| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunrong Yu, Bret B Friday, Lin Yang, Peter Atadja, Dennis Wigle, Jann Sarkaria, Alex A Adje. Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. Neuro-oncology. vol 10. issue 3. 2008-08-26. PMID:18445700. |
synergistic induction of apoptosis after exposure to lbh589 and bortezomib was partially mediated by bax translocation from the cytosol to the mitochondria resulting from bax conformational changes. |
2008-08-26 |
2023-08-12 |
Not clear |
| Chunrong Yu, Bret B Friday, Lin Yang, Peter Atadja, Dennis Wigle, Jann Sarkaria, Alex A Adje. Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. Neuro-oncology. vol 10. issue 3. 2008-08-26. PMID:18445700. |
bax translocation precedes cytochrome c release and apoptosis, and selective down-regulation of bax using sirna significantly mitigates the cytotoxicity of lbh589 and bortezomib. |
2008-08-26 |
2023-08-12 |
Not clear |
| Ying Piao, Li-Mei Liu, Xie-Qun Chen, Rong Liang, Gao-Sheng Huang, Yan Qiao, Ai-Qing Wang, Zhe Wan. [Role of Bcl-xL in the cathepsin D-associated apoptosis of K562 cells]. Zhongguo shi yan xue ye xue za zhi. vol 13. issue 3. 2008-08-25. PMID:15972124. |
light microscopy and wright-giemsa staining were used to investigate the morphologic evidences for apoptosis of k562 cells induced by glucosamine sulfate (gs); immunofluorescence was used to observe the translocation of cathepsin d and cytochrome c during the apoptosis; western blot was performed to detect the expression of bcl-xl, bid, bax in k562 cells treated by gs. |
2008-08-25 |
2023-08-12 |
Not clear |
| Ying Piao, Li-Mei Liu, Xie-Qun Chen, Rong Liang, Gao-Sheng Huang, Yan Qiao, Ai-Qing Wang, Zhe Wan. [Role of Bcl-xL in the cathepsin D-associated apoptosis of K562 cells]. Zhongguo shi yan xue ye xue za zhi. vol 13. issue 3. 2008-08-25. PMID:15972124. |
the results showed that many vacuoles were observed in the cytoplasma of the k562 cells treated by gs; fluorescent signals of cathepsin d and cytochrome were fransformed from granules to disperse form by using immunofluorescence; the expression of bcl-xl was found down-regulated in k562 cells treated by gs, but not in the cells pre-treated with pepstatin a; the significant changes were not detected in expression of bax and bid protein before or after apoptosis. |
2008-08-25 |
2023-08-12 |
Not clear |
| Athanasia Katsoulas, Zakaria Rachid, James P McNamee, Christopher Williams, Bertrand J Jean-Claud. Combi-targeting concept: an optimized single-molecule dual-targeting model for the treatment of chronic myelogenous leukemia. Molecular cancer therapeutics. vol 7. issue 5. 2008-08-22. PMID:18483293. |
however, sufficient level of the latter protein was available for transactivating p21 and bax, which are required for cell cycle arrest and apoptosis. |
2008-08-22 |
2023-08-12 |
Not clear |
| Michela Muscolini, Roberta Cianfrocca, Angela Sajeva, Simona Mozzetti, Gabriella Ferrandina, Antonio Costanzo, Loretta Tuost. Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells. Molecular cancer therapeutics. vol 7. issue 6. 2008-08-22. PMID:18566213. |
the analysis of expression of proteins involved in mitochondria-dependent apoptosis revealed a role of bax and p73 but not p53. |
2008-08-22 |
2023-08-12 |
human |
| Michela Muscolini, Roberta Cianfrocca, Angela Sajeva, Simona Mozzetti, Gabriella Ferrandina, Antonio Costanzo, Loretta Tuost. Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells. Molecular cancer therapeutics. vol 7. issue 6. 2008-08-22. PMID:18566213. |
pretreatment of resistant a2780 cis cells with the histone deacetylase inhibitor trichostatin a overcomes apoptosis resistance to cddp by restoring both p73 and bax but not p53 expression. |
2008-08-22 |
2023-08-12 |
human |
| Lan Zhang, Da Xing, Miaojuan Che. Bim(L) displacing Bcl-x(L) promotes Bax translocation during TNFalpha-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 13. issue 7. 2008-08-20. PMID:18500555. |
bim(l) displacing bcl-x(l) promotes bax translocation during tnfalpha-induced apoptosis. |
2008-08-20 |
2023-08-12 |
Not clear |
| Lan Zhang, Da Xing, Miaojuan Che. Bim(L) displacing Bcl-x(L) promotes Bax translocation during TNFalpha-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 13. issue 7. 2008-08-20. PMID:18500555. |
however, the molecular mechanism of bim(l) activating bax activation during tnfalpha-induced apoptosis is not fully understood. |
2008-08-20 |
2023-08-12 |
Not clear |
| Lan Zhang, Da Xing, Miaojuan Che. Bim(L) displacing Bcl-x(L) promotes Bax translocation during TNFalpha-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 13. issue 7. 2008-08-20. PMID:18500555. |
in this study, the role of bim(l) in bax activation during tnfalpha-induced apoptosis was investigated in differentiated pc12 and mcf7 cells, with real-time single-cell analysis. |
2008-08-20 |
2023-08-12 |
Not clear |
| Lan Zhang, Da Xing, Miaojuan Che. Bim(L) displacing Bcl-x(L) promotes Bax translocation during TNFalpha-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 13. issue 7. 2008-08-20. PMID:18500555. |
by comprehensively analyzing these data, it is concluded that bim(l) displaces bcl-x(l) in the mitochondria and promotes bax translocation during tnfalpha-induced apoptosis. |
2008-08-20 |
2023-08-12 |
Not clear |
| Gabriella Marfè, Emanuela Morgante, Carla Di Stefano, Livia Di Renzo, Luisa De Martino, Giuseppe Iovane, Matteo Antonio Russo, Paola Sinibaldi-Salime. Sorbitol-induced apoptosis of human leukemia is mediated by caspase activation and cytochrome c release. Archives of toxicology. vol 82. issue 6. 2008-08-19. PMID:18046541. |
this sorbitol-induced apoptosis in human k562 cells was also accompanied by the up-regulation of bax, and down-regulation of p-bcl-2, but no effect on the levels of bcl-x(l). |
2008-08-19 |
2023-08-12 |
human |
| Y Matsui, J Watanabe, M Ikegawa, T Kamoto, O Ogawa, H Nishiyam. Cancer-specific enhancement of cisplatin-induced cytotoxicity with triptolide through an interaction of inactivated glycogen synthase kinase-3beta with p53. Oncogene. vol 27. issue 33. 2008-08-19. PMID:18391982. |
as the mechanism, triptolide suppressed cddp-induced p53 transcriptional activity, leading to p21 attenuation, which promoted apoptosis via the activation of c-jun n-terminal kinase (jnk) and bax. |
2008-08-19 |
2023-08-12 |
mouse |
| Hirohito Yamaguchi, Nicholas T Woods, Jay F Dorsey, Yoshinori Takahashi, Nicole R Gjertsen, Timothy Yeatman, Jie Wu, Hong-Gang Wan. SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis. The Journal of biological chemistry. vol 283. issue 27. 2008-08-19. PMID:18474606. |
bif-1 interacts with bax and enhances its conformational rearrangement, resulting in apoptosis. |
2008-08-19 |
2023-08-12 |
Not clear |
| Hirohito Yamaguchi, Nicholas T Woods, Jay F Dorsey, Yoshinori Takahashi, Nicole R Gjertsen, Timothy Yeatman, Jie Wu, Hong-Gang Wan. SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis. The Journal of biological chemistry. vol 283. issue 27. 2008-08-19. PMID:18474606. |
together, these results suggest that phosphorylation of bif-1 impairs its binding to bax and represses apoptosis, providing another mechanism by which src oncogenic signaling can prevent cell death. |
2008-08-19 |
2023-08-12 |
Not clear |
| Stephanie L Bissonnette, Jessica E Teague, David H Sherr, Jennifer J Schlezinge. An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 3. 2008-08-19. PMID:18641309. |
significant bax translocation to the mitochondria supports its role in initiating release of cytochrome c. both chemicals induced bid cleavage, a result consistent with a truncated bid-mediated release of cytochrome c in an apoptosis amplification feedback loop; however, significantly more bid was cleaved following 15d-pgj(2) treatment, potentially differentiating the two pathways. |
2008-08-19 |
2023-08-12 |
Not clear |
| Stephanie L Bissonnette, Jessica E Teague, David H Sherr, Jennifer J Schlezinge. An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 3. 2008-08-19. PMID:18641309. |
indeed, bid cleavage and cytochrome c release following 15d-pgj(2) but not mehp treatment was profoundly inhibited by z-vad-fmk, suggesting that 15d-pgj(2) activates apoptosis via two pathways, bax mobilization and protease-dependent bid cleavage. |
2008-08-19 |
2023-08-12 |
Not clear |
| Yong-feng Chen, He-ping Yang, Jian-lin Hu, Xiang-dong Zhou, Wei Xiong, Xiao-tian Dai, Xue-jun L. [Expression of hypoxia inducible factor-1alpha and relationship thereof to apoptosis related protein in non-small cell lung cancer]. Zhonghua yi xue za zhi. vol 87. issue 13. 2008-08-18. PMID:17650407. |
to investigate the expression of hypoxia inducible factor-1alpha (hif-1alpha) and relationship thereof to survivin and bax, apoptosis related proteins, in non-small cell lung cancer (nsclc). |
2008-08-18 |
2023-08-12 |
Not clear |
| Bin Wu, Qiang Zhang, Weiming Shen, Jun Zh. Anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cell line. Molecular and cellular biochemistry. vol 313. issue 1-2. 2008-08-18. PMID:18398671. |
western blotting showed that luteolin treatment significantly increased the levels of pro-apoptotic proteins, including caspase-3, 6, 9, bax, and p53, and decreased the levels of anti-apoptotic protein bcl-2, thus shifting the bax/bcl ratio in favor of apoptosis. |
2008-08-18 |
2023-08-12 |
human |
| Kazunari Nohara, Yoshiko Yokoyama, Kazutaka Kan. The important role of caspase-10 in sodium butyrate-induced apoptosis. The Kobe journal of medical sciences. vol 53. issue 5. 2008-08-13. PMID:18204303. |
sodium butyrate-induced apoptosis has been reported to associate with the up-regulation of pro-apoptotic bax expression, and the down-regulation of anti-apoptotic bcl-2 and bcl-xl expressions. |
2008-08-13 |
2023-08-12 |
human |