| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W S Chai, X M Zhu, S H Li, J X Fan, B Y Che. Role of Bcl-2 family members in caspase-3/9-dependent apoptosis during Pseudomonas aeruginosa infection in U937 cells. Apoptosis : an international journal on programmed cell death. vol 13. issue 6. 2008-07-09. PMID:18415681. |
it is concluded that p. aeruginosa can induce apoptosis with an up-regulated expression of bax and a down-regulated expression of bcl-2, which resulted in increased levels of cytochrome c release and increased caspase-3 and -9 in human u937 cells. |
2008-07-09 |
2023-08-12 |
human |
| Lilian Sewing, Florian Steinberg, Harald Schmidt, Rüdiger Gök. The bisphosphonate zoledronic acid inhibits the growth of HCT-116 colon carcinoma cells and induces tumor cell apoptosis. Apoptosis : an international journal on programmed cell death. vol 13. issue 6. 2008-07-09. PMID:18437576. |
the induction of the mitochondrial pathway of apoptosis was accompanied by a translocation of bax into the mitochondria, bid activation and a decrease of overall bcl-2 expression. |
2008-07-09 |
2023-08-12 |
human |
| Lakshmishri Lahiry, Baisakhi Saha, Juni Chakraborty, Sankar Bhattacharyya, Sreya Chattopadhyay, Shuvomoy Banerjee, Tathagata Choudhuri, Debaprasad Mandal, Arindam Bhattacharyya, Gaurisankar Sa, Tanya Da. Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis. Apoptosis : an international journal on programmed cell death. vol 13. issue 6. 2008-07-09. PMID:18454316. |
contribution of p53-mediated bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis. |
2008-07-09 |
2023-08-12 |
Not clear |
| Lakshmishri Lahiry, Baisakhi Saha, Juni Chakraborty, Sankar Bhattacharyya, Sreya Chattopadhyay, Shuvomoy Banerjee, Tathagata Choudhuri, Debaprasad Mandal, Arindam Bhattacharyya, Gaurisankar Sa, Tanya Da. Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis. Apoptosis : an international journal on programmed cell death. vol 13. issue 6. 2008-07-09. PMID:18454316. |
in contrast, bax over-expression restored back theaflavin-induced apoptosis in pifithrin-alpha-inhibited/dominant-negative p53-expressing cells. |
2008-07-09 |
2023-08-12 |
Not clear |
| Lakshmishri Lahiry, Baisakhi Saha, Juni Chakraborty, Sankar Bhattacharyya, Sreya Chattopadhyay, Shuvomoy Banerjee, Tathagata Choudhuri, Debaprasad Mandal, Arindam Bhattacharyya, Gaurisankar Sa, Tanya Da. Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis. Apoptosis : an international journal on programmed cell death. vol 13. issue 6. 2008-07-09. PMID:18454316. |
inhibition of bax by rna-interference also reduced theaflavin-induced apoptosis. |
2008-07-09 |
2023-08-12 |
Not clear |
| Lakshmishri Lahiry, Baisakhi Saha, Juni Chakraborty, Sankar Bhattacharyya, Sreya Chattopadhyay, Shuvomoy Banerjee, Tathagata Choudhuri, Debaprasad Mandal, Arindam Bhattacharyya, Gaurisankar Sa, Tanya Da. Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis. Apoptosis : an international journal on programmed cell death. vol 13. issue 6. 2008-07-09. PMID:18454316. |
these results not only indicated the requirement of p53-mediated transcriptional activation of bax but also its role as down-stream effecter in theaflavin-induced apoptosis. |
2008-07-09 |
2023-08-12 |
Not clear |
| Melissa Braga, Amiya P Sinha Hikim, Sanjit Datta, Monica G Ferrini, Danielle Brown, Ekaterina L Kovacheva, Nestor F Gonzalez-Cadavid, Indrani Sinha-Hiki. Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis : an international journal on programmed cell death. vol 13. issue 6. 2008-07-09. PMID:18461459. |
to test the hypothesis that caspase 2 and c-jun nh(2)-terminal kinase (jnk)-mediated intrinsic pathway signaling contribute to skeletal muscle cell apoptosis in aging, we compared activation of caspase 2 and jnk and the in vivo expression of 4-hydroxynonenal protein adducts (4-hne), inducible nitric oxide synthase (inos), glucose-6-phosphate dehydrogenase (g6pdh), b-cell lymphoma-2 (bcl-2), bax, and phospho-bcl-2 in gastrocnemius muscles of young (5 months old) and old (25 months old) mice. |
2008-07-09 |
2023-08-12 |
mouse |
| L Vandaele, K Goossens, L Peelman, A Van Soo. mRNA expression of Bcl-2, Bax, caspase-3 and -7 cannot be used as a marker for apoptosis in bovine blastocysts. Animal reproduction science. vol 106. issue 1-2. 2008-07-08. PMID:18272300. |
mrna expression of bcl-2, bax, caspase-3 and -7 cannot be used as a marker for apoptosis in bovine blastocysts. |
2008-07-08 |
2023-08-12 |
cattle |
| L Vandaele, K Goossens, L Peelman, A Van Soo. mRNA expression of Bcl-2, Bax, caspase-3 and -7 cannot be used as a marker for apoptosis in bovine blastocysts. Animal reproduction science. vol 106. issue 1-2. 2008-07-08. PMID:18272300. |
the aim of the present study was to investigate if the mrna expression of a set of genes involved in apoptosis (bax, bcl-2, caspase-3 and -7) at an earlier point in the apoptotic cascade could be a good marker for apoptosis in in vitro produced bovine embryos. |
2008-07-08 |
2023-08-12 |
cattle |
| L Vandaele, K Goossens, L Peelman, A Van Soo. mRNA expression of Bcl-2, Bax, caspase-3 and -7 cannot be used as a marker for apoptosis in bovine blastocysts. Animal reproduction science. vol 106. issue 1-2. 2008-07-08. PMID:18272300. |
after normalization to the geometric mean of three reference genes, gapd, ywhaz and sdha, mrna expression levels of bax, bcl-2, caspase-3 and -7 were compared in embryos treated with an apoptosis inducer, staurosporine and in non-treated embryos. |
2008-07-08 |
2023-08-12 |
cattle |
| L Vandaele, K Goossens, L Peelman, A Van Soo. mRNA expression of Bcl-2, Bax, caspase-3 and -7 cannot be used as a marker for apoptosis in bovine blastocysts. Animal reproduction science. vol 106. issue 1-2. 2008-07-08. PMID:18272300. |
in conclusion, mrna expression of bax, bcl-2, caspase-3 and-7 cannot be used as a reliable apoptosis detection method. |
2008-07-08 |
2023-08-12 |
cattle |
| Yih-Giun Cherng, Hua-Chia Chang, Yi-Ling Lin, Ming-Liang Kuo, Wen-Ta Chiu, Ruei-Ming Che. Apoptotic insults to human chondrocytes induced by sodium nitroprusside are involved in sequential events, including cytoskeletal remodeling, phosphorylation of mitogen-activated protein kinase kinase kinase-1/c-Jun N-terminal kinase, and Bax-mitochondria-mediated caspase activation. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 26. issue 7. 2008-07-08. PMID:18306405. |
this study shows that snp can induce apoptosis of human chondrocytes through sequential events, including cytoskeletal remodeling, activation of mekk1/jnk, bax translocation, mitochondrial dysfunction, cytochrome c release, caspase activation, and dna fragmentation. |
2008-07-08 |
2023-08-12 |
human |
| Wenqi Chen, Jian Kang, Jiping Xia, Yanhua Li, Bo Yang, Bin Chen, Weiling Sun, Xiuzu Song, Wenzhong Xiang, Xiaoyong Wang, Fei Wang, Yinsheng Wan, Zhigang B. p53-related apoptosis resistance and tumor suppression activity in UVB-induced premature senescent human skin fibroblasts. International journal of molecular medicine. vol 21. issue 5. 2008-07-08. PMID:18425358. |
a real time pcr array to investigate the mrna expression of p53-related genes involved in growth arrest, apoptosis and tumorigenesis indicated that p53, p21, p19, hdm2, and bax were up-regulated, and bcl, hif-1alpha and vegf were down-regulated. |
2008-07-08 |
2023-08-12 |
human |
| Séverine Wack, Soukaina Rejiba, Céline Parmentier, Marc Aprahamian, Amor Hajr. Telomerase transcriptional targeting of inducible Bax/TRAIL gene therapy improves gemcitabine treatment of pancreatic cancer. Molecular therapy : the journal of the American Society of Gene Therapy. vol 16. issue 2. 2008-07-03. PMID:17984977. |
our data showed that treatment with the adenoviral systems resulted in high-level expression of bax and trail genes directly related to apoptosis induction, leading to a significant sensitization of resistant pancreatic tumor cells. |
2008-07-03 |
2023-08-12 |
human |
| Anthony J Valentijn, John-Paul Upton, Andrew P Gilmor. Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization. The Biochemical journal. vol 412. issue 2. 2008-07-03. PMID:18307410. |
analysis of endogenous bax complexes during apoptosis using blue native page: implications for bax activation and oligomerization. |
2008-07-03 |
2023-08-12 |
Not clear |
| Anthony J Valentijn, John-Paul Upton, Andrew P Gilmor. Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization. The Biochemical journal. vol 412. issue 2. 2008-07-03. PMID:18307410. |
bax, a pro-apoptotic bcl-2 family protein, translocates to mitochondria during apoptosis, where it causes momp (mitochondrial outer membrane permeabilization). |
2008-07-03 |
2023-08-12 |
Not clear |
| Anthony J Valentijn, John-Paul Upton, Andrew P Gilmor. Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization. The Biochemical journal. vol 412. issue 2. 2008-07-03. PMID:18307410. |
in the present study, we have examined endogenous bax in epithelial cells undergoing anoikis, a physiologically relevant form of apoptosis that occurs when normal cells lose contact with the ecm (extracellular matrix). |
2008-07-03 |
2023-08-12 |
Not clear |
| Vilmante Borutait. AMPK, MAPK and Bax in the heart: some questions answered. The Biochemical journal. vol 412. issue 2. 2008-07-03. PMID:18466112. |
the question of how bax is activated during apoptosis to perform its role in permeabilization of mitochondrial membranes is intriguing for investigators in the wide field of cell death research. |
2008-07-03 |
2023-08-12 |
Not clear |
| Vilmante Borutait. AMPK, MAPK and Bax in the heart: some questions answered. The Biochemical journal. vol 412. issue 2. 2008-07-03. PMID:18466112. |
this was the first report on the molecular mechanism of bax activation and migration during ischaemia-induced apoptosis in cardiomyocytes. |
2008-07-03 |
2023-08-12 |
Not clear |
| Yan Cheng, Feng Qiu, Jian Huang, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejim. Apoptosis-suppressing and autophagy-promoting effects of calpain on oridonin-induced L929 cell death. Archives of biochemistry and biophysics. vol 475. issue 2. 2008-07-03. PMID:18468506. |
we found that inhibition of calpain increased oridonin-induced bax activation, cytochrome c release and parp cleavage, indicating that calpain plays an anti-apoptotic role in oridonin-induced l929 cell apoptosis. |
2008-07-03 |
2023-08-12 |
Not clear |