| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chih-Hsiang Hsu, Ching-Lung Lin, Sheue-Er Wang, Shuenn-Jyi Sheu, Chiang-Ting Chien, Chung-Hsin W. Oral treatment with herbal formula B401 alleviates penile toxicity in aging mice with manganism. Clinical interventions in aging. vol 10. 2016-02-04. PMID:26064043. |
nitric oxide (no) production, levels of neuronal nitric oxide synthase (nnos) and endothelial nitric oxide synthase (enos), expression levels of factors governing angiogenesis (vascular endothelial growth factor), oxidative stress (catalase, superoxide dismutase 2,4-hydroxynonenal), inflammation (tumor necrosis factor alpha), apoptosis (b-cell lymphoma 2 [bcl-2], bcl-2-associated x protein [bax], cleaved poly(adenosine diphosphate-ribose) polymerase [c-parp], cytochrome c, caspase-12, and caspase-3) were evaluated in penile corpus cavernosum of the mice. |
2016-02-04 |
2023-08-13 |
mouse |
| Wei Cui, Zhijun Huang, Hongjuan He, Ning Gu, Geng Qin, Jie Lv, Tao Zheng, Kenkichi Sugimoto, Qiong W. MiR-1188 at the imprinted Dlk1-Dio3 domain acts as a tumor suppressor in hepatoma cells. Molecular biology of the cell. vol 26. issue 8. 2016-02-03. PMID:25694452. |
moreover, overexpressed mir-1188 promotes apoptosis, enhances caspase-3 activity, and also up-regulates the expression of bax and p53. |
2016-02-03 |
2023-08-13 |
mouse |
| Li Wang, Dong Chen, Ze Min, Jia-Hui Wan. [Effect of Yijing Recipe on apoptosis of testis spermatogenic cells and the expression of Bcl-2 and Bax protein in infertility rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 34. issue 5. 2016-02-02. PMID:24941852. |
[effect of yijing recipe on apoptosis of testis spermatogenic cells and the expression of bcl-2 and bax protein in infertility rats]. |
2016-02-02 |
2023-08-13 |
rat |
| Ming Guo, Zhou-Ling Wu, Chun-Ge Wang, Xiao-Yan Ga. [Synthesis and anti-tumor activity of baicalin-metal complex]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 49. issue 3. 2016-02-02. PMID:24961104. |
which indicates that bmc restrain cell proliferation and cell apoptosis by stopping cell cycle, reducing the expression of bcl-2 and increasing that of bax; the anti-tumor activities of three kinds of complexes were: baicalin-copper (bc-cu) > baicalin-cobalt (bc-co) > baicalin-nickel (bc-ni) > baicalin (bc), showing the dose-response relationship. |
2016-02-02 |
2023-08-13 |
Not clear |
| Yan Du, Jiannan Gong, Xinrui Tian, Xiaomei Yan, Tao Guo, Min Huang, Bingtai Zhang, Xiaoyun Hu, Hui Liu, Yinping Wang, Jianqiang Li, Maolan L. Japonicone A inhibits the growth of non-small cell lung cancer cells via mitochondria-mediated pathways. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 10. 2016-02-02. PMID:25908173. |
this product also blocked cell cycle progression at s phase and induced mitochondrial-related apoptosis by upregulating bax, cleaved caspase-9, cleaved caspase-3, and cleaved poly(adp-ribose) polymerase (parp) protein levels and by downregulating bcl-2, cyclin d1, cdc25a, and cdk2 protein levels. |
2016-02-02 |
2023-08-13 |
Not clear |
| Mudit Vaid, Tripti Singh, Ram Prasad, Santosh K Katiya. Silymarin inhibits melanoma cell growth both in vitro and in vivo by targeting cell cycle regulators, angiogenic biomarkers and induction of apoptosis. Molecular carcinogenesis. vol 54. issue 11. 2016-02-01. PMID:25174976. |
the silymarin-induced apoptosis of human melanoma cells was associated with a reduction in the levels of anti-apoptotic proteins (bcl-2 and bcl-xl), an increase in the levels of pro-apoptotic protein (bax), and activation of caspases. |
2016-02-01 |
2023-08-13 |
human |
| Hongxue Zhu, Xuechao Li, Yarong Song, Peng Zhang, Yajun Xiao, Yifei Xin. Long non-coding RNA ANRIL is up-regulated in bladder cancer and regulates bladder cancer cell proliferation and apoptosis through the intrinsic pathway. Biochemical and biophysical research communications. vol 467. issue 2. 2016-02-01. PMID:26449463. |
knockdown of anril repressed cell proliferation and increased cell apoptosis, along with decreased expression of bcl-2 and increased expressions of bax, cytoplasmic cytochrome c and smac and cleaved caspase-9, caspase-3 and parp. |
2016-02-01 |
2023-08-13 |
mouse |
| Kevin J O'Donovan, Catherine O'Keeffe, Jian Zhon. Whole-mount imaging of mouse embryo sensory axon projections. Journal of visualized experiments : JoVE. issue 94. 2016-01-29. PMID:25549235. |
we further breed the trka(taulacz) line onto a bax null background, which essentially abolishes neuronal apoptosis, in order to assess growth-related questions independently of possible effects of genetic manipulations on neuronal survival. |
2016-01-29 |
2023-08-13 |
mouse |
| Liwei Sun, Hang Fan, Lingguang Yang, Lingling Shi, Yujun Li. Tyrosol prevents ischemia/reperfusion-induced cardiac injury in H9c2 cells: involvement of ROS, Hsp70, JNK and ERK, and apoptosis. Molecules (Basel, Switzerland). vol 20. issue 3. 2016-01-29. PMID:25723850. |
besides, tyrosol inhibited i/r-induced apoptosis, associated with retained anti-apoptotic bcl-2 protein, and attenuated pro-apoptotic bax protein, resulting in a preservation of bcl-2/bax ratio. |
2016-01-29 |
2023-08-13 |
Not clear |
| Haiming Dai, Husheng Ding, X Wei Meng, Kevin L Peterson, Paula A Schneider, Judith E Karp, Scott H Kaufman. Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells. Genes & development. vol 29. issue 20. 2016-01-29. PMID:26494789. |
collectively, these results inform current understanding of momp and provide new insight into the ability of bh3 mimetics to induce apoptosis without directly activating bax or bak. |
2016-01-29 |
2023-08-13 |
Not clear |
| Ceren Kizmazoglu, Hasan Emre Aydin, Ismail Ertan Sevin, Orhan Kalemci, Nurullah Yüceer, Metin Ant Ataso. Neuroprotective Effect of Resveratrol on Acute Brain Ischemia Reperfusion Injury by Measuring Annexin V, p53, Bcl-2 Levels in Rats. Journal of Korean Neurosurgical Society. vol 58. issue 6. 2016-01-28. PMID:26819684. |
there are some useful markers for apoptosis like bcl-2, bax, and p53. |
2016-01-28 |
2023-08-13 |
rat |
| J Q Zhang, B S Xing, C C Zhu, M Shen, F X Yu, H L Li. Protective effect of proanthocyanidin against oxidative ovarian damage induced by 3-nitropropionic acid in mice. Genetics and molecular research : GMR. vol 14. issue 1. 2016-01-27. PMID:25867394. |
after the animals were sacrificed, their ovaries were collected to measure reactive oxygen species (ros) levels, the activities of superoxide dismutase (sod) and catalase (cat), and the mrna expression levels of relevant granulosa cell apoptosis genes (bcl-2, bax, bim, fasl, and caspase-3). |
2016-01-27 |
2023-08-13 |
mouse |
| Anna Kakehashi, Ayumi Kato, Naomi Ishii, Min Wei, Keiichirou Morimura, Shoji Fukushima, Hideki Wanibuch. Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling. PloS one. vol 9. issue 11. 2016-01-26. PMID:25419570. |
cell proliferation was significantly inhibited, while apoptosis was induced in areas of gst-p(+) foci of valerian groups associated with suppression of c-myc, mafb, cyclin d1 and induction of p21(waf1/cip1), p53 and bax mrna expression. |
2016-01-26 |
2023-08-13 |
rat |
| Ramin Hassankhani, Mohammad Reza Sam, Mohammad Esmaeilou, Prinaz Ahanga. Prodigiosin isolated from cell wall of Serratia marcescens alters expression of apoptosis-related genes and increases apoptosis in colorectal cancer cells. Medical oncology (Northwood, London, England). vol 32. issue 1. 2016-01-26. PMID:25429836. |
malignant cells were treated to various concentrations of prodigiosin and proliferation rate, survivin, bcl-2, bax and bad mrna levels, caspase 3 activation and apoptosis were evaluated by different cellular and molecular techniques. |
2016-01-26 |
2023-08-13 |
Not clear |
| Ramin Hassankhani, Mohammad Reza Sam, Mohammad Esmaeilou, Prinaz Ahanga. Prodigiosin isolated from cell wall of Serratia marcescens alters expression of apoptosis-related genes and increases apoptosis in colorectal cancer cells. Medical oncology (Northwood, London, England). vol 32. issue 1. 2016-01-26. PMID:25429836. |
low mrna levels of bcl-2 combined with high levels of bax and bad mrnas were correlated to higher apoptosis rate in treated cells. |
2016-01-26 |
2023-08-13 |
Not clear |
| Min Wang, Xingjiao Lu, Xueguang Dong, Fengyun Hao, Zimin Liu, Guangzhen Ni, Dong Che. pERK1/2 silencing sensitizes pancreatic cancer BXPC-3 cell to gemcitabine-induced apoptosis via regulating Bax and Bcl-2 expression. World journal of surgical oncology. vol 13. 2016-01-26. PMID:25880226. |
perk1/2 silencing sensitizes pancreatic cancer bxpc-3 cell to gemcitabine-induced apoptosis via regulating bax and bcl-2 expression. |
2016-01-26 |
2023-08-13 |
Not clear |
| Min Wang, Xingjiao Lu, Xueguang Dong, Fengyun Hao, Zimin Liu, Guangzhen Ni, Dong Che. pERK1/2 silencing sensitizes pancreatic cancer BXPC-3 cell to gemcitabine-induced apoptosis via regulating Bax and Bcl-2 expression. World journal of surgical oncology. vol 13. 2016-01-26. PMID:25880226. |
it has also shown that bcl-2 confers resistance and bax sensitizes to gemcitabine-induced apoptosis in pancreatic cancer cells. |
2016-01-26 |
2023-08-13 |
Not clear |
| Anuradha Cingeetham, Sugunakar Vuree, Nageswara Rao Dunna, Manjula Gorre, Santhoshi Rani Nanchari, Prajitha Mohandas Edathara, Phannibhushann Meka, Sandhya Annamaneni, Raghunadharao Digumarthi, Sudha Sinha, Vishnupriya Satt. Influence of BCL2-938C>A and BAX-248G>A promoter polymorphisms in the development of AML: case-control study from South India. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 10. 2016-01-26. PMID:25957891. |
b-cell lymphoma 2 (bcl2) and bcl2-associated x protein (bax) proteins are anti-apoptotic and pro-apoptotic determinants of mitochondrial-mediated apoptosis, and their relative expression determines the cell fate. |
2016-01-26 |
2023-08-13 |
Not clear |
| Peng Wang, Xiaofeng Xie, Jian Wang, Yuan Shi, Na Shen, Xinsheng Huan. Ultra-small superparamagnetic iron oxide mediated magnetic hyperthermia in treatment of neck lymph node metastasis in rabbit pyriform sinus VX2 carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 10. 2016-01-26. PMID:25971580. |
after hyperthermia, the detection of apoptosis for the two groups was tested by terminal deoxynucleotidyl transferase (tdt)-mediated dutp nick end labeling (tunel), transmission electron microscopy (tem), and the expression of bcl-2 and bax evaluated by immunohistochemical analysis. |
2016-01-26 |
2023-08-13 |
rabbit |
| Hui-Chen Chen, Masayuki Kanai, Akane Inoue-Yamauchi, Ho-Chou Tu, Yafen Huang, Decheng Ren, Hyungjin Kim, Shugaku Takeda, Denis E Reyna, Po M Chan, Yogesh Tengarai Ganesan, Chung-Ping Liao, Evripidis Gavathiotis, James J Hsieh, Emily H Chen. An interconnected hierarchical model of cell death regulation by the BCL-2 family. Nature cell biology. vol 17. issue 10. 2016-01-26. PMID:26344567. |
multidomain pro-apoptotic bax and bak, once activated, permeabilize mitochondria to trigger apoptosis, whereas anti-apoptotic bcl-2 members preserve mitochondrial integrity. |
2016-01-26 |
2023-08-13 |
Not clear |