| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Irene Paterniti, Emanuela Esposito, Emanuela Mazzon, Maria Galuppo, Rosanna Di Paola, Placido Bramanti, Amar Kapoor, Christoph Thiemermann, Salvatore Cuzzocre. Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury. The Journal of pharmacology and experimental therapeutics. vol 333. issue 2. 2010-05-10. PMID:20176685. |
1 and 6 h after the sci significantly reduced 1) the degree of spinal cord inflammation and tissue injury (histological score), 2) neutrophil infiltration (myeloperoxidase activity), 3) nitrotyrosine formation, 4) proinflammatory cytokines expression, 5) nuclear factor-kappab activation, 6) inducible nitric-oxide synthase expression, and 6) apoptosis (terminal deoxynucleotidyl transferase dutp nick-end labeling staining, fasl, bax, and bcl-2 expression). |
2010-05-10 |
2023-08-12 |
mouse |
| Yu Zhang, Liang Zhou, Yong Li Bao, Yin Wu, Chun Lei Yu, Yan Xin Huang, Ying Sun, Li Hua Zheng, Yu Xin L. Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells. Chemico-biological interactions. vol 185. issue 3. 2010-05-10. PMID:20346929. |
the expression of anti-apoptotic protein bcl-2 decreased, whereas the apoptotic protein bax increased in a dose-dependent manner during butyrate-induced apoptosis. |
2010-05-10 |
2023-08-12 |
human |
| Shehua Zhang, Junli Ye, Guoxiong Don. Neuroprotective effect of baicalein on hydrogen peroxide-mediated oxidative stress and mitochondrial dysfunction in PC12 cells. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:19731100. |
exposure of pc12 cells to 0.15 mm h2o2 for 20 min induced a significant decrease in cell viability accompanied by increased oxidative stress, mitochondrial dysfunction, downregulation of bcl-2, upregulation of bax, and cell apoptosis. |
2010-05-07 |
2023-08-12 |
Not clear |
| Shehua Zhang, Junli Ye, Guoxiong Don. Neuroprotective effect of baicalein on hydrogen peroxide-mediated oxidative stress and mitochondrial dysfunction in PC12 cells. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:19731100. |
and the mitochondrial pathway involving the mitochondrial dysfunction associated with cell apoptosis including membrane potential loss, the release of cytochrome c, the downregulation of bcl-2, upregulation of bax induced by h2o2 were also abrogated in the presence of baicalein. |
2010-05-07 |
2023-08-12 |
Not clear |
| Yiguo Sun, Yun Zhang, Ming Yan, Yabin Wu, Xiaoxiang Zhen. B-type natriuretic peptide-induced cardioprotection against reperfusion is associated with attenuation of mitochondrial permeability transition. Biological & pharmaceutical bulletin. vol 32. issue 9. 2010-05-06. PMID:19721230. |
further investigation of underlying mechanisms revealed that these were associated with bnp-mediated repolarization of mitochondrial membrane potential (deltapsi(m)), inhibition of reactive oxygen species (ros) generation, improvement of bcl-2 level, and inhibition of bax and second mitochondria-derived activator of caspases/direct inhibitor of apoptosis protein-binding protein with a low isoelectric point (smac/diablo) levels. |
2010-05-06 |
2023-08-12 |
Not clear |
| Wen-jun ZHOU, Cheng ZHANG, Yi LIU, Ping LIU, Ming MA, Shi-fan ZHAN. [Influence of oxidative stress on apoptosis and expression of bax and bcl-2 of enterocytes in burn rats with delayed resuscitation on the plateau]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 25. issue 4. 2010-05-06. PMID:19951548. |
[influence of oxidative stress on apoptosis and expression of bax and bcl-2 of enterocytes in burn rats with delayed resuscitation on the plateau]. |
2010-05-06 |
2023-08-12 |
rat |
| Wen-jun ZHOU, Cheng ZHANG, Yi LIU, Ping LIU, Ming MA, Shi-fan ZHAN. [Influence of oxidative stress on apoptosis and expression of bax and bcl-2 of enterocytes in burn rats with delayed resuscitation on the plateau]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 25. issue 4. 2010-05-06. PMID:19951548. |
to explore influence of oxidative stress reaction on apoptosis rate and expression of apoptosis-related genes bax and bcl-2 of enterocytes in severely burned rats with delayed resuscitation on the plateau. |
2010-05-06 |
2023-08-12 |
rat |
| Loriano Ballarin, Filippo Schiavon, Lucia Mann. Natural apoptosis during the blastogenetic cycle of the colonial ascidian Botryllus schlosseri: a morphological analysis. Zoological science. vol 27. issue 2. 2010-05-06. PMID:20141414. |
the generation change, or take-over, is characterized by massive cell death by apoptosis, as indicated by nuclear condensation, activation of caspases, overexpression of molecules recognized by antibodies against mammalian bax, fas, and fasl, changes in the expression of surface molecules by senescent cells of zooid tissues, and recruitment of circulating phagocytes in zooid tissues which ensure the complete clearing of dying cells. |
2010-05-06 |
2023-08-12 |
Not clear |
| Leah J Siskind, Thomas D Mullen, Kimberly Romero Rosales, Christopher J Clarke, María José Hernandez-Corbacho, Aimee L Edinger, Lina M Obei. The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis. The Journal of biological chemistry. vol 285. issue 16. 2010-05-06. PMID:20172858. |
the bcl-2 family members bak and bax are required for apoptosis and trigger mitochondrial outer membrane permeabilization (momp). |
2010-05-06 |
2023-08-12 |
mouse |
| Leah J Siskind, Thomas D Mullen, Kimberly Romero Rosales, Christopher J Clarke, María José Hernandez-Corbacho, Aimee L Edinger, Lina M Obei. The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis. The Journal of biological chemistry. vol 285. issue 16. 2010-05-06. PMID:20172858. |
by establishing a unique role for bak in long-chain ceramide metabolism, these studies further demonstrate that the seemingly redundant proteins bak and bax have distinct mechanisms of action during apoptosis induction. |
2010-05-06 |
2023-08-12 |
mouse |
| S Shimizu, A Konishi, Y Nishida, T Mizuta, H Nishina, A Yamamoto, Y Tsujimot. Involvement of JNK in the regulation of autophagic cell death. Oncogene. vol 29. issue 14. 2010-05-05. PMID:20101227. |
the bcl-2 family proteins are well-characterized regulators of apoptosis, among which multidomain pro-apoptotic members (such as bax and bak) function as a mitochondrial gateway at which various apoptotic signals converge. |
2010-05-05 |
2023-08-12 |
mouse |
| Xiao-Feng Wang, Xiao-Ming Lou, Ying Shen, Ming-Luan Xing, Li-Hong X. Apoptotic-related protein changes induced by hexavalent chromium in mice liver. Environmental toxicology. vol 25. issue 1. 2010-05-04. PMID:19219935. |
this study was undertaken to determine effects of single oral 0, 25, 50, and 100 mg/kg body weight doses of potassium dichromate on the expression level of p53, bcl-2, bax, cytochrome c, and caspase-3, which are vital regulators of apoptosis, in mice liver. |
2010-05-04 |
2023-08-12 |
mouse |
| Xiao-Feng Wang, Xiao-Ming Lou, Ying Shen, Ming-Luan Xing, Li-Hong X. Apoptotic-related protein changes induced by hexavalent chromium in mice liver. Environmental toxicology. vol 25. issue 1. 2010-05-04. PMID:19219935. |
all these results suggested that p53, bcl-2, bax, cytochrome c, and caspase-3 may be involved in the regulation of cr(vi) induced apoptosis in vivo. |
2010-05-04 |
2023-08-12 |
mouse |
| H Garg, R Salcedo, G Trinchieri, R Blumentha. Improved nonviral cancer suicide gene therapy using survivin promoter-driven mutant Bax. Cancer gene therapy. vol 17. issue 3. 2010-05-04. PMID:19816523. |
we tested apoptotic activity of several mutants of proapoptotic gene bax that constitutively translocate to the mitochondria and induce apoptosis. |
2010-05-04 |
2023-08-12 |
mouse |
| Christopher P Baine. The cardiac mitochondrion: nexus of stress. Annual review of physiology. vol 72. 2010-05-04. PMID:20148667. |
a panoply of mitochondrial proteins/complexes ranging from canonical apoptosis proteins such as bcl2 and bax, through the mitochondrial permeability transition pore, to ion channels such as mitochondrial k(atp) channels and connexin-43 have now been implicated as critical regulators of cardiac cell death. |
2010-05-04 |
2023-08-12 |
Not clear |
| Nuria López-Royuela, Patricia Pérez-Galán, Patricia Galán-Malo, Victor J Yuste, Alberto Anel, Santos A Susín, Javier Naval, Isabel Marz. Different contribution of BH3-only proteins and caspases to doxorubicin-induced apoptosis in p53-deficient leukemia cells. Biochemical pharmacology. vol 79. issue 12. 2010-05-04. PMID:20188077. |
first, we have found that caspases are dispensable for the induction phase of doxorubicin-induced apoptosis in both cell lines but they are needed to speed up the execution phase in jurkat cells, not expressing bax. |
2010-05-04 |
2023-08-12 |
Not clear |
| Tobias Schilling, Astrid Kairat, Gerry Melino, Peter H Krammer, Wolfgang Stremmel, Moshe Oren, Martina Mülle. Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma. Biochemical and biophysical research communications. vol 394. issue 3. 2010-05-04. PMID:20233581. |
in addition, these mutants repress the expression of the bax gene and attenuate mitochondria-mediated apoptosis signaling. |
2010-05-04 |
2023-08-12 |
Not clear |
| Anna Hsu, Tammy M Bray, William G Helferich, Daniel R Doerge, Emily H. Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells. Experimental biology and medicine (Maywood, N.J.). vol 235. issue 1. 2010-05-04. PMID:20404023. |
soy extracts also increased bax expression in pc3 cells, but no significant changes in nuclear factor kappab (nf kappab) activation were detected, suggesting that the induction of apoptosis was independent of the nf kappab pathway. |
2010-05-04 |
2023-08-12 |
Not clear |
| Weidong Cao, Xiaoliang Yang, Jie Zhou, Zenghui Teng, Lei Cao, Xiang Zhang, Zhou Fe. Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice. Apoptosis : an international journal on programmed cell death. vol 15. issue 2. 2010-05-03. PMID:20033782. |
furthermore, rt-pcr and western blot assay further substantiated that difopein had strong effects to induce glioma cell apoptosis through down-regulating bcl-2, up-regulating bax and activating caspase-9 and caspase-3. |
2010-05-03 |
2023-08-12 |
mouse |
| Xian-ping Li, Mei-hua Ga. [Effect of peptide seals specific to CD59 on the expression of apoptosis-related genes in HeLa cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 24. issue 1. 2010-04-30. PMID:18177611. |
to study the effect of peptide seals specific to cd59 on the expression of apoptosis-related survivin, caspase-3 and bax in hela cells and investigate the mechanism of peptide seals specific to cd59 in inducing apoptosis of hela cells. |
2010-04-30 |
2023-08-12 |
Not clear |