| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diana Steckley, Meera Karajgikar, Lianne B Dale, Ben Fuerth, Patrick Swan, Chris Drummond-Main, Michael O Poulter, Stephen S G Ferguson, Andreas Strasser, Sean P Crega. Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 47. 2007-12-18. PMID:18032672. |
puma is a dominant regulator of oxidative stress induced bax activation and neuronal apoptosis. |
2007-12-18 |
2023-08-12 |
Not clear |
| Diana Steckley, Meera Karajgikar, Lianne B Dale, Ben Fuerth, Patrick Swan, Chris Drummond-Main, Michael O Poulter, Stephen S G Ferguson, Andreas Strasser, Sean P Crega. Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 47. 2007-12-18. PMID:18032672. |
overall, we have identified puma as a dominant regulator of oxidative stress induced bax activation and neuronal apoptosis, and suggest that puma may be an effective therapeutic target for the treatment of a number of neurodegenerative conditions. |
2007-12-18 |
2023-08-12 |
Not clear |
| Andrew D Steele, Oliver D King, Walker S Jackson, Claudio A Hetz, Andrew W Borkowski, Peter Thielen, Robert Wollmann, Susan Lindquis. Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 47. 2007-12-18. PMID:18032675. |
diminishing apoptosis by deletion of bax or overexpression of bcl-2 does not protect against infectious prion toxicity in vivo. |
2007-12-18 |
2023-08-12 |
mouse |
| Arnaud Pigneux, François-Xavier Mahon, François Moreau-Gaudry, Maialene Uhalde, Hubert de Verneuil, Francis Lacombe, Josy Reiffers, Noel Milpied, Vincent Praloran, Francis Bello. Proteasome inhibition specifically sensitizes leukemic cells to anthracyclin-induced apoptosis through the accumulation of Bim and Bax pro-apoptotic proteins. Cancer biology & therapy. vol 6. issue 4. 2007-12-17. PMID:17374988. |
proteasome inhibition specifically sensitizes leukemic cells to anthracyclin-induced apoptosis through the accumulation of bim and bax pro-apoptotic proteins. |
2007-12-17 |
2023-08-12 |
Not clear |
| Jing Yu, Haili Qian, Yunfeng Li, Yang Wang, Xueyan Zhang, Xiao Liang, Ming Fu, Chen Li. Therapeutic effect of arsenic trioxide (As2O3) on cervical cancer in vitro and in vivo through apoptosis induction. Cancer biology & therapy. vol 6. issue 4. 2007-12-17. PMID:17374990. |
the apoptosis was triggered by mitochondrial pathway and associated with dissociation of bcl-2 from bax and vdac, then the release of cytochrome c from bax and vdac channel, resulting in the activation of caspase-9 and caspase-3. |
2007-12-17 |
2023-08-12 |
mouse |
| M Gloria Luciani, Christoph Campregher, Christoph Gasch. Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM. Carcinogenesis. vol 28. issue 10. 2007-12-14. PMID:17510082. |
to determine which cell cycle checkpoint pathways are involved in this response, colorectal cell lines wild-type or defective for p53 and p21waf1/cip1 were treated with aspirin or the anti-proliferative drug sulindac sulfide, then assayed for proliferative activity, for cell cycle progression and apoptosis, for the activation and phosphorylation of checkpoint components and for the transcriptional up-regulation of p21waf1/cip1 and bax. |
2007-12-14 |
2023-08-12 |
Not clear |
| Kazuhiro Matsumura, Benny Hung-Junn Chang, Mineko Fujimiya, Weiqin Chen, Rohit N Kulkarni, Yutaka Eguchi, Hiroshi Kimura, Hideto Kojima, Lawrence Cha. Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Molecular and cellular biology. vol 27. issue 17. 2007-12-12. PMID:17576812. |
concomitantly, there was a decreased rate of apoptosis, as reflected by terminal deoxynucleotidyltransferase-mediated dutp-biotin nick end labeling and caspase 3 and bax expression in aqp7-/- mice. |
2007-12-12 |
2023-08-12 |
mouse |
| Maria Antonietta Panaro, Antonia Cianciulli, Vincenzo Mitolo, Carlo Ivan Mitolo, Angela Acquafredda, Olga Brandonisio, Pasqua Cavall. Caspase-dependent apoptosis of the HCT-8 epithelial cell line induced by the parasite Giardia intestinalis. FEMS immunology and medical microbiology. vol 51. issue 2. 2007-12-12. PMID:17714487. |
furthermore, g. intestinalis infection induces activation of both the intrinsic and the extrinsic apoptotic pathways, down-regulation of the antiapoptotic protein bcl-2 and up-regulation of the proapoptotic bax, suggesting a possible role for caspase-dependent apoptosis in the pathogenesis of giardiasis. |
2007-12-12 |
2023-08-12 |
human |
| C Chipoy, B Brounais, V Trichet, S Battaglia, M Berreur, L Oliver, P Juin, F Rédini, D Heymann, F Blanchar. Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. Oncogene. vol 26. issue 46. 2007-12-11. PMID:17471233. |
pharmacological inhibitors, dominant-negative signal transducer and activator of transcriptions (stats), stable rna interference and knockout cells indicated that the transcription factors p53 and stat5, which are activated by osm, are implicated in the sensitization to apoptosis, being responsible for bax induction and bcl-2 reduction, respectively. |
2007-12-11 |
2023-08-12 |
Not clear |
| A-L Pauleau, N Larochette, F Giordanetto, S R Scholz, D Poncet, N Zamzami, V S Goldmacher, G Kroeme. Structure-function analysis of the interaction between Bax and the cytomegalovirus-encoded protein vMIA. Oncogene. vol 26. issue 50. 2007-12-11. PMID:17496930. |
the viral mitochondrial inhibitor of apoptosis (vmia) encoded by the human cytomegalovirus exerts cytopathic effects and neutralizes the proapoptotic endogenous bcl-2 family member bax by recruiting it to mitochondria, inducing its oligomerization and membrane insertion. |
2007-12-11 |
2023-08-12 |
human |
| I Lang-Rollin, M Maniati, O Jabado, K Vekrellis, S Papantonis, H J Rideout, L Stefani. Apoptosis and the conformational change of Bax induced by proteasomal inhibition of PC12 cells are inhibited by bcl-xL and bcl-2. Apoptosis : an international journal on programmed cell death. vol 10. issue 4. 2007-12-06. PMID:16133871. |
apoptosis and the conformational change of bax induced by proteasomal inhibition of pc12 cells are inhibited by bcl-xl and bcl-2. |
2007-12-06 |
2023-08-12 |
Not clear |
| I Lang-Rollin, M Maniati, O Jabado, K Vekrellis, S Papantonis, H J Rideout, L Stefani. Apoptosis and the conformational change of Bax induced by proteasomal inhibition of PC12 cells are inhibited by bcl-xL and bcl-2. Apoptosis : an international journal on programmed cell death. vol 10. issue 4. 2007-12-06. PMID:16133871. |
significantly, antiapoptotic bcl-2 family members prevent apoptosis by inhibiting bax conformational change. |
2007-12-06 |
2023-08-12 |
Not clear |
| I Vitale, A Antoccia, P Crateri, S Leone, G Arancia, C Tanzarell. Caspase-independent apoptosis is activated by diazepam-induced mitotic failure in HeLa cells, but not in human primary fibroblasts. Apoptosis : an international journal on programmed cell death. vol 10. issue 4. 2007-12-06. PMID:16133880. |
dz-treated samples showed certain biochemical hallmarks of apoptosis, such as induction of the proapototic bax protein, mitochondrial alterations assessed by jc-1 staining and tem analysis, parp cleavage, and dna fragmentation. |
2007-12-06 |
2023-08-12 |
human |
| An-Chin Cheng, Cheng-Bang Jian, Yu-Ting Huang, Ching-Shu Lai, Ping-Chi Hsu, Min-Hsiung Pa. Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 45. issue 11. 2007-12-06. PMID:17619071. |
in addition, the apoptosis induced by cc-ea was accompanied by up-regulation of bax, down-regulation of bcl-x(l) and cleavage of mcl-1, suggesting that cc-ea may have some compounds that have anti-cancer activities and that further studies using cat's claw extracts need to be pursued. |
2007-12-06 |
2023-08-12 |
human |
| Takuma Uo, Yoshito Kinoshita, Richard S Morriso. Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 45. 2007-12-06. PMID:17989286. |
puma (p53-upregulated modulator of apoptosis) was one such gene induced by camptothecin, and its overexpression was sufficient to induce bax (bcl-2-associated x protein)-dependent neuronal death, whereas noxa was not apoptogenic. |
2007-12-06 |
2023-08-12 |
Not clear |
| Franck Meslin, Ahmed Hamaï, Ping Gao, Abdelali Jalil, Nathalie Cahuzac, Salem Chouaib, Maryam Mehrpou. Silencing of prion protein sensitizes breast adriamycin-resistant carcinoma cells to TRAIL-mediated cell death. Cancer research. vol 67. issue 22. 2007-12-03. PMID:18006836. |
our findings support the notion that silencing of prpc facilitates the activation of proapoptotic bax by down-regulation of bcl-2 expression, thereby abolishing the resistance of breast cancer cells to trail-induced apoptosis. |
2007-12-03 |
2023-08-12 |
human |
| Kalpana Barhwal, Shashi Bala Singh, Sunil Kumar Hota, K Jayalakshmi, G Ilavazhaga. Acetyl-L-carnitine ameliorates hypobaric hypoxic impairment and spatial memory deficits in rats. European journal of pharmacology. vol 570. issue 1-3. 2007-11-30. PMID:17610872. |
caspase-3, apoptosis activating factor (apaf-1), bax, cytochrome c] and anti-apoptotic protein-bcl-2 were studied in the hippocampus. |
2007-11-30 |
2023-08-12 |
rat |
| Susanne Gahr, Matthias Ocker, Marion Ganslmayer, Steffen Zopf, Kinya Okamoto, Andrea Hartl, Sandra Leitner, Eckhart G Hahn, Christoph Herol. The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells. International journal of oncology. vol 31. issue 3. 2007-11-30. PMID:17671683. |
bax, an apoptosis inducing protein, which destabilizes the mitochondrial membrane potential, was increasingly expressed. |
2007-11-30 |
2023-08-12 |
human |
| N Zantl, G Weirich, H Zall, B M Seiffert, S F Fischer, S Kirschnek, C Hartmann, R M Fritsch, B Gillissen, P T Daniel, G Häcke. Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance. Oncogene. vol 26. issue 49. 2007-11-29. PMID:17486061. |
bcl-2, bcl-x(l), mcl-1, bax and bak expression did not correlate with apoptosis sensitivity. |
2007-11-29 |
2023-08-12 |
Not clear |
| N Zantl, G Weirich, H Zall, B M Seiffert, S F Fischer, S Kirschnek, C Hartmann, R M Fritsch, B Gillissen, P T Daniel, G Häcke. Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance. Oncogene. vol 26. issue 49. 2007-11-29. PMID:17486061. |
all cell lines underwent apoptosis upon forced expression of bax and bim, suggesting an upstream difference. |
2007-11-29 |
2023-08-12 |
Not clear |