| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hayato Hikita, Tetsuo Takehara, Takahiro Kodama, Satoshi Shimizu, Minoru Shigekawa, Atsushi Hosui, Takuya Miyagi, Tomohide Tatsumi, Hisashi Ishida, Wei Li, Tatsuya Kanto, Naoki Hiramatsu, Shigeomi Shimizu, Yoshihide Tsujimoto, Norio Hayash. Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fas activation in Bak/Bax-deficient mice. Hepatology (Baltimore, Md.). vol 54. issue 1. 2011-09-30. PMID:21425311. |
fas-induced rapid fulminant hepatocyte apoptosis was partially ameliorated in bak knockout mice but not in bax knockout mice, and was completely abolished in double knockout mice 3 hours after jo2 injection. |
2011-09-30 |
2023-08-12 |
mouse |
| In Youb Chang, Jin Nam Kim, Jae Yeoul Jun, Ho Jin You, Young Jin Jeon, Kyeong-Soo Park, Sang Pil Yoo. Repression of apurinic/apyrimidinic endonuclease by p53-dependent apoptosis in hydronephrosis-induced rat kidney. Free radical research. vol 45. issue 6. 2011-09-30. PMID:21473738. |
p53 plays a major role in apoptosis through activation of pro-apoptotic gene bax. |
2011-09-30 |
2023-08-12 |
rat |
| Yashu Wang, Linhong Deng, Yajie Wang, Hongzhe Zhong, Xuemei Jiang, Jun Che. Natural plant extract tubeimoside I induces cytotoxicity via the mitochondrial pathway in human normal liver cells. Molecular medicine reports. vol 4. issue 4. 2011-09-30. PMID:21537846. |
subsequently, the cell survival rate was evaluated by the mtt dye method, and several key molecular events associated with apoptosis were assayed, including mitochondrial depolarization, release of cytochrome c (cyt-c), activation of caspases, and the balance between bax and bcl-2 protein expression. |
2011-09-30 |
2023-08-12 |
human |
| Yashu Wang, Linhong Deng, Yajie Wang, Hongzhe Zhong, Xuemei Jiang, Jun Che. Natural plant extract tubeimoside I induces cytotoxicity via the mitochondrial pathway in human normal liver cells. Molecular medicine reports. vol 4. issue 4. 2011-09-30. PMID:21537846. |
the tbms i-induced growth inhibition of l-02 cells was accompanied by the collapse of mitochondrial membrane potential, release of cyt-c from the mitochondria to the cytosol, activation of caspase-9 and -3, decrease of anti-apoptotic protein bcl-2 levels and increase of the pro-apoptotic protein bax levels, all indicative of apoptosis through the mitochondrial pathway. |
2011-09-30 |
2023-08-12 |
human |
| Sona Mitra, Magomed Khaidakov, Jingjun Lu, Srinivas Ayyadevara, Jackob Szwedo, Xian Wei Wang, Chien Chen, Said Khaidakov, Srikanth Reddy Kasula, Annjanette Stone, Igor Pogribny, Jawahar L Meht. Prior exposure to oxidized low-density lipoprotein limits apoptosis in subsequent generations of endothelial cells by altering promoter methylation. American journal of physiology. Heart and circulatory physiology. vol 301. issue 2. 2011-09-30. PMID:21602467. |
ox-ldl-induced apoptosis was associated with upregulation of proapoptotic lox-1, anxa5, bax, and casp3 and inhibition of antiapoptotic bcl2 and ciap-1 genes accompanied with reciprocal changes in the methylation of promoter regions of these genes. |
2011-09-30 |
2023-08-12 |
human |
| Denis Selimovic, Mutmid Ahmad, Abdelouahid El-Khattouti, Matthias Hannig, Youssef Haïkel, Mohamed Hassa. Apoptosis-related protein-2 triggers melanoma cell death by a mechanism including both endoplasmic reticulum stress and mitochondrial dysregulation. Carcinogenesis. vol 32. issue 8. 2011-09-30. PMID:21693538. |
also, the activation of apoptosis signal-regulating kinase (ask) 1, c-jun-n-terminal kinase (jnk) and the transcription factors ap-1 and p53, and the induction of bax expression were noted in apr-2-expressing cells. |
2011-09-30 |
2023-08-12 |
Not clear |
| Jing-Xing Yu, Xin Liu, Bo X. [Docetaxel induces apoptosis and influences the expression of P-gp, BCL-2 and BAX protein in HL-60/ADR cells]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 2. 2011-09-29. PMID:20416158. |
[docetaxel induces apoptosis and influences the expression of p-gp, bcl-2 and bax protein in hl-60/adr cells]. |
2011-09-29 |
2023-08-12 |
Not clear |
| Jing-Xing Yu, Xin Liu, Bo X. [Docetaxel induces apoptosis and influences the expression of P-gp, BCL-2 and BAX protein in HL-60/ADR cells]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 2. 2011-09-29. PMID:20416158. |
the morphological changes of hl-60/adr were observed by light and transmission electron microscopes; the cell apoptosis was detected by flow cytometry with annexin v fitc/pi double labeling; the expressions of p-gp, bcl-2 and bax were determined by immunohistochemical technique and computer image analysis system. |
2011-09-29 |
2023-08-12 |
Not clear |
| Jing-Xing Yu, Xin Liu, Bo X. [Docetaxel induces apoptosis and influences the expression of P-gp, BCL-2 and BAX protein in HL-60/ADR cells]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 2. 2011-09-29. PMID:20416158. |
it is concluded that the docetaxel induces apoptosis of hl-60/adr cells, decreases the expression of bcl-2 protein and increases the expression of bax protein. |
2011-09-29 |
2023-08-12 |
Not clear |
| Li Su, Yuantao Deng, Yingmei Zhang, Chengyun Li, Rui Zhang, Yingbiao Sun, Ke Zhang, Jin Li, Shixia Ya. Protective effects of grape seed procyanidin extract against nickel sulfate-induced apoptosis and oxidative stress in rat testes. Toxicology mechanisms and methods. vol 21. issue 6. 2011-09-28. PMID:21417627. |
this study determined whether nickel sulfate (ni)-induced reproductive damage occurs via apoptosis and oxidative stress and to examine the expression of bax and c-kit and their effects on ni exposure. |
2011-09-28 |
2023-08-12 |
rat |
| Li Su, Yuantao Deng, Yingmei Zhang, Chengyun Li, Rui Zhang, Yingbiao Sun, Ke Zhang, Jin Li, Shixia Ya. Protective effects of grape seed procyanidin extract against nickel sulfate-induced apoptosis and oxidative stress in rat testes. Toxicology mechanisms and methods. vol 21. issue 6. 2011-09-28. PMID:21417627. |
these results demonstrate the following: (1) ni exhibits reproductive toxicity in rats by decreasing sperm at concentrations of 2.5 and 5 mg; (2) intratesticular apoptosis, oxidative stress, and c-kit overexpression play pivotal roles in reproductive damage induced by ni; and (3) gspe enhances sperm motility by down-regulating c-kit expression and offsetting the apoptosis and oxidative stress induced by ni by directly decreasing mda and no, scavenging h₂o₂, and down-regulating bax expression. |
2011-09-28 |
2023-08-12 |
rat |
| Yi Jiang, Ze-Hong Miao, Lei Xu, Bing Yu, Jing-Xu Gong, Lin-Jiang Tong, Yi Chen, Zhao-Li Zhou, Hong-Chun Liu, Yi Wang, Yue-Wei Guo, Jian Din. Drug transporter-independent liver cancer cell killing by a marine steroid methyl spongoate via apoptosis induction. The Journal of biological chemistry. vol 286. issue 30. 2011-09-28. PMID:21659517. |
mesp inhibited the phosphorylation of stat3, a critical survival signaling factor that reduced the expression of the antiapoptotic protein x-linked inhibitor of apoptosis protein but enhanced the expression of the proapoptotic protein bax, thus promoting caspase-dependent apoptosis. |
2011-09-28 |
2023-08-12 |
Not clear |
| Shilpa Bharti, M M Misro, Amitabh Mathur, Umesh Ra. Role of estrogen in the regulation of spermatogenesis in the Indian wall lizard Hemidactylus flaviviridis. General and comparative endocrinology. vol 172. issue 2. 2011-09-27. PMID:21414318. |
simultaneously, there was a significant rise in germ cell apoptosis which was associated with an up-regulation of extrinsic (caspase 8, fas, fasl) and intrinsic (caspase 9, bax, bcl2) markers in these cells. |
2011-09-27 |
2023-08-12 |
Not clear |
| Xiaoyan Mo, Nana Zhao, Xiaoyang Du, Liyuan Bai, Jiankang Li. The protective effect of peony extract on acute myocardial infarction in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 18. issue 6. 2011-09-26. PMID:21112198. |
myocardial enzymes, cytokines, oxidative stress, blood coagulation times, a marker for early stage apoptosis, caspase-3 activity, and expression levels of bax, bcl-2 and fas in isolated primary cardiomyocytes were examined. |
2011-09-26 |
2023-08-12 |
rat |
| Xiaoyan Mo, Nana Zhao, Xiaoyang Du, Liyuan Bai, Jiankang Li. The protective effect of peony extract on acute myocardial infarction in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 18. issue 6. 2011-09-26. PMID:21112198. |
in ami cardiomyocytes, compared with control and sham groups, the left ventricular end-diastolic pressure, early stage apoptosis, caspase-3 activity and expression levels of bax, bcl-2 and fas significantly increased, while the ratio bcl-2/bax decreased. |
2011-09-26 |
2023-08-12 |
rat |
| J H Oh, M-C Cho, J-H Kim, S Y Lee, H J Kim, E S Park, J O Ban, J-W Kang, D-H Lee, J-H Shim, S B Han, D C Moon, Y H Park, D-Y Yu, J-M Kim, S H Kim, D-Y Yoon, J T Hon. IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals. Oncogene. vol 30. issue 30. 2011-09-26. PMID:21423208. |
the expression of antiapoptotic, cell proliferation and tumor-promoting genes (bcl-2, x-chromosome inhibitor of apoptosis protein (iap), cellular iap and cellular fadd-like il-1β-converting enzyme-inhibitory protein, cyclin d), cyclin-dependent kinase 4, cycolooxygenase-2 and inducible nitric oxide synthase was decreased, whereas the expression of apoptotic target genes (caspase-3 and -9, bax) increased. |
2011-09-26 |
2023-08-12 |
mouse |
| Shiyong Yang, Zhi Wang, Colin Farquharson, Rashad Alkasir, Mohammad Zahra, Gaixian Ren, Bo Ha. Sodium fluoride induces apoptosis and alters bcl-2 family protein expression in MC3T3-E1 osteoblastic cells. Biochemical and biophysical research communications. vol 410. issue 4. 2011-09-23. PMID:21708129. |
the objectives of this study were to determine the effects of fluoride treatment on mc3t3-e1 osteoblastic cell viability, cell cycle analysis, apoptosis and the expression levels of bcl-2 family members: bcl-2 and bax. |
2011-09-23 |
2023-08-12 |
Not clear |
| Shiyong Yang, Zhi Wang, Colin Farquharson, Rashad Alkasir, Mohammad Zahra, Gaixian Ren, Bo Ha. Sodium fluoride induces apoptosis and alters bcl-2 family protein expression in MC3T3-E1 osteoblastic cells. Biochemical and biophysical research communications. vol 410. issue 4. 2011-09-23. PMID:21708129. |
this increased apoptosis was due to alterations in the expression of both pro-apoptotic bax and anti-apoptotic bcl-2. |
2011-09-23 |
2023-08-12 |
Not clear |
| Yongkyu Lee, Hejin Kim, Jinhwa Lee, Kyongtai Ki. Anticancer activity of S-allylmercapto-L-cysteine on implanted tumor of human gastric cancer cell. Biological & pharmaceutical bulletin. vol 34. issue 5. 2011-09-21. PMID:21532156. |
these results suggest that samc may regulate bcl-2 and bax to induce apoptosis in transplanted tumor cells. |
2011-09-21 |
2023-08-12 |
human |
| Yudong Jia, Jinxing Lin, Yuling Mi, Caiqiao Zhan. Quercetin attenuates cadmium-induced oxidative damage and apoptosis in granulosa cells from chicken ovarian follicles. Reproductive toxicology (Elmsford, N.Y.). vol 31. issue 4. 2011-09-20. PMID:21262342. |
furthermore, cadmium provoked higher bax expression, inhibited expression of bcl2 and x-linked inhibitor of apoptosis protein (xiap) and activated caspase-3. |
2011-09-20 |
2023-08-12 |
chicken |