| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Hong Zhang, Xian-Xiang Xu, Tao X. Ginsenoside Ro suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-κB. Chinese journal of natural medicines. vol 13. issue 4. 2016-01-12. PMID:25908625. |
ro could suppress il-1β-induced apoptosis by inhibiting levels of bax and bad, decreasing p53 phosphorylation and promoting the expression of bcl-xl and pcna. |
2016-01-12 |
2023-08-13 |
rat |
| Cheuk-Kwan Sun, Fan-Yen Lee, Ying-Hsien Kao, Hsin-Ju Chiang, Pei-Hsun Sung, Tzu-Hsien Tsai, Yu-Chun Lin, Steve Leu, Ying-Chung Wu, Hung-I Lu, Yung-Lung Chen, Sheng-Ying Chung, Hong-Lin Su, Hon-Kan Yi. Systemic combined melatonin-mitochondria treatment improves acute respiratory distress syndrome in the rat. Journal of pineal research. vol 58. issue 2. 2016-01-11. PMID:25491480. |
protein expression of indices of inflammation (mmp-9, tnf-α, nf-κb), oxidative stress (oxidized protein, no-1, nox-2, nox-4), apoptosis (mitochondrial bax, cleaved caspase-3, and parp), fibrosis (smad3, tgf-β), mitochondrial damage (cytochrome c), and dna damage (γ-h2ax+) exhibited an opposite pattern compared to sao2 in all groups, whereas protein (ho-1, nqo-1, gr, gpx) and cellular (ho-1+) expressions of antioxidants exhibited a progressively increased pattern from normal controls to ards combined melatonin-mitochondria group (all p < 0.001). |
2016-01-11 |
2023-08-13 |
rat |
| Xiaolong Gu, Tariq Ali, Rongrong Chen, Guoliang Hu, Yu Zhuang, Junrong Luo, Huabin Cao, Bo Ha. In vivo studies of molybdenum-induced apoptosis in kidney cells of caprine. Biological trace element research. vol 165. issue 1. 2016-01-11. PMID:25627418. |
kidney tissues were taken from individual goat at days 0, 25, and 50 for determining expression of apoptosis genes including bax, bcl-2, cyt c, caspase-3, and smac. |
2016-01-11 |
2023-08-13 |
human |
| Jin Meng, Feng Zhang, Xu-Tao Zhang, Tao Zhang, Yu-Hua Li, Lei Fan, Yang Sun, He-Long Zhang, Qi-Bing Me. Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis. Molecular medicine reports. vol 12. issue 1. 2016-01-11. PMID:25695595. |
it was previously reported that the histone deacetylase inhibitor (hdaci) trichostatin a (tsa) induced b cell lymphoma 2 (bcl-2)-associated x protein (bax)-dependent apoptosis in colorectal cancer (crc) cells. |
2016-01-11 |
2023-08-13 |
Not clear |
| Jin Meng, Feng Zhang, Xu-Tao Zhang, Tao Zhang, Yu-Hua Li, Lei Fan, Yang Sun, He-Long Zhang, Qi-Bing Me. Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis. Molecular medicine reports. vol 12. issue 1. 2016-01-11. PMID:25695595. |
in addition, ku70 has been identified as a regulator of apoptosis, the mechanism of which proceeds via interacting with bax. |
2016-01-11 |
2023-08-13 |
Not clear |
| Jin Meng, Feng Zhang, Xu-Tao Zhang, Tao Zhang, Yu-Hua Li, Lei Fan, Yang Sun, He-Long Zhang, Qi-Bing Me. Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis. Molecular medicine reports. vol 12. issue 1. 2016-01-11. PMID:25695595. |
furthermore, knockdown of ku70 using small interfering rna decreased tsa-induced apoptosis as well as downregulated the expression of bax. |
2016-01-11 |
2023-08-13 |
Not clear |
| Jin Meng, Feng Zhang, Xu-Tao Zhang, Tao Zhang, Yu-Hua Li, Lei Fan, Yang Sun, He-Long Zhang, Qi-Bing Me. Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis. Molecular medicine reports. vol 12. issue 1. 2016-01-11. PMID:25695595. |
in addition, ku70 was found to be indispensable in tsa-induced apoptosis due to its role in protecting bax from proteosomal degradation. |
2016-01-11 |
2023-08-13 |
Not clear |
| Małgorzata Latocha, Andrzej Zięba, Renata Polaniak, Dariusz Kuśmierz, Ada Nowosad, Magdalena Jurzak, Ewa Romuk, Mirosława Kokocińska, Elektra Sliupkas-Dyrd. MOLECULAR EFFECTS OF AMINE DERIVATIVES OF PHENOTHIAZINE ON CANCER CELLS C-32 AND SNB-19 IN VITRO. Acta poloniae pharmaceutica. vol 72. issue 5. 2016-01-11. PMID:26665397. |
cell cycle regulatory genes expression (tp53 and cdkn1a), s-phase marker--h3 gene and intracellular apoptosis pathway genes (bax, bcl-2) were analyzed using rt-qpcr method. |
2016-01-11 |
2023-08-13 |
Not clear |
| Małgorzata Latocha, Andrzej Zięba, Renata Polaniak, Dariusz Kuśmierz, Ada Nowosad, Magdalena Jurzak, Ewa Romuk, Mirosława Kokocińska, Elektra Sliupkas-Dyrd. MOLECULAR EFFECTS OF AMINE DERIVATIVES OF PHENOTHIAZINE ON CANCER CELLS C-32 AND SNB-19 IN VITRO. Acta poloniae pharmaceutica. vol 72. issue 5. 2016-01-11. PMID:26665397. |
cell cycle regulatory genes (tp53, cdkn1a) expression and protein products of genes involved in mitochondial apoptosis pathway (bax, bcl-2) expression are changed by the presence of phenothiazine derivatives during culturing. |
2016-01-11 |
2023-08-13 |
Not clear |
| Shweta Sharma, Jayanta Sarkar, Chandana Haldar, Sudhir Sinh. Melatonin Reverses Fas, E2F-1 and Endoplasmic Reticulum Stress Mediated Apoptosis and Dysregulation of Autophagy Induced by the Herbicide Atrazine in Murine Splenocytes. PloS one. vol 9. issue 9. 2016-01-08. PMID:25259610. |
mel also attenuated the atr-induced, p53 independent mitochondrial apoptosis through upregulation of e2f-1 and puma and suppression of their downstream target bax. |
2016-01-08 |
2023-08-13 |
mouse |
| Javad Baharara, Farideh Namvar, Tayebe Ramezani, Marzieh Mousavi, Rosfarizan Mohama. Silver nanoparticles biosynthesized using Achillea biebersteinii flower extract: apoptosis induction in MCF-7 cells via caspase activation and regulation of Bax and Bcl-2 gene expression. Molecules (Basel, Switzerland). vol 20. issue 2. 2016-01-08. PMID:25665064. |
silver nanoparticles biosynthesized using achillea biebersteinii flower extract: apoptosis induction in mcf-7 cells via caspase activation and regulation of bax and bcl-2 gene expression. |
2016-01-08 |
2023-08-13 |
human |
| Xiaodong Weng, Lei Wang, Hui Chen, Xiuheng Liu, Tao Qiu, Zhiyuan Che. Ischemic postconditioning inhibits apoptosis in an in vitro proximal tubular cell model. Molecular medicine reports. vol 12. issue 1. 2016-01-08. PMID:25672392. |
the results demonstrated that apoptosis occurred in cells subjected to ischemia/reperfusion (i/r) alone or with postconditioning following reperfusion for 24 h. cells subjected to i/r demonstrated increased expression of bax, cleaved caspase-3 and caspase-8 at the end of reperfusion. |
2016-01-08 |
2023-08-13 |
rat |
| Frank Spillmann, Christiane Trimpert, Jun Peng, Lars G Eckerle, Alexander Staudt, Katrin Warstat, Stephan B Felix, Burkert Pieske, Carsten Tschöpe, Sophie Van Linthou. High-density lipoproteins reduce palmitate-induced cardiomyocyte apoptosis in an AMPK-dependent manner. Biochemical and biophysical research communications. vol 466. issue 2. 2016-01-08. PMID:26362182. |
we found that hdls decreased palmitate-induced cardiomyocyte apoptosis as indicated by a reduction in annexin v-positive cardiomyocytes and an increase in bcl-2 versus bax ratio. |
2016-01-08 |
2023-08-13 |
rat |
| Xiaoying Huang, Lizhen Zou, Xiaoming Yu, Mayun Chen, Rui Guo, Hui Cai, Dan Yao, Xiaomei Xu, Yanfan Chen, Cheng Ding, Xueding Cai, Liangxing Wan. Salidroside attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2a receptor related mitochondria-dependent apoptosis pathway. Journal of molecular and cellular cardiology. vol 82. 2016-01-06. PMID:25772255. |
to explore the potential mechanisms, the apoptosis of pasmcs after salidroside treatment under hypoxia conditions were determined in vivo and in vitro, and also the mitochondria-dependent apoptosis factors, bax, bcl-2, cytochrome c, and caspase 9 were examined. |
2016-01-06 |
2023-08-13 |
mouse |
| Daniela Verzola, Elena Ratto, Barbara Villaggio, Emanuele Luigi Parodi, Roberto Pontremoli, Giacomo Garibotto, Francesca Viazz. Uric acid promotes apoptosis in human proximal tubule cells by oxidative stress and the activation of NADPH oxidase NOX 4. PloS one. vol 9. issue 12. 2016-01-04. PMID:25514209. |
uric acid up-regulated bax (+60% with respect to ctrl; p<0.05) and down regulated x-linked inhibitor of apoptosis protein. |
2016-01-04 |
2023-08-13 |
human |
| Rachelle R Olsen, Michelle N Mary-Sinclair, Zhirong Yin, Kevin W Freema. Antagonizing Bcl-2 family members sensitizes neuroblastoma and Ewing's sarcoma to an inhibitor of glutamine metabolism. PloS one. vol 10. issue 1. 2016-01-04. PMID:25615615. |
we further showed that induction of apoptosis by don in myc-overexpressing cancers is via the pro-apoptotic factor bax. |
2016-01-04 |
2023-08-13 |
mouse |
| Yue Jia, Aikoui Ohanyan, Yan-He Lue, Ronald S Swerdloff, Peter Y Liu, Pinchas Cohen, Christina Wan. The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs. Apoptosis : an international journal on programmed cell death. vol 20. issue 4. 2016-01-04. PMID:25666707. |
to understand the mechanisms of hn on male germ cell apoptosis, we studied five hn analogues including: hng (hn-s14g, a potent agonist), hng-f6a (no binding to igfbp-3), hn-s7a (no self-dimerization), hn-c8p (no binding to bax), and hn-l12a (a hn antagonist) on cp-induced male germ cell apoptosis in mice. |
2016-01-04 |
2023-08-13 |
mouse |
| Haiyan Chen, Ji-Ping Wang, Richard J Santen, Wei Yu. Adenosine monophosphate activated protein kinase (AMPK), a mediator of estradiol-induced apoptosis in long-term estrogen deprived breast cancer cells. Apoptosis : an international journal on programmed cell death. vol 20. issue 6. 2016-01-04. PMID:25721362. |
activation of ampk by aicar also increased expression of bax in mcf-7 cells and its localization to mitochondria, which is a required process for apoptosis. |
2016-01-04 |
2023-08-13 |
Not clear |
| Ning Han, Li Yu, Zhidu Song, Lifu Luo, Yazhen W. Agmatine protects Müller cells from high-concentration glucose-induced cell damage via N-methyl-D-aspartic acid receptor inhibition. Molecular medicine reports. vol 12. issue 1. 2016-01-04. PMID:25816073. |
in addition, agmatine treatment inhibited glucose-induced müller cell apoptosis, which was associated with the regulation of bax and bcl-2 expression. |
2016-01-04 |
2023-08-13 |
Not clear |
| R Kamaraj Kennedy, V Veena, P Ravindra Naik, Pragna Lakshmi, R Krishna, S Sudharani, N Sakthive. Phenazine-1-carboxamide (PCN) from Pseudomonas sp. strain PUP6 selectively induced apoptosis in lung (A549) and breast (MDA MB-231) cancer cells by inhibition of antiapoptotic Bcl-2 family proteins. Apoptosis : an international journal on programmed cell death. vol 20. issue 6. 2016-01-04. PMID:25820140. |
at molecular level, pcn instigates apoptosis by mitochondrial intrinsic apoptotic pathway via the overexpression of p53, bax, cytochrome c release and activation of caspase-3 with the inhibition of oncogenic anti-apoptotic proteins such as parp and bcl-2 family proteins (bcl-2, bcl-w and bcl-xl). |
2016-01-04 |
2023-08-13 |
Not clear |