| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Havasi, Zhijian Li, Zhiyong Wang, Jody L Martin, Venugopal Botla, Kathleen Ruchalski, John H Schwartz, Steven C Borka. Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism. The Journal of biological chemistry. vol 283. issue 18. 2008-06-19. PMID:18299320. |
hsp27 inhibits bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism. |
2008-06-19 |
2023-08-12 |
Not clear |
| Andrea Havasi, Zhijian Li, Zhiyong Wang, Jody L Martin, Venugopal Botla, Kathleen Ruchalski, John H Schwartz, Steven C Borka. Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism. The Journal of biological chemistry. vol 283. issue 18. 2008-06-19. PMID:18299320. |
to test the hypothesis that hsp27 decreases apoptosis by inhibiting bax, hsp27 expression was manipulated in renal epithelial cells before transient metabolic stress, an insult that activates bax, induces mitochondrial injury, and causes apoptosis. |
2008-06-19 |
2023-08-12 |
Not clear |
| Hui-Jun Zhou, Zeng Wang, Ao L. Dihydroartemisinin induces apoptosis in human leukemia cells HL60 via downregulation of transferrin receptor expression. Anti-cancer drugs. vol 19. issue 3. 2008-06-19. PMID:18510170. |
cell growth inhibition was assessed by trypan blue exclusive staining; the expression of caspase-3, bcl-2, and bax in hl60 cells was evaluated by western blotting; dha-induced apoptosis was determined by ao/eb double staining, dna fragmentation assay, and flow cytometric analysis; the expression of tfr in hl60 cells was examined by real-time pcr assays, western blotting, and flow cytometric analysis. |
2008-06-19 |
2023-08-12 |
human |
| Ruidong Miao, Yin Han, Lizhe An, Jinbo Yang, Qin Wan. Seleno-podophyllotoxin derivatives induce hepatoma SMMC-7721 cell apoptosis through Bax pathway. Cell biology international. vol 32. issue 2. 2008-06-18. PMID:17993285. |
seleno-podophyllotoxin derivatives induce hepatoma smmc-7721 cell apoptosis through bax pathway. |
2008-06-18 |
2023-08-12 |
human |
| Yun-fei Qian, Hua Wang, Wen-bing Yao, Xiang-dong Ga. Aqueous extract of the Chinese medicine, Danggui-Shaoyao-San, inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade. Cell biology international. vol 32. issue 2. 2008-06-18. PMID:18093848. |
the apoptosis in h2o2-induced pc12 cells was accompanied by downregulation of bcl-2, upregulation of bax, the release of mitochondrial cytochrome c into cytosol, and sequential activation of caspase-9 and -3. |
2008-06-18 |
2023-08-12 |
rat |
| Shu-Chun Hsu, Jih-Hung Lu, Chao-Lin Kuo, Jai-Sing Yang, Meng-Wei Lin, Guang-Wei Chen, Chin-Cheng Su, Hsu-Fung Lu, Jing-Gung Chun. Crude extracts of Solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line (colo 205). Anticancer research. vol 28. issue 2A. 2008-06-18. PMID:18507053. |
western blotting analysis indicated that sle 300 increased bax levels and decreased bcl-2 levels, which caused the loss of deltapsi(m) followed by cytochrome c release and caspase-9 and -3 activation, finally leading to apoptosis. |
2008-06-18 |
2023-08-12 |
human |
| S L McElroy, J H Kim, S Kim, Y W Jeong, E G Lee, S M Park, M S Hossein, O J Koo, M D Abul Hashem, G Jang, S K Kang, B C Lee, W S Hwan. Effects of culture conditions and nuclear transfer protocols on blastocyst formation and mRNA expression in pre-implantation porcine embryos. Theriogenology. vol 69. issue 4. 2008-06-16. PMID:18055008. |
this study investigated the effects of culture conditions and somatic cell nuclear transfer (scnt) protocols on in vitro development of porcine scnt embryos and on expression patterns of genes involved in stress (heat shock protein 70.2, hsp70.2), trophoblastic function (integrin beta1, itgb1), metabolism (phosphoglycerate kinase 1, pgk1), apoptosis (bax), and imprinted gene (insulin-like growth factor 2 receptor, igf2r). |
2008-06-16 |
2023-08-12 |
Not clear |
| Dae-Hee Lee, Miroslaw Szczepanski, Yong J Le. Role of Bax in quercetin-induced apoptosis in human prostate cancer cells. Biochemical pharmacology. vol 75. issue 12. 2008-06-16. PMID:18455702. |
role of bax in quercetin-induced apoptosis in human prostate cancer cells. |
2008-06-16 |
2023-08-12 |
human |
| Tehmina Mustafa, Harald G Wiker, Odd Mørkve, Lisbet Svilan. Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis. Virchows Archiv : an international journal of pathology. vol 452. issue 4. 2008-06-12. PMID:18266005. |
lymph node biopsies from 30 cases of lymphadenitis were studied for expression of the secreted mycobacterial protein mpt64, caspase 3 as a marker of apoptosis, apoptosis-related proteins (fas ligand, fas and bax) and inflammatory cytokines (interleukin-10, transforming growth factor-beta (tgf-beta), tumour necrosis factor-alpha and interferon-gamma) by immunohistochemistry. |
2008-06-12 |
2023-08-12 |
Not clear |
| Kwang Sup So, Ji Eun Oh, Jee Hye Han, Hong Keun Jung, Young Suk Lee, Sang Hee Kim, Young Jin Chun, Mie Young Ki. Induction of apoptosis by a stilbene analog involves Bax translocation regulated by p38 MAPK and Akt. Archives of pharmacal research. vol 31. issue 4. 2008-06-11. PMID:18449500. |
induction of apoptosis by a stilbene analog involves bax translocation regulated by p38 mapk and akt. |
2008-06-11 |
2023-08-12 |
Not clear |
| Kwang Sup So, Ji Eun Oh, Jee Hye Han, Hong Keun Jung, Young Suk Lee, Sang Hee Kim, Young Jin Chun, Mie Young Ki. Induction of apoptosis by a stilbene analog involves Bax translocation regulated by p38 MAPK and Akt. Archives of pharmacal research. vol 31. issue 4. 2008-06-11. PMID:18449500. |
in hl-60 cells, sa induced apoptosis through activation of p38 mapk and inactivation of akt, which in turn activated bad and mitochondrial death signaling pathway, as evidenced by bax translocation and cytochrome c release. |
2008-06-11 |
2023-08-12 |
Not clear |
| Kwang Sup So, Ji Eun Oh, Jee Hye Han, Hong Keun Jung, Young Suk Lee, Sang Hee Kim, Young Jin Chun, Mie Young Ki. Induction of apoptosis by a stilbene analog involves Bax translocation regulated by p38 MAPK and Akt. Archives of pharmacal research. vol 31. issue 4. 2008-06-11. PMID:18449500. |
expression of dominant negative p38 mapk or constitutively active akt significantly prevented cell death and mitochondrial bax translocation, implicating that p38 mapk and akt signaling pathways play crucial roles in stilbene-induced apoptosis of hl-60 cells. |
2008-06-11 |
2023-08-12 |
Not clear |
| Chuangying Hu, Liang Chen, Yong Jiang, Yi Li, Shaofeng Wan. The effect of fatty acid-CoA ligase 4 on the growth of hepatic cancer cells. Cancer biology & therapy. vol 7. issue 1. 2008-06-10. PMID:18059177. |
the expression related to apoptosis of protein, wt-p53, bax and bcl-2, in hepg2 cells were evaluated by s-p immunocytochemical dyeing. |
2008-06-10 |
2023-08-12 |
human |
| Chuangying Hu, Liang Chen, Yong Jiang, Yi Li, Shaofeng Wan. The effect of fatty acid-CoA ligase 4 on the growth of hepatic cancer cells. Cancer biology & therapy. vol 7. issue 1. 2008-06-10. PMID:18059177. |
besides, the increased apoptosis was accompanied by increased bax, and decreased wtp53 and bcl-2 protein levels. |
2008-06-10 |
2023-08-12 |
human |
| Chuangying Hu, Liang Chen, Yong Jiang, Yi Li, Shaofeng Wan. The effect of fatty acid-CoA ligase 4 on the growth of hepatic cancer cells. Cancer biology & therapy. vol 7. issue 1. 2008-06-10. PMID:18059177. |
the increased apoptosis was accompanied by upregulation of bax, and decreased wt-p53 and bcl-2 protein level. |
2008-06-10 |
2023-08-12 |
human |
| Giuseppe Nocentini, Salvatore Cuzzocrea, Tiziana Genovese, Rodolfo Bianchini, Emanuela Mazzon, Simona Ronchetti, Emanuela Esposito, Di Paola Rosanna, Placido Bramanti, Carlo Riccard. Glucocorticoid-induced tumor necrosis factor receptor-related (GITR)-Fc fusion protein inhibits GITR triggering and protects from the inflammatory response after spinal cord injury. Molecular pharmacology. vol 73. issue 6. 2008-06-10. PMID:18322000. |
administration of gitr-fc ameliorated sci-induced inflammation in gitr(+/+) mice as evaluated through: 1) histological damage and apoptosis, 2) modulation of apoptosis-related transduction factors (bax and bcl-2), 3) expression of inflammatory markers [nitrotyrosine, inducible nitric-oxide synthase, interleukin (il)-2, il-12, and tumor necrosis factor-alpha], and 4) t-lymphocyte infiltration. |
2008-06-10 |
2023-08-12 |
mouse |
| Christin Tse, Alexander R Shoemaker, Jessica Adickes, Mark G Anderson, Jun Chen, Sha Jin, Eric F Johnson, Kennan C Marsh, Michael J Mitten, Paul Nimmer, Lisa Roberts, Stephen K Tahir, Yu Xiao, Xiufen Yang, Haichao Zhang, Stephen Fesik, Saul H Rosenberg, Steven W Elmor. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer research. vol 68. issue 9. 2008-06-10. PMID:18451170. |
in human tumor cells, abt-263 induces bax translocation, cytochrome c release, and subsequent apoptosis. |
2008-06-10 |
2023-08-12 |
human |
| Hong Yang, Chenguo Deng, Shengguo Shen, Duanlian Zhang, Ying Y. Expression and significance of Bcl-2, Bax, Fas and caspase-3 in different phases of human hemangioma. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 26. issue 4. 2008-06-06. PMID:17120732. |
bax, fas and caspase-3 promote the switch of hemangioma from proliferation to involution by inducing the apoptosis of hemangioma endothelia. |
2008-06-06 |
2023-08-12 |
human |
| Soumya Chatterjee, Subhadip Kundu, Arindam Bhattacharyy. Mechanism of cadmium induced apoptosis in the immunocyte. Toxicology letters. vol 177. issue 2. 2008-06-06. PMID:18281164. |
here we showed that cadmium induced p53-dependent apoptosis through cooperation between bcl-xl down regulation without changing the bcl-2 and bax expression, the common target of p53. |
2008-06-06 |
2023-08-12 |
mouse |
| So Yong Lee, Dong Yeon Yuk, Ho Seub Song, Do Young Yoon, Jae Kyung Jung, Dong Cheul Moon, Byung Seok Lee, Jin Tae Hon. Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB. European journal of pharmacology. vol 582. issue 1-3. 2008-06-05. PMID:18241858. |
correlated well with the induction of apoptosis, obovatol increased the expression of the apoptotic genes; bax, caspase-3, caspase-9, whereas inhibited expression of anti-apoptotic genes; bcl-2, inhibitor of apoptosis protein (iap-1) and x chromosome iap (xiap) as well as the cell proliferation marker genes; cox-2, c-fos, c-jun and cyclin d1. |
2008-06-05 |
2023-08-12 |
Not clear |