| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A P C Piyathilaka, M M Pathmalal, K H Tennekoon, B G D N K De Silva, S R Samarakoon, S Chanthirik. Microcystin-LR-induced cytotoxicity and apoptosis in human embryonic kidney and human kidney adenocarcinoma cell lines. Microbiology (Reading, England). vol 161. issue Pt 4. 2016-03-14. PMID:25635275. |
both bax and p53 functioned as promoters of mc-lr-mediated apoptosis in achn and hek-293 cells. |
2016-03-14 |
2023-08-13 |
human |
| Xin-Ling Wang, Tao Yu, Qi-Chang Yan, Wei Wang, Nan Meng, Xue-Jiao Li, Ya-Hong Lu. AGEs Promote Oxidative Stress and Induce Apoptosis in Retinal Pigmented Epithelium Cells RAGE-dependently. Journal of molecular neuroscience : MN. vol 56. issue 2. 2016-03-14. PMID:25682235. |
moreover, the age-bsa treatment promoted a significantly high level of apoptotic cells, and the bcl-2 family was implicated in the age-bsa-induced apoptosis, there was a significant high level of cyt c release, bcl-2-associated x protein (bax) induction, bcl-2 reduction, and caspase 9 activation in the age-bsa-treated cells. |
2016-03-14 |
2023-08-13 |
Not clear |
| Yoon-Jin Lee, David M Lee, Sang-Han Le. Nrf2 Expression and Apoptosis in Quercetin-treated Malignant Mesothelioma Cells. Molecules and cells. vol 38. issue 5. 2016-03-14. PMID:25896339. |
knockdown of nrf2 expression with sirna enhanced cytotoxicity due to the induction of apoptosis, as evidenced by an increase in the level of proapoptotic bax, a decrease in the level of antiapoptotic bcl-2 with enhanced cleavage of caspase-3 and parp proteins, the appearance of a sub-g0/g1 peak in the flow cytometric assay, and increased percentage of apoptotic propensities in the annexin v binding assay. |
2016-03-14 |
2023-08-13 |
Not clear |
| Thibaud T Renault, Oscar Teijido, Florent Missire, Yogesh Tengarai Ganesan, Gisèle Velours, Hubert Arokium, Florian Beaumatin, Raul Llanos, Axel Athané, Nadine Camougrand, Muriel Priault, Bruno Antonsson, Laurent M Dejean, Stéphen Mano. Bcl-xL stimulates Bax relocation to mitochondria and primes cells to ABT-737. The international journal of biochemistry & cell biology. vol 64. 2016-03-11. PMID:25862283. |
bax cytosol-to-mitochondria translocation is a central event of the intrinsic pathway of apoptosis. |
2016-03-11 |
2023-08-13 |
Not clear |
| Thibaud T Renault, Oscar Teijido, Florent Missire, Yogesh Tengarai Ganesan, Gisèle Velours, Hubert Arokium, Florian Beaumatin, Raul Llanos, Axel Athané, Nadine Camougrand, Muriel Priault, Bruno Antonsson, Laurent M Dejean, Stéphen Mano. Bcl-xL stimulates Bax relocation to mitochondria and primes cells to ABT-737. The international journal of biochemistry & cell biology. vol 64. 2016-03-11. PMID:25862283. |
interestingly, cells overexpressing bcl-xl were more sensitive to apoptosis upon treatment with the bh3-mimetic abt-737, suggesting that despite its role in bax inhibition, bcl-xl also primes mitochondria to permeabilization and cytochrome c release. |
2016-03-11 |
2023-08-13 |
Not clear |
| R M Chura-Chambi, M H Bellini, J F Jacysyn, L N Andrade, L P Medina, A R B Prieto-da-Silva, G P Amarante-Mendes, L Morgant. Improving the therapeutic potential of endostatin by fusing it with the BAX BH3 death domain. Cell death & disease. vol 5. 2016-03-10. PMID:25118931. |
bax is a member of the bcl-2 family of proteins; its proapoptotic (bh3) domain interacts with other members of the family in the cytoplasm, to induce apoptosis. |
2016-03-10 |
2023-08-13 |
mouse |
| R M Chura-Chambi, M H Bellini, J F Jacysyn, L N Andrade, L P Medina, A R B Prieto-da-Silva, G P Amarante-Mendes, L Morgant. Improving the therapeutic potential of endostatin by fusing it with the BAX BH3 death domain. Cell death & disease. vol 5. 2016-03-10. PMID:25118931. |
the presence of the bax domain enhances endothelial cell death by apoptosis by 1.8-fold and diminishes microvessel outgrowth in the rat aortic ring assay by 6.5-fold. |
2016-03-10 |
2023-08-13 |
mouse |
| Tejia Zhang, Loren D Walensky, Alan Saghatelia. A nonapoptotic role for BAX and BAK in eicosanoid metabolism. ACS chemical biology. vol 10. issue 6. 2016-03-10. PMID:25815636. |
our approach uncovers a novel, nonapoptotic function for bax in regulation of the cellular inflammatory response and suggests that inflammation and apoptosis are more tightly connected than previously anticipated. |
2016-03-10 |
2023-08-13 |
mouse |
| Ying-Hua Liu, Xiao-Li Wei, Guo-Qiang Hu, Tian-Xiao Wan. Quinolone-indolone conjugate induces apoptosis by inhibiting the EGFR-STAT3-HK2 pathway in human cancer cells. Molecular medicine reports. vol 12. issue 2. 2016-03-10. PMID:25937091. |
in addition, it resulted in cell apoptosis, in association with increased expression of bax and reduced expression of bcl-2. |
2016-03-10 |
2023-08-13 |
human |
| Jing Sun, Fangyan Wang, Haixiao Li, Huiqing Zhang, Jiangtao Jin, Wenqian Chen, Mengqi Pang, Junjie Yu, Yiwen He, Jiaming Liu, Chunfeng Li. Neuroprotective Effect of Sodium Butyrate against Cerebral Ischemia/Reperfusion Injury in Mice. BioMed research international. vol 2015. 2016-03-10. PMID:26064905. |
10 mg/kg nab treatment also remarkably inhibited the apoptosis, decreasing the levels of caspase-3 and bax and increasing the levels of bcl-2, p-akt, and bdnf. |
2016-03-10 |
2023-08-13 |
mouse |
| Manoj Paul, Mahadevappa Hemshekhar, Ram M Thushara, Mahalingam S Sundaram, Somanathapura K NaveenKumar, Shivanna Naveen, Sannaningaiah Devaraja, Kumar Somyajit, Robert West, Basappa, Siddaiah C Nayaka, Uzma I Zakai, Ganesh Nagaraju, Kanchugarakoppal S Rangappa, Kempaiah Kemparaju, Kesturu S Giris. Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide. PloS one. vol 10. issue 6. 2016-03-10. PMID:26083398. |
mtx (10 μm) induced activation of pro-apoptotic proteins bid, bax and bad through jnk phosphorylation leading to ΔΨm dissipation, cytochrome c release and caspase activation, culminating in apoptosis. |
2016-03-10 |
2023-08-13 |
human |
| Wei Zhang, En-hai Cu. [Study on effect of lycorine in inducing apoptosis of pulmonary carcinoma cell A549]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 16. 2016-03-10. PMID:26790307. |
the results showed that lycorine significantly inhibited the proliferation of a549 cells (p < 0.05), induced the apoptosis on a549 cells (p < 0.05), increased the activities of bax and p53, reduced bcl-2 activity and mitochondrial membrane potential, and notably changed the gene expressions of bcl-2, bax, p53 and survivin (p < 0.05). |
2016-03-10 |
2023-08-13 |
human |
| Stephanie Puukila, Sean Bryan, Anna Laakso, Jessica Abdel-Malak, Carli Gurney, Adrian Agostino, Adriane Belló-Klein, Kailash Prasad, Neelam Khape. Secoisolariciresinol diglucoside abrogates oxidative stress-induced damage in cardiac iron overload condition. PloS one. vol 10. issue 3. 2016-03-09. PMID:25822525. |
increased apoptosis was evident by increased active caspase 3/7 activity and increased protein expression of forkhead box o3a, caspase 3 and bax. |
2016-03-09 |
2023-08-13 |
Not clear |
| Chih-Hua Tseng, Cherng-Chyi Tzeng, Chih-Yao Hsu, Chih-Mei Cheng, Chia-Ning Yang, Yeh-Long Che. Discovery of 3-phenylquinolinylchalcone derivatives as potent and selective anticancer agents against breast cancers. European journal of medicinal chemistry. vol 97. 2016-03-09. PMID:26005780. |
compound 7 ultimately induced cell apoptosis by the increase of apoptotic protein bax and the decrease of anti-apoptotic protein bcl-2. |
2016-03-09 |
2023-08-13 |
Not clear |
| Jun Liu, Qiao-Chu Wang, Jun Han, Bo Xiong, Shao-Chen Su. Aflatoxin B1 is toxic to porcine oocyte maturation. Mutagenesis. vol 30. issue 4. 2016-03-08. PMID:25778688. |
annexin v-fitc staining assay revealed that afb1 treatment (50 μm) resulted in oocyte early apoptosis, which was confirmed by increased bak, bax, bcl-xl mrna levels. |
2016-03-08 |
2023-08-13 |
Not clear |
| A Kolesarova, A V Sirotkin, M Mellen, S Roychoudhur. Possible intracellular regulators of female sexual maturation. Physiological research. vol 64. issue 3. 2016-03-07. PMID:25536325. |
for this purpose, proliferation (expression of proliferating cell nuclear antigen - pcna, mitogen-activated protein kinases - erk 1,2 related mapk and cyclin b1), apoptosis (expression of the apoptotic protein bax and apoptosis regulator bcl-2 protein), expression of some protein kinases (camp dependent protein kinase - pka, cgmp-dependent protein kinase - pkg, tyrosine kinase - tk) and camp responsive element binding protein 1 (creb-1) was examined in granulosa cells isolated from ovaries of immature and mature gilts. |
2016-03-07 |
2023-08-13 |
Not clear |
| Peng Li, Tie Liu, David W Kamp, Ziying Lin, Yahong Wang, Donghong Li, Lawei Yang, Huijuan He, Gang Li. The c-Jun N-terminal kinase signaling pathway mediates chrysotile asbestos-induced alveolar epithelial cell apoptosis. Molecular medicine reports. vol 11. issue 5. 2016-03-04. PMID:25530474. |
chrysotile asbestos was also shown to induce intrinsic aec apoptosis, as evidenced by the upregulation of the pro‑apoptotic genes bax and bak, alongside the activation of caspase‑9, poly (adp‑ribose) polymerase (parp), and the release of cytochrome c. furthermore, the specific jnk inhibitor sp600125 blocked chrysotile asbestos‑induced jnk activation and subsequent apoptosis, as assessed by both caspase‑9 cleavage and parp activation. |
2016-03-04 |
2023-08-13 |
human |
| Shaohua Wei, Hua Cao, Xiaoyan Zhou, Haorong Wu, Jicheng Yan. Prokaryotically and eukaryotically expressed interleukin-24 induces breast cancer growth suppression via activation of apoptosis and inhibition of tumor angiogenesis. Molecular medicine reports. vol 11. issue 5. 2016-03-04. PMID:25544477. |
the retarded in vitro and in vivo breast cancer growth elicited by rhil‑24 was closely associated with the upregulation of the ratio of anti‑apoptotic b cell lymphoma 2 (bcl‑2) to pro‑apoptotic bcl‑2‑associated x protein (bax), as well as the activation of caspase‑3 followed by marked induction of apoptosis, and the notable inhibition of tumor angiogenesis. |
2016-03-04 |
2023-08-13 |
mouse |
| Arpna Sharma, Himanshu Agrawal, Nowsheen Mullani, Anjit Sandhu, Manoj Kumar Singh, Manmohan Singh Chauhan, Suresh Kumar Singla, Prabhat Palta, Radhay Sham Mani. Supplementation of tauroursodeoxycholic acid during IVC did not enhance in vitro development and quality of buffalo IVF embryos but combated endoplasmic reticulum stress. Theriogenology. vol 84. issue 2. 2016-03-04. PMID:25881988. |
tauroursodeoxycholic acid did not improve the developmental potential of buffalo embryos; however, it attenuated the tm-induced apoptosis by downregulating bax and er chaperones. |
2016-03-04 |
2023-08-13 |
Not clear |
| Julhiany de Fátima da Silva, Juliana Vicentim, Haroldo Cesar de Oliveira, Caroline Maria Marcos, Patricia Akemi Assato, Patrícia Ferrari Andreotti, Juliana Leal Monteiro da Silva, Christiane Pienna Soares, Gil Benard, Ana Marisa Fusco Almeida, Maria José Soares Mendes-Giannin. Influence of the Paracoccidioides brasiliensis 14-3-3 and gp43 proteins on the induction of apoptosis in A549 epithelial cells. Memorias do Instituto Oswaldo Cruz. vol 110. issue 4. 2016-03-04. PMID:26038961. |
accordingly, epithelial cells were treated with these molecules for different periods of time and the expression of the apoptosis regulating-proteins bak, bax, bcl-2, p53 and caspases were evaluated by terminal deoxynucleotidyl transferase dutp nick end labelling, flow cytometry and real-time polymerase chain reaction analysis. |
2016-03-04 |
2023-08-13 |
human |