| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liming Wu, Chi A Ma, Yongge Zhao, Ashish Jai. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. The Journal of biological chemistry. vol 286. issue 3. 2011-02-24. PMID:20959462. |
functionally, overexpression of aurora b or nir suppresses p53 transcriptional activity, and depletion of aurora b or nir causes p53-dependent apoptosis and cell growth arrest, due to the up-regulation of p21 and bax. |
2011-02-24 |
2023-08-12 |
Not clear |
| Araya Dharmkrong-at Chusattayanond, Siriphan Boonsilp, Jitra Kasisit, Atsadang Boonmee, Saradee Wari. Thai Acanthamoeba isolate (T4) induced apoptotic death in neuroblastoma cells via the Bax-mediated pathway. Parasitology international. vol 59. issue 4. 2011-02-23. PMID:20601106. |
involvement of caspase enzymes and mitochondrial pro- and anti-apoptotic proteins (bax and bcl-2) in as-induced apoptosis was determined. |
2011-02-23 |
2023-08-12 |
mouse |
| Araya Dharmkrong-at Chusattayanond, Siriphan Boonsilp, Jitra Kasisit, Atsadang Boonmee, Saradee Wari. Thai Acanthamoeba isolate (T4) induced apoptotic death in neuroblastoma cells via the Bax-mediated pathway. Parasitology international. vol 59. issue 4. 2011-02-23. PMID:20601106. |
this is the first report on the role of bax in mediating apoptosis induced by acanthamoeba. |
2011-02-23 |
2023-08-12 |
mouse |
| Chun Liang, Yan Ding, Huu Tung Nguyen, Jeong-Ah Kim, Hye-Jin Boo, Hee-Kyoung Kang, Mahn Cuong Nguyen, Young Ho Ki. Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities. Bioorganic & medicinal chemistry letters. vol 20. issue 23. 2011-02-23. PMID:20951582. |
furthermore, compounds 1 and 2 in hct-116 cells activated intrinsic and extrinsic apoptosis pathways by upregulating dr-5 and bax, downregulating bcl-2, activating caspase-9, and cleaving poly-adp-ribose polymerase (parp). |
2011-02-23 |
2023-08-12 |
Not clear |
| Piyajit Watcharasit, Sumitra Suntararuks, Daranee Visitnonthachai, Apinya Thiantanawat, Jutamaad Satayaviva. Acrylonitrile induced apoptosis via oxidative stress in neuroblastoma SH-SY5Y cell. Journal of applied toxicology : JAT. vol 30. issue 7. 2011-02-22. PMID:20981856. |
taken together, the results indicate that acn induces apoptosis in sh-sy5y cells via a mechanism involving generation of oxidative stress-mediated bax induction. |
2011-02-22 |
2023-08-12 |
human |
| J C Su, K L Lin, C M Chien, C H Tseng, Y L Chen, L S Chang, S R Li. Furano-1,2-naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells. Cell biochemistry and function. vol 28. issue 8. 2011-02-22. PMID:21104938. |
fnq-induced apoptosis was accompanied with bax up-regulation and the down-regulation of bcl-2, x-linked inhibitor of apoptosis (xiap), and survivin, resulting in cytochrome c release and sequential activation of caspase-9 and caspase-3. |
2011-02-22 |
2023-08-12 |
Not clear |
| J C Su, K L Lin, C M Chien, C H Tseng, Y L Chen, L S Chang, S R Li. Furano-1,2-naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells. Cell biochemistry and function. vol 28. issue 8. 2011-02-22. PMID:21104938. |
the combined treatment of fnq with ag1478 (a specific egfr inhibitor) significantly enhanced the g(2)/m arrest and apoptosis, and also led to up-regulation in bax, p53, p21, p27, release of mitochondrial cytochrome c, and down-regulation of bcl-2, xiap, survivin, cyclin a, cyclin b, cdk1, and cdk2 in a549 cells. |
2011-02-22 |
2023-08-12 |
Not clear |
| Marc Germain, Angela P Nguyen, J Nicole Le Grand, Nicole Arbour, Jacqueline L Vanderluit, David S Park, Joseph T Opferman, Ruth S Slac. MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner. The EMBO journal. vol 30. issue 2. 2011-02-22. PMID:21139567. |
this autophagic response can, however, be converted to apoptosis by either reducing the levels of the autophagy regulator beclin-1, or by a concomitant activation of bax. |
2011-02-22 |
2023-08-12 |
mouse |
| Rong Li, Li Cai, Xue-feng Xie, Lei Peng, Jun L. 7,3'-dimethoxy hesperetin induces apoptosis of fibroblast-like synoviocytes in rats with adjuvant arthritis through caspase 3 activation. Phytotherapy research : PTR. vol 24. issue 12. 2011-02-17. PMID:20564462. |
bcl-2, bax, caspase 3 gene expressions and caspase 3 activity were assayed to identify whether caspase 3 was involved in the apoptosis induced by dmhp. |
2011-02-17 |
2023-08-12 |
rat |
| Lina Ghibelli, Marc Diederic. Multistep and multitask Bax activation. Mitochondrion. vol 10. issue 6. 2011-02-16. PMID:20709625. |
bax is a pro-apoptotic protein allowing apoptosis to occur through the intrinsic, damage-induced pathway, and amplifying that one occurring via the extrinsic, receptor mediated pathway. |
2011-02-16 |
2023-08-12 |
Not clear |
| Y L Zheng, X L Lu, J Lin, H M Chen, X J Yan, F Wang, W F X. Direct effects of fascaplysin on human umbilical vein endothelial cells attributing the anti-angiogenesis activity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 64. issue 8. 2011-02-09. PMID:19932581. |
this apoptosis response was further confirmed by the detection of active caspase-3 and by western blotting using antibodies against bax, bcl-2, procaspase-8, and bid, indicating that apoptosis in huvec cells may involve a mitochondria pathway, by the demonstration of an increase in the bax/bcl-2 ratio. |
2011-02-09 |
2023-08-12 |
human |
| Li Xiang-yong, Chen Yang-chao, Zhou Ke-yuan, Zhang Mei-hong, Luo Hai-qing, Kung Hsiang-fu, Zhou Xi. Overexpression of Bax inhibitor-1 (BI-1) induces cell transformation in NIH3T3 cells. Cell biology international. vol 34. issue 11. 2011-02-07. PMID:20597862. |
bi-1 (bax inhibitor-1), an apoptosis-inhibiting gene belonging to the bcl-2 protein family, plays an important role in mitochondrial apoptosis pathway to suppress bax-induced apoptosis. |
2011-02-07 |
2023-08-12 |
mouse |
| Natalia R Salvetti, Matías L Stangaferro, Martín M Palomar, Natalia S Alfaro, Florencia Rey, Eduardo J Gimeno, Hugo H Orteg. Cell proliferation and survival mechanisms underlying the abnormal persistence of follicular cysts in bovines with cystic ovarian disease induced by ACTH. Animal reproduction science. vol 122. issue 1-2. 2011-02-07. PMID:20800980. |
the relatively minimal proliferation found by immunohistochemistry with ki-67 marker were confirmed by the gene expression of cyclin d1 and e. lesser apoptotic rates were associated with decreased amounts of apoptotic-related proteins bax, faslg and caspase-3 as well as the in situ apoptosis detected by tunel assay, and increased amounts of the anti-apoptotic survival factor cellular bcl2 in the cystic follicles of the cod group. |
2011-02-07 |
2023-08-12 |
cattle |
| Shao-Ping Lu, Pin-Ting Zha. Chemical characterization of Lycium barbarum polysaccharides and their reducing myocardial injury in ischemia/reperfusion of rat heart. International journal of biological macromolecules. vol 47. issue 5. 2011-02-07. PMID:20813126. |
in addition, l. barbarum polysaccharides still markedly decreased myocardium bax positive rate and myocardial cell apoptosis and increased bcl-2 positive rate in a dose-dependent manner. |
2011-02-07 |
2023-08-12 |
rat |
| Donatella Aldinucci, Marta Celegato, Cinzia Borghese, Alfonso Colombatti, Antonino Carbon. IRF4 silencing inhibits Hodgkin lymphoma cell proliferation, survival and CCL5 secretion. British journal of haematology. vol 152. issue 2. 2011-02-07. PMID:21114485. |
irf4 silencing induced apoptosis, as evaluated by caspase-3 activation and annexin-v staining and up-regulation of the pro-apoptotic molecule bax. |
2011-02-07 |
2023-08-12 |
Not clear |
| Zhongdong Li, Jie Zhao, Quanmin Li, Wenqi Yang, Qinglin Song, Wenyong Li, Junwen Li. KLF4 promotes hydrogen-peroxide-induced apoptosis of chronic myeloid leukemia cells involving the bcl-2/bax pathway. Cell stress & chaperones. vol 15. issue 6. 2011-02-04. PMID:20401760. |
the results showed that h(2)o(2) treatment of cells resulted in an increase in klf4 levels; klf4 induced apoptosis and slowed cell growth, potentially resulting from up-regulation of bax and down-regulation of bcl-2. |
2011-02-04 |
2023-08-12 |
Not clear |
| Subhasree Roy Choudhury, Surajit Karmakar, Naren L Banik, Swapan K Ra. Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplification. Investigational new drugs. vol 28. issue 6. 2011-02-03. PMID:19777160. |
combination therapy showed activation of caspase-8, cleavage of bid to tbid, increase in p53 and p21 expression, down regulation of anti-apoptotic mcl-1, and increase in bax:bcl-2 ratio to trigger apoptosis. |
2011-02-03 |
2023-08-12 |
human |
| Tiziana Genovese, Irene Paterniti, Emanuela Mazzon, Emanuela Esposito, Rosanna Di Paola, Maria Galuppo, Placido Bramanti, Salvatore Cuzzocre. Efficacy of treatment with verbascoside, biotechnologically produced by Syringa vulgaris plant cell cultures in an experimental mice model of spinal cord trauma. Naunyn-Schmiedeberg's archives of pharmacology. vol 382. issue 4. 2011-02-02. PMID:20799028. |
immunohistochemical examination demonstrated a marked increase on expression for nitrotyrosine, inducible nitric oxide synthase, poly(adp-ribose), and apoptosis events (increase of bax and bcl-2 expression) in the spinal cord tissue. |
2011-02-02 |
2023-08-12 |
mouse |
| Yu Zhao, Jie Hui, Dan Wang, Li Zhu, Jing-Huai Fang, Xiao-Dong Zha. Synthesis, cytotoxicity and pro-apoptosis of novel benzoisoindolin hydrazones as anticancer agents. Chemical & pharmaceutical bulletin. vol 58. issue 10. 2011-02-02. PMID:20930398. |
western blot analysis disclosed that compound 4 induced apoptosis via the mitochondrial pathway accompanied by an increased expression of bax and a decreased expression of bcl-2. |
2011-02-02 |
2023-08-12 |
Not clear |
| Xianlong Ling, Yuan Zhou, Shi-Wei Li, Bin Yan, Lei We. Modulation of mitochondrial permeability transition pore affects multidrug resistance in human hepatocellular carcinoma cells. International journal of biological sciences. vol 6. issue 7. 2011-02-01. PMID:21152118. |
results suggested that atr accelerated the decrease of mitochondrial membrane potential (ΔΨm), reduced the bax activity, and increased the apoptosis of sk-hep1/cddp cells; while csa inhibited mptp opening, reduced and delayed the decline of mitochondrial membrane potential, and increased the bax activity, leading to increased tolerance of sk-hep1/cddp cells to apoptosis induction. |
2011-02-01 |
2023-08-12 |
human |