| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryuji Yamaguchi, Lydia Lartigue, Guy Perkins, Ray T Scott, Amruta Dixit, Yulia Kushnareva, Tomomi Kuwana, Mark H Ellisman, Donald D Newmeye. Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Molecular cell. vol 31. issue 4. 2008-09-16. PMID:18691924. |
pharmacological blockade of momp did not prevent opa1 disassembly and cjo; moreover, expression of a disassembly-resistant mutant opa1 (q297v) blocked cytochrome c release and apoptosis but not bax activation. |
2008-09-16 |
2023-08-12 |
Not clear |
| Clare Sheridan, Petrina Delivani, Sean P Cullen, Seamus J Marti. Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release. Molecular cell. vol 31. issue 4. 2008-09-16. PMID:18722181. |
bax and bak promote apoptosis by perturbing the permeability of the mitochondrial outer membrane and facilitating the release of cytochrome c by a mechanism that is still poorly defined. |
2008-09-16 |
2023-08-12 |
human |
| Clare Sheridan, Petrina Delivani, Sean P Cullen, Seamus J Marti. Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release. Molecular cell. vol 31. issue 4. 2008-09-16. PMID:18722181. |
during apoptosis, bax and bak also promote fragmentation of the mitochondrial network, possibly by activating the mitochondrial fission machinery. |
2008-09-16 |
2023-08-12 |
human |
| Chung-Yi Chen, Tsan-Zon Liu, Wei-Chang Tseng, Fung-Jou Lu, Ray-Ping Hung, Chi-Hung Chen, Ching-Hsein Che. (-)-Anonaine induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 46. issue 8. 2008-09-15. PMID:18524447. |
the apoptosis and expression of bax induced by (-)-anonaine could be inhibited when the hela cells were pretreated with boc-asp(ome)-fmk, which is a broad caspases inhibitor. |
2008-09-15 |
2023-08-12 |
human |
| Sujit K Bhutia, Sanjaya K Mallick, Swatilekha Maiti, Tapas K Mait. Antitumor and proapoptotic effect of Abrus agglutinin derived peptide in Dalton's lymphoma tumor model. Chemico-biological interactions. vol 174. issue 1. 2008-09-15. PMID:18550041. |
further, the western blotting showed apoptosis was mediated by reduction in ratio of bcl-2 and bax protein expression, and activation of caspase-3 through release of cytochrome-c in dl cells. |
2008-09-15 |
2023-08-12 |
mouse |
| Eric Christenson, Sean Merlin, Mitsu Saito, Paul Schlesinge. Cholesterol effects on BAX pore activation. Journal of molecular biology. vol 381. issue 5. 2008-09-15. PMID:18590739. |
one of the key members of this family, bax, has soluble, membrane-bound, and membrane-integrated forms that are central to the regulation of apoptosis. |
2008-09-15 |
2023-08-12 |
human |
| Eric Christenson, Sean Merlin, Mitsu Saito, Paul Schlesinge. Cholesterol effects on BAX pore activation. Journal of molecular biology. vol 381. issue 5. 2008-09-15. PMID:18590739. |
in cells, bax targets several intracellular membranes but notably does not target the plasma membrane while initiating apoptosis. |
2008-09-15 |
2023-08-12 |
human |
| Yasuko Yamamura, Wei Lin Lee, Mei Xian Goh, Yoshiaki It. Role of TAp73alpha in induction of apoptosis by transforming growth factor-beta in gastric cancer cells. FEBS letters. vol 582. issue 17. 2008-09-15. PMID:18593586. |
here, we report that tap73alpha, which is a member of the p53 family, binds to p53-binding sites in the promoters of proapoptotic bax and puma to activate their transcription, and mediates tgf-beta-induced apoptosis in gastric cancer cells. |
2008-09-15 |
2023-08-12 |
Not clear |
| Bruna Pucci, Francesca Bertani, Natalie O Karpinich, Manuela Indelicato, Matteo A Russo, John L Farber, Marco Tafan. Detailing the role of Bax translocation, cytochrome c release, and perinuclear clustering of the mitochondria in the killing of HeLa cells by TNF. Journal of cellular physiology. vol 217. issue 2. 2008-09-12. PMID:18546202. |
the data demonstrate that apoptosis in hela cells is atp dependent and requires the translocation of bax. |
2008-09-12 |
2023-08-12 |
Not clear |
| N V Riazantseva, V V Novitskiĭ, N Iu Chasovskikh, E V Kaĭgorodova, E G Starikova, Iu V Stariko. [Redox-dependent regulation of apoptosis as a function of intracellular reactive oxygen species in oxidative stress]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 94. issue 6. 2008-09-12. PMID:18727380. |
the disturbance of the balance of pro- and antiapoptotic proteins of bcl-2, family (the increase of the bax level without changes of bcl-x(l) and bcl-2) leads to the growth of apoptosis process of mononuclear leucocytes activity in oxidative stress conditions. |
2008-09-12 |
2023-08-12 |
Not clear |
| Sheng-Huei Yang, Zchong-Zcho Wu, Ching-Ming Chien, Yu-Hsiang Lo, Ming-Jung Wu, Long-Sen Chang, Shinne-Ren Li. JNK and ERK mitogen-activated protein kinases mediate THDA-induced apoptosis in K562 cells. Cell biology and toxicology. vol 24. issue 4. 2008-09-11. PMID:17934787. |
thda-induced apoptosis was associated with the upregulation of bax, downregulation of x-linked inhibitor of apoptosis (xiap), as well as the activation of caspase-3 and caspase-9. |
2008-09-11 |
2023-08-12 |
human |
| G Roué, V Pichereau, H Lincet, D Colomer, B Sol. Cyclin D1 mediates resistance to apoptosis through upregulation of molecular chaperones and consequent redistribution of cell death regulators. Oncogene. vol 27. issue 36. 2008-09-11. PMID:18438428. |
the chaperone, heat shock protein (hsp)70, bound to both bax and the mitochondrial apoptosis inducing factor following cytokine withdrawal, and impeded inhibitors of kappab (ikappab)-mediated inhibition of nuclear factor-kappab anti-apoptotic signalling. |
2008-09-11 |
2023-08-12 |
Not clear |
| Dan Liu, Yuanyan Wei, Fengbiao Zhou, Yuqing Ge, Jiejie Xu, Hong Chen, Wei Zhang, Xiaojing Yun, Jianhai Jian. E1AF promotes mithramycin A-induced Huh-7 cell apoptosis depending on its DNA-binding domain. Archives of biochemistry and biophysics. vol 477. issue 1. 2008-09-10. PMID:18510939. |
the expression of e1af at protein level was obviously increased during huh-7 and hep3b cells apoptosis induced by the anticancer agent mithramycin a. e1af overexpression markedly enhanced mithramycin a-induced huh-7 cell apoptosis and the expression of pro-apoptotic protein bax depending on its dna-binding domain. |
2008-09-10 |
2023-08-12 |
Not clear |
| Dan Liu, Yuanyan Wei, Fengbiao Zhou, Yuqing Ge, Jiejie Xu, Hong Chen, Wei Zhang, Xiaojing Yun, Jianhai Jian. E1AF promotes mithramycin A-induced Huh-7 cell apoptosis depending on its DNA-binding domain. Archives of biochemistry and biophysics. vol 477. issue 1. 2008-09-10. PMID:18510939. |
furthermore, reducing the expression of bax significantly inhibited e1af-increased huh-7 cell apoptosis induced by mithramycin a. |
2008-09-10 |
2023-08-12 |
Not clear |
| Dan Liu, Yuanyan Wei, Fengbiao Zhou, Yuqing Ge, Jiejie Xu, Hong Chen, Wei Zhang, Xiaojing Yun, Jianhai Jian. E1AF promotes mithramycin A-induced Huh-7 cell apoptosis depending on its DNA-binding domain. Archives of biochemistry and biophysics. vol 477. issue 1. 2008-09-10. PMID:18510939. |
taken together, e1af increases mithramycin a-induced huh-7 cells apoptosis and bax expression depending on its dna-binding domain, indicating that e1af might contribute to the therapeutic efficiency of mithramycin a for hepatoma. |
2008-09-10 |
2023-08-12 |
Not clear |
| K Tello, H Christiansen, H Gürleyen, J Dudas, M Rave-Fränk, C F Hess, G Ramadori, B Sail. Irradiation leads to apoptosis of Kupffer cells by a Hsp27-dependant pathway followed by release of TNF-alpha. Radiation and environmental biophysics. vol 47. issue 3. 2008-09-09. PMID:18493784. |
overexpression of hsp27 in kupffer cells was shown to prevent the effect of irradiation on bax expression, apoptosis and, at the same time, on increase of tnf-alpha concentration in the kupffer cell medium. |
2008-09-09 |
2023-08-12 |
Not clear |
| K Tello, H Christiansen, H Gürleyen, J Dudas, M Rave-Fränk, C F Hess, G Ramadori, B Sail. Irradiation leads to apoptosis of Kupffer cells by a Hsp27-dependant pathway followed by release of TNF-alpha. Radiation and environmental biophysics. vol 47. issue 3. 2008-09-09. PMID:18493784. |
we conclude that irradiation of kupffer cells leads to apoptosis because of downregulation of hsp27 and consecutive upregulation of bax expression. |
2008-09-09 |
2023-08-12 |
Not clear |
| Feng Zhao, En-Qi He, Lu Wang, Ke Li. Anti-tumor activities of andrographolide, a diterpene from Andrographis paniculata, by inducing apoptosis and inhibiting VEGF level. Journal of Asian natural products research. vol 10. issue 5-6. 2008-09-08. PMID:18464090. |
it induced apoptosis of prostate cancer (pc-3) cells (the most sensitive cell line among the cell lines screened) via the activation of caspase 3, up-regulation of bax, and down-regulation of bcl-2. |
2008-09-08 |
2023-08-12 |
Not clear |
| A V F F Teles, T R Rosenstock, C S Okuno, G S Lopes, C R A Bertoncini, S S Smail. Increase in bax expression and apoptosis are associated in Huntington's disease progression. Neuroscience letters. vol 438. issue 1. 2008-09-08. PMID:18468793. |
increase in bax expression and apoptosis are associated in huntington's disease progression. |
2008-09-08 |
2023-08-12 |
mouse |
| Meenakshi Upreti, Rong Chu, Elena Galitovskaya, Sherri K Smart, Timothy C Chamber. Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine. Molecular cancer therapeutics. vol 7. issue 7. 2008-09-08. PMID:18645031. |
furthermore, bcl-xl overexpression prevented bak and bax interaction and strongly inhibited apoptosis, whereas bcl-2 overexpression did not prevent bak-bax interaction and only weakly inhibited apoptosis. |
2008-09-08 |
2023-08-12 |
Not clear |