| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Radogna, M C Albertini, M De Nicola, M Diederich, I Bejarano, L Ghibell. Melatonin promotes Bax sequestration to mitochondria reducing cell susceptibility to apoptosis via the lipoxygenase metabolite 5-hydroxyeicosatetraenoic acid. Mitochondrion. vol 21. 2015-11-20. PMID:25702644. |
melatonin promotes bax sequestration to mitochondria reducing cell susceptibility to apoptosis via the lipoxygenase metabolite 5-hydroxyeicosatetraenoic acid. |
2015-11-20 |
2023-08-13 |
Not clear |
| F Radogna, M C Albertini, M De Nicola, M Diederich, I Bejarano, L Ghibell. Melatonin promotes Bax sequestration to mitochondria reducing cell susceptibility to apoptosis via the lipoxygenase metabolite 5-hydroxyeicosatetraenoic acid. Mitochondrion. vol 21. 2015-11-20. PMID:25702644. |
here we show that bcl-2 sequesters pro-apoptotic bax into mitochondria in an inactive form after melatonin treatment, thus reducing cell propensity to apoptosis. |
2015-11-20 |
2023-08-13 |
Not clear |
| Carmela Fimognari, Eleonora Turrini, Piero Sestili, Cinzia Calcabrini, Giovanni Carulli, Giulia Fontanelli, Martina Rousseau, Giorgio Cantelli-Forti, Patrizia Hreli. Antileukemic activity of sulforaphane in primary blasts from patients affected by myelo- and lympho-proliferative disorders and in hypoxic conditions. PloS one. vol 9. issue 7. 2015-11-17. PMID:25019218. |
as to its cytotoxic mechanism, we found that sulforaphane creates an oxidative cellular environment that induces dna damage and bax and p53 gene activation, which in turn helps trigger apoptosis. |
2015-11-17 |
2023-08-13 |
Not clear |
| Xianhong Ou, You Lu, Liufeng Liao, Danni Li, Limin Liu, Huagang Liu, Heng X. Nitidine chloride induces apoptosis in human hepatocellular carcinoma cells through a pathway involving p53, p21, Bax and Bcl-2. Oncology reports. vol 33. issue 3. 2015-11-17. PMID:25530218. |
nitidine chloride induces apoptosis in human hepatocellular carcinoma cells through a pathway involving p53, p21, bax and bcl-2. |
2015-11-17 |
2023-08-13 |
mouse |
| Xianhong Ou, You Lu, Liufeng Liao, Danni Li, Limin Liu, Huagang Liu, Heng X. Nitidine chloride induces apoptosis in human hepatocellular carcinoma cells through a pathway involving p53, p21, Bax and Bcl-2. Oncology reports. vol 33. issue 3. 2015-11-17. PMID:25530218. |
these data elucidate a pathway of apoptosis in smmc‑7721 cells that involves g2/m arrest, upregulation of p53, bax, caspase-3 and p21, and downregulation of bcl-2. |
2015-11-17 |
2023-08-13 |
mouse |
| Shagun Arora, Simran Tando. Achyranthes aspera root extracts induce human colon cancer cell (COLO-205) death by triggering the mitochondrial apoptosis pathway and S phase cell cycle arrest. TheScientificWorldJournal. vol 2014. 2015-11-16. PMID:25401123. |
mechanisms leading to apoptosis and cell cycle arrest were also investigated by expression studies of caspase-9, caspase-3, bax, bcl-2, p16, p21, and p27 genes, followed by flow cytometric analysis for cell cycle distribution. |
2015-11-16 |
2023-08-13 |
human |
| Chung-Ming Lin, Wei-Chien Kao, Chun-An Yeh, Hui-Jye Chen, Shinn-Zong Lin, Hsien-Hsu Hsieh, Wei-Shen Sun, Chih-Hsuan Chang, Huey-Shan Hun. Hyaluronic acid-fabricated nanogold delivery of the inhibitor of apoptosis protein-2 siRNAs inhibits benzo[a]pyrene-induced oncogenic properties of lung cancer A549 cells. Nanotechnology. vol 26. issue 10. 2015-11-16. PMID:25693888. |
incubation of bap-challenged cells with aunp-ha-iap-2 sirnas silenced the expression of iap-2, decreased cell proliferation and triggered pronounced cell apoptosis by the decrease in bcl-2 protein and the increase in bax protein as well as the active form of caspases-3. |
2015-11-16 |
2023-08-13 |
Not clear |
| Yuhui Hao, Jiawei Huang, Ying Gu, Cong Liu, Hong Li, Jing Liu, Jiong Ren, Zhangyou Yang, Shuangqing Peng, Weidong Wang, Rong L. Metallothionein deficiency aggravates depleted uranium-induced nephrotoxicity. Toxicology and applied pharmacology. vol 287. issue 3. 2015-11-16. PMID:26148447. |
the apoptosis rate in mt-/- mice significantly increased, with a significant increase in both bax and caspase 3 and a decrease in bcl-2. |
2015-11-16 |
2023-08-13 |
mouse |
| Bidya Dhar Sahu, Madhusudana Kuncha, Shyam Sunder Rachamalla, Ramakrishna Sistl. Lagerstroemia speciosa L. attenuates apoptosis in isoproterenol-induced cardiotoxic mice by inhibiting oxidative stress: possible role of Nrf2/HO-1. Cardiovascular toxicology. vol 15. issue 1. 2015-11-12. PMID:24853613. |
cardiac tissue was examined for lipid peroxidation, protein carbonyl content, antioxidant (gsh, gr, gpx, gst, sod, cat, nqo1, and ho-1), and apoptosis (cleaved caspase-3, bax, bcl-2, p53, and dna fragmentation) status. |
2015-11-12 |
2023-08-13 |
mouse |
| Muhammad Imran Naseer, Ikram Ullah, Mahmood Rasool, Shakeel Ahmed Ansari, Ishfaq Ahmed Sheikh, Fehmida Bibi, Adeel Gulzar Chaudhary, Mohammed H Al-Qahtani, Myeong Ok Ki. Downregulation of dopamine D₁ receptors and increased neuronal apoptosis upon ethanol and PTZ exposure in prenatal rat cortical and hippocampal neurons. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 11. 2015-11-10. PMID:24810836. |
the results of present study showed that ethanol and ptz exposure significantly decreased d1r expression and induced neuronal death by significantly increasing the expression of pro-apoptotic bax, bak and decreasing anti-apoptotic protein bcl-2 leading to the apoptosis by increasing cleaved caspase-3 expression in cortical and hippocampal primary neuronal cell cultures. |
2015-11-10 |
2023-08-13 |
rat |
| Liming Chen, Yinghui Liu, Liangliang Dong, Xiaoxia Ch. Edaravone protects human peripheral blood lymphocytes from γ-irradiation-induced apoptosis and DNA damage. Cell stress & chaperones. vol 20. issue 2. 2015-11-10. PMID:25181965. |
importantly, we also report that edaravone reduced γ-irradiation-induced apoptosis through downregulation of bax, upregulation of bcl-2, and consequent reduction of the bax:bcl-2 ratio. |
2015-11-10 |
2023-08-13 |
human |
| Lelin Bing, Junfeng Wu, Jianfeng Zhang, Yinghui Chen, Zhen Hong, Hengbing Z. DHT inhibits the Aβ25-35-induced apoptosis by regulation of seladin-1, survivin, XIAP, bax, and bcl-xl expression through a rapid PI3-K/Akt signaling in C6 glial cell lines. Neurochemical research. vol 40. issue 1. 2015-11-10. PMID:25347962. |
dht inhibits the aβ25-35-induced apoptosis by regulation of seladin-1, survivin, xiap, bax, and bcl-xl expression through a rapid pi3-k/akt signaling in c6 glial cell lines. |
2015-11-10 |
2023-08-13 |
Not clear |
| Lelin Bing, Junfeng Wu, Jianfeng Zhang, Yinghui Chen, Zhen Hong, Hengbing Z. DHT inhibits the Aβ25-35-induced apoptosis by regulation of seladin-1, survivin, XIAP, bax, and bcl-xl expression through a rapid PI3-K/Akt signaling in C6 glial cell lines. Neurochemical research. vol 40. issue 1. 2015-11-10. PMID:25347962. |
collectively, in a c6 glial cell model, we firstly found that dht inhibits aβ25-35-induced apoptosis by a rapid nongenic pi-3k/akt activation as well as regulation of seladin-1, survivin, xiap, bcl-xl, and bax proteins. |
2015-11-10 |
2023-08-13 |
Not clear |
| Xiali Zhang, Hongfei Lu, Yibing Wang, Chunju Liu, Weifeng Zhu, Shuangyan Zheng, Fusheng Wa. Taurine induces the apoptosis of breast cancer cells by regulating apoptosis-related proteins of mitochondria. International journal of molecular medicine. vol 35. issue 1. 2015-11-09. PMID:25395275. |
reverse transcription-polymerase chain reaction and western blot analysis were used to detect the levels of mrna and proteins of p53-upregulated modulator of apoptosis (puma), bax and bcl-2. |
2015-11-09 |
2023-08-13 |
mouse |
| Xiali Zhang, Hongfei Lu, Yibing Wang, Chunju Liu, Weifeng Zhu, Shuangyan Zheng, Fusheng Wa. Taurine induces the apoptosis of breast cancer cells by regulating apoptosis-related proteins of mitochondria. International journal of molecular medicine. vol 35. issue 1. 2015-11-09. PMID:25395275. |
further studies showed that tau promoted apoptosis in human breast cancer cells and inhibited the growth of tumor in nude mice by inducing the expression of puma, which further up- and downregulated the expression of bax and bcl-2 protein, giving rise to increased activation of caspase-3. |
2015-11-09 |
2023-08-13 |
mouse |
| Yan Chen, Jinping Liu, Shoujun Li, Fuxia Yan, Qinghua Xue, Huiying Wang, Peng Sun, Cun Lon. Histidine-tryptophan-ketoglutarate solution with added ebselen augments myocardial protection in neonatal porcine hearts undergoing ischemia/reperfusion. Artificial organs. vol 39. issue 2. 2015-11-09. PMID:25511318. |
myocardial antioxidant activities, myocytes apoptosis and mitochondrial structures, as well as the release of cytochrome c and the expression of bax, bcl-2, and hsp72 protein in myocardium were measured. |
2015-11-09 |
2023-08-13 |
Not clear |
| Yongjun Wang, Jianzhen Liu, Airui Ma, Yanqiang Che. Cardioprotective effect of berberine against myocardial ischemia/reperfusion injury via attenuating mitochondrial dysfunction and apoptosis. International journal of clinical and experimental medicine. vol 8. issue 8. 2015-11-09. PMID:26550442. |
berberine up-regulates the expression of bcl-2 and mitochondrial cytochrome c and down-regulates the expression of bax and cytosolic cytochrome c. in conclusion, berberine protects the heart from ischemia/reperfusion injury via attenuating mitochondrial dysfunction and myocardial apoptosis. |
2015-11-09 |
2023-08-13 |
rat |
| H Ma, J X Ma, P Xue, Y Gao, Y K L. Osteoblast proliferation is enhanced upon the insulin receptor substrate 1 overexpression via PI3K signaling leading to down-regulation of NFκB and BAX pathway. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 123. issue 2. 2015-11-05. PMID:25372512. |
the nfκb signaling pathway leads to increased expression of bax, which contributes to osteoblast apoptosis. |
2015-11-05 |
2023-08-13 |
Not clear |
| Yao Yu, Yu Yang, Jing Wan. Anti-apoptotic and apoptotic pathway analysis of arsenic trioxide‑induced apoptosis in human gastric cancer SGC-7901 cells. Oncology reports. vol 32. issue 3. 2015-11-03. PMID:24969414. |
the protein expression patterns of the apoptosis factors, bax, fas and caspase-8, and anti-apoptosis factors, akt, p-akt, mtor and p-mtor, were evaluated by western blot analysis following treatment of the cells with different as2o3 concentrations in the cell growth media for 48 h. |
2015-11-03 |
2023-08-13 |
human |
| Tomoaki Nagasawa, Rie Matsushima-Nishiwaki, Hidenori Toyoda, Junya Matsuura, Takashi Kumada, Osamu Kozaw. Heat shock protein 20 (HSPB6) regulates apoptosis in human hepatocellular carcinoma cells: Direct association with Bax. Oncology reports. vol 32. issue 3. 2015-11-03. PMID:24969689. |
heat shock protein 20 (hspb6) regulates apoptosis in human hepatocellular carcinoma cells: direct association with bax. |
2015-11-03 |
2023-08-13 |
human |