| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingchun Wu, Ji Jia, Chong Lei, Ling Ji, Xiaodan Chen, Hanfei Sang, Lize Xion. Cannabinoid receptor CB1 is involved in nicotine-induced protection against Aβ1-42 neurotoxicity in HT22 cells. Journal of molecular neuroscience : MN. vol 55. issue 3. 2015-10-15. PMID:25262246. |
the apoptosis of ht22 cells was assessed by flow cytometry and expressions of bcl-2 and bax. |
2015-10-15 |
2023-08-13 |
Not clear |
| Vladislav Volarevic, Verica Paunovic, Zoran Markovic, Bojana Simovic Markovic, Maja Misirkic-Marjanovic, Biljana Todorovic-Markovic, Sanja Bojic, Ljubica Vucicevic, Svetlana Jovanovic, Nebojsa Arsenijevic, Ivanka Holclajtner-Antunovic, Momir Milosavljevic, Miroslav Dramicanin, Tamara Kravic-Stevovic, Darko Ciric, Miodrag L Lukic, Vladimir Trajkovi. Large graphene quantum dots alleviate immune-mediated liver damage. ACS nano. vol 8. issue 12. 2015-10-15. PMID:25415137. |
the cleavage of apoptotic markers caspase-3/parp and mrna levels of proapoptotic mediators puma, noxa, bax, bak1, bim, apaf1, and p21, as well as lc3-i conversion to autophagosome-associated lc3-ii and expression of autophagy-related (atg) genes atg4b, atg7, atg12, and beclin-1, were attenuated by gqds, indicating a decrease in both apoptosis and autophagy in the liver tissue. |
2015-10-15 |
2023-08-13 |
mouse |
| Wei Qian, Joseph Salamoun, Jingnan Wang, Vera Roginskaya, Bennett Van Houten, Peter Wip. The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak. Bioorganic & medicinal chemistry letters. vol 25. issue 4. 2015-10-15. PMID:25582599. |
the combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of bax and bak. |
2015-10-15 |
2023-08-13 |
Not clear |
| Wei Qian, Joseph Salamoun, Jingnan Wang, Vera Roginskaya, Bennett Van Houten, Peter Wip. The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak. Bioorganic & medicinal chemistry letters. vol 25. issue 4. 2015-10-15. PMID:25582599. |
the proapoptotic bcl-2 family proteins bax and bak are essential for cisplatin-induced apoptosis. |
2015-10-15 |
2023-08-13 |
Not clear |
| Fangfang Yang, Yang Yu, Qian Lei, Anqi Zeng, Yali Li, Yongmei Xie, TingHong Ye, Yuquan We. Lobaplatin arrests cell cycle progression, induces apoptosis and impairs migration and invasion in B16-F10 melanoma cell line in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 69. 2015-10-15. PMID:25661389. |
in addition, the apoptosis was associated with downregulation of anti-apoptotic protein bcl-2 while upregulation of pro-apoptotic protein bax. |
2015-10-15 |
2023-08-13 |
human |
| Ko-Chung Tsui, Tzu-Hsuan Chiang, Jinn-Shyan Wang, Li-Ju Lin, Wei-Chih Chao, Bing-Huei Chen, Jyh-Feng L. Flavonoids from Gynostemma pentaphyllum exhibit differential induction of cell cycle arrest in H460 and A549 cancer cells. Molecules (Basel, Switzerland). vol 19. issue 11. 2015-10-14. PMID:25365293. |
on the contrary, apoptosis and concomitant alteration in balance of bcl-2 and bax expression as well as activation of caspase-3 were equally affected between both cells by flavonoid treatment. |
2015-10-14 |
2023-08-13 |
Not clear |
| Minji Park, Yuri Choi, Hyeonhae Choi, Jaesook Ro. Wilms' tumor suppressor gene (WT1) suppresses apoptosis by transcriptionally downregulating BAX expression in immature rat granulosa cells. Journal of ovarian research. vol 7. 2015-10-13. PMID:25491731. |
wilms' tumor suppressor gene (wt1) suppresses apoptosis by transcriptionally downregulating bax expression in immature rat granulosa cells. |
2015-10-13 |
2023-08-13 |
rat |
| Bin Han, Ping Fu, Yun Ye, Hong Zhang, Guojun Wan. Protective effects of tetrandrine on brain cells in phenobarbital-dependent and -withdrawn rats. Molecular medicine reports. vol 11. issue 3. 2015-10-12. PMID:25434925. |
tet alleviates the phenobarbital withdrawal symptoms and protects the brain cells against apoptosis, which may be a result of the regulation of the mrna and protein expression levels of bcl‑2 and bax. |
2015-10-12 |
2023-08-13 |
rat |
| Xinhong Guo, Wenjiang Cao, Jiaming Yao, Yong Yuan, Ye Hong, Xinchun Wang, Jianguo Xin. Cardioprotective effects of tilianin in rat myocardial ischemia-reperfusion injury. Molecular medicine reports. vol 11. issue 3. 2015-10-09. PMID:25405380. |
notably, the administration of tilianin significantly inhibited apoptosis, as evidenced by an increase in bcl‑2 expression, and reductions in bax and caspase‑3 mrna expression levels (p<0.01 and p<0.05). |
2015-10-09 |
2023-08-13 |
mouse |
| Milan Zaric, Marina Mitrovic, Ivana Nikolic, Dejan Baskic, Suzana Popovic, Predrag Djurdjevic, Zoran Milosavljevic, Ivanka Zele. Chrysin induces apoptosis in peripheral blood lymphocytes isolated from human chronic lymphocytic leukemia. Anti-cancer agents in medicinal chemistry. vol 15. issue 2. 2015-10-06. PMID:25257897. |
our findings demonstrated that chrysin induces the activation of proapoptotic bax and decreases the expression of antiapoptotic bcl-2 protein, releases cytochrome c from mitochondria into cytosol and cleavages/activates caspase-3, subsequently leading to the activation of apoptosis of b-cll cells. |
2015-10-06 |
2023-08-13 |
human |
| Hong-Feng Zhang, Di Wu, Jian-Kuo Du, Yan Zhang, Yun-Ming S. Inhibitory effects of phenolic alkaloids of Menispermum dauricum on gastric cancer in vivo. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 24. 2015-10-06. PMID:25605184. |
pamd could suppress gastric tumor growth in vivo, possibly through inhibiting oncogenic k-ras, and induce cell apoptosis possibly by targeting the cell apoptosis-related genes of p53, bcl-2, bax, caspase-3. |
2015-10-06 |
2023-08-13 |
mouse |
| Yi-wen Tao, Yong-cheng Lin, Zhi-gang She, Min-ting Lin, Pin-xian Chen, Jian-ye Zhan. Anticancer activity and mechanism investigation of beauvericin isolated from secondary metabolites of the mangrove endophytic fungi. Anti-cancer agents in medicinal chemistry. vol 15. issue 2. 2015-10-06. PMID:25641103. |
additionally, regulation of bcl-2 or bax was not involved in the apoptosis induced by beauvericin in kb and kbv200 cells. |
2015-10-06 |
2023-08-13 |
Not clear |
| Swati Mandal, Ajeet Mandal, Myung Hee Par. Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N¹-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells. The Biochemical journal. vol 468. issue 3. 2015-10-06. PMID:25849284. |
apoptosis in the polyamine-depleted cells occurs by the mitochondrial intrinsic pathway, as evidenced by loss of mitochondrial membrane potential, increase in pro-apoptotic bax, decrease in anti-apoptotic bcl-xl, bcl2 and mcl-1 and release of cytochrome c from mitochondria, upon transduction with adsat1. |
2015-10-06 |
2023-08-13 |
human |
| Alessandra Ciucci, Gian Franco Zannoni, Daniele Travaglia, Giovanni Scambia, Daniela Gall. Mitochondrial estrogen receptor β2 drives antiapoptotic pathways in advanced serous ovarian cancer. Human pathology. vol 46. issue 8. 2015-10-06. PMID:26003478. |
this interaction, precluding the bcl-xl (b-cell lymphoma extra large)/bad heterodimer formation, inhibited bax (bcl-2-like protein 4) oligomerization, the release of cytochrome c, and ultimately apoptosis. |
2015-10-06 |
2023-08-13 |
Not clear |
| Yu Leng Phua, Jessica Y S Chu, April K Marrone, Andrew J Bodnar, Sunder Sims-Lucas, Jacqueline H. Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival. Physiological reports. vol 3. issue 10. 2015-10-06. PMID:26438731. |
although the initial lineage specification of foxd1(+) stroma was not perturbed, both the glomerular mesangium and renal interstitium exhibited ectopic apoptosis, which was associated with increased expression of bcl2l11 (bim) and p53 effector genes (bax, trp53inp1, jun, cdkn1a, mmp2, and arid3a). |
2015-10-06 |
2023-08-13 |
mouse |
| Longchuan Bai, Jianfang Chen, Donna McEachern, Liu Liu, Haibin Zhou, Angelo Aguilar, Shaomeng Wan. BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo. PloS one. vol 9. issue 6. 2015-10-05. PMID:24901320. |
mechanistic studies performed in the mcl-1 knockout mouse embryonic fibroblast (mef) cells revealed that bm-1197 potently disassociates the heterodimeric interactions between anti-apoptotic and pro-apoptotic bcl-2 family proteins, concomitant with conformational changes in bax protein, loss of mitochondrial membrane potential and subsequent cytochrome c release to the cytosol, leading to activation of the caspase cascade and apoptosis. |
2015-10-05 |
2023-08-13 |
mouse |
| Bin Fu, Yibing Wang, Xiali Zhang, Bin Lang, Xiaocheng Zhou, Xiaoyuan Xu, Tao Zeng, Weipeng Liu, Xu Zhang, Ju Guo, Gongxian Wan. MiR-221-induced PUMA silencing mediates immune evasion of bladder cancer cells. International journal of oncology. vol 46. issue 3. 2015-10-05. PMID:25585941. |
as a result, the repression of mir‑221 on p53 upregulated modulator of apoptosis (puma) was abolished, resulting in increased expression of the pro-apoptotic bax and reduced expression of the anti-apoptotic bcl-2, which promotes apoptosis of bladder cancer cells. |
2015-10-05 |
2023-08-13 |
Not clear |
| Laura A Gillies, Han Du, Bjoern Peters, C Michael Knudson, Donald D Newmeyer, Tomomi Kuwan. Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes. Molecular biology of the cell. vol 26. issue 2. 2015-10-02. PMID:25411335. |
bax induces mitochondrial outer membrane permeabilization (momp), a critical step in apoptosis in which proteins are released into the cytoplasm. |
2015-10-02 |
2023-08-13 |
Not clear |
| Chia-Jung Tsai, Sophia Liu, Chien-Lun Hung, Siao-Ru Jhong, Tai-Ching Sung, Yun-Wei Chian. BAX-induced apoptosis can be initiated through a conformational selection mechanism. Structure (London, England : 1993). vol 23. issue 1. 2015-10-01. PMID:25497728. |
bax protein plays a key role in the mitochondria-mediated apoptosis. |
2015-10-01 |
2023-08-13 |
Not clear |
| Chia-Jung Tsai, Sophia Liu, Chien-Lun Hung, Siao-Ru Jhong, Tai-Ching Sung, Yun-Wei Chian. BAX-induced apoptosis can be initiated through a conformational selection mechanism. Structure (London, England : 1993). vol 23. issue 1. 2015-10-01. PMID:25497728. |
however, it remains unclear by what mechanism bax is triggered to initiate apoptosis. |
2015-10-01 |
2023-08-13 |
Not clear |