| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Cuzzocrea, T Genovese, E Mazzon, E Esposito, C Muià, M Abdelrahman, R Di Paola, P Bramanti, C Thiemerman. Glycogen synthase kinase-3beta inhibition attenuates the development of bleomycin-induced lung injury. International journal of immunopathology and pharmacology. vol 20. issue 3. 2007-11-29. PMID:17880775. |
in contrast, administration of blm-treated mice with tdzd-8 (1 mg/kg daily) significantly reduced (i) the degree of lung injury, (ii) the increase in staining (immunohistochemistry) for myeloperoxidase (mpo), nitrotyrosine, inos, tnf-alpha and il-1beta and (iii) the degree of apoptosis, as evaluated by bax and bcl-2 immunoreactivity and tunel staining. |
2007-11-29 |
2023-08-12 |
mouse |
| Xia Xiao, Jiangxue Wu, Xiaofeng Zhu, Peng Zhao, Jinlin Zhou, Quentin Qiang Liu, Limin Zheng, Musheng Zeng, Ranyi Liu, Wenlin Huan. Induction of cell cycle arrest and apoptosis in human nasopharyngeal carcinoma cells by ZD6474, an inhibitor of VEGFR tyrosine kinase with additional activity against EGFR tyrosine kinase. International journal of cancer. vol 121. issue 9. 2007-11-27. PMID:17631646. |
the apoptosis mechanisms involved reduction of bcl-2 and/or bcl-xl, induction of bak and/or bax, and activation of caspases-3, -9 and/or -8. |
2007-11-27 |
2023-08-12 |
mouse |
| Annie Beauséjour, Véronique Houde, Karine Bibeau, Rébecca Gaudet, Jean St-Louis, Michèle Broch. Renal and cardiac oxidative/nitrosative stress in salt-loaded pregnant rat. American journal of physiology. Regulatory, integrative and comparative physiology. vol 293. issue 4. 2007-11-27. PMID:17652367. |
then, molecules (na(+)-k(+)-atpase and aconitase) or process [apoptosis (bax and bcl-2), inflammation (monocyte chemoattractant protein-1, connective tissue growth factor, and tnf-alpha)] susceptible to free radicals was determined. |
2007-11-27 |
2023-08-12 |
rat |
| Jae-Kyun Ko, Kyoung-Han Choi, Zui Pan, Peihui Lin, Noah Weisleder, Chul-Woo Kim, Jianjie M. The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis. Journal of cell science. vol 120. issue Pt 16. 2007-11-27. PMID:17666431. |
here we show that atap targets specifically to mitochondria, and induces caspase-dependent apoptosis that does not require bax or bak. |
2007-11-27 |
2023-08-12 |
Not clear |
| Teresa Nieto-Miguel, Rosalba I Fonteriz, Laura Vay, Consuelo Gajate, Silvia López-Hernández, Faustino Mollined. Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells. Cancer research. vol 67. issue 21. 2007-11-27. PMID:17974980. |
this er accumulation of the drug leads to the inhibition of phosphatidylcholine and protein synthesis, g(2)-m arrest, depletion of er-stored ca(2+), bax up-regulation and activation, transcriptional factor growth arrest and dna damage-inducible gene 153 up-regulation, caspase-4 and caspase-8 activation, and eventually to apoptosis. |
2007-11-27 |
2023-08-12 |
Not clear |
| Teresa Nieto-Miguel, Rosalba I Fonteriz, Laura Vay, Consuelo Gajate, Silvia López-Hernández, Faustino Mollined. Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells. Cancer research. vol 67. issue 21. 2007-11-27. PMID:17974980. |
bax(-/-)bak(-/-) double-knockout cells fail to undergo edelfosine-induced er-stored ca(2+) release and apoptosis. |
2007-11-27 |
2023-08-12 |
Not clear |
| Tao Zhang, Ming Guan, Chong Xu, Yuming Chen, Yuan L. Pigment epithelium-derived factor inhibits glioma cell growth in vitro and in vivo. Life sciences. vol 81. issue 16. 2007-11-26. PMID:17919663. |
meanwhile pedf induced apoptosis was associated with increases of p53 and bax and inhibition of bcl-2. |
2007-11-26 |
2023-08-12 |
mouse |
| Dariusz J Skarzynski, Masami Shibaya, Yukari Tasaki, Anna Korzekwa, Shuko Murakami, Izabela Woclawek-Potocka, Magdalena Majewska, Kiyoshi Okud. Fas-mediated apoptosis is suppressed by calf serum in cultured bovine luteal cells. Reproductive biology. vol 7. issue 1. 2007-11-20. PMID:17435830. |
to examine whether a culture system including cs is appropriate for studying apoptosis in bovine luteal cells, we examined the influence of cs on the expression of fas, bcl-2 and bax gene. |
2007-11-20 |
2023-08-12 |
cattle |
| Swatee Dey, Diane M Sno. Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons through TNF-alpha-mediated induction of Bax and phosphorylated c-Jun NH(2)-terminal kinase. Journal of neurochemistry. vol 103. issue 2. 2007-11-20. PMID:17635674. |
cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons through tnf-alpha-mediated induction of bax and phosphorylated c-jun nh(2)-terminal kinase. |
2007-11-20 |
2023-08-12 |
rat |
| Swatee Dey, Diane M Sno. Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons through TNF-alpha-mediated induction of Bax and phosphorylated c-Jun NH(2)-terminal kinase. Journal of neurochemistry. vol 103. issue 2. 2007-11-20. PMID:17635674. |
we previously showed that cocaine exposure in vitro activates pro-apoptotic bax, caspase-9, and caspase-3 in lc neurons dissected from embryonic day 14 rats, implicating that apoptosis may be orchestrated via signal transduction events. |
2007-11-20 |
2023-08-12 |
rat |
| Swatee Dey, Diane M Sno. Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons through TNF-alpha-mediated induction of Bax and phosphorylated c-Jun NH(2)-terminal kinase. Journal of neurochemistry. vol 103. issue 2. 2007-11-20. PMID:17635674. |
these simultaneous molecular events triggered by cocaine and tnf-alpha implicate a potential apoptotic signal transduction pathway via induction of phospho-c-jun nh(2)-terminal kinase and bax that may lead to caspase-3 activation and apoptosis in cocaine-exposed fetal lc neurons. |
2007-11-20 |
2023-08-12 |
rat |
| Manali Mody, Nachiket Dharker, Mark Bloomston, Pei-Shan Wang, Fu-Sheng Chou, Theodore S Glickman, Timothy McCaffrey, Zhaoqing Yang, Anne Pumfery, Daniel Lee, Matthew D Ringel, Joseph J Pinzon. Rosiglitazone sensitizes MDA-MB-231 breast cancer cells to anti-tumour effects of tumour necrosis factor-alpha, CH11 and CYC202. Endocrine-related cancer. vol 14. issue 2. 2007-11-20. PMID:17639046. |
we selectively confirmed rosiglitazone-mediated effects on expression of key regulators of breast cancer proliferation and apoptosis, including p53, p21 and bax. |
2007-11-20 |
2023-08-12 |
human |
| Chiachen Chen, Yuan-Ching Chang, Chien-Liang Liu, Tsang-Pai Liu, King-Jen Chang, Ing-Cherng Gu. Leptin induces proliferation and anti-apoptosis in human hepatocarcinoma cells by up-regulating cyclin D1 and down-regulating Bax via a Janus kinase 2-linked pathway. Endocrine-related cancer. vol 14. issue 2. 2007-11-20. PMID:17639064. |
the reduced ratio between anti-apoptotic (bcl-2) and pro-apoptotic (bax) bcl-2 family proteins by transforming growth factor (tgf)-beta 1 caused hcc cells degradation of poly(adp-ribose) polymerase and consequential apoptosis; whereas, leptin protected cells from apoptosis by reversing tgf-beta 1-reduced bcl-2/bax ratio as a result of down-regulating bax. |
2007-11-20 |
2023-08-12 |
human |
| Dalhia Abramovich, Fernanda Parborell, Marta Teson. Effect of a vascular endothelial growth factor (VEGF) inhibitory treatment on the folliculogenesis and ovarian apoptosis in gonadotropin-treated prepubertal rats. Biology of reproduction. vol 75. issue 3. 2007-11-13. PMID:16775226. |
the effect of an intrabursal administration of a vegfa antagonist on follicular development, apoptosis, and levels of pro- and antiapoptotic proteins of bcl2 family members (bax, bcl2, and bcl2l1), as well as of tnfrsf6 (also known as fas) and fas ligand (faslg), was examined. |
2007-11-13 |
2023-08-12 |
rat |
| Joon-Seok Choi, Soona Shin, Ying Hua Jin, Hyungshin Yim, Kyo-Tan Koo, Kwang-Hoon Chun, You-Take Oh, Won Hee Lee, Seung-Ki Le. Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 12. issue 7. 2007-11-13. PMID:17252195. |
cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis. |
2007-11-13 |
2023-08-12 |
human |
| Joon-Seok Choi, Soona Shin, Ying Hua Jin, Hyungshin Yim, Kyo-Tan Koo, Kwang-Hoon Chun, You-Take Oh, Won Hee Lee, Seung-Ki Le. Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 12. issue 7. 2007-11-13. PMID:17252195. |
here, we show that upregulated cyclin a/cdk2 activity precedes the proteolytic cleavage of parp and is correlated with the mitochondrial translocation of bax and the loss of mitochondrial transmembrane potential (deltapsim) during etoposide-induced apoptosis in human cervical adenocarcinoma (hela) cells. |
2007-11-13 |
2023-08-12 |
human |
| James E P Brown, Simon J Dunmor. Leptin decreases apoptosis and alters BCL-2 : Bax ratio in clonal rodent pancreatic beta-cells. Diabetes/metabolism research and reviews. vol 23. issue 6. 2007-11-13. PMID:17318810. |
leptin decreases apoptosis and alters bcl-2 : bax ratio in clonal rodent pancreatic beta-cells. |
2007-11-13 |
2023-08-12 |
Not clear |
| James E P Brown, Simon J Dunmor. Leptin decreases apoptosis and alters BCL-2 : Bax ratio in clonal rodent pancreatic beta-cells. Diabetes/metabolism research and reviews. vol 23. issue 6. 2007-11-13. PMID:17318810. |
this study investigated the effects of leptin upon apoptosis induced by serum depletion and on expression of the apoptotic regulators b-cell leukaemia 2 gene product (bcl-2) and bcl2-associated x protein (bax) in the glucose-responsive brin-bd11 beta-cell line. |
2007-11-13 |
2023-08-12 |
Not clear |
| Sung-Ho Kook, Young-Ok Son, Song-Woo Chung, Seung-Ah Lee, Jong-Ghee Kim, Young-Mi Jeon, Jeong-Chae Le. Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. Apoptosis : an international journal on programmed cell death. vol 12. issue 7. 2007-11-13. PMID:17356895. |
rcmf was shown to be capable of inducing apoptosis in hos cells by inducing p53 in the cells resulting in the decrease in bcl-2 level, activation of bax, and cytoplasmic release of cytochrome c, which led to the translocation of apoptosis-inducing factor (aif) and endonuclease g (endog) into the nucleus. |
2007-11-13 |
2023-08-12 |
human |
| Chun-Shiang Chung, Yaping Chen, Patricia S Grutkoski, Lesley Doughty, Alfred Ayal. SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis. Apoptosis : an international journal on programmed cell death. vol 12. issue 7. 2007-11-13. PMID:17364147. |
in contrast, socs-1 expression in thymus declined significantly after sepsis and this down-regulation of socs-1 was associated with increased thymocyte apoptosis as well as augmented bax recruitment to the mitochondria. |
2007-11-13 |
2023-08-12 |
mouse |