| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazunari Nohara, Yoshiko Yokoyama, Kazutaka Kan. The important role of caspase-10 in sodium butyrate-induced apoptosis. The Kobe journal of medical sciences. vol 53. issue 5. 2008-08-13. PMID:18204303. |
however, in some cases, butyrate has also been shown to cause apoptosis without change in bcl-2, bcl-xl and/or bax. |
2008-08-13 |
2023-08-12 |
human |
| Chamel M Khoury, Michael T Greenwoo. The pleiotropic effects of heterologous Bax expression in yeast. Biochimica et biophysica acta. vol 1783. issue 7. 2008-08-13. PMID:18243144. |
we also discuss the evidence for pleiotropic roles of bax in yeast apoptosis. |
2008-08-13 |
2023-08-12 |
Not clear |
| Christopher Runyan, Ying Gu, Amanda Shoemaker, Leendert Looijenga, Christopher Wyli. The distribution and behavior of extragonadal primordial germ cells in Bax mutant mice suggest a novel origin for sacrococcygeal germ cell tumors. The International journal of developmental biology. vol 52. issue 4. 2008-08-13. PMID:18415933. |
in the mouse, germ cells that do not reach the genital ridges rapidly die by a wave of apoptosis that requires the pro-apoptotic protein bax. |
2008-08-13 |
2023-08-12 |
mouse |
| Ivan Kalousek, Barbora Brodska, Petra Otevrelova, Pavla Röselov. BimEL-dependent apoptosis induced in peripheral blood lymphocytes with n-butyric acid is moderated by variation in expression of c-myc and p21(WAF1). Cell biochemistry and function. vol 26. issue 4. 2008-08-12. PMID:18348176. |
the bax activator bimel increased rapidly, driving cells toward apoptosis likely controlled by c-myc and p21(waf1) activities. |
2008-08-12 |
2023-08-12 |
Not clear |
| Jie Mei, Qi-Ya Zhang, Zhi Li, Shuo Lin, Jian-Fang Gu. C1q-like inhibits p53-mediated apoptosis and controls normal hematopoiesis during zebrafish embryogenesis. Developmental biology. vol 319. issue 2. 2008-08-12. PMID:18514183. |
real-time quantitative pcr showed the up-regulation expression of several apoptosis regulators such as p53, mdm2, p21, bax and caspase 3, and down-regulation expression of hbae1 in the c1q-like morphant embryos. |
2008-08-12 |
2023-08-12 |
zebrafish |
| Yeung-Leung Cheng, Shih-Chun Lee, Horng-Jyh Harn, Hsin-Chieh Huang, Wen-Liang Chan. The extract of Hibiscus syriacus inducing apoptosis by activating p53 and AIF in human lung cancer cells. The American journal of Chinese medicine. vol 36. issue 1. 2008-08-11. PMID:18306460. |
the expression of caspases, p53, apoptosis induced factor (aif), bcl-2 and bax were evaluated with western blotting. |
2008-08-11 |
2023-08-12 |
human |
| E H A Nijhuis, S Le Gac, A A Poot, J Feijen, I Verme. Bax-mediated mitochondrial membrane permeabilization after heat treatment is caspase-2 dependent. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. vol 24. issue 4. 2008-08-11. PMID:18465420. |
heat-induced apoptosis proceeds via mitochondria by permeabilization of the outer mitochondrial membrane (momp), resulting in the release of cytochrome c. this essential step is mediated by bcl-2 family proteins, such as bax. |
2008-08-11 |
2023-08-12 |
Not clear |
| Zhengli Hu, Fumin Zhang, Zhijian Yang, Naiquan Yang, Dingguo Zhang, Jinying Zhang, Kejiang Ca. Combination of simvastatin administration and EPC transplantation enhances angiogenesis and protects against apoptosis for hindlimb ischemia. Journal of biomedical science. vol 15. issue 4. 2008-08-08. PMID:18327656. |
importantly, this combination therapy significantly reduced apoptosis of ischemic skeletal muscle cells in part through downregulation of bax and upregulation of bcl-2 compared with the other groups. |
2008-08-08 |
2023-08-12 |
mouse |
| Zhengli Hu, Fumin Zhang, Zhijian Yang, Naiquan Yang, Dingguo Zhang, Jinying Zhang, Kejiang Ca. Combination of simvastatin administration and EPC transplantation enhances angiogenesis and protects against apoptosis for hindlimb ischemia. Journal of biomedical science. vol 15. issue 4. 2008-08-08. PMID:18327656. |
the combination therapy not only inhibites apoptosis of ischemic skeletal muscle cells partially via downregulation of bax and upregulation of bcl-2, but also activates akt phosphorylation significantly. |
2008-08-08 |
2023-08-12 |
mouse |
| W Wei-Lynn Wong, Hamsa Puthalakat. Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway. IUBMB life. vol 60. issue 6. 2008-08-07. PMID:18425793. |
these signals are transmitted through the upstream molecules in the pathway, that is, the bh3-only molecules that results in the activation of the adaptor molecules, bax and bak, at the mitochondrial surface ensuing mitochondrial dysfunction and apoptosis. |
2008-08-07 |
2023-08-12 |
Not clear |
| Hye Jin Kim, Sang Yong Kim, Jinchul Kim, Heemin Lee, Misun Choi, Jeong Ki Kim, Jeong Keun Ah. Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria. IUBMB life. vol 60. issue 7. 2008-08-07. PMID:18481805. |
hepatitis b virus x protein induces apoptosis by enhancing translocation of bax to mitochondria. |
2008-08-07 |
2023-08-12 |
Not clear |
| Hye Jin Kim, Sang Yong Kim, Jinchul Kim, Heemin Lee, Misun Choi, Jeong Ki Kim, Jeong Keun Ah. Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria. IUBMB life. vol 60. issue 7. 2008-08-07. PMID:18481805. |
in the present study, we report that hbx induces apoptosis by enhancing the translocation of bax to mitochondria, followed by inducing the loss of mitochondrial membrane potential and release of cytochrome c. in addition, bcl-2, inhibitor of bax, rescues the disruption of mitochondrial membrane potential and dna fragmentation induced by serum starvation in hepg2-x cells expressing hbx. |
2008-08-07 |
2023-08-12 |
Not clear |
| Hye Jin Kim, Sang Yong Kim, Jinchul Kim, Heemin Lee, Misun Choi, Jeong Ki Kim, Jeong Keun Ah. Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria. IUBMB life. vol 60. issue 7. 2008-08-07. PMID:18481805. |
taken together, our data suggest that hbx induces apoptosis by interacting with bax and enhancing its translocation to mitochondria. |
2008-08-07 |
2023-08-12 |
Not clear |
| Kristi L Norris, Richard J Youl. Cytomegalovirus proteins vMIA and m38.5 link mitochondrial morphogenesis to Bcl-2 family proteins. Journal of virology. vol 82. issue 13. 2008-08-06. PMID:18417572. |
human cytomegalovirus encodes viral mitochondria-localized inhibitor of apoptosis (vmia; also known as pul37x1), which is targeted to mitochondria and functions as a potent cell death suppressor by binding to and inhibiting proapoptotic bcl-2 family members bax and bak. |
2008-08-06 |
2023-08-12 |
human |
| Kristi L Norris, Richard J Youl. Cytomegalovirus proteins vMIA and m38.5 link mitochondrial morphogenesis to Bcl-2 family proteins. Journal of virology. vol 82. issue 13. 2008-08-06. PMID:18417572. |
consistently with bax-selective inactivation by m38.5, m38.5 fragments mitochondria in bak knockout (ko) cells and protects bak ko cells from apoptosis better than bax ko cells. |
2008-08-06 |
2023-08-12 |
human |
| Kristi L Norris, Richard J Youl. Cytomegalovirus proteins vMIA and m38.5 link mitochondrial morphogenesis to Bcl-2 family proteins. Journal of virology. vol 82. issue 13. 2008-08-06. PMID:18417572. |
thus, vmia and m38.5 share some, but not all, features of apoptosis regulation through bcl-2 family interaction and allow the dissection of bax translocation into discrete steps. |
2008-08-06 |
2023-08-12 |
human |
| Carmen Bergom, Cathy Paddock, Cunji Gao, Trudy Holyst, Debra K Newman, Peter J Newma. An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling. Journal of cell science. vol 121. issue Pt 8. 2008-08-05. PMID:18388311. |
delta15 pecam-1 was unable, however, to protect against apoptosis induced by overexpression of bax or treatment with the chemotherapy agent etoposide. |
2008-08-05 |
2023-08-12 |
human |
| Jens Hoffmann, Ilio Vitale, Bernd Buchmann, Lorenzo Galluzzi, Wolfgang Schwede, Laura Senovilla, Werner Skuballa, Sonia Vivet, Rosemarie B Lichtner, José M Vicencio, Theocharis Panaretakis, Gerhard Siemeister, Hermann Lage, Lisa Nanty, Stefanie Hammer, Kevin Mittelstaedt, Sebastian Winsel, Julia Eschenbrenner, Maria Castedo, Carine Demarche, Ulrich Klar, Guido Kroeme. Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone. Cancer research. vol 68. issue 13. 2008-08-05. PMID:18593931. |
in hct 116 colon carcinoma cells, sagopilone-induced apoptosis was partly antagonized by the knockdown of proapoptotic members of the bcl-2 family, including bax, bak, and puma, whereas knockdown of bcl-2, bcl-x(l), or chk1 sensitized cells to sagopilone-induced cell death. |
2008-08-05 |
2023-08-12 |
human |
| Mark D McKenzie, Emma M Carrington, Thomas Kaufmann, Andreas Strasser, David C S Huang, Thomas W H Kay, Janette Allison, Helen E Thoma. Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells. Diabetes. vol 57. issue 5. 2008-08-04. PMID:18252892. |
we investigated the role of the bh3-only protein bid and the multi-bh domain proapoptotic bax and bak, as well as prosurvival bcl-2, in beta-cell apoptosis. |
2008-08-04 |
2023-08-12 |
Not clear |
| N Gavaldà, E Pérez-Navarro, J M García-Martínez, S Marco, A Benito, J Alberc. Bax deficiency promotes an up-regulation of Bim(EL) and Bak during striatal and cortical postnatal development, and after excitotoxic injury. Molecular and cellular neurosciences. vol 37. issue 4. 2008-08-04. PMID:18272391. |
in contrast, bax is required to induce apoptosis after excitotoxicity in the adult striatum. |
2008-08-04 |
2023-08-12 |
mouse |