| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chiang-Ting Chien, Shih-Chen Fan, Shao-Chieh Lin, Chang-Chih Kuo, Chih-Hui Yang, Tzu-Ying Yu, Shih-Pin Lee, Dai-Yu Cheng, Ping-Chia L. Glucagon-like peptide-1 receptor agonist activation ameliorates venous thrombosis-induced arteriovenous fistula failure in chronic kidney disease. Thrombosis and haemostasis. vol 112. issue 5. 2015-07-28. PMID:25030617. |
apoptosis was also increased due to nadph oxidase gp91 activation and mitochondrial bax translocation in the proximal end of the jugular vein of ckd rats. |
2015-07-28 |
2023-08-13 |
mouse |
| Zhao Zhao, Tao Sun, Yun Jiang, Lijiang Wu, Xiangzhong Cai, Xiaodong Sun, Xiangjun Su. Photooxidative damage in retinal pigment epithelial cells via GRP78 and the protective role of grape skin polyphenols. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 74. 2015-07-28. PMID:25447759. |
exposure of a2e containing arpe-19 cells to blue light resulted in significant apoptosis and increases in levels of grp78, chop, p-jnk, bax, cleaved caspase-9, and cleaved caspase-3, indicating that photooxidative damage to rpe cells is mediated by the er-stress-induced intrinsic apoptotic pathway. |
2015-07-28 |
2023-08-13 |
Not clear |
| Peiyan Hua, Mei Sun, Guangxin Zhang, Yifan Zhang, Xin Tian, Xin Li, Ranji Cui, Xingyi Zhan. Cepharanthine induces apoptosis through reactive oxygen species and mitochondrial dysfunction in human non-small-cell lung cancer cells. Biochemical and biophysical research communications. vol 460. issue 2. 2015-07-28. PMID:25747710. |
in addition, cepharanthine triggered apoptosis in non-small lung cancer cells via the upregulation of bax, downregulation of bcl-2 and significant activation of caspase-3 and parp. |
2015-07-28 |
2023-08-13 |
human |
| Cheng Liu, Jen-Jie Lin, Zih-Yan Yang, Chi-Chu Tsai, Jue-Liang Hsu, Yu-Jen W. Proteomic study reveals a co-occurrence of gallic acid-induced apoptosis and glycolysis in B16F10 melanoma cells. Journal of agricultural and food chemistry. vol 62. issue 48. 2015-07-27. PMID:25397718. |
according to western blotting data, overexpressions of cleaved forms of caspase-9, caspase-3, and parp-1 and pro-apoptotic bax and bad, accompanied by underexpressed anti-apoptotic bcl-2 and bcl-xl indicate that ga induces b16f10 cell apoptosis via mitochondrial pathway. |
2015-07-27 |
2023-08-13 |
Not clear |
| Stéphan Hardivillé, Adelma Escobar-Ramirez, Soccoro Pina-Canceco, Elisabeth Elass, Annick Pierc. Delta-lactoferrin induces cell death via the mitochondrial death signaling pathway by upregulating bax expression. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 27. issue 5. 2015-07-24. PMID:24824995. |
apoptosis induction by ∆lf is concomitant with increased cellular levels of bax protein. |
2015-07-24 |
2023-08-13 |
Not clear |
| Jianyuan Wu, Qingdi Quentin Li, Huiping Zhou, Yinying Lu, Jueli M Li, Yao Ma, Li Wang, Tingting Fu, Xingjiang Gong, Michael Weintraub, Shuangchan Wu, Hong Din. Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas. Medical oncology (Northwood, London, England). vol 31. issue 7. 2015-07-24. PMID:24880464. |
triptolide-induced apoptosis was accompanied by cytochrome c release and caspase-3 activation and was associated with downregulation of bcl-2 and upregulation of bax. |
2015-07-24 |
2023-08-13 |
human |
| Xiao-Chao Huang, Le Jin, Meng Wang, Dong Liang, Zhen-Feng Chen, Ye Zhang, Ying-Ming Pan, Heng-Shan Wan. Design, synthesis and in vitro evaluation of novel dehydroabietic acid derivatives containing a dipeptide moiety as potential anticancer agents. European journal of medicinal chemistry. vol 89. 2015-07-24. PMID:25462253. |
in addition, further investigation showed that apoptosis were associated with loss of mitochondrial membrane potential, enhancement of mitochondrial cytochrome c release and intracellular ros production, elevation of bax expression, down-regulation of bcl-2, and the activation of caspase-9 and -3. |
2015-07-24 |
2023-08-13 |
human |
| Zhao-Yu Han, Tian Mu, Zhen Yan. Methionine protects against hyperthermia-induced cell injury in cultured bovine mammary epithelial cells. Cell stress & chaperones. vol 20. issue 1. 2015-07-23. PMID:25108357. |
the aim of this study was to investigate the effects of methionine on cell proliferation, antioxidant activity, apoptosis, the expression levels of related genes (hsf-1, hsp70, bax and bcl-2) and the expression levels of protein (hsp70) in mammary epithelial cells, after heat treatment. |
2015-07-23 |
2023-08-13 |
cattle |
| Xiaori He, Zongde Xie, Qingyi Dong, Pingyang Chen, Jingtao Hu, Tao Wan. Apoptosis in the kidneys of rats that experienced intrauterine growth restriction. Nephrology (Carlton, Vic.). vol 20. issue 1. 2015-07-23. PMID:25243775. |
this study investigated cell apoptosis and bcl-2 and bax expression in the kidney of iugr pups. |
2015-07-23 |
2023-08-13 |
rat |
| X J Zang, S X An, Z Feng, Y P Xia, Y Song, Q Y. In vivo mechanism study of NGAL in rat renal ischemia-reperfusion injury. Genetics and molecular research : GMR. vol 13. issue 4. 2015-07-23. PMID:25366765. |
hematoxylin-eosin staining was performed to observe the renal pathological changes in the 3 groups; serum creatinine (scr) and blood urea nitrogen (bun) determined in blood samples taken from the inferior vena cava 24 h after the reperfusion were measured; tunel was used to observe the apoptosis of renal tubular epithelial cells; immunohistochemistry was performed to evaluate the expressions of bax and activated caspase-3; western blotting was used to determine the expression changes in apoptotic proteins fas and bcl-2. |
2015-07-23 |
2023-08-13 |
rat |
| Feili Wu, Yao Zheng, Jiancao Gao, Shu Chen, Zaizhao Wan. Induction of oxidative stress and the transcription of genes related to apoptosis in rare minnow (Gobiocypris rarus) larvae with Aroclor 1254 exposure. Ecotoxicology and environmental safety. vol 110. 2015-07-22. PMID:25265027. |
the gene expression patterns reveal that waterborne aroclor 1254-induced apoptosis is probably through dna damage (p53 and p53 upregulated modulator of apoptosis (puma)), disrupting mitochondrial membrane integrity (b-cell lymphoma 2 (bcl-2) and bcl-2-associated x (bax)) and c-jin n-terminal kinase (jnk)-mediated apoptotic pathway (thioredoxin 1 (trx1) and c-jun n-terminal kinase (jnk)). |
2015-07-22 |
2023-08-13 |
cat |
| Xiaolan Feng, Yi Zhang, Pan Wang, Quanhong Liu, Xiaobing Wan. Energy metabolism targeted drugs synergize with photodynamic therapy to potentiate breast cancer cell death. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. vol 13. issue 12. 2015-07-22. PMID:25363473. |
synergistic potentiation of mitochondria- and caspase-dependent cell apoptosis was observed, including a mitochondrial membrane potential (mmp) drop, bax translocation, and caspase-3 activation. |
2015-07-22 |
2023-08-13 |
human |
| Chin-Cheng S. Tanshinone IIA inhibits human gastric carcinoma AGS cell growth by decreasing BiP, TCTP, Mcl‑1 and Bcl‑xL and increasing Bax and CHOP protein expression. International journal of molecular medicine. vol 34. issue 6. 2015-07-21. PMID:25270224. |
the other may be through decreasing the protein expression of mcl-1, bcl-xl and tctp, but increasing bax, caspase-9 and caspase-3 to induce apoptosis. |
2015-07-21 |
2023-08-13 |
human |
| Da Hee Lee, Yoon Jeong Nam, Yun Jeong Kim, Min Won Lee, Chung Soo Le. Rotundarpene prevents TRAIL-induced apoptosis in human keratinocytes by suppressing the caspase-8- and Bid-pathways and the mitochondrial pathway. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 12. 2015-07-21. PMID:25273175. |
trail triggers apoptosis by inducing a decrease in the cytosolic levels of bid, bcl-2, bcl-xl, and survivin proteins, increase in the cytosolic levels of bax, and increase in the mitochondrial levels of vdac1, loss of the mitochondrial transmembrane potential, release of cytochrome c, activation of caspases (-8, -9, and -3), cleavage of parp-1, and an increase in the tumor suppressor p53 levels. |
2015-07-21 |
2023-08-13 |
human |
| Richard G Carroll, Emilie Hollville, Seamus J Marti. Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1. Cell reports. vol 9. issue 4. 2015-07-21. PMID:25456142. |
parkin-dependent apoptosis required pink1 and was efficiently blocked by prosurvival members of the bcl-2 family or knockdown of bax and bak. upon mitochondrial depolarization, the bcl-2 family member mcl-1 underwent rapid parkin- and pink1-dependent polyubiquitination and degradation, which sensitized toward apoptosis via opening of the bax/bak channel. |
2015-07-21 |
2023-08-13 |
Not clear |
| Juan-Juan Sheng, Yan Chen, Hui Chang, Yun-Ying Wang, Bo Jiao, Zhi-Bin Y. Multisite phosphorylation of Bcl-2 via protein kinase Cδ facilitates apoptosis of hypertrophic cardiomyocytes. Clinical and experimental pharmacology & physiology. vol 41. issue 11. 2015-07-20. PMID:25132161. |
the aim of the present study was to investigate whether mitochondrial translocation of pkcδ phosphorylates multiple sites of bcl-2, resulting in an imbalance between bcl-2 and bak or bax, thus enhancing the susceptibility of hypertrophic cardiomyocytes to angiotensin ii (angii)-induced apoptosis. |
2015-07-20 |
2023-08-13 |
rat |
| Ou Huang, Weili Zhang, Qiaoming Zhi, Xiaofeng Xue, Hongchun Liu, Daoming Shen, Meiyu Geng, Zuoquan Xie, Min Jian. Teriflunomide, an immunomodulatory drug, exerts anticancer activity in triple negative breast cancer cells. Experimental biology and medicine (Maywood, N.J.). vol 240. issue 4. 2015-07-20. PMID:25304315. |
among them, we identified down-regulation of growth factor receptors to abolish growth maintenance, suppression of c-myc, and cyclin d1 to contribute to its anti-proliferative effect, modulation of components of cell cycle to induce s-phase arrest, degradation of bcl-xl, and up-regulation of bax via activation of mapk pathway to induce apoptosis, and inhibition of epithelial-mesenchymal transition (emt) process, matrix metalloproteinase-9 (mmp9) expression, and inactivation of src/fak to reduce tnbc migration and invasion. |
2015-07-20 |
2023-08-13 |
human |
| Yongquan Chen, Guangxiang Hu, Qun Fu, Xiaoju Ji. [Effect of stellate ganglion block on cardiomyocyte apoptosis and expression of Bcl-2/Bax protein in spontaneously hypertensive rats]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 38. issue 9. 2015-07-17. PMID:24071700. |
to investigate the relationship between apoptosis of myocardial cells in spontaneously hypertensive rats (shrs) and the expressions of bcl-2 and bax protein, and the protective effect of stellate ganglion block on apoptosis of myocardial cells. |
2015-07-17 |
2023-08-12 |
rat |
| Huai Wang, Lijun Tang, Yajie Tang, Zhanpeng Yua. SAR analysis and biological studies of synthesized podophyllum derivates obtained by N linkage modification at C-4 position. Bioorganic & medicinal chemistry. vol 22. issue 21. 2015-07-16. PMID:25282651. |
both compounds resulted in g2/m phase arrest and apoptosis, purportedly by increasing the expression of p53, followed by bax up-regulation, bcl-2 down-regulation, and caspase-3 activation. |
2015-07-16 |
2023-08-13 |
Not clear |
| Chi-Chang Chang, Hsia-Fen Hsu, Kuo-Hung Huang, Jing-Mei Wu, Shyh-Ming Kuo, Xue-Hua Ling, Jer-Yiing Houn. Anti-proliferative effects of Siegesbeckia orientalis ethanol extract on human endometrial RL-95 cancer cells. Molecules (Basel, Switzerland). vol 19. issue 12. 2015-07-16. PMID:25470271. |
treating rl95-2 cells with soe caused cell arrest in the g2/m phase and induced apoptosis of rl95-2 cells by up-regulating bad, bak and bax protein expression and down-regulation of bcl-2 and bcl-xl protein expression. |
2015-07-16 |
2023-08-13 |
human |