| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elham Karimizadeh, Farhad Gharibdoost, Nasrin Motamed, Saeideh Jafarinejad-Farsangi, Ahmadreza Jamshidi, Mahdi Mahmoud. c-Abl silencing reduced the inhibitory effects of TGF-β1 on apoptosis in systemic sclerosis dermal fibroblasts. Molecular and cellular biochemistry. vol 405. issue 1-2. 2016-02-16. PMID:25876876. |
the aim of this study was to evaluate whether tgf-β1 and inhibition of c-abl influence bax to bcl-2 ratio and apoptosis in ssc and healthy dermal fibroblasts. |
2016-02-16 |
2023-08-13 |
Not clear |
| Elham Karimizadeh, Farhad Gharibdoost, Nasrin Motamed, Saeideh Jafarinejad-Farsangi, Ahmadreza Jamshidi, Mahdi Mahmoud. c-Abl silencing reduced the inhibitory effects of TGF-β1 on apoptosis in systemic sclerosis dermal fibroblasts. Molecular and cellular biochemistry. vol 405. issue 1-2. 2016-02-16. PMID:25876876. |
our results demonstrated that inhibition of c-abl increased ssc and healthy dermal fibroblasts susceptibility to apoptosis through increasing in bax to bcl-2 mrna and protein ratios, whereas tgf-β1 promoted healthy fibroblasts resistance to apoptosis via decreasing bax to bcl-2 mrna and protein ratios. |
2016-02-16 |
2023-08-13 |
Not clear |
| Xiaomin Zhao, Xiangjun Song, Xiaoyuan Bai, Naijiao Fei, Yong Huang, Zhimin Zhao, Qian Du, Hongling Zhang, Liang Zhang, Dewen Ton. miR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1). PeerJ. vol 4. 2016-02-12. PMID:26870610. |
in this study we demonstrated that the over-expression of mir-27b led to the inhibition of tgev-induced apoptosis, reduction of bax protein level, and decrease of caspase-3 and -9 activities. |
2016-02-12 |
2023-08-13 |
Not clear |
| Xiaomin Zhao, Xiangjun Song, Xiaoyuan Bai, Naijiao Fei, Yong Huang, Zhimin Zhao, Qian Du, Hongling Zhang, Liang Zhang, Dewen Ton. miR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1). PeerJ. vol 4. 2016-02-12. PMID:26870610. |
conversely, silencing of mir-27b by mir-27b inhibitors enhanced apoptosis via up-regulating bax expression and promoting the activities of caspase-3 and -9 in tgev-infected cells. |
2016-02-12 |
2023-08-13 |
Not clear |
| Xiaomin Zhao, Xiangjun Song, Xiaoyuan Bai, Naijiao Fei, Yong Huang, Zhimin Zhao, Qian Du, Hongling Zhang, Liang Zhang, Dewen Ton. miR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1). PeerJ. vol 4. 2016-02-12. PMID:26870610. |
the over-expression of runx1 increased apoptosis and knockdown runx1blocked apoptosis of viral-infected cells via regulating bax expression and the activities of caspase-3 and -9. |
2016-02-12 |
2023-08-13 |
Not clear |
| Yi Zhang, Zhi-Wei Zhou, Hua Jin, Chengbin Hu, Zhi-Xu He, Zhi-Ling Yu, Kam-Ming Ko, Tianxin Yang, Xueji Zhang, Si-Yuan Pan, Shu-Feng Zho. Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity. Drug design, development and therapy. vol 9. 2016-02-09. PMID:25926716. |
furthermore, sch b markedly increased the apoptosis of aml-12 and raw 264.7 cells with a decrease in the expression of b-cell lymphoma-extra-large and (bcl-xl) b-cell lymphoma 2 (bcl-2), but an increase in the expression of b-cell lymphoma 2-associated x protein (bax). |
2016-02-09 |
2023-08-13 |
mouse |
| Yasuhiro Kubota, Hirofumi Noguchi, Masayuki Seita, Takeshi Yuasa, Hiromi Sasamoto, Shuhei Nakaji, Teru Okitsu, Toshiyoshi Fujiwara, Naoya Kobayash. Maintenance of Viability and Function of Rat Islets With the Use of ROCK Inhibitor Y-27632. Cell medicine. vol 6. issue 1-2. 2016-02-09. PMID:26858876. |
with strong expression of bcl-2 observed with the y-27632 group, and expression suppressed with bax, inhibition of apoptosis by y-27632 was confirmed. |
2016-02-09 |
2023-08-13 |
rat |
| Chunjin Li, Wanhong Li, Shuxiong Chen, Zhichen Kang, Lina Sun, Hongjiao Li, Lu Chen, Jiahui Rao, Yun Zhao, Jiaxin Yu, Xu Zho. 4-Methylcatechol-induced cell damage in TM4 Sertoli cells. Cell biology international. vol 39. issue 6. 2016-02-08. PMID:25639863. |
results showed that 4-mc could induce tm4 sertoli cell apoptosis, and the cytotoxic effect of 4-mc on tm4 sertoli cells may be associated with upregulated bax gene expression, which induced caspase cascade activation. |
2016-02-08 |
2023-08-13 |
mouse |
| Junchi He, Mindi Liu, Zhen Liu, Liangsheng Lu. Recombinant osteopontin attenuates experimental cerebral vasospasm following subarachnoid hemorrhage in rats through an anti-apoptotic mechanism. Brain research. vol 1611. 2016-02-08. PMID:25779039. |
r-opn significantly reduced expression of cleaved caspase-3 and bax in ba following sah, and increased the level of p-akt and bcl-2, coupled with reduced apoptosis of endothelial cell in ba. |
2016-02-08 |
2023-08-13 |
rat |
| K Yao, H C Xing, B Wu, Y Li, A J Liao, W Yang, Z G Li. Effect of TIEG1 on apoptosis and expression of Bcl-2/Bax and Pten in leukemic cell lines. Genetics and molecular research : GMR. vol 14. issue 1. 2016-02-08. PMID:25867342. |
during apoptosis induction, the expression of bcl-2 was decreased and the expressions of bax and pten were increased in the 4 leukemic cell lines induced by tieg1 (p < 0.05). |
2016-02-08 |
2023-08-13 |
Not clear |
| Miaki Uzu, Hiromi Sato, Ryota Yamada, Tatsuro Kashiba, Yukihiro Shibata, Katsunori Yamaura, Koichi Uen. Effect of enhanced expression of connexin 43 on sunitinib-induced cytotoxicity in mesothelioma cells. Journal of pharmacological sciences. vol 128. issue 1. 2016-02-08. PMID:26003083. |
furthermore, higher cx43 expression increased the production of a cleaved (active) form of bax during su-induced apoptosis with no alteration in total bax expression. |
2016-02-08 |
2023-08-13 |
Not clear |
| Weimin Ni, Yan Fang, Ling Xie, Xue Liu, Wei Shan, Ruixia Zeng, Jiansheng Liu, Xueyuan Li. Adipose-Derived Mesenchymal Stem Cells Transplantation Alleviates Renal Injury in Streptozotocin-Induced Diabetic Nephropathy. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 63. issue 11. 2016-02-08. PMID:26215800. |
we found that both admsc transplantation and co-incubation reduced the rate of cellular apoptosis, decreased bax and wnt/β-catenin levels, and elevated bcl-2 and klotho levels. |
2016-02-08 |
2023-08-13 |
mouse |
| Jone A Stanley, Joe A Arosh, Robert C Burghardt, Sakhila K Ban. A fetal whole ovarian culture model for the evaluation of CrVI-induced developmental toxicity during germ cell nest breakdown. Toxicology and applied pharmacology. vol 289. issue 1. 2016-02-08. PMID:26348139. |
results showed that crvi increased germ cell/oocyte apoptosis by increasing caspase 3, bax, p53 and puma; decreasing bcl2, bmp15, gdf9 and ckit; and altering cell cycle regulatory genes and proteins. |
2016-02-08 |
2023-08-13 |
human |
| Moon ho Do, Su nam Kim, Seung-Yong Seo, Eui-Ju Yeo, Sun Yeou Ki. δ-Tocopherol prevents methylglyoxal-induced apoptosis by reducing ROS generation and inhibiting apoptotic signaling cascades in human umbilical vein endothelial cells. Food & function. vol 6. issue 5. 2016-02-05. PMID:25832198. |
δ-tocopherol prevented mgo-induced apoptosis in huvecs by increasing bcl-2 expression and decreasing bax expression. |
2016-02-05 |
2023-08-13 |
human |
| Koichi Okamoto, Aziz Zaanan, Hisato Kawakami, Shengbing Huang, Frank A Sinicrop. Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. Molecular cancer research : MCR. vol 13. issue 4. 2016-02-04. PMID:25548100. |
concurrent bcl-xl antagonism by the bh3 mimetic abt-263 combined with carfilzomib synergistically enhanced apoptosis that was dependent on bax or p53, and was attenuated by noxa or bik shrna. |
2016-02-04 |
2023-08-13 |
human |
| Li Yang, Tingyan Shi, Fei Liu, Chunxia Ren, Ziliang Wang, Yingyi Li, Xiaoyu Tu, Gong Yang, Xi Chen. REV3L, a promising target in regulating the chemosensitivity of cervical cancer cells. PloS one. vol 10. issue 3. 2016-02-04. PMID:25781640. |
the suppression of rev3l expression enhanced the sensitivity of cervical cancer cells to cisplatin, and the overexpression of rev3l conferred resistance to cisplatin as evidenced by the alteration of apoptosis rates, and significantly expression level changes of anti-apoptotic proteins b-cell lymphoma 2 (bcl-2), myeloid cell leukemia sequence 1 (mcl-1) and b-cell lymphoma-extra large (bcl-xl) and proapoptotic bcl-2-associated x protein (bax). |
2016-02-04 |
2023-08-13 |
Not clear |
| Yunhui Hu, Kun Xu, Ernesto Yagü. miR-218 targets survivin and regulates resistance to chemotherapeutics in breast cancer. Breast cancer research and treatment. vol 151. issue 2. 2016-02-04. PMID:25900794. |
apoptosis was determined by flow cytometry after annexin v staining, by caspase 3/7 and caspase 9 activity assays and the levels of apoptosis-related proteins bcl-2 and bax by real-time pcr and western blot. |
2016-02-04 |
2023-08-13 |
mouse |
| Zheng Lu, Shengbo Cao, Hongbo Zhou, Ling Hua, Shishuo Zhang, Jiyue Ca. Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721. PloS one. vol 10. issue 5. 2016-02-04. PMID:25933104. |
furthermore, the following study showed that arg treatment led to a loss in the mitochondrial out membrane potential, up-regulation of bax, down-regulation of bcl-2, a release of cytochrome c, caspase-9 and caspase-3 activation and a cleavage of poly (adp-ribose) polymerase in both hep g2 and smmc7721 cells, suggesting arg-induced apoptosis was associated with the mitochondria mediated pathway. |
2016-02-04 |
2023-08-13 |
human |
| Yuqin Zhang, Huang Li, Mingqing Huang, Mei Huang, Kedan Chu, Wei Xu, Shengnan Zhang, Jinhua Que, Lidian Che. Paeoniflorin, a Monoterpene Glycoside, Protects the Brain from Cerebral Ischemic Injury via Inhibition of Apoptosis. The American journal of Chinese medicine. vol 43. issue 3. 2016-02-04. PMID:25967667. |
the in vitro study revealed that pf treatment protected against nmda-induced cell apoptosis and neuronal loss via up-regulation of neuronal specific marker neun, map-2 and bcl-2 and the down-regulation bax. |
2016-02-04 |
2023-08-13 |
rat |
| Yuqin Zhang, Huang Li, Mingqing Huang, Mei Huang, Kedan Chu, Wei Xu, Shengnan Zhang, Jinhua Que, Lidian Che. Paeoniflorin, a Monoterpene Glycoside, Protects the Brain from Cerebral Ischemic Injury via Inhibition of Apoptosis. The American journal of Chinese medicine. vol 43. issue 3. 2016-02-04. PMID:25967667. |
taken together, the present study demonstrates that pf produces its protective effect by inhibiting the over-activation of astrocytes, apoptosis of neurons and up-regulation of neuronal specific marker neun, map-2, and b-cell lymphoma-2 (bcl-2), and down-regulation bax. |
2016-02-04 |
2023-08-13 |
rat |