| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Imtiaz A Siddiqui, Dhruba J Bharali, Minakshi Nihal, Vaqar M Adhami, Naghma Khan, Jean Christopher Chamcheu, Mohammad Imran Khan, Sameh Shabana, Shaker A Mousa, Hasan Mukhta. Excellent anti-proliferative and pro-apoptotic effects of (-)-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivo. Nanomedicine : nanotechnology, biology, and medicine. vol 10. issue 8. 2015-07-15. PMID:24965756. |
nano-egcg also inhibited proliferation (ki-67 and pcna) and induced apoptosis (bax, parp) in tumors harvested from the treated mice. |
2015-07-15 |
2023-08-13 |
mouse |
| Shreyasi Palit, Susanta Kar, Gunjan Sharma, Pijush K Da. Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway. Journal of cellular physiology. vol 230. issue 8. 2015-07-15. PMID:25204891. |
apoptosis was associated with caspase-9 activation, mitochondrial membrane potential loss, release of cytochrome c, and increase in bax:bcl-2 ratio. |
2015-07-15 |
2023-08-13 |
human |
| Shreyasi Palit, Susanta Kar, Gunjan Sharma, Pijush K Da. Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway. Journal of cellular physiology. vol 230. issue 8. 2015-07-15. PMID:25204891. |
in addition, hesperetin also induced apoptosis in triple negative breast cancer mda-mb-231 cells via intrinsic pathway via activation of caspase -9 and -3 and increase in bax:bcl-2 ratio. |
2015-07-15 |
2023-08-13 |
human |
| S B Ma, T N Nguyen, I Tan, R Ninnis, S Iyer, D A Stroud, M Menard, R M Kluck, M T Ryan, G Dewso. Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function. Cell death and differentiation. vol 21. issue 12. 2015-07-14. PMID:25146925. |
during apoptosis, bax dissociates from vdac2 and homo-oligomerizes to form high molecular weight oligomers. |
2015-07-14 |
2023-08-13 |
Not clear |
| S B Ma, T N Nguyen, I Tan, R Ninnis, S Iyer, D A Stroud, M Menard, R M Kluck, M T Ryan, G Dewso. Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function. Cell death and differentiation. vol 21. issue 12. 2015-07-14. PMID:25146925. |
silencing of bak in vdac2-deficient cells indicated that bax required either vdac2 or bak in order to translocate to and oligomerize at the mitochondrial outer membrane to efficiently mediate apoptosis. |
2015-07-14 |
2023-08-13 |
Not clear |
| D Y Xia, L Liu, M W Hao, Q Liu, R A Chen, Y M Lian. A combination of STI571 and BCR-ABL1 siRNA with overexpressed p15INK4B induced enhanced proliferation inhibition and apoptosis in chronic myeloid leukemia. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 47. issue 12. 2015-07-14. PMID:25387678. |
overexpression of p15ink4b also induced apoptosis of k562 cells by upregulating bax expression and downregulating bcl-2 expression. |
2015-07-14 |
2023-08-13 |
Not clear |
| Lei Jiang, Hao Wang, Chunli Shi, Ke Liu, Meidong Liu, Nian Wang, Kangkai Wang, Huali Zhang, Guiliang Wang, Xianzhong Xia. ZNF667/Mipu1 is a novel anti-apoptotic factor that directly regulates the expression of the rat Bax gene in H9c2 cells. PloS one. vol 9. issue 11. 2015-07-14. PMID:25397408. |
we found that znf667 inhibited the expression and the promoter activity of the rat proapoptotic gene bax gene, and at the same time prevented apoptosis of h9c2 cells, induced by h2o2 and dox. |
2015-07-14 |
2023-08-13 |
rat |
| Eun-Sang Ji, You-Mi Kim, Mal-Soon Shin, Chang-Ju Kim, Kwang-Sik Lee, Kijeong Kim, Jonglin Ha, Yong-Rak Chun. Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington's disease rats. Journal of exercise rehabilitation. vol 11. issue 3. 2015-07-14. PMID:26171378. |
immunohistochemistry for caspase-3 and western blot for bax and bcl-2 were also conducted for the detection of apoptosis. |
2015-07-14 |
2023-08-13 |
rat |
| Arzu Z Karabay, Fugen Aktan, Asuman Sunguroğlu, Zeliha Buyukbingo. Methylsulfonylmethane modulates apoptosis of LPS/IFN-γ-activated RAW 264.7 macrophage-like cells by targeting p53, Bax, Bcl-2, cytochrome c and PARP proteins. Immunopharmacology and immunotoxicology. vol 36. issue 6. 2015-07-13. PMID:25211405. |
methylsulfonylmethane modulates apoptosis of lps/ifn-γ-activated raw 264.7 macrophage-like cells by targeting p53, bax, bcl-2, cytochrome c and parp proteins. |
2015-07-13 |
2023-08-13 |
Not clear |
| Lili Dai, Yanjing Han, Tieming Ma, Yuli Liu, Lu Ren, Zenghua Bai, Ye L. Effects of Deep Electroacupuncture Stimulation at "Huantiao" (GB 30) on Expression of Apoptosis-Related Factors in Rats with Acute Sciatic Nerve Injury. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-07-13. PMID:26167187. |
these results indicate that ea stimulation at gb 30 can improve the function of injured sciatic nerve, which is closely associated with its effects in upregulating the expression of apoptosis inhibitive factor bcl-2 and downregulating apoptosis promotive factor bax. |
2015-07-13 |
2023-08-13 |
rat |
| b' Iva Jel\\xc3\\xadnkov\\xc3\\xa1, Barbora \\xc5\\xa0afa\\xc5\\x99\\xc3\\xadkov\\xc3\\xa1, Olga Vond\\xc3\\xa1lov\\xc3\\xa1 Blan\\xc3\\xa1\\xc5\\x99ov\\xc3\\xa1, Belma Skender, Ji\\xc5\\x99ina Hofmanov\\xc3\\xa1, Petr Sova, Mary Pat Moyer, Alois Kozub\\xc3\\xadk, Zden\\xc4\\x9bk Kol\\xc3\\xa1\\xc5\\x99, Ji\\xc5\\x99\\xc3\\xad Ehrmann, Alena Hyr\\xc5\\xa1lov\\xc3\\xa1 Vaculov\\xc3\\xa. Platinum(IV) complex LA-12 exerts higher ability than cisplatin to enhance TRAIL-induced cancer cell apoptosis via stimulation of mitochondrial pathway. Biochemical pharmacology. vol 92. issue 3. 2015-07-09. PMID:25285768.' |
in contrast to cisplatin, la-12 was a potent inducer of erk-mediated noxa and biml protein upregulation, and more effectively enhanced trail-induced apoptosis in the absence of bax. |
2015-07-09 |
2023-08-13 |
human |
| Jing Zhao, Shouzhu Xu, Fan Song, Lun Nian, Xuanxuan Zhou, Siwang Wan. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside protects human umbilical vein endothelial cells against lysophosphatidylcholine-induced apoptosis by upregulating superoxide dismutase and glutathione peroxidase. IUBMB life. vol 66. issue 10. 2015-07-09. PMID:25382724. |
lpc treated cells showed typical apoptotic morphological changes including cytoplasmic vacuolation, swollen mitochondria, and characteristic biochemical hallmarks of apoptosis including loss of mitochondrial membrane potential, activation of caspase-3, decrease of bcl-2, increase of parp-1, upregulation of bax, and release of cytochrome c, all of which were apparently inhibited by tsg pretreatment. |
2015-07-09 |
2023-08-13 |
human |
| Bo Zhai, Xian Jiang, Changjun He, Dali Zhao, Lixin Ma, Lishan Xu, Hongchi Jiang, Xueying Su. Arsenic trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular carcinoma by inhibiting Akt activation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 4. 2015-07-09. PMID:25416439. |
ato downregulated the expression of bcl-2 and bcl-xl and upregulated the expression of bax, indicating that ato could induce the apoptosis of hcc cells through the intrinsic pathways; but sorafenib showed little effects on these proteins of bcl-2 family. |
2015-07-09 |
2023-08-13 |
mouse |
| Wei Xu, Min Cheng, Yuanzhi Lao, Xiaoyu Wang, Jiangbin Wu, Lingli Zhou, Yaou Zhang, Hongxi Xu, Naihan X. DNA damage and ER stress contribute to oblongifolin C-induced cell killing in Bax/Bak-deficient cells. Biochemical and biophysical research communications. vol 457. issue 3. 2015-07-09. PMID:25576357. |
tumor cells deficient in both of the proapoptotic proteins bax and bak are protected against most chemotherapeutic drug-induced apoptosis. |
2015-07-09 |
2023-08-13 |
Not clear |
| Li-Juan Deng, Li-Ping Hu, Qun-Long Peng, Xiao-Lin Yang, Liang-Liang Bai, Anita Yiu, Yong Li, Hai-Yan Tian, Wen-Cai Ye, Dong-Mei Zhan. Hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Chemico-biological interactions. vol 219. 2015-07-08. PMID:24954031. |
it was also found that hellebrigenin induced mitochondrial apoptosis, characterized by bax translocation to mitochondria, disruption of mitochondrial membrane potential, release of cytochrome c into cytosol and sequential activation of caspases and parp. |
2015-07-08 |
2023-08-13 |
human |
| Yogeeta O Agrawal, Pankaj Kumar Sharma, Birendra Shrivastava, Dharamvir Singh Arya, Sameer N Goya. Hesperidin blunts streptozotocin-isoproternol induced myocardial toxicity in rats by altering of PPAR-γ receptor. Chemico-biological interactions. vol 219. 2015-07-08. PMID:24954035. |
in western blot analysis, bcl-2 and ppar-γ expression were decreased where as bax expression was significantly increased, suggesting role of apoptosis in myocardial dysfunction. |
2015-07-08 |
2023-08-13 |
rat |
| Evangelos Pazarentzos, Anne-Laure Mahul-Mellier, Christoph Datler, Wanwisa Chaisaklert, Ming-Shih Hwang, Jan Kroon, Ding Qize, Foy Osborne, Abdullah Al-Rubaish, Amein Al-Ali, Nicholas D Mazarakis, Eric O Aboagye, Stefan Grim. IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF-κB retention. The EMBO journal. vol 33. issue 23. 2015-07-08. PMID:25361605. |
at mitochondria, iκbα stabilises the complex of vdac1 and hexokinase ii (hkii), thereby preventing bax recruitment to vdac1 and the release of cytochrome c for apoptosis induction. |
2015-07-08 |
2023-08-13 |
Not clear |
| Yigang Chen, Jun Yan, Xiaohu Wang, Song Yu, Zigang Wang, Xiaonong Zhang, Shaoxiang Zhang, Yufeng Zheng, Changli Zhao, Qi Zhen. In vivo and in vitro evaluation of effects of Mg-6Zn alloy on apoptosis of common bile duct epithelial cell. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 27. issue 6. 2015-07-07. PMID:25106461. |
results of immunohistochemical staining also showed mg-6zn stents did not increase expression levels of apoptosis related gene such as bax, bcl-2, bax/bcl-2 ratio, tnf-α, nf-κb and caspase-3 in cbd, which indicating mg-6zn did not induce significant apoptosis in the in vivo experiments. |
2015-07-07 |
2023-08-13 |
mouse |
| b' Maja Jazvin\\xc5\\xa1\\xc4\\x87ak Jembrek, Josipa Vlaini\\xc4\\x87, Vedrana Radovanovi\\xc4\\x87, Julija Erhardt, Nada Or\\xc5\\xa1oli\\xc4\\x8. Effects of copper overload in P19 neurons: impairment of glutathione redox homeostasis and crosstalk between caspase and calpain protease systems in ROS-induced apoptosis. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 27. issue 6. 2015-07-07. PMID:25216733.' |
in a dose-dependent manner copper also provoked transcriptional changes of genes involved in intracellular signaling and induction of apoptosis (p53, c-fos, bcl-2 and bax). |
2015-07-07 |
2023-08-13 |
Not clear |
| G Grazia, C Vegetti, F Benigni, I Penna, V Perotti, E Tassi, I Bersani, G Nicolini, S Canevari, C Carlo-Stella, A M Gianni, R Mortarini, A Anichin. Synergistic anti-tumor activity and inhibition of angiogenesis by cotargeting of oncogenic and death receptor pathways in human melanoma. Cell death & disease. vol 5. 2015-07-07. PMID:25275595. |
mechanistically, synergy was explained by enhanced induction of caspase-dependent apoptosis, mitochondrial depolarization and modulation of key regulators of extrinsic and intrinsic cell death pathways, including c-flip, bim, bax, clusterin, mcl-1 and several iap family members. |
2015-07-07 |
2023-08-13 |
mouse |