim, Ho-Shik Ki. Induction of the Intrinsic Apoptotic Pathway by 3-Deazaadenosine Is Mediated by BAX Activation in HL-60 Cells. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 14. issue 6. 2011-07-14. PMID:21311682. |
finally, the overexpression of bcl-xl protected hl-60 cells from apoptosis by blocking both the cyt c release and bax oligomerization. |
2011-07-14 |
2023-08-12 |
human |
| Sun-Young Lee, Kyoung-Won Ko, Won-Kyung Kang, Yun-Jeong Choe, Yoon-Hyoung Kim, In-Kyung Kim, Jin Kim, Ho-Shik Ki. Induction of the Intrinsic Apoptotic Pathway by 3-Deazaadenosine Is Mediated by BAX Activation in HL-60 Cells. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 14. issue 6. 2011-07-14. PMID:21311682. |
collectively, these findings suggest that dza may activate intrinsic apoptosis by stimulating bax activation and thereby the release of cyt c. |
2011-07-14 |
2023-08-12 |
human |
| Y S Wang, X Zhao, J M Su, Z X An, X R Xiong, L J Wang, J Liu, F S Quan, S Hua, Y Zhan. Lowering storage temperature during ovary transport is beneficial to the developmental competence of bovine oocytes used for somatic cell nuclear transfer. Animal reproduction science. vol 124. issue 1-2. 2011-07-14. PMID:21333472. |
the developmental competence of oocytes used for scnt was ascertained by cleavage and blastocyst formation rate, total cell number, apoptosis index, and the relative abundance of bax and hsp70.1 in day 7 blastocysts. |
2011-07-14 |
2023-08-12 |
cattle |
| Z Liu, M Cheng, Mz Ca. Potential targets for molecular imaging of apoptosis resistance in hepatocellular carcinoma. Biomedical imaging and intervention journal. vol 7. issue 1. 2011-07-14. PMID:21655114. |
loss of response to death receptors, transformation of growth factor-β induced apoptosis, upregulation of anti-apoptotic bcl-2 subgroup, as well as downregulation of pro-apoptotic bax subgroup and bh3-only subgroup, are associated with apoptosis resistance in hcc. |
2011-07-14 |
2023-08-12 |
Not clear |
| Qi-Tian Mu, Gui-Fang Ouyang, Yan-Ru Lou, Xiao-Pei Chen, Ying Lu, Wei Liang, Yi Zhang, Wei X. [Inducing-apoptosis effect of bortezomib on acute monocytic leukemia cell SHI-1 and its influence on expressions of Bcl2l12, Bcl-2 and Bax genes]. Zhongguo shi yan xue ye xue za zhi. vol 16. issue 5. 2011-07-12. PMID:18928586. |
this study was aimed to explore the effect of bortezomib on proliferation and apoptosis of acute monocytic leukemic cells shi-1 and the function of bcl-2 gene family including bcl2l12, bcl-2 and bax in its apoptosis. |
2011-07-12 |
2023-08-12 |
Not clear |