| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Khan, A Katoch, A Das, A Sharathchandra, R Lal, P Roy, S Das, S Chattopadhyay, S Da. Reversible induction of translational isoforms of p53 in glucose deprivation. Cell death and differentiation. vol 22. issue 7. 2016-04-08. PMID:25721046. |
rnai-mediated-transient smar1 knockdown decreased p53 ires activities in normal conditions and under glucose deprivation, this being reflected in changes in mrnas in the p53 and Δ40p53 target genes involved in cell-cycle arrest, metabolism and apoptosis such as p21, tigar and bax. |
2016-04-08 |
2023-08-13 |
mouse |
| Hongwei Gao, Wen Sun, Wenwen Zhao, Wenhui Hao, Chung-Hang Leung, Jinjian Lu, Xiuping Che. Total Tanshinones-Induced Apoptosis and Autophagy Via Reactive Oxygen Species in Lung Cancer 95D Cells. The American journal of Chinese medicine. vol 43. issue 6. 2016-04-08. PMID:26394653. |
annexin v/7-aad double staining, the depolarization of mitochondrial membrane potential (mmp) (Δψ), the up-regulation of pro-apoptotic proteins, such as cleaved-parp, cleaved-caspase-3, bax, and bad, and the down-regulation of anti-apoptotic protein bcl-2 were evidence of tdt-induced apoptosis. |
2016-04-08 |
2023-08-13 |
Not clear |
| Yunxia Tang, Qiongshu Li, Fanwei Meng, Xingyu Huang, Chan Li, Xin Zhou, Xiaoping Zeng, Yixin He, Jia Liu, Xiang Hu, Ji-Fan Hu, Tao L. Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure. International journal of hepatology. vol 2016. 2016-04-08. PMID:27057357. |
additionally, hgf-ucmscs modulated apoptosis by upregulating the antiapoptotic bcl2 and downregulating proapoptotic genes, including bax and tnfα. |
2016-04-08 |
2023-08-13 |
mouse |
| Yan-Lai Tang, Li-Bin Huang, Yun Tian, Li-Na Wang, Xiao-Li Zhang, Zhi-Yong Ke, Wu-Guo Deng, Xue-Qun Lu. Flavokawain B inhibits the growth of acute lymphoblastic leukemia cells via p53 and caspase-dependent mechanisms. Leukemia & lymphoma. vol 56. issue 8. 2016-04-06. PMID:25641429. |
it also induced cellular apoptosis by increasing the expression of p53, bax and puma, and activating the cleavage of caspase-3 and poly adp-ribose polymerase (parp). |
2016-04-06 |
2023-08-13 |
mouse |
| Yunyi Hong, Hui Nie, Xunbin Wei, Shen Fu, Weihai Yin. NAD+ treatment can prevent rotenone-induced increases in DNA damage, Bax levels and nuclear translocation of apoptosis-inducing factor in differentiated PC12 cells. Neurochemical research. vol 40. issue 4. 2016-04-05. PMID:25813492. |
in our current study, we determined the effects of nad(+) treatment on several major factors in apoptosis and necrosis, including levels of bax and nuclear translocation of apoptosis-inducing factor (aif), as well as levels of dna double-strand breaks (dsbs) and intracellular atp in rotenone-treated differentiated pc12 cells. |
2016-04-05 |
2023-08-13 |
Not clear |
| Bing-Ya Yang, Xiang-Yu Zhang, Sheng-Wen Guan, Zi-Chun Hu. Protective Effect of Procyanidin B2 against CCl4-Induced Acute Liver Injury in Mice. Molecules (Basel, Switzerland). vol 20. issue 7. 2016-04-05. PMID:26151119. |
results showed that procyanidin b2 significantly inhibited ccl4-induced hepatocyte apoptosis, markedly suppressed the upregulation of bax expression and restored the downregulation of bcl-xl expression. |
2016-04-05 |
2023-08-13 |
mouse |
| Qi Liu, Tianlei Si, Xiaoyun Xu, Fuqiang Liang, Lufeng Wang, Siyi Pa. Electromagnetic radiation at 900 MHz induces sperm apoptosis through bcl-2, bax and caspase-3 signaling pathways in rats. Reproductive health. vol 12. 2016-04-05. PMID:26239320. |
electromagnetic radiation at 900 mhz induces sperm apoptosis through bcl-2, bax and caspase-3 signaling pathways in rats. |
2016-04-05 |
2023-08-13 |
human |
| Danmin Huang, Wenjie Guo, Jing Gao, Jun Chen, Joshua Opeyemi Olatunj. Clinacanthus nutans (Burm. f.) Lindau Ethanol Extract Inhibits Hepatoma in Mice through Upregulation of the Immune Response. Molecules (Basel, Switzerland). vol 20. issue 9. 2016-04-05. PMID:26393569. |
western blot analysis of papr, caspase-3, bax, and bcl2 also showed that cn30 induced apoptosis in hepatoma cells. |
2016-04-05 |
2023-08-13 |
mouse |
| Dongdong Sun, Shuang Li, Hao Wu, Mingming Zhang, Xiaotian Zhang, Liping Wei, Xing Qin, Erhe Ga. Oncostatin M (OSM) protects against cardiac ischaemia/reperfusion injury in diabetic mice by regulating apoptosis, mitochondrial biogenesis and insulin sensitivity. Journal of cellular and molecular medicine. vol 19. issue 6. 2016-04-01. PMID:25752217. |
osm alleviated cardiac i/r injury by inhibiting cardiomyocyte apoptosis through inhibition of inositol pyrophosphate 7 (ip7) production, thus activating pi3k/akt/bad pathway, decreasing bax expression while up-regulating bcl-2 expression and decreasing the ratio of bax to bcl-2 in db/db mice. |
2016-04-01 |
2023-08-13 |
mouse |
| Shuang Lu, Mingliang Cheng, Demeng Yang, Yang Liu, Li Guan, Jun W. [Effects of blueberry on apoptosis and expression of Bcl-2 and Bax in HSC-T6]. Zhonghua yi xue za zhi. vol 95. issue 31. 2016-04-01. PMID:26711393. |
[effects of blueberry on apoptosis and expression of bcl-2 and bax in hsc-t6]. |
2016-04-01 |
2023-08-13 |
rat |
| Shuang Lu, Mingliang Cheng, Demeng Yang, Yang Liu, Li Guan, Jun W. [Effects of blueberry on apoptosis and expression of Bcl-2 and Bax in HSC-T6]. Zhonghua yi xue za zhi. vol 95. issue 31. 2016-04-01. PMID:26711393. |
to investigate the effects of blueberry on the apoptosis, expression of bcl-2 and bax in rat hepatic stellate cell (hsc-t6). |
2016-04-01 |
2023-08-13 |
rat |
| Bin Deng, Hao Xu, Jin Zhang, Jin Wang, Li-Chun Han, Li-Ya Li, Guang-Li Wu, Yan-Ning Hou, Guo-Zhen Guo, Qiang Wang, Han-Fei Sang, Li-Xian X. Neuroprotective effects of sevoflurane against electromagnetic pulse-induced brain injury through inhibition of neuronal oxidative stress and apoptosis. PloS one. vol 9. issue 3. 2016-03-31. PMID:24614080. |
additionally, sevoflurane increased sod activity, decreased mda levels and alleviated neuronal apoptosis by regulating the expression of cleaved caspase-3, bax and bcl-2. |
2016-03-31 |
2023-08-12 |
rat |
| Tengku Ahmad Damitri Al-Astani Tengku Din, Shazana Hilda Shamsuddin, Fauziah Mohamad Idris, Wan Nor Ariffin Wan Mansor, Muhammad Irfan Abdul Jalal, Hasnan Jaafa. Rapamycin and PF4 induce apoptosis by upregulating Bax and down-regulating survivin in MNU-induced breast cancer. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 9. 2016-03-31. PMID:24935577. |
rapamycin and pf4 induce apoptosis by upregulating bax and down-regulating survivin in mnu-induced breast cancer. |
2016-03-31 |
2023-08-13 |
Not clear |
| Tengku Ahmad Damitri Al-Astani Tengku Din, Shazana Hilda Shamsuddin, Fauziah Mohamad Idris, Wan Nor Ariffin Wan Mansor, Muhammad Irfan Abdul Jalal, Hasnan Jaafa. Rapamycin and PF4 induce apoptosis by upregulating Bax and down-regulating survivin in MNU-induced breast cancer. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 9. 2016-03-31. PMID:24935577. |
to elucidate the role of rapamycin and pf4 on apoptosis regulation via bax (pro-apoptosis), bcl-2 (anti-apoptosis) and survivin activation on the growth in the 1-methyl-1-nitrosourea -induced invasive breast carcinoma model. |
2016-03-31 |
2023-08-13 |
Not clear |
| Rather A Rafiq, Afnan Quadri, Lone A Nazir, Kaiser Peerzada, Bashir A Ganai, Sheikh A Tasdu. A Potent Inhibitor of Phosphoinositide 3-Kinase (PI3K) and Mitogen Activated Protein (MAP) Kinase Signalling, Quercetin (3, 3', 4', 5, 7-Pentahydroxyflavone) Promotes Cell Death in Ultraviolet (UV)-B-Irradiated B16F10 Melanoma Cells. PloS one. vol 10. issue 7. 2016-03-30. PMID:26148186. |
furthermore, combined uvb and quercetin treatment decreased the ratio of bcl-2 to that of bax, and upregulated the expression of bim and apoptosis inducing factor (aif). |
2016-03-30 |
2023-08-13 |
Not clear |
| Varsha Tembe, Estefania Martino-Echarri, Kamila A Marzec, Myth T S Mok, Kirsty M Brodie, Kate Mills, Ying Lei, Anna DeFazio, Helen Rizos, Emma Kettle, Ross Boadle, Beric R Henderso. The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function. Cellular signalling. vol 27. issue 9. 2016-03-29. PMID:26022179. |
deletion of the brct sequence caused major defects in the ability of bard1 to (1) bind p53, (2) localize to the cytoplasm and mitochondria, and (3) induce bax oligomerization and apoptosis. |
2016-03-29 |
2023-08-13 |
human |
| C Wu, X Zhao, X Zhang, S Liu, H Zhao, Y Che. Effect of Ginkgo biloba extract on apoptosis of brain tissues in rats with acute cerebral infarction and related gene expression. Genetics and molecular research : GMR. vol 14. issue 2. 2016-03-29. PMID:26125843. |
seventy-two hours after treatment, rats were euthanized, and brain tissues were removed to analyze the changes in caspase-3, b-cell lymphoma 2 (bcl-2), and bcl-2-associated x protein (bax) mrna and protein levels, and variation in brain tissue cells' apoptosis indices was measured. |
2016-03-29 |
2023-08-13 |
rat |
| Bingwu Zhong, Zhiping Hu, Jieqiong Tan, Tonglin Lu, Qiang Lei, Chunli Chen, Liuwang Zen. Hsp20 Protects against Oxygen-Glucose Deprivation/Reperfusion-Induced Golgi Fragmentation and Apoptosis through Fas/FasL Pathway. Oxidative medicine and cellular longevity. vol 2015. 2016-03-29. PMID:26199678. |
our data demonstrate that increased hsp20 expression protects against ogdr-induced golgi fragmentation and apoptosis, likely through interaction with bax and subsequent amelioration of the ogdr-induced elevation in p115 cleavage via the fas/fasl signaling pathway. |
2016-03-29 |
2023-08-13 |
mouse |
| Kyung Hye Seo, Hyung Won Ryu, Mi Jin Park, Ki Hun Park, Jin Hyo Kim, Mi-Ja Lee, Hyeon Jung Kang, Sun Lim Kim, Jin Hwan Lee, Woo Duck Se. Mangosenone F, A Furanoxanthone from Garciana mangostana, Induces Reactive Oxygen Species-Mediated Apoptosis in Lung Cancer Cells and Decreases Xenograft Tumor Growth. Phytotherapy research : PTR. vol 29. issue 11. 2016-03-29. PMID:26310849. |
msf treatment also showed in pronounced release of apoptogenic cytochrome c from the mitochondria to the cytosol, downregulation of bcl-2 and bcl-xl, and upregulation of bax, suggesting that caspase-mediated pathways were involved in msf-induced apoptosis. |
2016-03-29 |
2023-08-13 |
mouse |
| Chuanxiang Chen, Litao Qincao, Jingtao Xu, Sihao Du, Enping Huang, Chao Liu, Zhoumeng Lin, Wei-Bing Xie, Huijun Wan. Role of PUMA in methamphetamine-induced neuronal apoptosis. Toxicology letters. vol 240. issue 1. 2016-03-28. PMID:26524635. |
additionally, to investigate possible mechanisms of meth-induced puma-mediated neuronal apoptosis, we measured the protein expression of apoptotic markers, including cleaved caspase-3, cleaved parp, bax, b-cell leukemia/lymphoma-2 (bcl-2) and cytochrome c (cyto c), after meth treatment with or without puma knockdown. |
2016-03-28 |
2023-08-13 |
Not clear |