| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dae-Hee Lee, Clifford Kim, Lin Zhang, Yong J Le. Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. Biochemical pharmacology. vol 75. issue 10. 2008-05-16. PMID:18377871. |
role of p53, puma, and bax in wogonin-induced apoptosis in human cancer cells. |
2008-05-16 |
2023-08-12 |
human |
| Dae-Hee Lee, Clifford Kim, Lin Zhang, Yong J Le. Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. Biochemical pharmacology. vol 75. issue 10. 2008-05-16. PMID:18377871. |
taken together, these results indicate that p53-dependent transcriptional induction of puma and oligomerization of bax play important roles in the sensitivity of cancer cells to apoptosis induced by caspase activation through wogonin. |
2008-05-16 |
2023-08-12 |
human |
| Ling Yang, Xiaoyu Liu, Jinyu Hao, Yunlong Yang, Mingxia Zhao, Ji Zuo, Wen Li. Glucose-regulated protein 75 suppresses apoptosis induced by glucose deprivation in PC12 cells through inhibition of Bax conformational change. Acta biochimica et biophysica Sinica. vol 40. issue 4. 2008-05-14. PMID:18401532. |
glucose-regulated protein 75 suppresses apoptosis induced by glucose deprivation in pc12 cells through inhibition of bax conformational change. |
2008-05-14 |
2023-08-12 |
Not clear |
| Ling Yang, Xiaoyu Liu, Jinyu Hao, Yunlong Yang, Mingxia Zhao, Ji Zuo, Wen Li. Glucose-regulated protein 75 suppresses apoptosis induced by glucose deprivation in PC12 cells through inhibition of Bax conformational change. Acta biochimica et biophysica Sinica. vol 40. issue 4. 2008-05-14. PMID:18401532. |
here we report that grp75 could delay the release of cytochrome c and reduce apoptosis induced by gd, and we also found that grp75 could decrease bax/bcl-2 gene expression ratio and inhibit the conformational change of bax during this process. |
2008-05-14 |
2023-08-12 |
Not clear |
| Mi-Ran Ki, Hye-Rim Lee, Moon-Jung Goo, Il-Hwa Hong, Sun-Hee Do, Da-Hee Jeong, Hai-Jie Yang, Dong-Wei Yuan, Jin-Kyu Park, Kyu-Shik Jeon. Differential regulation of ERK1/2 and p38 MAP kinases in VacA-induced apoptosis of gastric epithelial cells. American journal of physiology. Gastrointestinal and liver physiology. vol 294. issue 3. 2008-05-13. PMID:18096609. |
these results suggest that sod-1 and villin are expressed differentially upon vaca insult depending on dose and exposure time via erk and p38 map kinases; decrease in sod-1 and villin expression coupled with bax dimerization leads to apoptosis of gastric epithelial cells. |
2008-05-13 |
2023-08-12 |
Not clear |
| Yan-Qiu Shi, Yong-Xiang Liao, Xian-Jun Qu, Hui-Qing Yuan, Song Li, Jian-Bo Qu, Hong-Xiang Lo. Marchantin C, a macrocyclic bisbibenzyl, induces apoptosis of human glioma A172 cells. Cancer letters. vol 262. issue 2. 2008-05-13. PMID:18215458. |
rt-pcr and western blot assay further substantiated that marchantin c, as a promising pro-apoptotic agent, had strong effects to induce a172 cell apoptosis, suggesting that the action was achieved through up-regulating bax and down-regulating bcl-2. |
2008-05-13 |
2023-08-12 |
human |
| Gang Ren, Yun-peng Zhao, Lu Yang, Cheng-xin F. Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis. Cancer letters. vol 262. issue 2. 2008-05-13. PMID:18222036. |
these results indicated that the induction of apoptosis by clitocine involved the multiple pathway including death receptor and mitochondrial pathways, and strongly suggested that the mitochondrial pathways were mediated by down-regulation of bcl-2 and up-regulation of bax, release of cytochrome c and subsequent activation of caspase-3 followed by down stream events leading to apoptotic mode of cell death. |
2008-05-13 |
2023-08-12 |
human |
| Igor Jurak, Uwe Schumacher, Hrvoje Simic, Sebastian Voigt, Wolfram Brun. Murine cytomegalovirus m38.5 protein inhibits Bax-mediated cell death. Journal of virology. vol 82. issue 10. 2008-05-13. PMID:18321965. |
using fibroblasts deficient in the proapoptotic bcl-2 family proteins bak and/or bax, we further demonstrated that m38.5 protected from bax- but not bak-mediated apoptosis and interacted with bax in infected cells. |
2008-05-13 |
2023-08-12 |
human |
| Jincheng Yao, Zhenzhou Jiang, Weigang Duan, Jingfeng Huang, Luyong Zhang, Ling Hu, Ling He, Fu Li, Yajie Xiao, Bin Shu, Chunhui Li. Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells. Biological & pharmaceutical bulletin. vol 31. issue 4. 2008-05-12. PMID:18379047. |
triptolide-induced apoptosis was accompanied by loss of mitochondrial membrane potential and release of cytochrome c (cyt-c) from the mitochondria to the cytosol and down-regulation of anti-apoptotic protein bcl-2 levels with concurrent up-regulation in pro-apoptotic protein bax levels and tumor suppressor protein p53 levels. |
2008-05-12 |
2023-08-12 |
human |
| Hirofumi Sawai, Naochika Doma. Release of cytochrome c from mitochondria precedes Bax translocation/activation in Triton X-100-induced apoptosis. Leukemia research. vol 32. issue 3. 2008-05-06. PMID:17689609. |
release of cytochrome c from mitochondria precedes bax translocation/activation in triton x-100-induced apoptosis. |
2008-05-06 |
2023-08-12 |
Not clear |
| Hirofumi Sawai, Naochika Doma. Release of cytochrome c from mitochondria precedes Bax translocation/activation in Triton X-100-induced apoptosis. Leukemia research. vol 32. issue 3. 2008-05-06. PMID:17689609. |
here we investigated whether activation of bax might play a role in triton x-100-induced apoptosis in cells. |
2008-05-06 |
2023-08-12 |
Not clear |
| Hirofumi Sawai, Naochika Doma. Release of cytochrome c from mitochondria precedes Bax translocation/activation in Triton X-100-induced apoptosis. Leukemia research. vol 32. issue 3. 2008-05-06. PMID:17689609. |
although bax translocation/activation was inhibited by caspase inhibitors, cytochrome c release from mitochondria was not affected in triton x-100-induced apoptosis in u-937 cells. |
2008-05-06 |
2023-08-12 |
Not clear |
| Hirofumi Sawai, Naochika Doma. Release of cytochrome c from mitochondria precedes Bax translocation/activation in Triton X-100-induced apoptosis. Leukemia research. vol 32. issue 3. 2008-05-06. PMID:17689609. |
these results demonstrate that translocation/activation of bax occurs downstream of cytochrome c release and caspase activation in triton x-100-induced apoptosis. |
2008-05-06 |
2023-08-12 |
Not clear |
| Lihui Chen, Jianming Jiang, Chunlei Cheng, Ajing Yang, Qiyang He, Diandong Li, Zhen Wan. P53 dependent and independent apoptosis induced by lidamycin in human colorectal cancer cells. Cancer biology & therapy. vol 6. issue 6. 2008-05-05. PMID:17534142. |
the primarily activation of mitochondria as well as the activation of p53 transcriptional targets such as puma, bad and bax in hct116 p53 wild type cells further demonstrates the key role of p53 in mediating the compound-induced apoptosis. |
2008-05-05 |
2023-08-12 |
human |
| Lihui Chen, Jianming Jiang, Chunlei Cheng, Ajing Yang, Qiyang He, Diandong Li, Zhen Wan. P53 dependent and independent apoptosis induced by lidamycin in human colorectal cancer cells. Cancer biology & therapy. vol 6. issue 6. 2008-05-05. PMID:17534142. |
this is further supported by the observation that the absence of bax or puma decreases apoptosis dramatically while bcl-2 overexpression confers partially resistance after drug treatment. |
2008-05-05 |
2023-08-12 |
human |
| Jun Fan, Haigang Ren, Nali Jia, Erkang Fei, Tian Zhou, Peng Jiang, Mian Wu, Guanghui Wan. DJ-1 decreases Bax expression through repressing p53 transcriptional activity. The Journal of biological chemistry. vol 283. issue 7. 2008-05-05. PMID:18042550. |
our data provide evidence that the protective effects of dj-1 on apoptosis are associated with its ability of decreasing bax level through inhibiting p53 transcriptional activity. |
2008-05-05 |
2023-08-12 |
Not clear |
| Rintaro Okoshi, Toshinori Ozaki, Hideki Yamamoto, Kiyohiro Ando, Nami Koida, Sayaka Ono, Tadayuki Koda, Takehiko Kamijo, Akira Nakagawara, Harutoshi Kizak. Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. The Journal of biological chemistry. vol 283. issue 7. 2008-05-05. PMID:18056705. |
thymocytes prepared from glucose-depleted wild-type mice but not from p53-deficient mice underwent apoptosis, which was accompanied by a remarkable phosphorylation of ampkalpha and a significant induction of p53 as well as pro-apoptotic bax. |
2008-05-05 |
2023-08-12 |
mouse |
| A E P Heazell, H A Lacey, C J P Jones, B Huppertz, P N Baker, I P Crocke. Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast. Placenta. vol 29. issue 2. 2008-05-01. PMID:18155142. |
the increased apoptosis is associated with exaggerated expression of p53, which promotes cell cycle arrest or apoptosis via downstream proteins such as p21 or bax. |
2008-05-01 |
2023-08-12 |
human |
| S Lucken-Ardjomande, S Montessuit, J-C Martino. Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes. Cell death and differentiation. vol 15. issue 3. 2008-04-30. PMID:18084240. |
bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes. |
2008-04-30 |
2023-08-12 |
Not clear |
| Lei Qiang, Yong Yang, Qi-Dong You, Yan-Jun Ma, Lan Yang, Fei-Fei Nie, Hong-Yan Gu, Li Zhao, Na Lu, Qi Qi, Wei Liu, Xiao-Tang Wang, Qing-Long Gu. Inhibition of glioblastoma growth and angiogenesis by gambogic acid: an in vitro and in vivo study. Biochemical pharmacology. vol 75. issue 5. 2008-04-25. PMID:18070617. |
to reveal an involvement of the intrinsic mitochondrial pathway of apoptosis, the mitochondrial membrane potential and the western blot evaluation of bax, bcl-2, caspase-3, caspase-9 and cytochrome c released from mitochondria were performed. |
2008-04-25 |
2023-08-12 |
rat |