| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah E Aiyar, Hoyong Park, Paulomi B Aldo, Gil Mor, John J Gildea, Aaron L Miller, E Brad Thompson, J David Castle, Sanghee Kim, Richard J Sante. TMS, a chemically modified herbal derivative of resveratrol, induces cell death by targeting Bax. Breast cancer research and treatment. vol 124. issue 1. 2011-01-31. PMID:20490654. |
fractionation studies uncovered that tms treatment causes cleavage of bax from the p21 form to a truncated p18 form which is associated with the induction of potent apoptosis. |
2011-01-31 |
2023-08-12 |
Not clear |
| Neekkan Dey, Archita Das, Arunava Ghosh, Indu B Chatterje. Activated charcoal filter effectively reduces p-benzosemiquinone from the mainstream cigarette smoke and prevents emphysema. Journal of biosciences. vol 35. issue 2. 2011-01-31. PMID:20689178. |
the charcoal filter also prevented cytotoxicity in a549 cells as evidenced by mtt assay, apoptosis as evidenced by facs analysis, tunel assay, overexpression of bax, activation of p53 and caspase 3, as well as emphysematous lung damage in a guinea pig model as seen by histology and morphometric analysis. |
2011-01-31 |
2023-08-12 |
cattle |
| Jehn-Hwa Kuo, Yung-Lin Chu, Jai-Sing Yang, Jing-Pin Lin, Kuang-Chi Lai, Hsiu-Maan Kuo, Te-Chun Hsia, Jing-Gung Chun. Cantharidin induces apoptosis in human bladder cancer TSGH 8301 cells through mitochondria-dependent signal pathways. International journal of oncology. vol 37. issue 5. 2011-01-25. PMID:20878071. |
cantharidin-induced apoptosis was accompanied with up-regulation of the protein expression of bax and parp, but down-regulation of the protein levels of bcl-2, resulting in dysfunction of mitochondria then led to endo g and aif release for causing induction of apoptosis. |
2011-01-25 |
2023-08-12 |
human |
| Jiumao Lin, Youqin Chen, Lihui Wei, Xuzhen Chen, Wei Xu, Zhenfeng Hong, Thomas J Sferra, Jun Pen. Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells. International journal of oncology. vol 37. issue 5. 2011-01-25. PMID:20878081. |
furthermore, we observed that eehdw treatment resulted in dna fragmentation, loss of plasma membrane asymmetry, collapse of mitochondrial membrane potential, activation of caspase-9 and caspase-3, and increase of the ratio of pro-apoptotic bax to anti-apoptotic bcl-2, suggesting that the ht-29 cell growth inhibitory activity of eehdw was due to mitochondrion-mediated apoptosis, which may partly explain the anti-cancer activity of hedyotis diffusa willd. |
2011-01-25 |
2023-08-12 |
human |
| L F Jacinto-Alemán, J C Hernández-Guerrero, C Trejo-Solís, M D Jiménez-Farfán, A M Fernández-Presa. In vitro effect of sodium fluoride on antioxidative enzymes and apoptosis during murine odontogenesis. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 39. issue 9. 2011-01-24. PMID:20738751. |
caspase 8, caspase 3, bax, bid increase expression and more tunel positive cells in both experimental groups than control, suggest that apoptosis induced by fluoride is related to oxidative stress due to reduction of the enzymatic antioxidant. |
2011-01-24 |
2023-08-12 |
mouse |
| Teresa Mòdol, Cristina Natal, María P Pérez de Obanos, Eduardo Domingo de Miguel, María J Iraburu, María J López-Zabalz. Apoptosis of hepatic stellate cells mediated by specific protein nitration. Biochemical pharmacology. vol 81. issue 3. 2011-01-21. PMID:21056031. |
we found the peroxynitrite generator sin-1 to promote apoptosis in human and rat hsc, based on oligonucleosomal dna fragmentation, caspase-3 and -9 activation, bcl-2 depletion and accumulation of bax protein. |
2011-01-21 |
2023-08-12 |
human |
| Shijin Xia, Xiantao Tai, Yaoli Wang, Xiaojing An, Guisheng Qian, Jingcheng Dong, Xun Wang, Baokang Sha, Diane Wang, Padma Murthi, Bill Kalionis, Xiangdong Wang, Chunxue Ba. Involvement of Gax gene in hypoxia-induced pulmonary hypertension, proliferation, and apoptosis of arterial smooth muscle cells. American journal of respiratory cell and molecular biology. vol 44. issue 1. 2011-01-20. PMID:20160044. |
the pasmcs with ad-gax transfection exhibited hyperexpression of the bcl-2-associated x protein (bax) and hypoexpression of b-cell lymphoma 2 (bcl-2), leading to cell apoptosis. |
2011-01-20 |
2023-08-12 |
rat |
| Meagan L Wisniewski, Brenda G Werner, Louis G Hom, Lynne J Anguish, Caroline M Coffey, John S L Parke. Reovirus infection or ectopic expression of outer capsid protein micro1 induces apoptosis independently of the cellular proapoptotic proteins Bax and Bak. Journal of virology. vol 85. issue 1. 2011-01-20. PMID:20980509. |
reovirus infection or ectopic expression of outer capsid protein micro1 induces apoptosis independently of the cellular proapoptotic proteins bax and bak. |
2011-01-20 |
2023-08-12 |
mouse |
| Meagan L Wisniewski, Brenda G Werner, Louis G Hom, Lynne J Anguish, Caroline M Coffey, John S L Parke. Reovirus infection or ectopic expression of outer capsid protein micro1 induces apoptosis independently of the cellular proapoptotic proteins Bax and Bak. Journal of virology. vol 85. issue 1. 2011-01-20. PMID:20980509. |
finally, we found that reovirus-induced apoptosis occurred in bax(-/-)bak(-/-) mefs, indicating that reovirus-induced apoptosis occurs independently of the proapoptotic bcl-2 family members bax and bak. |
2011-01-20 |
2023-08-12 |
mouse |
| Jianjian Shi, Yi-Wei Zhang, Yu Yang, Lumin Zhang, Lei We. ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice. Journal of molecular and cellular cardiology. vol 49. issue 5. 2011-01-18. PMID:20709073. |
increase in cardiomyocyte apoptosis was suppressed by rock1 deletion, associated with increased extracellular signal-regulated kinase/mitogen-activated protein kinase (erk/mapk) activation and inhibition of mitochondrial translocation of bax. |
2011-01-18 |
2023-08-12 |
mouse |
| Prasun Guha, Anindya Dey, Rupashree Sen, Mitali Chatterjee, Subrata Chattopadhyay, Sandip K Bandyopadhya. Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line. The Journal of pharmacology and experimental therapeutics. vol 336. issue 1. 2011-01-18. PMID:20876229. |
intracellular gsh depletion triggered mitochondrial bax translocation to accomplish resveratrol-induced apoptosis in the u937 cell line. |
2011-01-18 |
2023-08-12 |
human |
| Prasun Guha, Anindya Dey, Rupashree Sen, Mitali Chatterjee, Subrata Chattopadhyay, Sandip K Bandyopadhya. Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line. The Journal of pharmacology and experimental therapeutics. vol 336. issue 1. 2011-01-18. PMID:20876229. |
microscopic analysis and small interfering rna treatment emphasized that cellular gsh efflux triggered bax translocation to mitochondria, which resulted in the loss of mitochondrial membrane potential, ros generation, and caspase 3 activation and thus triggered apoptosis. |
2011-01-18 |
2023-08-12 |
human |
| Yang Cao, Gang Li, Yan-feng Wang, Zhong-kai Fan, De-shui Yu, Zai-de Wang, Yun-long B. Neuroprotective effect of baicalin on compression spinal cord injury in rats. Brain research. vol 1357. 2011-01-14. PMID:20708606. |
the bc therapy (100mg/kg) dramatically decreased (1) the water content of spinal cord tissue (by dry-wet weight method), (2) the permeability of blood-spinal cord barrier (measured by evans blue), (3) oxidant stress (malondialdehyde values and glutathione levels evaluation), (4) proinflammatory cytokines expression (tumor necrosis factor-α and nf-κb) (5) and apoptosis (measured by bax, bcl-2 and caspase-3 expression). |
2011-01-14 |
2023-08-12 |
human |
| Wei Wang, Xiao Yu, Qin Ning, Xiao-ping Lu. [Increased apoptosis after intra-amniotic endotoxin priming plus hyperoxic exposure in lungs of preterm newborn rats]. Zhonghua er ke za zhi = Chinese journal of pediatrics. vol 47. issue 10. 2011-01-11. PMID:20021812. |
the purpose of this study was to investigate the expression apoptosis index (ai), bax and bcl-2 in premature lungs of rats with intra-amniotic endotoxin priming and/or exposed to 60% o(2) and to elucidate the relationship between intrauterine inflammatory/chronic o(2) exposure and the pathogenesis of bronchopulmonary dysplasia (bpd). |
2011-01-11 |
2023-08-12 |
human |
| Nicola Sassi, Umberto De Marchi, Bernard Fioretti, Lucia Biasutto, Erich Gulbins, Fabio Franciolini, Ildikò Szabò, Mario Zoratt. An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1. Biochimica et biophysica acta. vol 1797. issue 6-7. 2011-01-10. PMID:20036632. |
functional assays explored the possibility that mtkca3.1 might be involved in cell proliferation or play a role similar to that of the shaker-type kv1.3 channel in lymphocytes, which interacts with outer mitochondrial membrane-inserted bax thereby promoting apoptosis (szabò, i. et al., proc. |
2011-01-10 |
2023-08-12 |
Not clear |
| b' Erich Gulbins, Nicola Sassi, Heike Grassm\\xc3\\xa8, Mario Zoratti, Ildik\\xc3\\xb2 Szab\\xc3\\xb. Role of Kv1.3 mitochondrial potassium channel in apoptotic signalling in lymphocytes. Biochimica et biophysica acta. vol 1797. issue 6-7. 2011-01-10. PMID:20114030.' |
upon induction of apoptosis, outer-membrane inserted bax binds to and inhibits kv1.3 resulting in hyperpolarization, an increase in reactive oxygen species production and cytochrome c release. |
2011-01-10 |
2023-08-12 |
Not clear |
| G Benard, N Bellance, C Jose, S Melser, K Nouette-Gaulain, R Rossigno. Multi-site control and regulation of mitochondrial energy production. Biochimica et biophysica acta. vol 1797. issue 6-7. 2011-01-10. PMID:20226160. |
lastly, advances in the understanding of mitochondrial apoptosis have suggested a supplementary role for bcl2 or bax in the regulation of mitochondrial respiration and dynamics, which has fostered the investigation of alternative mechanisms of energy regulation. |
2011-01-10 |
2023-08-12 |
Not clear |
| Siddik Sarkar, Abhijit Mazumdar, Rupesh Dash, Devanand Sarkar, Paul B Fisher, Mahitosh Manda. ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells. Cancer biology & therapy. vol 9. issue 8. 2011-01-06. PMID:20139705. |
zd6474 also downregulated anti-apoptotic markers including bcl-2, upregulated pro-apoptotic signaling events involving expression of bax, activation of caspase-3, and induction of poly (adp-ribose) polymerase during apoptosis. |
2011-01-06 |
2023-08-12 |
human |
| Siddik Sarkar, Abhijit Mazumdar, Rupesh Dash, Devanand Sarkar, Paul B Fisher, Mahitosh Manda. ZD6474 enhances paclitaxel antiproliferative and apoptotic effects in breast carcinoma cells. Journal of cellular physiology. vol 226. issue 2. 2011-01-06. PMID:20665703. |
the combination of zd6474 with paclitaxel versus either agent alone also more potently down-regulated the antiapoptotic bcl-2 protein, up-regulated pro-apoptotic signaling events involving expression of bax, activation of caspase-3 and caspase-7 proteins, and induced poly(adp-ribose) polymerase resulting in apoptosis. |
2011-01-06 |
2023-08-12 |
human |
| Shengnan Wu, Feifan Zhou, Zhenzhen Zhang, Da Xin. Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy. Journal of cellular physiology. vol 226. issue 2. 2011-01-06. PMID:20683914. |
bcl-2 family proteins are critical for the regulation of apoptosis, with the pro-apoptotic members bax essential for the release of cytochrome c from mitochondria in many instances. |
2011-01-06 |
2023-08-12 |
human |