| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shou-Sheng Liu, Xiao-Pai Wang, Xiu-Bo Li, Jia-Yi Liang, Ling-Ling Liu, Ying Lu, Xue-Yun Zhong, Yun-Xian Che. Zoledronic acid exerts antitumor effects in NB4 acute promyelocytic leukemia cells by inducing apoptosis and S phase arrest. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 68. issue 8. 2015-09-16. PMID:25312823. |
the western blot analysis confirmed the induction of apoptosis and s phase arrest, revealing that the pro-apoptosis proteins bax, puma and activated caspase-9 were upregulated and the anti-apoptosis proteins bcl-2 and bcl-xl were downregulated. |
2015-09-16 |
2023-08-13 |
human |
| Masanobu Tsubaki, Naoki Ogawa, Tomoya Takeda, Kotaro Sakamoto, Hirotaka Shimaoka, Arisa Fujita, Tatsuki Itoh, Motohiro Imano, Takao Satou, Shozo Nishid. Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-κB nuclear translocation and down-regulation of Bcl-xL and XIAP. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 68. issue 8. 2015-09-16. PMID:25443417. |
in addition, dmf suppressed b-cell lymphoma extra-large (bcl-xl) and x-linked inhibitor of apoptosis (xiap) expression whereas bcl-2, survivin, bcl-2-associated x protein (bax), and bim levels did not change. |
2015-09-16 |
2023-08-13 |
human |
| Lisa A Antonucci, Jacklynn V Egger, Nancy A Kruche. Phosphorylation of the Retinoblastoma protein (Rb) on serine-807 is required for association with Bax. Cell cycle (Georgetown, Tex.). vol 13. issue 22. 2015-09-16. PMID:25483096. |
the recent finding that the retinoblastoma protein (rb) is able to regulate apoptosis in a non-transcriptional manner directly at the mitochondria by interaction with the pro-apoptotic protein bax prompted this investigation of the complex formed between rb and bax. |
2015-09-16 |
2023-08-13 |
Not clear |
| Lisa A Antonucci, Jacklynn V Egger, Nancy A Kruche. Phosphorylation of the Retinoblastoma protein (Rb) on serine-807 is required for association with Bax. Cell cycle (Georgetown, Tex.). vol 13. issue 22. 2015-09-16. PMID:25483096. |
because the function of rb in the cellular processes of proliferation, apoptosis, senescence and differentiation is regulated by phosphorylation we endeavored to elucidate the phosphorylation status of rb with respect to its association with bax and its role in apoptosis. |
2015-09-16 |
2023-08-13 |
Not clear |
| Lisa A Antonucci, Jacklynn V Egger, Nancy A Kruche. Phosphorylation of the Retinoblastoma protein (Rb) on serine-807 is required for association with Bax. Cell cycle (Georgetown, Tex.). vol 13. issue 22. 2015-09-16. PMID:25483096. |
mutant rb proteins expressed in rb-null c33a cells showed that phosphorylation of s807 of rb promotes association with bax and that mimicking phosphorylation at s807 of rb can block the induction of apoptosis due to pnuts downregulation. |
2015-09-16 |
2023-08-13 |
Not clear |
| Lisa A Antonucci, Jacklynn V Egger, Nancy A Kruche. Phosphorylation of the Retinoblastoma protein (Rb) on serine-807 is required for association with Bax. Cell cycle (Georgetown, Tex.). vol 13. issue 22. 2015-09-16. PMID:25483096. |
finally using sirna to activate phosphatase activity in mcf7 cells, rb is dephosphorylated at several sites including s807/s811, dissociates from bax and apoptosis is triggered. |
2015-09-16 |
2023-08-13 |
Not clear |
| Lisa A Antonucci, Jacklynn V Egger, Nancy A Kruche. Phosphorylation of the Retinoblastoma protein (Rb) on serine-807 is required for association with Bax. Cell cycle (Georgetown, Tex.). vol 13. issue 22. 2015-09-16. PMID:25483096. |
these studies show that phosphorylation of rb regulates its association with bax and its role in apoptosis. |
2015-09-16 |
2023-08-13 |
Not clear |
| Siddhartha Kumar Mishra, Swati Tripathi, Archana Shukla, Seung Hyun Oh, Hwan Mook Ki. Andrographolide and analogues in cancer prevention. Frontiers in bioscience (Elite edition). vol 7. 2015-09-16. PMID:25553378. |
andrographolide induced both intrinsic and extrinsic apoptosis pathway in different cancer cells via expression of different anti-apoptotic protein like bax, p53, and activated caspases. |
2015-09-16 |
2023-08-13 |
human |
| Mohamed Fares, Wagdy M Eldehna, Sahar M Abou-Seri, Hatem A Abdel-Aziz, Mohamed H Aly, Mai F Tolb. Design, synthesis and in vitro antiproliferative activity of novel isatin-quinazoline hybrids. Archiv der Pharmazie. vol 348. issue 2. 2015-09-16. PMID:25664631. |
compounds 15b, 15g and 15l displayed the highest potency, with ic50 values ranging from 1.0 ± 0.2 to 2.4 ± 0.4 μm, and they were able to induce apoptosis in hepg2 cells, as evidenced by enhanced expression of the pro-apoptotic protein bax and reduced expression of the anti-apoptotic protein bcl-2, in addition to increased caspase-3 levels. |
2015-09-16 |
2023-08-13 |
Not clear |
| Alyaa M Mousa, Ameera S Al-Fadhli, Muddanna S Rao, Narayana Kilarkaj. Gestational lead exposure induces developmental abnormalities and up-regulates apoptosis of fetal cerebellar cells in rats. Drug and chemical toxicology. vol 38. issue 1. 2015-09-15. PMID:24724870. |
an increase in bax and caspase 3, and a decrease in bcl-2 (p < 0.05), but not in p53, showed apoptosis of the neurons. |
2015-09-15 |
2023-08-13 |
rat |
| Dao Gun Xu, Wang Lv, Chun Yan Dai, Fan Fan Zhu, Gua Hua Xu, Zhong Jun Ma, Zhe Che. 2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells. Anatomical record (Hoboken, N.J. : 2007). vol 298. issue 2. 2015-09-14. PMID:25178491. |
our results demonstrate that treatment of sw620 cells with pyddt leads to induction of mitochondrial-mediated apoptosis, which is characterized by the cleavage of parp, activation of caspase 9 and caspase 3, release of cytochrome c from mitochondria, loss of mitochondrial membrane potential, down-regulation of bcl-2, and mitochondrial translocation of bax. |
2015-09-14 |
2023-08-13 |
human |
| Dao Gun Xu, Wang Lv, Chun Yan Dai, Fan Fan Zhu, Gua Hua Xu, Zhong Jun Ma, Zhe Che. 2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells. Anatomical record (Hoboken, N.J. : 2007). vol 298. issue 2. 2015-09-14. PMID:25178491. |
specific jnk inhibitor sp600125 prevented the pyddt-induced down-regulation of bcl-2, mitochondrial translocation of bax, activation of caspase 3, and apoptosis of sw620 cells. |
2015-09-14 |
2023-08-13 |
human |
| Anne Benard, Connie M Janssen, Peter J van den Elsen, Marja C J A van Eggermond, Dave S B Hoon, Cornelis J H van de Velde, Peter J K Kuppe. Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25292014. |
using chromatin immunoprecipitation (chip), we measured the presence of transcription-activating histone modifications h3ac and h3k4me3 and silencing modifications h3k9me3 and h3k27me3 at the gene promoter regions of key apoptosis genes bax, bcl2, caspase-9, fas (cd95) and p53. |
2015-09-14 |
2023-08-13 |
Not clear |
| Anne Benard, Connie M Janssen, Peter J van den Elsen, Marja C J A van Eggermond, Dave S B Hoon, Cornelis J H van de Velde, Peter J K Kuppe. Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25292014. |
the chromatin status of the apoptosis genes reflected the activation status of the intrinsic (bax, bcl2, caspase-9 and p53) and extrinsic (fas) pathways. |
2015-09-14 |
2023-08-13 |
Not clear |
| Mandana Behbahan. Evaluation of in vitro anticancer activity of Ocimum basilicum, Alhagi maurorum, Calendula officinalis and their parasite Cuscuta campestris. PloS one. vol 9. issue 12. 2015-09-14. PMID:25548920. |
the induction of apoptosis was measured by the expression levels of p53, bcl-2, bax and caspase-3 genes using quantitative real time pcr. |
2015-09-14 |
2023-08-13 |
human |
| Fu Gao, Song Chen, Mingjuan Sun, Ronald E J Mitchel, Bailong Li, Zhiyong Chu, Jianming Cai, Cong Li. MiR-467a is upregulated in radiation-induced mouse thymic lymphomas and regulates apoptosis by targeting Fas and Bax. International journal of biological sciences. vol 11. issue 1. 2015-09-14. PMID:25552935. |
mir-467a is upregulated in radiation-induced mouse thymic lymphomas and regulates apoptosis by targeting fas and bax. |
2015-09-14 |
2023-08-13 |
mouse |
| Fu Gao, Song Chen, Mingjuan Sun, Ronald E J Mitchel, Bailong Li, Zhiyong Chu, Jianming Cai, Cong Li. MiR-467a is upregulated in radiation-induced mouse thymic lymphomas and regulates apoptosis by targeting Fas and Bax. International journal of biological sciences. vol 11. issue 1. 2015-09-14. PMID:25552935. |
bioinformatics prediction suggests mir-467a may potentially regulate apoptosis pathway via targeting fas and bax. |
2015-09-14 |
2023-08-13 |
mouse |
| Fu Gao, Song Chen, Mingjuan Sun, Ronald E J Mitchel, Bailong Li, Zhiyong Chu, Jianming Cai, Cong Li. MiR-467a is upregulated in radiation-induced mouse thymic lymphomas and regulates apoptosis by targeting Fas and Bax. International journal of biological sciences. vol 11. issue 1. 2015-09-14. PMID:25552935. |
to explain the mechanism of apoptosis suppression by mir-467a, we explore the expression of candidate target genes (fas and bax) in mir-467a-transfected relative to negative control transfected cells using flow cytometry and immunoblotting. |
2015-09-14 |
2023-08-13 |
mouse |
| Fu Gao, Song Chen, Mingjuan Sun, Ronald E J Mitchel, Bailong Li, Zhiyong Chu, Jianming Cai, Cong Li. MiR-467a is upregulated in radiation-induced mouse thymic lymphomas and regulates apoptosis by targeting Fas and Bax. International journal of biological sciences. vol 11. issue 1. 2015-09-14. PMID:25552935. |
to ascertain whether downregulation of fas and / or bax is involved in apoptosis suppression by mir-467a, we transfected vectors expressing fas and bax into mir-467a-upregulated el4 cells. |
2015-09-14 |
2023-08-13 |
mouse |
| Fu Gao, Song Chen, Mingjuan Sun, Ronald E J Mitchel, Bailong Li, Zhiyong Chu, Jianming Cai, Cong Li. MiR-467a is upregulated in radiation-induced mouse thymic lymphomas and regulates apoptosis by targeting Fas and Bax. International journal of biological sciences. vol 11. issue 1. 2015-09-14. PMID:25552935. |
then we found that both fas- and bax-overexpression decreased cell viability with increase of apoptosis rate, indicating that downregulation of fas and bax may be at least partly responsible for apoptosis suppression by mir-467a. |
2015-09-14 |
2023-08-13 |
mouse |