| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fu-Xiang Yu, Yin-Yan Teng, Qian-Dong Zhu, Qi-Yu Zhang, Yin-He Tan. Inhibitory effects of capsaicin on hepatic stellate cells and liver fibrosis. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 92. issue 5. 2015-07-07. PMID:25289759. |
moreover, capsaicin-induced cell apoptosis was associated with increased expression of bax, cytochrome c (cyt c), and caspase-3, but reduced levels of bcl-2. |
2015-07-07 |
2023-08-13 |
rat |
| N Chaudhary, K K Nakka, P L Chavali, J Bhat, S Chatterjee, S Chattopadhya. SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation. Cell death & disease. vol 5. 2015-07-07. PMID:25299772. |
thus, we provide mechanistic insights of smar1-mediated regulation of repair and apoptosis via a complex crosstalk involving ku70, hdac6 and bax. |
2015-07-07 |
2023-08-13 |
Not clear |
| N Yadav, A Pliss, A Kuzmin, P Rapali, L Sun, P Prasad, D Chandr. Transformations of the macromolecular landscape at mitochondria during DNA-damage-induced apoptotic cell death. Cell death & disease. vol 5. 2015-07-07. PMID:25299778. |
thus, we define previously unknown dynamic correlation of macromolecular structure of mitochondria and apoptosis progression in the presence and absence of bax protein. |
2015-07-07 |
2023-08-13 |
Not clear |
| R Majeed, A Hamid, P L Sangwan, P K Chinthakindi, S Koul, S Rayees, G Singh, D M Mondhe, M J Mintoo, S K Singh, S K Rath, A K Saxen. Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin. Cell death & disease. vol 5. 2015-07-07. PMID:25299784. |
also, this target-specific inhibition was associated with mitochondrial apoptosis as was reflected by the increased expression of mitochondrial bax, downregulated bcl2 and decreased mitochondrial levels of cytochrome c, together with reactive oxygen species generation and decline in mitochondrial membrane potential. |
2015-07-07 |
2023-08-13 |
human |
| Pengjun Zhao, Hao Jiang, Dan Su, Jianguo Feng, Shenglin Ma, Xinhai Zh. Inhibition of cell proliferation by mild hyperthermia at 43˚C with Paris Saponin I in the lung adenocarcinoma cell line PC-9. Molecular medicine reports. vol 11. issue 1. 2015-07-07. PMID:25322761. |
psi combined with hyperthermia significantly induced apoptosis through a multi regulatory process involving g2/m arrest and regulation of bax, bcl-2 and caspase-3 expression, resulting in cell death and tumor inhibition. |
2015-07-07 |
2023-08-13 |
Not clear |
| Anup S Pathania, Suresh Kumar, Santosh K Guru, Shashi Bhushan, Parduman R Sharma, Sravan K Aithagani, Parvinder P Singh, Ram A Vishwakarma, Ajay Kumar, Fayaz Mali. The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells. PloS one. vol 9. issue 11. 2015-07-07. PMID:25383546. |
it was further shown that apoptotic protein bax silencing in hl-60 cells resists tbr mediated erk dependent apoptosis. |
2015-07-07 |
2023-08-13 |
human |
| Chunyan Zhu, Ping Xie, Fei Zhao, Lingqiang Zhang, Wei An, Yutao Zha. Mechanism of the promotion of steatotic HepG2 cell apoptosis by cholesterol. International journal of clinical and experimental pathology. vol 7. issue 10. 2015-07-07. PMID:25400762. |
however, the apoptosis rate (p < 0.01) of the cholesterol group was significantly higher than that of the normal group or the steatosis group, and the protein expressions of bax and caspase-3, but not p53, bcl-2, cyclin a, cyclin b1 and cyclin e, were also increased in the cholesterol group. |
2015-07-07 |
2023-08-13 |
Not clear |
| Chunyan Zhu, Ping Xie, Fei Zhao, Lingqiang Zhang, Wei An, Yutao Zha. Mechanism of the promotion of steatotic HepG2 cell apoptosis by cholesterol. International journal of clinical and experimental pathology. vol 7. issue 10. 2015-07-07. PMID:25400762. |
those results suggested that cholesterol markedly promoted apoptosis of steatosis hepg2 cells in vitro, likely through the up-regulation of bax and caspase-3 expression. |
2015-07-07 |
2023-08-13 |
Not clear |
| Bin Li, Zhenquan Song, Guobiao Liang, Wei Lei, Zhijun Wang, Enzhi Liu, Xiaoming Li, Hongbo Li. The role of 8-OH-DPAT on the rat neuronal apoptosis after diffuse brain injury coupled with secondary brain injury. Die Pharmazie. vol 70. issue 4. 2015-07-07. PMID:26012255. |
the neuronal cell apoptosis index and the expression of bax and bcl-2 were detected by tunel method and immunohistochemistry respectively. |
2015-07-07 |
2023-08-13 |
rat |
| Wei Peng, Jian-Guo Wu, Yun-Bin Jiang, Yu-Jie Liu, Tao Sun, Na Wu, Chun-Jie W. Antitumor activity of 4-O-(2″-O-acetyl-6″-O-p-coumaroyl-β-D-glucopyranosyl)-p-coumaric acid against lung cancers via mitochondrial-mediated apoptosis. Chemico-biological interactions. vol 233. 2015-07-03. PMID:25824411. |
our results demonstrated that 4-acgc possessed notable anti-tumor activity on lung cancer in vivo and in vitro; the mechanisms were involved in inducing mitochondria-mediated apoptosis via up-regulations of caspase-3, caspase-9, bad and bax, and down-regulation of bcl-2. |
2015-07-03 |
2023-08-13 |
mouse |
| Zhongyong Jiang, Jie Xion. Induction of apoptosis in human hepatocarcinoma SMMC-7721 cells in vitro by psoralen from Psoralea corylifolia. Cell biochemistry and biophysics. vol 70. issue 2. 2015-07-02. PMID:24845152. |
we measured human hepatocarcinoma cell viability by mtt assay and annexin v-fitc/pi double staining, and evaluated the activity of caspase 3 and the expression of p53, bax, and bcl-2 proteins, involved in regulating cell apoptosis. |
2015-07-02 |
2023-08-13 |
human |
| Zhongyong Jiang, Jie Xion. Induction of apoptosis in human hepatocarcinoma SMMC-7721 cells in vitro by psoralen from Psoralea corylifolia. Cell biochemistry and biophysics. vol 70. issue 2. 2015-07-02. PMID:24845152. |
these results suggest that psoralen induces apoptosis in cancer cells via mechanisms that involve caspase-3, p53, bax, and bcl-2 pathway. |
2015-07-02 |
2023-08-13 |
human |
| Xiuyu Wang, Xiaoguang Tong, Hongmei Gao, Xiaoling Yan, Xinnv Xu, Shupeng Sun, Qiong Wang, Jinhuan Wan. Silencing HIWI suppresses the growth, invasion and migration of glioma cells. International journal of oncology. vol 45. issue 6. 2015-07-02. PMID:25269862. |
the expression of proteins related to apoptosis and the cell cycle, including p21, cyclin d1, bcl-2, and bax was significantly altered. |
2015-07-02 |
2023-08-13 |
human |
| S Y Yan, M M Chen, J G Fan, Y Q Wang, Y Q Du, Y Hu, L M X. Therapeutic mechanism of treating SMMC-7721 liver cancer cells with magnetic fluid hyperthermia using Fe₂O₃ nanoparticles. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 47. issue 11. 2015-07-02. PMID:25296356. |
fe₂o₃ mfh can induce high hsp70 expression at an early stage, enhance the expression of bax, and decrease the expression of mutant p53, which promotes the apoptosis of tumor cells. |
2015-07-02 |
2023-08-13 |
Not clear |
| Fernanda Barbisan, Jéssica de Rosso Motta, Alexis Trott, Verônica Azzolin, Eduardo Bortoluzzi Dornelles, Matheus Marcon, Thaís Doeler Algarve, Marta Maria Medeiros Frescura Duarte, Clarice Pinheiro Mostardeiro, Taís Cristina Unfer, Karen Lilian Schott, Ivana Beatrice Mânica da Cru. Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism. PloS one. vol 9. issue 10. 2015-07-02. PMID:25330300. |
caspase-8 and -3 levels were increased in cells exposed to mtx, but the modulation of these genes, as well as that of the bax and bcl-2 genes involved in the apoptosis pathway, presented a modulation that was dependent on the sod2 genotype. |
2015-07-02 |
2023-08-13 |
human |
| Lizhu Jiang, Peng Wang, Lili Chen, Hongyan Che. Down-regulation of FoxM1 by thiostrepton or small interfering RNA inhibits proliferation, transformation ability and angiogenesis, and induces apoptosis of nasopharyngeal carcinoma cells. International journal of clinical and experimental pathology. vol 7. issue 9. 2015-07-02. PMID:25337187. |
foxm1 inhibition by thiostrepton induced apoptosis of npc cells by down-regulation of bcl-2, up-regulation of bax and p53, and inducing release of cytochrome c accompanied by activation of caspase-9, cleaved caspase-3 and cleaved parp. |
2015-07-02 |
2023-08-13 |
human |
| Jin-Ping Lu, Jiang-Hua Ren, Ling Chen, Xia Li, Hui-Li Che. Involvement of CaSR in hyperglycemia-induced macroangiopathy and related mechanism. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 35. issue 1. 2015-07-02. PMID:25673191. |
cell-based assays also showed that the casr level and key apoptotic proteins (cleaved caspase-3 and -9, bax, phospho-p38 and phosphor-jnk) were elevated in response to stimulation, and inhibition of casr by using specific inhibitor (nps-2143, 10 μmol/l) could protect cells against apoptosis. |
2015-07-02 |
2023-08-13 |
human |
| Fei Fei, Dao-Li Zhu, Li-Jun Tao, Bao-Zhu Huang, Hong-Hong Zhan. Protective effect of ATP on skeletal muscle satellite cells damaged by H₂O₂. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 35. issue 1. 2015-07-02. PMID:25673197. |
it was concluded that atp could protect skeletal muscle satellite cells against h₂o₂damage in neonatal rats, which may be attributed to the up-regulation of the expression of bcl-2 and down-regulation of bax, resulting in the suppression of apoptosis. |
2015-07-02 |
2023-08-13 |
rat |
| Chuan-Jiang Wang, Dong Yang, Ying-Wei Lu. RhoBTB2 (DBC2) functions as a multifunctional tumor suppressor in thyroid cancer cells via mitochondrial apoptotic pathway. International journal of clinical and experimental medicine. vol 8. issue 4. 2015-07-01. PMID:26131191. |
in our study, we found that rhobtb2 decreases proliferation, increases apoptosis, inhibits mobility, and induces mitochondria damage in sw579 cells through increased bax and decreased bcl-2 and bcl-xl protein expression. |
2015-07-01 |
2023-08-13 |
Not clear |
| Yanqin Liu, Lei Shi, Chunyi Liu, Guiyun Zhu, Hao Li, Haitao Zhao, Suling L. Effect of combination therapy of propofol and sevoflurane on MAP2K3 level and myocardial apoptosis induced by ischemia-reperfusion in rats. International journal of clinical and experimental medicine. vol 8. issue 4. 2015-07-01. PMID:26131269. |
qrt-pcr was used to analyze the mrna levels of cell apoptosis related proteins such as bcl-2, bax, and map2k3. |
2015-07-01 |
2023-08-13 |
rat |