| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhitu Zhu, Hongzhi Sun, Guangyou Ma, Zhenghua Wang, Enze Li, Yangyang Liu, Yunpeng Li. Bufalin induces lung cancer cell apoptosis via the inhibition of PI3K/Akt pathway. International journal of molecular sciences. vol 13. issue 2. 2015-09-01. PMID:22408435. |
moreover, bufalin synergized with akt inhibitor to induce the apoptosis of a549 cells and this was associated with the upregulation of bax expression, the downregulation of bcl-2 and livin expression, and the activation of caspase-3. |
2015-09-01 |
2023-08-12 |
human |
| Zhi-Jun Dai, Jie Gao, Xiao-Bin Ma, Hua-Feng Kang, Bao-Feng Wang, Wang-Feng Lu, Shuai Lin, Xi-Jing Wang, Wen-Ying W. Antitumor effects of rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy. International journal of molecular sciences. vol 14. issue 1. 2015-08-31. PMID:23344033. |
rt-pcr revealed that the expression levels of p53, bax and beclin 1 were up-regulated in a dose-dependent manner, indicating that beclin 1 was involved in rapa induced autophagy and rapa induced apoptosis as well as p53 up-regulation in pc-2 cells. |
2015-08-31 |
2023-08-12 |
Not clear |
| Xin Wang, Chunyan Wang, Longjiang Zhang, Yanjun Li, Shouju Wang, Jiandong Wang, Caiyun Yuan, Jia Niu, Chengsheng Wang, Guangming L. Salvianolic acid A shows selective cytotoxicity against multidrug-resistant MCF-7 breast cancer cells. Anti-cancer drugs. vol 26. issue 2. 2015-08-31. PMID:25419632. |
in addition, saa-triggered apoptosis was associated with increased caspase-3 activity, disrupted mitochondrial membrane potential, downregulated bcl-2 expression, and upregulated bax expression in the resistant cells. |
2015-08-31 |
2023-08-13 |
human |
| Wagdy M Eldehna, Hany S Ibrahim, Hatem A Abdel-Aziz, Noha N Farrag, Mohieldin M Yousse. Design, synthesis and in vitro antitumor activity of novel N-substituted-4-phenyl/benzylphthalazin-1-ones. European journal of medicinal chemistry. vol 89. 2015-08-31. PMID:25462265. |
compounds 14e, 14g, 19d and 19g were able to induce apoptosis in hepg2, this was assured by; the significant increase in the percentage of annexin v-fitc-positive apoptotic cells (ur + lr), the down-regulation of the anti-apoptotic protein bcl-2 and the up-regulation of the pro-apoptotic protein bax, in addition to boosting caspase-3 levels. |
2015-08-31 |
2023-08-13 |
human |
| Majid Ghasemian, Majid Mahdavi, Payman Zare, Mohammad Ali Hosseinpour Feiz. Spiroquinazolinone-induced cytotoxicity and apoptosis in K562 human leukemia cells: alteration in expression levels of Bcl-2 and Bax. The Journal of toxicological sciences. vol 40. issue 1. 2015-08-31. PMID:25743751. |
spiroquinazolinone-induced cytotoxicity and apoptosis in k562 human leukemia cells: alteration in expression levels of bcl-2 and bax. |
2015-08-31 |
2023-08-13 |
human |
| Ahmed Nadeem, Naif O Alharbi, Harissios Vliagoftis, Manoj Tyagi, Sheikh F Ahmad, Mohamed M Sayed-Ahme. Proteinase activated receptor-2-mediated dual oxidase-2 up-regulation is involved in enhanced airway reactivity and inflammation in a mouse model of allergic asthma. Immunology. vol 145. issue 3. 2015-08-28. PMID:25684443. |
mice were then assessed for airway reactivity, inflammation, oxidative stress (duox-2, ros, inducible nitric oxide synthase, nitrite, nitrotyrosine and protein carbonyls) and apoptosis (bax, bcl-2, caspase-3). |
2015-08-28 |
2023-08-13 |
mouse |
| Emiko Sano, Shinya Tashiro, Kouhei Tsumoto, Takuya Ued. Differential Effects of IFN-β on the Survival and Growth of Human Vascular Smooth Muscle and Endothelial Cells. BioResearch open access. vol 4. issue 1. 2015-08-28. PMID:26309778. |
the induction of smc apoptosis and anti-apoptotic effect on ec linked to the expression of pro-apoptotic bax mrna and caspase-3 activities. |
2015-08-28 |
2023-08-13 |
human |
| Xi Peng, Shengqiang Zhang, Jing Fang, Hengmin Cui, Zhicai Zuo, Junliang Den. Protective roles of sodium selenite against aflatoxin B1-induced apoptosis of jejunum in broilers. International journal of environmental research and public health. vol 11. issue 12. 2015-08-27. PMID:25526081. |
in conclusion, 0.3 mg/kg afb1 in the diet can increase cell apoptosis, decrease bcl-2 mrna expression, and increase of bax and caspase-3 mrna expression in broiler's jejunum. |
2015-08-27 |
2023-08-13 |
Not clear |
| Xi Peng, Shengqiang Zhang, Jing Fang, Hengmin Cui, Zhicai Zuo, Junliang Den. Protective roles of sodium selenite against aflatoxin B1-induced apoptosis of jejunum in broilers. International journal of environmental research and public health. vol 11. issue 12. 2015-08-27. PMID:25526081. |
however, supplementation of dietary sodium selenite at the concentration of 0.4 mg/kg se may ameliorate afb1-induced apoptosis by increasing bcl-2 mrna expression, and decreasing bax and caspase-3 mrna expression. |
2015-08-27 |
2023-08-13 |
Not clear |
| Xiao Zhang, Yin-Lin Ge, Shu-Ping Zhang, Ping Yan, Run-Hua Tia. Downregulation of KDR expression induces apoptosis in breast cancer cells. Cellular & molecular biology letters. vol 19. issue 4. 2015-08-25. PMID:25182240. |
the results indicated that kdr-sirna treatment significantly inhibited the proliferation and induced the apoptosis of mcf-7 cells, reduced the levels of the anti-apoptotic proteins, bcl-2 and bcl-xl, and increased the level of the pro-apoptotic protein bax, resulting in a decreased bcl-2/bax ratio. |
2015-08-25 |
2023-08-13 |
human |
| Naoki Ishijima, Keita Kanki, Hiroki Shimizu, Goshi Shiot. Activation of AMP-activated protein kinase by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib. Cancer science. vol 106. issue 5. 2015-08-25. PMID:25683251. |
in the combination treatment using atra and sorafenib, increased apoptosis, followed by the activation of p38 mapk and jnk, the upregulation and translocation of bax to mitochondria, and the activation of caspase-3, was observed. |
2015-08-25 |
2023-08-13 |
Not clear |
| Woong-Hyun Kim, Hyun-Ok Song, Hwa-Jung Choi, Ho-Il Bang, Du-Young Choi, Hyun Par. Ethyl gallate induces apoptosis of HL-60 cells by promoting the expression of caspases-8, -9, -3, apoptosis-inducing factor and endonuclease G. International journal of molecular sciences. vol 13. issue 9. 2015-08-21. PMID:23109891. |
western blotting analysis indicated that eg-mediated hl-60 apoptosis mainly occurred through the mitochondrial pathway, as shown by the release of cytochrome c, apoptosis-inducing factor (aif), and endonuclease g (endo g), as well as the upregulation of bcl-2-associated x protein (bax). |
2015-08-21 |
2023-08-12 |
human |
| Caixia Guo, Xiangjun Zeng, Juanjuan Song, Min Zhang, Hongxia Wang, Xiaowei Xu, Fenghe Du, Buxing Che. A soluble receptor for advanced glycation end-products inhibits hypoxia/reoxygenation-induced apoptosis in rat cardiomyocytes via the mitochondrial pathway. International journal of molecular sciences. vol 13. issue 9. 2015-08-21. PMID:23109892. |
we hypothesized that exogenous administration of srage during hypoxia/reoxygenation (h/r) induces cardioprotection by inhibiting cardiomyocyte apoptosis via multiple signals, involving mitochondrial membrane potential (mmp), the mitochondrial permeability transition pore (mptp), mitochondrial cytochrome c, caspase-3, bcl-2 and bax. |
2015-08-21 |
2023-08-12 |
rat |
| Tieliang Ma, Jun Xu, Yuan Wang, Hao Yu, Yong Yang, Yang Liu, Weiliang Ding, Wenjiao Zhu, Ruhua Chen, Zhijun Ge, Yongfei Tan, Lei Jia, Taofeng Zh. Ternary copper(II) complexes with amino acid chains and heterocyclic bases: DNA binding, cytotoxic and cell apoptosis induction properties. Journal of inorganic biochemistry. vol 144. 2015-08-21. PMID:25555321. |
cell apoptosis were detected by annexinv/pi flow cytometry and by western blotting with the protein expression of p53, bax and bcl-2. |
2015-08-21 |
2023-08-13 |
human |
| J Cao, Q Miao, J Zhang, S Miao, L Bi, S Zhang, Q Yang, X Zhou, M Zhang, Y Xie, S Wan. INHIBITORY EFFECT OF TETRAMETHYLPYRAZINE ON HEPATOCELLULAR CARCINOMA: POSSIBLE ROLE OF APOPTOSIS AND CELL CYCLE ARREST. Journal of biological regulators and homeostatic agents. vol 29. issue 2. 2015-08-21. PMID:26122217. |
tmp induced apoptosis through increasing bax, decreasing bcl-2, increasing the release of cytochrome c, and activating caspase, which consisted of the mitochondrial apoptotic pathway. |
2015-08-21 |
2023-08-13 |
rat |
| Jian Zheng, Mei Jing Piao, Ki Cheon Kim, Cheng Wen Yao, Ji Won Cha, Jennifer H Shin, Suk Jae Yoo, Jin Won Hyu. Photo-protective effect of americanin B against ultraviolet B-induced damage in cultured human keratinocytes. Environmental toxicology and pharmacology. vol 38. issue 3. 2015-08-14. PMID:25461549. |
these protective activities were associated with down-regulation of apoptosis-promoting proteins, bax, caspase-9, and caspase-3 and up-regulation of an apoptosis inhibitor, bcl-2. |
2015-08-14 |
2023-08-13 |
human |
| Peng Wang, Chunhua Luo, Qianyuan Li, Sai Chen, Yong H. Mitochondrion-mediated apoptosis is involved in reproductive damage caused by BPA in male rats. Environmental toxicology and pharmacology. vol 38. issue 3. 2015-08-14. PMID:25461564. |
our data revealed that bpa exposure increased the protein and mrna levels of cytochrome c, apoptosis-inducing factor, caspase-3/9, and bax; caspase-3 and caspase-9 activities; and the apoptosis indices of spermatogenic cells. |
2015-08-14 |
2023-08-13 |
rat |
| Eduardo Homsi, Diego Duarte Andreazzi, Jose Butori Lopes de Faria, Patrícia Janin. TNF-α-mediated cardiorenal injury after rhabdomyolysis in rats. American journal of physiology. Renal physiology. vol 308. issue 11. 2015-08-13. PMID:25391899. |
tnf-α played a positive regulatory role in the transcription of proapoptotic bax and p53-upregulated modulator of apoptosis (puma) proteins. |
2015-08-13 |
2023-08-13 |
rat |
| Eduardo Homsi, Diego Duarte Andreazzi, Jose Butori Lopes de Faria, Patrícia Janin. TNF-α-mediated cardiorenal injury after rhabdomyolysis in rats. American journal of physiology. Renal physiology. vol 308. issue 11. 2015-08-13. PMID:25391899. |
tnf-α up regulates bax and puma proapoptotic proteins, resulting in activation of the intrinsic pathway of apoptosis in the kidney and heart. |
2015-08-13 |
2023-08-13 |
rat |
| Li Fan, Yalin Ma, Ying Liu, Dongping Zheng, Guangrong Huan. Silymarin induces cell cycle arrest and apoptosis in ovarian cancer cells. European journal of pharmacology. vol 743. 2015-08-11. PMID:25242120. |
additionally, silymarin treatment for 24h at 50 and 100µg/ml resulted in a reduction of mitochondrial membrane potential and cytochrome c release, and significantly induced apoptosis in a2780s and pa-1 cells by increasing bax and decreasing bcl-2 protein expression, and activation of caspase-9 and caspase-3. |
2015-08-11 |
2023-08-13 |
human |