| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Ding, Jinghong Shi, Ying Wang, Jia Guo, Juhui Zhao, Lei Don. Neferine inhibits cultured hepatic stellate cell activation and facilitates apoptosis: A possible molecular mechanism. European journal of pharmacology. vol 650. issue 1. 2011-03-24. PMID:20969858. |
our data indicate that neferine efficiently inhibits cultured hsc-t6 cell activation and induces apoptosis by increasing bax and caspase 3 expression via the mitochondrial pathway. |
2011-03-24 |
2023-08-12 |
Not clear |
| Snjezana Mardesic Brakus, Danijela Kalibovic Govorko, Katarina Vukojevic, Ivana Alujevic Jakus, Dominko Carev, Josko Petricevic, Mirna Saraga-Babi. Apoptotic and anti-apoptotic factors in early human mandible development. European journal of oral sciences. vol 118. issue 6. 2011-03-24. PMID:21083614. |
the regulators of apoptosis bcl-2, bax, caspase-3, p53, and hsp70 were analyzed immunohistochemically in the developing human mandible of eight human conceptuses from weeks 5 to 10 of gestation. |
2011-03-24 |
2023-08-12 |
human |
| M Galuppo, R Di Paola, E Mazzon, E Esposito, I Paterniti, A Kapoor, C Thiemermann, S Cuzzocre. GW0742, a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice. International journal of immunopathology and pharmacology. vol 23. issue 4. 2011-03-24. PMID:21244753. |
has therapeutic effects on pulmonary damage, decreasing many inflammatory and apoptotic parameters detected by measurement of: 1) cytokine production; 2) leukocyte accumulation, indirectly measured as decrease of myeloperoxidase (mpo) activity; 3) ikbα degradation and nf-kb nuclear translocation; 4) erk phosphorylation; 5) stress oxidative by no formation due to inos expression; 6) nitrotyrosine and par localization; 7) the degree of apoptosis, evaluated by bax and bcl-2 balance, fas ligand expression and tunel staining. |
2011-03-24 |
2023-08-12 |
mouse |
| Faris Q Alenz. Cell type specific expression of the apoptosis stimulating protein (ASPP-2) in human tissues. Acta microbiologica et immunologica Hungarica. vol 57. issue 4. 2011-03-23. PMID:21183427. |
apoptosis stimulating proteins of p53 (aspp-l and aspp-2) are a novel family of proteins that have been found to co-stimulate p53 activation of bax (bcl-2 associated protein x) inducing caspase-mediated apoptosis. |
2011-03-23 |
2023-08-12 |
mouse |
| Ning Wang, Yibin Feng, Meifen Zhu, Chi-Man Tsang, Kwan Man, Yao Tong, Sai-Wah Tsa. Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism. Journal of cellular biochemistry. vol 111. issue 6. 2011-03-22. PMID:20830746. |
mechanistic studies showed that berberine may activate mitochondrial apoptosis in hepg2 and mhcc97-l cells by increasing bax expression, the formation of permeable transition pores, cytochrome c release to cytosol, and subsequent activation of the caspases 3 and 9 execution pathway. |
2011-03-22 |
2023-08-12 |
human |
| Cheng Chang, Youqing Zhu, Xiaoyan Tang, Wenhui Ta. The anti-proliferative effects of norcantharidin on human HepG2 cells in cell culture. Molecular biology reports. vol 38. issue 1. 2011-03-21. PMID:20333548. |
by western blot analysis, we found the level of bcl-2 were down-regulated, whereas, the level of bcl-2 up-regulated.so we suggest that up-regulation of mitochondrial bax expression and down-regulation of bcl-2 expression participated in the apoptosis induced by nctd. |
2011-03-21 |
2023-08-12 |
human |
| Bulent Karabulut, Burcak Karaca, Harika Atmaca, Asli Kisim, Selim Uzunoglu, Canfeza Sezgin, Ruchan Usl. Regulation of apoptosis-related molecules by synergistic combination of all-trans retinoic acid and zoledronic acid in hormone-refractory prostate cancer cell lines. Molecular biology reports. vol 38. issue 1. 2011-03-21. PMID:20349282. |
while expression of proapoptotic genes such as tumor necrosis factor receptor superfamily (tnfrsf), bad, bax, fas, fadd are induced with the exposure of the combination, expression of antiapoptotic genes or proteins such as members of inhibitor apoptosis family (iaps), mcl-1, ltbr, p53 and bcl-2 are reduced. |
2011-03-21 |
2023-08-12 |
human |
| Deepak Sharma, Santosh K Sandur, R Rashmi, D K Maurya, Shweta Suryavanshi, Rahul Checker, Sunil Krishnan, K B Saini. Differential activation of NF-κB and nitric oxide in lymphocytes regulates in vitro and in vivo radiosensitivity. Mutation research. vol 703. issue 2. 2011-03-21. PMID:20732448. |
addition of sodium nitroprusside (snp), a nitric oxide donor to cells irradiated in vitro inhibited the repair of dna damage and enhanced apoptosis (increased bax to bcl-2 ratio). |
2011-03-21 |
2023-08-12 |
mouse |
| Sheila J Semaan, Robert W Nickell. The apoptotic response in HCT116BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein. BMC cancer. vol 10. 2011-03-21. PMID:20942963. |
although stoichiometirc interactions between anti-apoptotic and bh3-only bcl2 family proteins have been well documented as affecting cell death, the association between changes in bax concentration and intrinsic apoptosis are poorly understood. |
2011-03-21 |
2023-08-12 |
Not clear |
| Thanh Chi Hoang, Thi Kim Ly Bui, Takahiro Taguchi, Toshiki Watanabe, Yuko Sat. All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein. Journal of experimental & clinical cancer research : CR. vol 29. 2011-03-18. PMID:21159206. |
all-trans retinoic acid inhibits kit activity and induces apoptosis in gastrointestinal stromal tumor gist-t1 cell line by affecting on the expression of survivin and bax protein. |
2011-03-18 |
2023-08-12 |
Not clear |
| Di Na, Funan Liu, Zhifeng Miao, Zongmin Du, Huimian X. Destruction of gastric cancer cells to mesothelial cells by apoptosis in the early peritoneal metastasis. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 2. 2011-03-17. PMID:19399397. |
the abnormal expressions of bcl-2 and bax may contribute to the apoptosis. |
2011-03-17 |
2023-08-12 |
human |
| Drew Williams, Grant Norman, Chamel Khoury, Naomi Metcalfe, Jennie Briard, Aimee Laporte, Sara Sheibani, Liam Portt, Craig A Mandato, Michael T Greenwoo. Evidence for a second messenger function of dUTP during Bax mediated apoptosis of yeast and mammalian cells. Biochimica et biophysica acta. vol 1813. issue 2. 2011-03-15. PMID:21145358. |
evidence for a second messenger function of dutp during bax mediated apoptosis of yeast and mammalian cells. |
2011-03-15 |
2023-08-12 |
mouse |
| Drew Williams, Grant Norman, Chamel Khoury, Naomi Metcalfe, Jennie Briard, Aimee Laporte, Sara Sheibani, Liam Portt, Craig A Mandato, Michael T Greenwoo. Evidence for a second messenger function of dUTP during Bax mediated apoptosis of yeast and mammalian cells. Biochimica et biophysica acta. vol 1813. issue 2. 2011-03-15. PMID:21145358. |
using yeast as a model of eukaryotic mitochondrial apoptosis, we show that a cdna corresponding to the mitochondrial variant of the human dut gene (dut-m) encoding the deoxyuridine triphosphatase (dutpase) enzyme can prevent apoptosis in yeast in response to internal (bax expression) and to exogenous (h(2)o(2) and cadmium) stresses. |
2011-03-15 |
2023-08-12 |
mouse |
| Yujuan He, Jin Wang, Xiaoling Liu, Ling Zhang, Gang Yi, Chenwei Li, Xiao He, Peng Wang, Hui Jian. Toosendanin inhibits hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis. Planta medica. vol 76. issue 13. 2011-03-14. PMID:20157879. |
results from morphological analysis, annexin v staining, detection of caspases activity, and expressions of bcl-2, bax, and fas indicated that the anticancer effects of toosendanin were associated with its induction of apoptosis via the mitochondria-dependent pathway in p53- and p53+ hepatocellular carcinoma cells. |
2011-03-14 |
2023-08-12 |
mouse |
| Yujuan He, Jin Wang, Xiaoling Liu, Ling Zhang, Gang Yi, Chenwei Li, Xiao He, Peng Wang, Hui Jian. Toosendanin inhibits hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis. Planta medica. vol 76. issue 13. 2011-03-14. PMID:20157879. |
results from the immunohistochemistry for bcl-2, bax, as well as for fas showed that the anticancer effects of toosendanin were induced via apoptosis in a mitochondria-dependent manner, which confirmed the findings in the in vitro experiment. |
2011-03-14 |
2023-08-12 |
mouse |
| A Bender, D Opel, I Naumann, R Kappler, L Friedman, D von Schweinitz, K-M Debatin, S Fuld. PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis. Oncogene. vol 30. issue 4. 2011-03-14. PMID:20856197. |
bcl-2 overexpression inhibits bax activation, mitochondrial perturbations, cleavage of caspases and bid, and apoptosis, confirming the central role of the mitochondrial pathway for chemosensitization. |
2011-03-14 |
2023-08-12 |
Not clear |
| A Bender, D Opel, I Naumann, R Kappler, L Friedman, D von Schweinitz, K-M Debatin, S Fuld. PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis. Oncogene. vol 30. issue 4. 2011-03-14. PMID:20856197. |
interestingly, the broad-range caspase inhibitor zvad.fmk does not interfere with bax activation or mitochondrial outer membrane permeabilization, whereas it blocks caspase activation and apoptosis, thus placing mitochondrial events upstream of caspase activation. |
2011-03-14 |
2023-08-12 |
Not clear |
| Bo Ra You, Woo Hyun Par. Suberoyl bishydroxamic acid inhibits the growth of A549 lung cancer cells via caspase-dependent apoptosis. Molecular and cellular biochemistry. vol 344. issue 1-2. 2011-03-10. PMID:20652372. |
sbha-induced apoptosis was accompanied by the loss of mitochondrial membrane potential (mmp; ΔΨ(m)), bcl-2 decrease, bax increase, and the activation of caspase-3. |
2011-03-10 |
2023-08-12 |
Not clear |
| Emmanouil S Papadakis, Monika A Cichoń, Jashmin J Vyas, Nakul Patel, Lucy Ghali, Rino Cerio, Alan Storey, Edel A O'Tool. Axl promotes cutaneous squamous cell carcinoma survival through negative regulation of pro-apoptotic Bcl-2 family members. The Journal of investigative dermatology. vol 131. issue 2. 2011-03-10. PMID:21068757. |
we show that, although axl knock-down has no effect on cell proliferation, it sensitizes cells to uv-induced apoptosis through increased activation of the pro-apoptotic protein bad, a change in the conformation of bax and bak, release of cytochrome c into the cytosol, and activation of caspases. |
2011-03-10 |
2023-08-12 |
Not clear |
| Prabakaran Ravichandran, Sudhakar Baluchamy, Bindhu Sadanandan, Ramya Gopikrishnan, Santosh Biradar, Vani Ramesh, Joseph C Hall, Govindarajan T Rames. Multiwalled carbon nanotubes activate NF-κB and AP-1 signaling pathways to induce apoptosis in rat lung epithelial cells. Apoptosis : an international journal on programmed cell death. vol 15. issue 12. 2011-03-09. PMID:20694747. |
furthermore, mwcnt activated several death related proteins including apoptosis inducing factor, p53, p21 and bax. |
2011-03-09 |
2023-08-12 |
rat |