| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-Ping Hsiao, Wan-Wen Lai, Shi-Bei Wu, Chung-Hung Tsai, Sheau-Chung Tang, Jing-Gung Chung, Jen-Hung Yan. Triggering apoptotic death of human epidermal keratinocytes by malic Acid: involvement of endoplasmic reticulum stress- and mitochondria-dependent signaling pathways. Toxins. vol 7. issue 1. 2015-09-14. PMID:25584429. |
the occurrence of apoptosis was proved by the increased expressions of fasl, fas, bax, bid, caspases-3, -8, -9, cytochrome c, and the declined expressions of bcl-2, parp. |
2015-09-14 |
2023-08-13 |
human |
| Leitao Wu, Haijun Dong, Jiao Zhao, Yuzhen Wang, Qianqian Yang, Chengming Jia, Jing M. Diosgenin stimulates rat TM4 cell proliferation through activating plasma membrane translocation and transcriptional activity of estrogen receptors. Biology of reproduction. vol 92. issue 1. 2015-09-11. PMID:25429088. |
diosgenin significantly inhibited apoptosis, as reflected by decreased percentage of tunel-positive cells; decreased expression of bax (bcl-2-associated x protein), aif (apoptosis-inducing factor), and cleaved caspases 3 and 9; and increased expression of bcl-2 (b-cell lymphoma 2). |
2015-09-11 |
2023-08-13 |
rat |
| Faiz-Ur Rahman, Amjad Ali, Rong Guo, Yun-Chang Zhang, Hui Wang, Zhan-Ting Li, Dan-Wei Zhan. Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt(II)(salicylaldiminato)(DMSO or Picolino)Cl complexes. Dalton transactions (Cambridge, England : 2003). vol 44. issue 5. 2015-09-11. PMID:25510629. |
mechanistically these complexes induced pro-apoptotic gene expression such as bax, puma and noxa and thereby enhanced apoptosis. |
2015-09-11 |
2023-08-13 |
human |
| J-J Guan, X-D Zhang, W Sun, L Qi, J-C Wu, Z-H Qi. DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX. Cell death & disease. vol 6. 2015-09-11. PMID:25633293. |
dram1 regulates apoptosis through increasing protein levels and lysosomal localization of bax. |
2015-09-11 |
2023-08-13 |
Not clear |
| J-J Guan, X-D Zhang, W Sun, L Qi, J-C Wu, Z-H Qi. DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX. Cell death & disease. vol 6. 2015-09-11. PMID:25633293. |
here we report a novel pathway by which dram1 regulates apoptosis involving bax and lysosomes. |
2015-09-11 |
2023-08-13 |
Not clear |
| J-J Guan, X-D Zhang, W Sun, L Qi, J-C Wu, Z-H Qi. DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX. Cell death & disease. vol 6. 2015-09-11. PMID:25633293. |
these results indicate that dram1 regulates apoptosis by inhibiting bax degradation. |
2015-09-11 |
2023-08-13 |
Not clear |
| Manjunath Ramanjaneya, Bee K Tan, Marcin Rucinski, Mohamed Kawan, Jiamiao Hu, Jaspreet Kaur, Vanlata H Patel, Ludwik K Malendowicz, Hanna Komarowska, Hendrik Lehnert, Harpal S Randev. Nesfatin-1 inhibits proliferation and enhances apoptosis of human adrenocortical H295R cells. The Journal of endocrinology. vol 226. issue 1. 2015-09-11. PMID:25869615. |
stimulation with nesfatin-1 inhibits the growth of h295r cells and promotes apoptosis, potentially via the involvement of bax, bcl-xl and bcl-2 genes as well as erk1/2, p38 and jnk1/2 signalling cascades. |
2015-09-11 |
2023-08-13 |
human |
| Chongshan Dai, Jichang Li, Shusheng Tang, Jian Li, Xilong Xia. Colistin-induced nephrotoxicity in mice involves the mitochondrial, death receptor, and endoplasmic reticulum pathways. Antimicrobial agents and chemotherapy. vol 58. issue 7. 2015-09-10. PMID:24798292. |
it was evident that colistin-induced apoptosis involved the mitochondrial pathway (downregulation of bcl-2 and upregulation of cytochrome c [cytc] and bax), death receptor pathway (upregulation of fas, fasl, and fas-associated death domain [fadd]), and endoplasmic reticulum pathway (upregulation of grp78/bip, atf6, gadd153/chop, and caspase-12). |
2015-09-10 |
2023-08-13 |
mouse |
| Zhiming Xiang, Fufa Qu, Fuxuan Wang, Shu Xiao, Li Jun, Yang Zhang, Ziniu Y. ChBax/Bak as key regulators of the mitochondrial apoptotic pathway: cloned and characterized in Crassostrea hongkongensis. Fish & shellfish immunology. vol 42. issue 2. 2015-09-10. PMID:25463302. |
the proteins bax and bak play critical roles in the mitochondrial apoptosis pathway and in determining cell fate. |
2015-09-10 |
2023-08-13 |
Not clear |
| Mitsuko Takenaga, Yuki Yamamoto, Tomoki Takeuchi, Yuki Ohta, Yukie Tokura, Akemi Hamaguchi, Daisuke Asai, Hideki Nakashima, Shinya Oishi, Nobutaka Fuji. Potential new chemotherapy strategy for human ovarian carcinoma with a novel KSP inhibitor. Biochemical and biophysical research communications. vol 463. issue 3. 2015-09-10. PMID:25998394. |
apoptosis after mitotic arrest was associated with an increase in the ratio of pro-apoptotic bax to anti-apoptotic bcl-2. |
2015-09-10 |
2023-08-13 |
human |
| Yue-Jun Fu, Jie Zhao, Ai-Hua Liang, Feng-Yun H. AcMNPV-mediated expression of BmK IT promotes the apoptosis of Sf9 cells and replication of AcMNPV. Sheng li xue bao : [Acta physiologica Sinica]. vol 67. issue 3. 2015-09-10. PMID:26109303. |
spodopter frugiperda 9 (sf9) cells were infected with acmnpv and acmnpv-bmk it respectively for 24 h. results from the mtt assay, tunel assay, analysis of the expression level of apoptosis-related proteins (c-myc, cleaved-caspase3, bcl-2 and bax) of sf9 cells, the transcription level of key genes (38k, c42, p78, f) of acmnpv, and viral propagation assay demonstrated that acmnpv-mediated expression of bmk it promoted the apoptosis of sf9 cells and replication of acmnpv. |
2015-09-10 |
2023-08-13 |
Not clear |
| Re: Ling Y-H, Lin R, and Perez-Soler R (2008) Erlotinib Induces Mitochondrial-Mediated Apoptosis in Human H3255 Non-Small-Cell Lung Cancer Cells with Epidermal Growth Factor ReceptorL858R Mutation through Mitochondrial Oxidative Phosphorylation-Dependent Activation of BAX and BAK Mol Pharmacol 74:793-806; doi:10.1124/mol.107.044396. Molecular pharmacology. vol 88. issue 2. 2015-09-10. PMID:26130290. |
re: ling y-h, lin r, and perez-soler r (2008) erlotinib induces mitochondrial-mediated apoptosis in human h3255 non-small-cell lung cancer cells with epidermal growth factor receptorl858r mutation through mitochondrial oxidative phosphorylation-dependent activation of bax and bak mol pharmacol 74:793-806; doi:10.1124/mol.107.044396. |
2015-09-10 |
2023-08-13 |
human |
| Yongbiao Zheng, Haiyue Pang, Jifeng Wang, Guowei Shi, Jianzhong Huan. New apoptosis-inducing sesquiterpenoids from the mycelial culture of Chinese edible fungus Pleurotus cystidiosus. Journal of agricultural and food chemistry. vol 63. issue 2. 2015-09-09. PMID:25537793. |
furthermore, pleuroton b (2) could trigger the apoptosis of du-145 cells through the detection of apoptosis cells using annexin v-fitc staining by flow cytometry, the observation of condensed nuclei in the apoptosis cells, and the western blot analysis for the expression of apoptosis-related proteins bcl-2, bak, and bax. |
2015-09-09 |
2023-08-13 |
human |
| Pei-Hua Li, Jin-Xia Wu, Jun-Nian Zheng, Dong-Sheng Pe. A sphingosine kinase-1 inhibitor, SKI-II, induces growth inhibition and apoptosis in human gastric cancer cells. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 23. 2015-09-09. PMID:25556479. |
after treatment with ski-ii, cell growth, cell cycle distribution, apoptosis, expression of sphk1, nf-κb, bcl-2, bax and p27 were assessed by mtt assay, flow cytometry, electron microscopy, immunocytochemistry and western-blot assay, respectively. |
2015-09-09 |
2023-08-13 |
human |
| Chen-Long Li, Liang Chang, Lin Guo, Dan Zhao, Hui-Bin Liu, Qiu-Shi Wang, Ping Zhang, Wen-Zhong Du, Xing Liu, Hai-Tao Zhang, Yang Liu, Yao Zhang, Jing-Hong Xie, Jian-Guang Ming, Yu-Qiong Cui, Ying Sun, Zhi-Ren Zhang, Chuan-Lu Jian. β-elemene induces caspase-dependent apoptosis in human glioma cells in vitro through the upregulation of Bax and Fas/ FasL and downregulation of Bcl-2. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 23. 2015-09-09. PMID:25556484. |
β-elemene induces caspase-dependent apoptosis in human glioma cells in vitro through the upregulation of bax and fas/ fasl and downregulation of bcl-2. |
2015-09-09 |
2023-08-13 |
human |
| Meng-Liang Lin, Shih-Shun Chen, Ren-Yu Huang, Yao-Cheng Lu, Yu-Ren Liao, Mopuru Vijaya Bhaskar Reddy, Chuan-Chun Lee, Tian-Shung W. Suppression of PI3K/Akt signaling by synthetic bichalcone analog TSWU-CD4 induces ER stress- and Bax/Bak-mediated apoptosis of cancer cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 11. 2015-09-04. PMID:25183449. |
using subcellular fractionation, the er calcium (ca(++)) channel inhibitor dantrolene and small interfering rna (sirna) against bax or bak, we show that the new synthetic bichalcone analog tswu-cd4 induces apoptosis in human cancer cells by releasing endoplasmic reticulum (er)-stored ca(++) through er/mitochondrial oligomerization of bax/bak. |
2015-09-04 |
2023-08-13 |
human |
| Yuan-Fei Liu, Yun-Min Lu, Guo-Qiang Qu, Yuan Liu, Wei-Xiong Chen, Xiao-Hong Liao, Wu-Ming Kon. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. International journal of molecular sciences. vol 16. issue 1. 2015-09-04. PMID:25588213. |
bcl-2 expression was down-regulated remarkably while bax expression and the active form of caspase-3 were increased after apoptosis occurred. |
2015-09-04 |
2023-08-13 |
Not clear |
| Chubiao Zhao, Guiqi Qin, Weijie Gao, Jingqin Chen, Hongyu Liu, Gaina Xi, Tan Li, Shengnan Wu, Tongsheng Che. Potent proapoptotic actions of dihydroartemisinin in gemcitabine-resistant A549 cells. Cellular signalling. vol 26. issue 10. 2015-09-02. PMID:25018064. |
more importantly, after treatment with dha, a549gr cells showed more potent induction in bax activation, loss of mitochondrial membrane potential (ΔΨm), caspase activation and apoptosis than a549 cells. |
2015-09-02 |
2023-08-13 |
Not clear |
| Chubiao Zhao, Guiqi Qin, Weijie Gao, Jingqin Chen, Hongyu Liu, Gaina Xi, Tan Li, Shengnan Wu, Tongsheng Che. Potent proapoptotic actions of dihydroartemisinin in gemcitabine-resistant A549 cells. Cellular signalling. vol 26. issue 10. 2015-09-02. PMID:25018064. |
furthermore, nac pretreatment potently prevented dha-induced ros generation and loss of ΔΨm as well as apoptosis, and silencing bax by shrna or inhibition of one of caspase-3, -8 and -9 also significantly prevented dha-induced apoptosis in both cell lines, indicating the key roles of ros and bax as well as the caspases. |
2015-09-02 |
2023-08-13 |
Not clear |
| Zhaohu Yuan, Huili Wang, Ziyou Hu, Yanqing Huang, Fang Yao, Shumei Sun, Bingyi W. Quercetin inhibits proliferation and drug resistance in KB/VCR oral cancer cells and enhances its sensitivity to vincristine. Nutrition and cancer. vol 67. issue 1. 2015-09-02. PMID:25514492. |
apoptosis analysis showed that quercetin at 50 or 100 μmol/l induced apoptosis of kb/vcr cells by suppressing expression of bax and inducing the expression of caspase-3 and bcl-2. |
2015-09-02 |
2023-08-13 |
Not clear |