| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meiguo Xin, Rui Li, Maohua Xie, Dongkyoo Park, Taofeek K Owonikoko, Gabriel L Sica, Patrick E Corsino, Jia Zhou, Chunyong Ding, Mark A White, Andrew T Magis, Suresh S Ramalingam, Walter J Curran, Fadlo R Khuri, Xingming Den. Small-molecule Bax agonists for cancer therapy. Nature communications. vol 5. 2015-12-17. PMID:25230299. |
bax, a central death regulator, is required at the decisional stage of apoptosis. |
2015-12-17 |
2023-08-13 |
human |
| Meiguo Xin, Rui Li, Maohua Xie, Dongkyoo Park, Taofeek K Owonikoko, Gabriel L Sica, Patrick E Corsino, Jia Zhou, Chunyong Ding, Mark A White, Andrew T Magis, Suresh S Ramalingam, Walter J Curran, Fadlo R Khuri, Xingming Den. Small-molecule Bax agonists for cancer therapy. Nature communications. vol 5. 2015-12-17. PMID:25230299. |
smba1 potently suppresses lung tumour growth via apoptosis by selectively activating bax in vivo without significant normal tissue toxicity. |
2015-12-17 |
2023-08-13 |
human |
| Kai-Ti Chang, Andriy Anishkin, Gauri A Patwardhan, Levi J Beverly, Leah J Siskind, Marco Colombin. Ceramide channels: destabilization by Bcl-xL and role in apoptosis. Biochimica et biophysica acta. vol 1848. issue 10 Pt A. 2015-12-17. PMID:26215742. |
weakening the inhibition of either bax or ceramide channels decreased the ability of bcl-xl to protect cells from apoptosis in a stimulus-dependent manner. |
2015-12-17 |
2023-08-13 |
Not clear |
| Ai-guo Yan, Jian-xun Liu, Xin-zhi Li, Xiao-xia Dong, Hong-kun L. [Effect of Gualou Xiebai Banxia decoction combined with Xuefu Zhuyu decoction on myocardial apoptosis and relevant protein expressions in miniature swine phlegm and blood stasis type coronary heart disease model]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 11. 2015-12-17. PMID:26552176. |
in this experiment, gualou xiebai banxia decoction combined with-xuefu zhuyu decoction were used to intervene the miniature swine phlegm and blood stasis type coronary heart disease model, in order to observe the effect of the combined prescription on the myocardial apoptosis and the expressions of bcl-2, bax, caspase-3, caspase-9 in the model. |
2015-12-17 |
2023-08-13 |
Not clear |
| Raktim Biswas, Phil-Sang Chung, Jeong Hwan Moon, Seung-Ha Lee, Jin-Chul Ah. Carboplatin synergistically triggers the efficacy of photodynamic therapy via caspase 3-, 8-, and 12-dependent pathways in human anaplastic thyroid cancer cells. Lasers in medical science. vol 29. issue 3. 2015-12-15. PMID:24114422. |
several parameters like cytotoxicity assay by mtt, apoptosis study by annexin v and propidium iodide, cell cycle analysis by flow cytometry, confocal microscopic study, and western blot analysis for different apoptosis-related proteins like bax, cytochrome c, caspases 3, 9, 8, and 12, etc. |
2015-12-15 |
2023-08-12 |
human |
| Zhenbiao Wu, Emily Y He, Glenda I Scott, Jun Re. α,β-Unsaturated aldehyde pollutant acrolein suppresses cardiomyocyte contractile function: Role of TRPV1 and oxidative stress. Environmental toxicology. vol 30. issue 6. 2015-12-15. PMID:24376112. |
however, the acrolein-induced cardiomyocyte contractile and intracellular ca(2+) anomalies, as well as apoptosis (as evidenced by bcl-2, bax, fasl, caspase-3 and -8), were negated by the reactive oxygen species (ros) scavenger glutathione or the trpv1 antagonist capsazepine. |
2015-12-15 |
2023-08-12 |
Not clear |
| Zhuo Wang, Xiaohong Pan, Dan Wang, Hongliu Sun, Fang Han, Changjun Lv, Xiuli Zhan. Protective effects of protocatechuic acid on retinal ganglion cells from oxidative damage induced by H2O2. Neurological research. vol 37. issue 2. 2015-12-15. PMID:25029628. |
the possible protective mechanism was investigated via detecting apoptosis by hoechst staining, bcl-2 and bax protein levels by elisa, caspase-3 activation and membrane potential by immunofluorescence, and caspase-3 mrna expression by polymerase chain reaction (pcr) method. |
2015-12-15 |
2023-08-13 |
Not clear |
| Manasa K Nayak, Ayusman Dash, Nitesh Singh, Debabrata Das. Aspirin delimits platelet life span by proteasomal inhibition. PloS one. vol 9. issue 8. 2015-12-15. PMID:25126950. |
aspirin-treated human platelets were found to be phagocytosed more efficiently by macrophages, associated with attenuation in platelet proteasomal activity and upregulation of conformationally active bax, which were consistent with enhanced platelet apoptosis. |
2015-12-15 |
2023-08-13 |
mouse |
| Chun-Mei Yan, Er-Qing Chai, Hong-Yi Cai, Guo-Ying Miao, Wen M. Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol 3-kinase/protein kinase B pathway in HepG2 human hepatoma cell line. Molecular medicine reports. vol 11. issue 6. 2015-12-15. PMID:25634350. |
proapoptotic bcl‑2 family members, bax and bcl‑2, were involved in oleuropein‑induced apoptosis. |
2015-12-15 |
2023-08-13 |
human |
| Zhouqing Huang, Bozhi Ye, Zhenyu Dai, Xinlei Wu, Zhongqiu Lu, Peiren Shan, Weijian Huan. Curcumin inhibits autophagy and apoptosis in hypoxia/reoxygenation-induced myocytes. Molecular medicine reports. vol 11. issue 6. 2015-12-15. PMID:25673156. |
these findings suggested that the protective effect of curcumin against h/r injury in the h9c2 myocytes was through the inhibition of apoptosis and autophagy by inducing the expression of bcl‑2 and inhibiting the expression levels of bax, beclin‑1, bnip3 and sirt1. |
2015-12-15 |
2023-08-13 |
Not clear |
| Qian Xiao, Yeting Hu, Yue Liu, Zhanhuai Wang, Haitao Geng, Lifeng Hu, Dengyong Xu, Ke Wang, Lei Zheng, Shu Zheng, Kefeng Din. BEX1 promotes imatinib-induced apoptosis by binding to and antagonizing BCL-2. PloS one. vol 9. issue 3. 2015-12-14. PMID:24626299. |
furthermore, we demonstrated that the interaction between bcl-2 and bex1 promotes imatinib-induced apoptosis by suppressing the formation of anti-apoptotic bcl-2/bcl-2-associated x protein (bax) heterodimers. |
2015-12-14 |
2023-08-12 |
Not clear |
| Chun Huang, Xuan Wang, Baocun Sun, Man Li, Xiulan Zhao, Yanjun Gu, Yanfen Cui, Yan L. Study on mouse model of triple-negative breast cancer: association between higher parity and triple-negative breast cancer. Targeted oncology. vol 10. issue 1. 2015-12-09. PMID:24838619. |
immunohistochemistry revealed increased cell proliferation and apoptosis were related with upregulation of erα, pr, bcl-2, bax, caspase-3, and caspase-9 expression, especially during the fourth pregnancy. |
2015-12-09 |
2023-08-13 |
mouse |
| Hee-Seong Jang, Babu J Padanila. Simultaneous deletion of Bax and Bak is required to prevent apoptosis and interstitial fibrosis in obstructive nephropathy. American journal of physiology. Renal physiology. vol 309. issue 6. 2015-12-08. PMID:26180237. |
simultaneous deletion of bax and bak is required to prevent apoptosis and interstitial fibrosis in obstructive nephropathy. |
2015-12-08 |
2023-08-13 |
mouse |
| Hee-Seong Jang, Babu J Padanila. Simultaneous deletion of Bax and Bak is required to prevent apoptosis and interstitial fibrosis in obstructive nephropathy. American journal of physiology. Renal physiology. vol 309. issue 6. 2015-12-08. PMID:26180237. |
dual deficiency of bax and bak inhibited tubular apoptosis and atrophy. |
2015-12-08 |
2023-08-13 |
mouse |
| Hee-Seong Jang, Babu J Padanila. Simultaneous deletion of Bax and Bak is required to prevent apoptosis and interstitial fibrosis in obstructive nephropathy. American journal of physiology. Renal physiology. vol 309. issue 6. 2015-12-08. PMID:26180237. |
bax or bak deficiency was insufficient to prevent apoptosis and all other aforementioned malevolent effects, suggesting compensatory mediation by each other in the respective signaling pathways. |
2015-12-08 |
2023-08-13 |
mouse |
| Hee-Seong Jang, Babu J Padanila. Simultaneous deletion of Bax and Bak is required to prevent apoptosis and interstitial fibrosis in obstructive nephropathy. American journal of physiology. Renal physiology. vol 309. issue 6. 2015-12-08. PMID:26180237. |
these data suggest that dual ablation of bax and bak in the kidney is required to prevent uuo-induced tubular apoptosis and the consequent kidney inflammation and fibrosis. |
2015-12-08 |
2023-08-13 |
mouse |
| Shou-Li Sun, Li Guo, Ya-Chao Ren, Bing Wang, Rong-Hui Li, Yu-Shan Qi, Hui Yu, Nai-Dan Chang, Ming-Hui Li, Hai-Sheng Pen. Anti-apoptosis effect of polysaccharide isolated from the seeds of Cuscuta chinensis Lam on cardiomyocytes in aging rats. Molecular biology reports. vol 41. issue 9. 2015-12-07. PMID:24972571. |
caspase-3 and cyt c were determined by fluorescence spectrometer, the apoptosis rate was assessed by annexinv-fitc method by flow-cytometry, [ca(2+)]i and [ca(2+)]i overloaded by kcl were observed by laser scanning confocal microscopy (lscm); bcl-2 and bax were examined by immunohistochemistry. |
2015-12-07 |
2023-08-13 |
rat |
| Shou-Li Sun, Li Guo, Ya-Chao Ren, Bing Wang, Rong-Hui Li, Yu-Shan Qi, Hui Yu, Nai-Dan Chang, Ming-Hui Li, Hai-Sheng Pen. Anti-apoptosis effect of polysaccharide isolated from the seeds of Cuscuta chinensis Lam on cardiomyocytes in aging rats. Molecular biology reports. vol 41. issue 9. 2015-12-07. PMID:24972571. |
on the other hand, the content of cyt c, [ca(2+)]i of cardiomyocytes, the activity of caspase-3 and apoptosis rate, as well as bax expression level in all three pccl groups were decreased compared to galactose induced group (p < 0.05). |
2015-12-07 |
2023-08-13 |
rat |
| Nonkululeko N Mthembu, Lesetja Raymond Motad. Apoptotic potential role of Agave palmeri and Tulbaghia violacea extracts in cervical cancer cells. Molecular biology reports. vol 41. issue 9. 2015-12-07. PMID:24993114. |
to achieve this, ag and tv crude extracts were utilized to screen for apoptosis induction, inhibition of cell proliferation followed by elucidation of the role of bax, bcl-2, p53, rb, rbbp and mdm2 genes in cervical cancer. |
2015-12-07 |
2023-08-13 |
mouse |
| Jiangyan Wang, Yu'an Xie, Yan Feng, Litu Zhang, Xinping Huang, Xiaoyun Shen, Xiaoling Lu. (-)-Epigallocatechingallate induces apoptosis in B lymphoma cells via caspase-dependent pathway and Bcl-2 family protein modulation. International journal of oncology. vol 46. issue 4. 2015-12-07. PMID:25647297. |
cell proliferation and cytotoxicity were determined by the cell counting kit (cck-8) assay; apoptosis was assessed by flow cytometry using the annexin v-pe/7aad double staining; fas, bcl-2 and bax mrna expression levels were determined by real-time pcr; caspase activity was measured by the caspase activity assay kit; the expression levels of apoptosis-associated proteins were determined by western blot analysis. |
2015-12-07 |
2023-08-13 |
Not clear |