| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mahnaz Norouzi, Shaghayegh Norouzi, Mohsen Amini, Amir Amanzadeh, Saeed Irian, Mona Salim. Apoptotic effects of two COX-2 inhibitors on breast adenocarcinoma cells through COX-2 independent pathway. Journal of cellular biochemistry. vol 116. issue 1. 2016-01-25. PMID:25142612. |
elevation of bax to bcl-2 ratio and activation of caspase-3 were found to be associated with the initiation of apoptosis induced by compound 1. |
2016-01-25 |
2023-08-13 |
Not clear |
| Nobuteru Kubo, Shin-ei Noda, Akihisa Takahashi, Yukari Yoshida, Takahiro Oike, Kazutoshi Murata, Atsushi Musha, Yoshiyuki Suzuki, Tatsuya Ohno, Takeo Takahashi, Takashi Nakan. Radiosensitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small-cell lung cancer cell line H460. Journal of radiation research. vol 56. issue 2. 2016-01-25. PMID:25599995. |
carboplatin and paclitaxel treatment combined with carbon-ion beams increased tunel-positive cells and the expression of cleaved caspase-3 and bax, indicating the enhancement of apoptosis. |
2016-01-25 |
2023-08-13 |
human |
| Xiao Geng, Hua Shao, Zhihu Zhang, Jack C Ng, Cheng Pen. Malathion-induced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats. Environmental toxicology and pharmacology. vol 39. issue 2. 2016-01-25. PMID:25686724. |
we found malathion at 54 mg/kg increased spermatogenic apoptosis rate which was confirmed by changes in protein expression of bax and bcl-2. |
2016-01-25 |
2023-08-13 |
rat |
| Rong Tian, You Li, Mei Ga. Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF-κB signalling pathway in human epidermoid carcinoma A431 cells. Bioscience reports. vol 35. issue 2. 2016-01-25. PMID:25720435. |
in addition, shikonin evidently induced apoptosis due to decreasing bcl-2 expression, increasing bax expression, activating caspase and inactivating nf-κb, while pretreatment with a pan-caspase inhibitor z-asp-ch2-dcb abrogated shikonin-induced apoptosis. |
2016-01-25 |
2023-08-13 |
human |
| Yuhong Ma, Weizu Li, Yanyan Yin, Weiping L. AST IV inhibits H₂O₂-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-β1/Smad2 pathway. International journal of molecular medicine. vol 35. issue 6. 2016-01-25. PMID:25891879. |
we demonstrated that hydrogen peroxide (h2o2) increased nox4-dependent-ros aggregation, as well as the expression of tgf-β1, smad2, bax and caspase-3, decreased bcl-2 expression and increased the apoptosis of human umbilical vein endothelial cells (huvecs). |
2016-01-25 |
2023-08-13 |
human |
| Yufang Zhong, Panpan Guo, Xiu Wang, Jing A. Aroclor 1254 inhibits cell viability and induces apoptosis of human A549 lung cancer cells by modulating the intracellular Ca(2+) level and ROS production through the mitochondrial pathway. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. vol 50. issue 8. 2016-01-25. PMID:26030686. |
then after 4 h of aroclor 1254 exposure, the intracellular calcium level increased and mitochondrial transmembrane potential (ΔΨm) collapsed, accompanying with cytochrome c (cyt-c) leakage, boosting expression of bax, apaf-1 and mirna155, which were involved in the mitochondrial apoptosis pathway. |
2016-01-25 |
2023-08-13 |
human |
| Cynthia D Bronzi, Adriana S Vega Orozco, Diego Rodriguez, Ana María Rastrilla, Zulema Y Sosa, Marilina Casai. Noradrenaline modulates the presence of gonadotropin-releasing hormone in ovary. The importance of its interrelation on the ovarian steroidogenesis and apoptosis on dioestrus II in rat. The Journal of steroid biochemistry and molecular biology. vol 154. 2016-01-19. PMID:26144997. |
however, in the ovary incubation, p4, gnrh, the expression of 3β-hsd and bax increased; e2, the expression of 20α-hsd and bcl-2 decreased while the bax/bcl-2 ratio increased, thus favoring apoptosis. |
2016-01-19 |
2023-08-13 |
rat |
| Li Huang, Junjie Han, Danya Ben-Hail, Luwei He, Baowei Li, Ziheng Chen, Yueying Wang, Yanlei Yang, Lei Liu, Yushan Zhu, Varda Shoshan-Barmatz, Hongwei Liu, Quan Che. A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells. The Journal of biological chemistry. vol 290. issue 39. 2016-01-19. PMID:26253170. |
the pro-apoptotic bax and bak proteins are considered central to apoptosis, yet apoptosis occurs in their absence. |
2016-01-19 |
2023-08-13 |
mouse |
| W P Wu, J Cao, J Y Wu, H Chen, D Wan. Anticancer activity of Bombyx batryticatus ethanol extract against the human tumor cell line HeLa. Genetics and molecular research : GMR. vol 14. issue 1. 2016-01-18. PMID:25729938. |
the mrna and protein expression levels of bax were remarkably higher whereas those of bcl-2 were lower than those in the control cells; this led to an increased bax/bcl-2 ratio in cells treated with the bbe for 36 h. the results suggest that the bbe might play an important role in tumor growth suppression by inducing apoptosis in human cervical cancer cells via the regulation of the bcl-2- and bax-mediated apoptotic pathways. |
2016-01-18 |
2023-08-13 |
human |
| Grant Dewso. Investigating Bax subcellular localization and membrane integration. Cold Spring Harbor protocols. vol 2015. issue 5. 2016-01-18. PMID:25934936. |
bax is a pivotal effector of apoptosis responsible for permeabilization of the mitochondrial outer membrane (mom). |
2016-01-18 |
2023-08-13 |
Not clear |
| Grant Dewso. Investigating Bak/Bax activating conformation change by immunoprecipitation. Cold Spring Harbor protocols. vol 2015. issue 5. 2016-01-18. PMID:25934937. |
activation of both bax and bak during apoptosis involves significant conformation change. |
2016-01-18 |
2023-08-13 |
Not clear |
| Grant Dewso. Investigating the Oligomerization of Bak and Bax during Apoptosis by Cysteine Linkage. Cold Spring Harbor protocols. vol 2015. issue 5. 2016-01-18. PMID:25934939. |
investigating the oligomerization of bak and bax during apoptosis by cysteine linkage. |
2016-01-18 |
2023-08-13 |
human |
| Liang Pang, Xin Zhao, Weiwei Liu, Jiang Deng, Xiaotong Tan, Lihua Qi. Anticancer Effect of Ursodeoxycholic Acid in Human Oral Squamous Carcinoma HSC-3 Cells through the Caspases. Nutrients. vol 7. issue 5. 2016-01-15. PMID:25951128. |
after different concentrations of udca treatment, the mrna and protein expressions of caspase-3, caspase-8, caspase-9, bax, fas/fasl (fas ligand), trail (tnf-related apoptosis-inducing ligand), dr4 (death receptor 4) and dr5 (death receptor 5) were increased in hsc-3 cells, and mrna and protein expressions of bcl-2 (b-cell lymphoma 2), bcl-xl (b-cell lymphoma-extra large), xiap (x-linked inhibitor of apoptosis protein), ciap-1 (cellular inhibitor of apoptosis 1), ciap-2 (cellular inhibitor of apoptosis 2) and survival were decreased. |
2016-01-15 |
2023-08-13 |
human |
| Manel Boussabbeh, Intidhar Ben Salem, Alexandre Prola, Arnaud Guilbert, Hassen Bacha, Salwa Abid-Essefi, Christophe Lemair. Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 144. issue 2. 2016-01-14. PMID:25577197. |
further, we showed that deficiency of the proapoptotic protein bax or bak protected cells against pat-induced apoptosis. |
2016-01-14 |
2023-08-13 |
human |
| Vishal Sharma, Ramandeep Kaur, Archana Bhatnagar, Jagdeep Kau. Low-pH-induced apoptosis: role of endoplasmic reticulum stress-induced calcium permeability and mitochondria-dependent signaling. Cell stress & chaperones. vol 20. issue 3. 2016-01-14. PMID:25823563. |
on the other hand, real-time-based upregulation of bax gene expression and flow cytometric analysis of cytochrome c release as well as enhanced active caspase-3 further confirmed mitochondrion-mediated events leading to induction of apoptosis. |
2016-01-14 |
2023-08-13 |
Not clear |
| Zelal Adiguzel, Nazli Arda, Omer Kacar, Muge Serhatli, Serpil Gezer Tas, Ahmet Tarik Baykal, Kemal Baysal, Ceyda Acila. Evaluation of apoptotic molecular pathways for smooth muscle cells isolated from thoracic aortic aneurysms in response to oxidized sterols. Molecular biology reports. vol 41. issue 12. 2016-01-13. PMID:25266234. |
efficient silencing of other targets including apoptotic proteins (p53, bax), and survival proteins (akt1, akt2) showed that apoptosis can occur through p53, and bax independent pathways. |
2016-01-13 |
2023-08-13 |
Not clear |
| Cindrilla Chumduri, Bernhard Gillissen, Anja Richter, Antje Richter, Ana Milojkovic, Tim Overkamp, Anja Müller, Christiane Pott, Peter T Danie. Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma. Journal of molecular medicine (Berlin, Germany). vol 93. issue 5. 2016-01-12. PMID:25548804. |
mechanistically, apoptosis resistance was linked to failure of caspase activation, which was most pronounced in cells lacking the pro-apoptotic multidomain bcl-2 homologs bax and bak. |
2016-01-12 |
2023-08-13 |
Not clear |
| Mingxing Li, Peng Liu, Guanhui Gao, Jizhe Deng, Zhengyin Pan, Xu Wu, Gaofeng Xie, Caixia Yue, Chi Hin Cho, Yifan Ma, Lintao Ca. Smac therapeutic Peptide nanoparticles inducing apoptosis of cancer cells for combination chemotherapy with Doxorubicin. ACS applied materials & interfaces. vol 7. issue 15. 2016-01-12. PMID:25815797. |
smac-nps also significantly induced apoptosis of mda-mb-231 and h460 cells through activating pro-caspase-3, down-regulating the expression of antiapoptotic protein bcl-2 and up-regulating the pro-apoptotic protein bax. |
2016-01-12 |
2023-08-13 |
Not clear |
| Vishnu Vignesh Kanagaraj, Lakshmikanthan Panneerselvam, Vimal Govindarajan, Jaishabanu Ameeramja, Ekambaram Peruma. Caffeic acid, a phyto polyphenol mitigates fluoride induced hepatotoxicity in rats: A possible mechanism. BioFactors (Oxford, England). vol 41. issue 2. 2016-01-12. PMID:25845575. |
in addition, ca inhibits fluoride induced apoptosis by altering the bax and caspase-3p20 expressions. |
2016-01-12 |
2023-08-13 |
rat |
| Xiao-Hong Zhang, Xian-Xiang Xu, Tao X. Ginsenoside Ro suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-κB. Chinese journal of natural medicines. vol 13. issue 4. 2016-01-12. PMID:25908625. |
apoptosis related proteins bax, bad, bcl-xl, pcna, p53 and phospho-p53, along with inflammation related protein mmp 3, mmp 9 and cox-2, and the expression of phospho-nf-κb p65 were assayed by western blotting analyses. |
2016-01-12 |
2023-08-13 |
rat |