| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuefang Cao, Richard L Bennett, W Stratford Ma. c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis. The Journal of biological chemistry. vol 283. issue 21. 2008-07-18. PMID:18375382. |
to test whether c-myc and caspase-2 cooperate to activate bax and thereby mediate intrinsic apoptosis, small interfering rna was used to efficiently knock down the expression of c-myc, caspase-2, and apaf-1, an activating component in the apoptosome, in two human cancer cell lines, lung adenocarcinoma a-549 and osteosarcoma u2-os cells. |
2008-07-18 |
2023-08-12 |
human |
| Yasushi Sasaki, Hideaki Negishi, Masashi Idogawa, Hiromu Suzuki, Hiroaki Mita, Minoru Toyota, Yasuhisa Shinomura, Kohzoh Imai, Takashi Tokin. Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models. Molecular cancer therapeutics. vol 7. issue 4. 2008-07-18. PMID:18413792. |
the double knockdown of bax and noxa expression by small interfering rna antagonized the synergistic effect of ad-p53 and fk228 on apoptosis induction. |
2008-07-18 |
2023-08-12 |
human |
| Andrew R Cuddihy, Farid Jalali, Carla Coackley, Robert G Bristo. WTp53 induction does not override MTp53 chemoresistance and radioresistance due to gain-of-function in lung cancer cells. Molecular cancer therapeutics. vol 7. issue 4. 2008-07-18. PMID:18413811. |
transient transfection of wtp53 into h1299 cells, or shift-down of h1299-p53(a138v) stable transfectants to 32 degrees c to induce wtp53, led to increased p21(waf1) expression and g(1) and g(2) arrests following dna damage but did not increase bax expression or apoptosis. |
2008-07-18 |
2023-08-12 |
human |
| Jing-hong Chen, Jun-ling Cao, Yong-lie Chu, Zhi-lun Wang, Zhan-tian Yang, Hong-lin Wan. T-2 toxin-induced apoptosis involving Fas, p53, Bcl-xL, Bcl-2, Bax and caspase-3 signaling pathways in human chondrocytes. Journal of Zhejiang University. Science. B. vol 9. issue 6. 2008-07-18. PMID:18543398. |
t-2 toxin-induced apoptosis involving fas, p53, bcl-xl, bcl-2, bax and caspase-3 signaling pathways in human chondrocytes. |
2008-07-18 |
2023-08-12 |
human |
| Chunlai Nie, Changhai Tian, Lixia Zhao, Patrice Xavier Petit, Maryam Mehrpour, Quan Che. Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis. The Journal of biological chemistry. vol 283. issue 22. 2008-07-17. PMID:18344566. |
cysteine 62 of bax is critical for its conformational activation and its proapoptotic activity in response to h2o2-induced apoptosis. |
2008-07-17 |
2023-08-12 |
human |
| Chunlai Nie, Changhai Tian, Lixia Zhao, Patrice Xavier Petit, Maryam Mehrpour, Quan Che. Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis. The Journal of biological chemistry. vol 283. issue 22. 2008-07-17. PMID:18344566. |
bax is activated and translocated onto mitochondria to mediate cytochrome c release and apoptosis. |
2008-07-17 |
2023-08-12 |
human |
| Chunlai Nie, Changhai Tian, Lixia Zhao, Patrice Xavier Petit, Maryam Mehrpour, Quan Che. Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis. The Journal of biological chemistry. vol 283. issue 22. 2008-07-17. PMID:18344566. |
the molecular mechanisms of bax activation during apoptosis remain a subject of debate. |
2008-07-17 |
2023-08-12 |
human |
| Chunlai Nie, Changhai Tian, Lixia Zhao, Patrice Xavier Petit, Maryam Mehrpour, Quan Che. Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis. The Journal of biological chemistry. vol 283. issue 22. 2008-07-17. PMID:18344566. |
we addressed the question of whether reactive oxygen species could directly activate bax for its subsequent translocation and apoptosis. |
2008-07-17 |
2023-08-12 |
human |
| Chunlai Nie, Changhai Tian, Lixia Zhao, Patrice Xavier Petit, Maryam Mehrpour, Quan Che. Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis. The Journal of biological chemistry. vol 283. issue 22. 2008-07-17. PMID:18344566. |
mutation of cysteine 62, but not cysteine 126, to serine or alanine abolished its activation by h2o2 but not other death stimuli, both in sw480 and bax-deficient hct116 cells, whereas wild type bax sensitizes these cells to apoptosis. |
2008-07-17 |
2023-08-12 |
human |
| Chunlai Nie, Changhai Tian, Lixia Zhao, Patrice Xavier Petit, Maryam Mehrpour, Quan Che. Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis. The Journal of biological chemistry. vol 283. issue 22. 2008-07-17. PMID:18344566. |
our results identify a critical role of cysteine 62 in oxidative stress-induced bax activation and subsequent apoptosis. |
2008-07-17 |
2023-08-12 |
human |
| Xiongjie Shi, Yongbing Du, Paul K S Lam, Rudolf S S Wu, Bingsheng Zho. Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS. Toxicology and applied pharmacology. vol 230. issue 1. 2008-07-17. PMID:18407306. |
certain genes related to cell apoptosis, p53 and bax, were both significantly up-regulated upon exposure to all the concentrations tested. |
2008-07-17 |
2023-08-12 |
zebrafish |
| Jun Li, David A Vesey, David W Johnson, Glenda Gob. Erythropoietin reduces cisplatin-induced apoptosis in renal carcinoma cells via a PKC dependent pathway. Cancer biology & therapy. vol 6. issue 12. 2008-07-16. PMID:18075299. |
cells were treated with 50 microm cisplatin with and without 200 iu/ml rhepo and were compared for apoptosis, mitosis and protein expression of epor, nuclear factor-kappab (nfkappab), protein kinase c (pkc), bcl-2, bax and cyclin-d1. |
2008-07-16 |
2023-08-12 |
human |
| Piyajit Watcharasit, Apinya Thiantanawat, Jutamaad Satayaviva. GSK3 promotes arsenite-induced apoptosis via facilitation of mitochondria disruption. Journal of applied toxicology : JAT. vol 28. issue 4. 2008-07-15. PMID:17849503. |
moreover, arsenite induced the translocation of bax and p53 to the mitochondria and the activation-associated oligomerization of bax, and these crucial events were reduced by inhibition of gsk3, indicating that gsk3 promotes arsenite-induced apoptosis by facilitating signals leading to mitochondrial apoptotic events. |
2008-07-15 |
2023-08-12 |
human |
| Luena Papa, Patricia Rockwel. Persistent mitochondrial dysfunction and oxidative stress hinder neuronal cell recovery from reversible proteasome inhibition. Apoptosis : an international journal on programmed cell death. vol 13. issue 4. 2008-07-15. PMID:18299995. |
recovery from proteasome inhibition showed a time and dose-dependent cell death that was accompanied by ros overproduction, caspase activation and mitochondrial membrane permeabilization with the subcellular relocalizations of the proapoptotic proteins, bax, cytochrome c and the apoptosis inducing factor (aif). |
2008-07-15 |
2023-08-12 |
mouse |
| Karl T Butterworth, Helen O McCarthy, Andrea Devlin, Louise Ming, Tracy Robson, Stephanie R McKeown, Jenny Worthingto. Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype. International journal of cancer. vol 123. issue 4. 2008-07-15. PMID:18512241. |
furthermore, these cells were resistant to mitochondrial-mediated apoptosis, probably since the endogenous levels of bax was lower and bcl-2 higher than in the parental lncap cells. |
2008-07-15 |
2023-08-12 |
human |
| Shi-Jin Xia, Jing-Cheng Dong, Li Bai, Ming-Dong Hu, Gui-Sheng Qian, Xian-Tao Tai, Jin-Yu Xi. [The effects of Ad-Gax transfection on apoptosis and related gene expression in pulmonary arterial smooth muscle cells in hypoxic rat model]. Zhonghua nei ke za zhi. vol 46. issue 9. 2008-07-11. PMID:18028807. |
to explore the effects of growth arrest-specific homeobox (gax) transfection on apoptosis and expressions of bcl-2 and bax proteins of rat pulmonary arterial smooth muscle cells (pasmcs) exposed to hypoxia. |
2008-07-11 |
2023-08-12 |
rat |
| Britta Krampe, Halina Swiderek, Mohamed Al-Rubea. Transcriptome and proteome analysis of antibody-producing mouse myeloma NS0 cells cultivated at different cell densities in perfusion culture. Biotechnology and applied biochemistry. vol 50. issue Pt 3. 2008-07-10. PMID:18302537. |
hsp60, which inhibits apoptosis by complexing with pro-apoptotic proteins such as bax and bak, was repressed at hcd. |
2008-07-10 |
2023-08-12 |
mouse |
| Jung Young Oh, Yu Mi Baek, Sang Woo Kim, Hye Jin Hwang, Hee Sun Hwang, Sung Hak Lee, Jong Won Yu. Apoptosis of human hepatocarcinoma (HepG2) and neuroblastoma (SKN-SH) cells induced by polysaccharides-peptide complexes produced by submerged mycelial culture of an entomopathogenic fungus Cordyceps sphecocephala. Journal of microbiology and biotechnology. vol 18. issue 3. 2008-07-10. PMID:18388470. |
our investigation also showed that ppc-induced apoptosis of both cancer cells was associated with intracellular events including dna fragmentation, activation of caspase-3, and modulation of bcl-2 and bax. |
2008-07-10 |
2023-08-12 |
human |
| Jang-In Shin, Jung-Hyun Shim, Ki-Hong Kim, Hee-Sook Choi, Jae-Wha Kim, Hee-Gu Lee, Bo-Yeon Kim, Sue-Nie Park, Ok-Jin Park, Do-Young Yoo. Sensitization of the apoptotic effect of gamma-irradiation in genistein-pretreated CaSki cervical cancer cells. Journal of microbiology and biotechnology. vol 18. issue 3. 2008-07-10. PMID:18388472. |
in general, apoptosis signaling cascades were activated by the following events: release of cytochrome c, upregulation of bax, downregulation of bcl-2, and activation of caspase-3 and -8 in the treatment of genistein and irradiation. |
2008-07-10 |
2023-08-12 |
human |
| W S Chai, X M Zhu, S H Li, J X Fan, B Y Che. Role of Bcl-2 family members in caspase-3/9-dependent apoptosis during Pseudomonas aeruginosa infection in U937 cells. Apoptosis : an international journal on programmed cell death. vol 13. issue 6. 2008-07-09. PMID:18415681. |
to explore the expression of bcl-2 and bax as well as caspase-3/9 activation in the apoptosis of human u937 cells induced by p. aeruginosa, hoechst 33258 staining and giemsa staining as well as flow cytometry analysis were used to determine the rate of apoptosis, and the expressions of bcl-2 and bax were assayed by rt-pcr and western blotting respectively. |
2008-07-09 |
2023-08-12 |
human |