| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming Zhan, Irtaza M Usman, Lin Sun, Yashpal S Kanwa. Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney disease. Journal of the American Society of Nephrology : JASN. vol 26. issue 6. 2015-08-11. PMID:25270067. |
furthermore, dysfunctional mitochondria accumulated in the cytoplasm, which coincided with increased reactive oxygen species generation, bax activation, cytochrome c release, and apoptosis. |
2015-08-11 |
2023-08-13 |
mouse |
| Geethu Emily Thomas, Jamuna S Sreeja, K K Gireesh, Hindol Gupta, Tapas K Mann. +TIP EB1 downregulates paclitaxel‑induced proliferation inhibition and apoptosis in breast cancer cells through inhibition of paclitaxel binding on microtubules. International journal of oncology. vol 46. issue 1. 2015-08-11. PMID:25310526. |
p53 and bax were upregulated and bcl2 was downregulated in the eb1‑depleted ptx‑treated mcf‑7 cells, indicating that the apoptosis occurs via a p53‑dependent pathway. |
2015-08-11 |
2023-08-13 |
Not clear |
| Xiaoli Ma, Hua Duan, Jia Liu, Qingqing Mo, Chengjuan Sun, Ding Ma, Jiandong Wan. Effect of LIV1 on the sensitivity of ovarian cancer cells to trichostatin A. Oncology reports. vol 33. issue 2. 2015-08-11. PMID:25420545. |
using western blot analysis, we demostrated that the inhibition of tsa-induced apoptosis by knockdown of liv1 might be associated with decreased endogenous levels of bcl-2, enhanced levels of bax and cleavage of procaspase-3. |
2015-08-11 |
2023-08-13 |
Not clear |
| Hao Zhou, Junjie Yang, Ting Xin, Dandan Li, Jun Guo, Shunyin Hu, Shanshan Zhou, Tao Zhang, Ying Zhang, Tianwen Han, Yundai Che. Exendin-4 protects adipose-derived mesenchymal stem cells from apoptosis induced by hydrogen peroxide through the PI3K/Akt-Sfrp2 pathways. Free radical biology & medicine. vol 77. 2015-08-11. PMID:25452142. |
western blots revealed that increased antiapoptotic proteins bcl-2 and c-iap1/2 as well as decreased proapoptotic proteins bax and cytochrome c appeared in admscs with ex-4 incubation, which inhibited the caspase-9-involved mitochondrial apoptosis pathways with evidence showing inactivation of caspase-9/3 and preservation of mitochondrial membrane potential. |
2015-08-11 |
2023-08-13 |
Not clear |
| Guanghua Li, Guoyuan Liu, Na Song, Cong Kong, Qi Huang, Haibo Su, Aixiao Bi, Liulin Luo, Lin Zhu, Ying Xu, Honghai Wan. A novel recombinant BCG-expressing pro-apoptotic protein BAX enhances Th1 protective immune responses in mice. Molecular immunology. vol 66. issue 2. 2015-08-11. PMID:25942359. |
in our study, we constructed a novel recombinant bcg strain expressing pro-apoptotic bax (rbcg::bax) and demonstrated that it significantly induced the apoptosis of macrophages infected with rbcg::bax both in vitro and in vivo. |
2015-08-11 |
2023-08-13 |
mouse |
| Wei-Xia Duan, Min-Di He, Lin Mao, Feng-Hua Qian, Yu-Ming Li, Hui-Feng Pi, Chuan Liu, Chun-Hai Chen, Yong-Hui Lu, Zheng-Wang Cao, Lei Zhang, Zheng-Ping Yu, Zhou Zho. NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells. Toxicology and applied pharmacology. vol 286. issue 2. 2015-08-10. PMID:25840356. |
however, overexpression of sirt1 through resveratrol treatment or transfection clearly attenuated the nionps-induced apoptosis and activation of p53 and bax. |
2015-08-10 |
2023-08-13 |
human |
| Wei-Xia Duan, Min-Di He, Lin Mao, Feng-Hua Qian, Yu-Ming Li, Hui-Feng Pi, Chuan Liu, Chun-Hai Chen, Yong-Hui Lu, Zheng-Wang Cao, Lei Zhang, Zheng-Ping Yu, Zhou Zho. NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells. Toxicology and applied pharmacology. vol 286. issue 2. 2015-08-10. PMID:25840356. |
our results suggest that the repression of sirt1 may underlie the nionps-induced apoptosis via p53 hyperacetylation and subsequent bax activation. |
2015-08-10 |
2023-08-13 |
human |
| Chong Xu, Guibo Sun, Guangxin Yuan, Rui Wang, Xiaobo Su. Effects of platycodin D on proliferation, apoptosis and PI3K/Akt signal pathway of human glioma U251 cells. Molecules (Basel, Switzerland). vol 19. issue 12. 2015-08-07. PMID:25532840. |
the results showed that compared with the control group, pd could increase the proliferation inhibition rate of u251 cells in a dose- and time -dependent manner; pd could also elevate the early and late apoptotic rate, apoptotic index and the level of pro-apoptotic proteins of glioma u251 cells, such as bax and cleaved caspase-3, but lower the level of apoptosis inhibitory protein, such as bcl-2; pd could increase the ratio of g0/g1 phase u251 cells, and lower the proportion of sphase u251 cells and the ratio of g2/m phase u251 cells; pd could reduce the ratio of p-akt/akt. |
2015-08-07 |
2023-08-13 |
human |
| Subhadeep Mukherjee, Tapas Biswa. Activation of TOLLIP by porin prevents TLR2-associated IFN-γ and TNF-α-induced apoptosis of intestinal epithelial cells. Cellular signalling. vol 26. issue 12. 2015-08-06. PMID:25152369. |
proinflammatory cytokines induce apoptosis by activation of caspase 8 that triggers caspase 9 through bax finally leading to activation of caspase 3, the executioner caspase. |
2015-08-06 |
2023-08-13 |
Not clear |
| Ji Young Lee, Su Bean Jee, Won Young Park, Yu Jin Choi, Bokyung Kim, Yoon Hee Kim, Do Youn Jun, Young Ho Ki. Tumor suppressor protein p53 promotes 2-methoxyestradiol-induced activation of Bak and Bax, leading to mitochondria-dependent apoptosis in human colon cancer HCT116 cells. Journal of microbiology and biotechnology. vol 24. issue 12. 2015-08-04. PMID:25179905. |
tumor suppressor protein p53 promotes 2-methoxyestradiol-induced activation of bak and bax, leading to mitochondria-dependent apoptosis in human colon cancer hct116 cells. |
2015-08-04 |
2023-08-13 |
human |
| Ji Young Lee, Su Bean Jee, Won Young Park, Yu Jin Choi, Bokyung Kim, Yoon Hee Kim, Do Youn Jun, Young Ho Ki. Tumor suppressor protein p53 promotes 2-methoxyestradiol-induced activation of Bak and Bax, leading to mitochondria-dependent apoptosis in human colon cancer HCT116 cells. Journal of microbiology and biotechnology. vol 24. issue 12. 2015-08-04. PMID:25179905. |
the bak-specific and bax-specific sirna approaches confirmed the necessity of both bak and bax activations for the 2-meo-e2-induced apoptosis in hct116 cells. |
2015-08-04 |
2023-08-13 |
human |
| M Obulesu, M Jhansi Lakshm. Apoptosis in Alzheimer's disease: an understanding of the physiology, pathology and therapeutic avenues. Neurochemical research. vol 39. issue 12. 2015-08-04. PMID:25322820. |
apoptosis, a biological process that plays an essential role in normal physiology to oust a few cells and contribute to the normal growth, when impaired or influenced by various factors such as bcl2, bax, caspases, amyloid beta, tumor necrosis factor-α, amyloid precursor protein intracellular c-terminal domain, reactive oxygen species, perturbation of enzymes leads to deleterious neurodegenerative disorders like ad. |
2015-08-04 |
2023-08-13 |
Not clear |
| Yosuke Harazono, Dhong Hyo Kho, Vitaly Balan, Kosei Nakajima, Tianpeng Zhang, Victor Hogan, Avraham Ra. Galectin-3 leads to attenuation of apoptosis through Bax heterodimerization in human thyroid carcinoma cells. Oncotarget. vol 5. issue 20. 2015-08-04. PMID:25393982. |
galectin-3 leads to attenuation of apoptosis through bax heterodimerization in human thyroid carcinoma cells. |
2015-08-04 |
2023-08-13 |
human |
| Jason Karch, Jeffery D Molkenti. Regulated necrotic cell death: the passive aggressive side of Bax and Bak. Circulation research. vol 116. issue 11. 2015-08-04. PMID:25999420. |
in apoptosis, the b-cell leukemia/lymphoma 2 (bcl-2) family members bcl-2-associated protein x (bax) and bcl-2 homologues antagonist/killer (bak) undergo oligomerization in the outer mitochondrial membrane resulting in the release of apoptosis inducing substrates and the activation of caspases and nucleases. |
2015-08-04 |
2023-08-13 |
Not clear |
| Ming Ren, Yi-Mei Wang, Jing Zhao, Jun Zhao, Zeng-Ming Zhao, Ting-Fen Zhang, Jun He, Shu-Ping Ren, Shuang-Qing Pen. Metallothioneins attenuate paraquat-induced acute lung injury in mice through the mechanisms of anti-oxidation and anti-apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 73. 2015-08-03. PMID:25111661. |
pq also induced more apoptosis in pneumocytes from mt(-/-) mice, and the expressions of apoptosis-related proteins bax, bcl-2, cleaved-caspase-3, and the ratio of bax/bcl-2 were all more significantly increased in pq-treated mt(-/-) mice. |
2015-08-03 |
2023-08-13 |
mouse |
| Sharda Kumari, Susheel N Chaurasia, Manasa K Nayak, Ram L Mallick, Debabrata Das. Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia. The Journal of biological chemistry. vol 290. issue 19. 2015-08-03. PMID:25829495. |
expression of acetylated p53 and the conformationally active form of bax were found to be significantly higher in both sirtinol- and ex-527-treated platelets, implicating the p53-bax axis in apoptosis induced by sirtuin inhibitors. |
2015-08-03 |
2023-08-13 |
mouse |
| Mohammad Reza Aliparasti, Mohammad Reza Alipour, Shohreh Almasi, Hadi Feiz. Ghrelin Administration Increases the Bax/Bcl-2 Gene Expression Ratio in the Heart of Chronic Hypoxic Rats. Advanced pharmaceutical bulletin. vol 5. issue 2. 2015-08-03. PMID:26236657. |
bax and bcl-2 are among the agents that regulate apoptosis. |
2015-08-03 |
2023-08-13 |
rat |
| Victor Maso, Andrana Karla Calgarotto, Gilberto Carlos Franchi, Alexandre Eduardo Nowill, Paulo Latuf Filho, José Vassallo, Sara Teresinha Olalla Saa. Multitarget effects of quercetin in leukemia. Cancer prevention research (Philadelphia, Pa.). vol 7. issue 12. 2015-07-30. PMID:25293876. |
quercetin caused pronounced apoptosis in p39 leukemia cells, followed by bcl-2, bcl-xl, mcl-1 downregulation, bax upregulation, and mitochondrial translocation, triggering cytochrome c release and caspases activation. |
2015-07-30 |
2023-08-13 |
Not clear |
| Yingying Fan, Shaoju Jin, Jun He, Zhenjun Shao, Jiao Yan, Ting Feng, Hong L. Effect of β,β-dimethylacrylshikonin on inhibition of human colorectal cancer cell growth in vitro and in vivo. International journal of molecular sciences. vol 13. issue 7. 2015-07-29. PMID:22942759. |
western blotting results demonstrated that the induction of apoptosis by da correlated with the induction of pro-apoptotic proteins bax, and bid, and a decrease in the expression of anti-apoptotic proteins bcl-2 and bcl-xl. |
2015-07-29 |
2023-08-12 |
mouse |
| Xue-Jiao Lv, Li-Jing Zhao, Yu-Qiu Hao, Zhen-Zhong Su, Jun-Yao Li, Yan-Wei Du, Jie Zhan. Schisandrin B inhibits the proliferation of human lung adenocarcinoma A549 cells by inducing cycle arrest and apoptosis. International journal of clinical and experimental medicine. vol 8. issue 5. 2015-07-29. PMID:26221229. |
furthermore, sch b triggered a549 cell apoptosis by increasing bax, cleaved caspase-3, 9, cyto c, but decreasing bcl-2 and pcna expression. |
2015-07-29 |
2023-08-13 |
human |