| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuemin Zhang, Wenyu Hu, Fang Wu, Xue Yuan, Jian H. Shikonin inhibits TNF-α-induced growth and invasion of rat aortic vascular smooth muscle cells. Canadian journal of physiology and pharmacology. vol 93. issue 8. 2016-05-03. PMID:26042337. |
further study revealed that shikonin regulates the activation of nuclear factor kappa b and phosphatidyl inositol 3-kinase signaling pathways; modulates the expression of cyclin d1, cyclin e, b-cell lymphoma 2, and bax; activates caspase-3 and caspase-9; induces cell cycle arrest; and promotes the apoptosis of vsmcs. |
2016-05-03 |
2023-08-13 |
rat |
| Yun Luo, Ping Zhang, Han-Qing Zeng, Shi-Feng Lou, Dao-Xin Wan. Ginsenoside Rg3 induces apoptosis in human multiple myeloma cells via the activation of Bcl-2-associated X protein. Molecular medicine reports. vol 12. issue 3. 2016-05-02. PMID:25998024. |
notably, knockdown of bax protected the u266 cells from rg3‑induced apoptosis. |
2016-05-02 |
2023-08-13 |
human |
| Yun Luo, Ping Zhang, Han-Qing Zeng, Shi-Feng Lou, Dao-Xin Wan. Ginsenoside Rg3 induces apoptosis in human multiple myeloma cells via the activation of Bcl-2-associated X protein. Molecular medicine reports. vol 12. issue 3. 2016-05-02. PMID:25998024. |
overall, these findings suggested that ginsenoside rg3 induced apoptosis in multiple myeloma cells, at least partially, through upregulation of the expression of bax. |
2016-05-02 |
2023-08-13 |
human |
| Bangyuan Wu, Hongrui Guo, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Jianying Huan. Pathway underlying small intestine apoptosis by dietary nickel chloride in broiler chickens. Chemico-biological interactions. vol 243. 2016-05-02. PMID:26585591. |
the aims of this study were to investigate the pathways which dietary nickel chloride (nicl2) affects small intestine apoptosis in broiler chickens by observing the ultrastructure, and bcl-2, bax, and caspase-3 protein expression and mrna expression, and cytochrome c, bak and caspase-9 mrna expression of the small intestine. |
2016-05-02 |
2023-08-13 |
Not clear |
| Zhimin Chen, Dawei Gu, Ming Zhou, Hui Shi, Shu Yan, Yunqing Ca. Regulatory role of miR-125a/b in the suppression by selenium of cadmium-induced apoptosis via the mitochondrial pathway in LLC-PK1 cells. Chemico-biological interactions. vol 243. 2016-05-02. PMID:26607349. |
both se and over-expression of mir-125a/b attenuated cd-induced apoptosis through significant enhancement of the anti-apoptotic protein bcl-2, reduction of the pro-apoptotic proteins bax and bak, the release of cytochrome c and the inactivation of caspase-9 and caspase-3. |
2016-05-02 |
2023-08-13 |
Not clear |
| Ji In Kang, Ji-Young Hong, Jae Sue Choi, Sang Kook Le. Columbianadin Inhibits Cell Proliferation by Inducing Apoptosis and Necroptosis in HCT116 Colon Cancer Cells. Biomolecules & therapeutics. vol 24. issue 3. 2016-05-02. PMID:27098859. |
the induction of apoptosis by cbn was correlated with the modulation of caspase-9, caspase-3, bax, bcl-2, bim and bid, and the induction of necroptosis was related with rip-3, and caspase-8. |
2016-05-02 |
2023-08-13 |
human |
| Fang Zhang, Xingtong Wang, Xiaochen Qiu, Junjie Wang, He Fang, Zhihong Wang, Yu Sun, Zhaofan Xi. The protective effect of Esculentoside A on experimental acute liver injury in mice. PloS one. vol 9. issue 11. 2016-04-29. PMID:25405982. |
unfortunately, our results exhibited that esa had no effects on ccl4-induced hepatocyte apoptosis which were showed by tunel staining and bax, caspase-3 and cleaved caspase-3 expression. |
2016-04-29 |
2023-08-13 |
mouse |
| Jiancheng Yang, Xiaomeng Zong, Gaofeng Wu, Shumei Lin, Ying Feng, Jianmin H. Taurine increases testicular function in aged rats by inhibiting oxidative stress and apoptosis. Amino acids. vol 47. issue 8. 2016-04-29. PMID:25957528. |
finally, we found taurine effectively reduced testicular dna fragmentation, increased testicular bcl-2 protein expression, and decreased cytochrome c, bax, fas, fasl and caspase-3 expression, suggesting taurine can prohibit aged testicular apoptosis by mitochondrial dependent and independent signal pathway. |
2016-04-29 |
2023-08-13 |
rat |
| Ariele Viacava Follis, Fabien Llambi, Parker Merritt, Jerry E Chipuk, Douglas R Green, Richard W Kriwack. Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis. Molecular cell. vol 59. issue 4. 2016-04-29. PMID:26236013. |
pin1-induced proline isomerization in cytosolic p53 mediates bax activation and apoptosis. |
2016-04-29 |
2023-08-13 |
Not clear |
| Ariele Viacava Follis, Fabien Llambi, Parker Merritt, Jerry E Chipuk, Douglas R Green, Richard W Kriwack. Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis. Molecular cell. vol 59. issue 4. 2016-04-29. PMID:26236013. |
the cytosolic fraction of the tumor suppressor p53 activates the apoptotic effector protein bax to trigger apoptosis. |
2016-04-29 |
2023-08-13 |
Not clear |
| Lin Deng, Ming Chen, Motofumi Tanaka, Yonson Ku, Tomoo Itoh, Ikuo Shoji, Hak Hott. HCV upregulates Bim through the ROS/JNK signalling pathway, leading to Bax-mediated apoptosis. The Journal of general virology. vol 96. issue 9. 2016-04-29. PMID:26296767. |
in this study, we showed that the hcv-induced activation and mitochondrial accumulation of bax were significantly attenuated by treatment with a general antioxidant, n-acetyl cysteine (nac), or a specific c-jun n-terminal kinase (jnk) inhibitor, sp600125, with the result suggesting that the reactive oxygen species (ros)/jnk signalling pathway is upstream of bax activation in hcv-induced apoptosis. |
2016-04-29 |
2023-08-13 |
Not clear |
| Lin Deng, Ming Chen, Motofumi Tanaka, Yonson Ku, Tomoo Itoh, Ikuo Shoji, Hak Hott. HCV upregulates Bim through the ROS/JNK signalling pathway, leading to Bax-mediated apoptosis. The Journal of general virology. vol 96. issue 9. 2016-04-29. PMID:26296767. |
taken together, these observations suggest that hcv-induced ros/jnk signalling transcriptionally activates bim expression, which leads to bax activation and apoptosis induction. |
2016-04-29 |
2023-08-13 |
Not clear |
| Qin-Ying Liu, Tong Zhou, Yang-Yang Zhao, Li Chen, Mei-Wei Gong, Qi-Wen Xia, Min-Gang Ying, Qiu-Hong Zheng, Qi-Qing Zhan. Antitumor Effects and Related Mechanisms of Penicitrinine A, a Novel Alkaloid with a Unique Spiro Skeleton from the Marine Fungus Penicillium citrinum. Marine drugs. vol 13. issue 8. 2016-04-28. PMID:26264002. |
morphologic evaluation, apoptosis rate analysis, western blot and real-time quantitative pcr (rt-qpcr) results showed penicitrinine a could significantly induce a-375 cell apoptosis by decreasing the expression of bcl-2 and increasing the expression of bax. |
2016-04-28 |
2023-08-13 |
human |
| Mahmoud Salah Khali. The postulated mechanism of the protective effect of ginger on the aspirin induced gastric ulcer: Histological and immunohistochemical studies. Histology and histopathology. vol 30. issue 7. 2016-04-27. PMID:25652595. |
aspirin induced a significant increase of the macroscopic ulcer score, shed and disrupted epithelium, mucosal hemorrhage, submucosal edema and leukocyte infiltration, loss of the mucus of the mucosal surface significantly increased expression of apoptosis regulator bax, inducible nitric oxide synthase (inos) and heat shock protein 70 (hsp70). |
2016-04-27 |
2023-08-13 |
rat |
| Young Hwi Kwon, Kausik Bishayee, Ataur Rahman, Jae Seung Hong, Soon-Sung Lim, Sung-Oh Hu. Morus alba Accumulates Reactive Oxygen Species to Initiate Apoptosis via FOXO-Caspase 3-Dependent Pathway in Neuroblastoma Cells. Molecules and cells. vol 38. issue 7. 2016-04-27. PMID:25921607. |
an expression study of p-akt also suggested that there was a reduction in cellular proliferation and transcription along with the process of apoptosis, which was further evidenced by an increase in bax and cleaved-caspase 3 activity. |
2016-04-27 |
2023-08-13 |
Not clear |
| Yamunadevi Subburaj, Katia Cosentino, Markus Axmann, Esteban Pedrueza-Villalmanzo, Eduard Hermann, Stephanie Bleicken, Joachim Spatz, Ana J García-Sáe. Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species. Nature communications. vol 6. 2016-04-27. PMID:26271728. |
bax is a key regulator of apoptosis that mediates the release of cytochrome c to the cytosol via oligomerization in the outer mitochondrial membrane before pore formation. |
2016-04-27 |
2023-08-13 |
Not clear |
| Decui Shao, Jun Ni, Yang Shen, Jia Liu, Li Zhou, Hong Xue, Yu Huang, Wei Zhang, Limin L. CHOP mediates XBP1S-induced renal mesangial cell necrosis following high glucose treatment. European journal of pharmacology. vol 758. 2016-04-26. PMID:25857226. |
apoptosis and necrosis were quantified by flow cytometry; protein levels of xbp1s, caspase3, bax, bcl2, bnip3, and chop were analyzed by western blotting. |
2016-04-26 |
2023-08-13 |
Not clear |
| Aisha Siddiqi, Sana Nafees, Summya Rashid, Sarwat Sultana, Bano Saidulla. Hesperidin ameliorates trichloroethylene-induced nephrotoxicity by abrogation of oxidative stress and apoptosis in wistar rats. Molecular and cellular biochemistry. vol 406. issue 1-2. 2016-04-25. PMID:25994504. |
caspase-3 and bax expression were found to be elevated, while that of bcl-2 reduced suggesting that tce induces apoptosis. |
2016-04-25 |
2023-08-13 |
rat |
| Ali Gheysarzadeh, Razieh Yazdanparas. STAT5 reactivation by catechin modulates H2O 2-induced apoptosis through miR-182/FOXO1 pathway in SK-N-MC cells. Cell biochemistry and biophysics. vol 71. issue 2. 2016-04-21. PMID:25231457. |
finally, pro-apoptotic gene targets of foxo1 e.g., bim and bax are up-regulated leading to apoptosis. |
2016-04-21 |
2023-08-13 |
Not clear |
| Hui Tian, Jin-Xia Wu, Feng-Xiao Shan, Shang-Nuan Zhang, Qian Cheng, Jun-Nian Zheng, Dong-Sheng Pe. Gamma-aminobutyric acid induces tumor cells apoptosis via GABABR1·β-arrestins·JNKs signaling module. Cell biochemistry and biophysics. vol 71. issue 2. 2016-04-21. PMID:25234615. |
additionally, gaba up-regulated the ratio of pro-apoptotic protein bax to anti-apoptotic protein bcl-2, and thus facilitated caspase-3 cleavage, leading to tumor cells apoptosis in a mitochondrial-dependent pathway. |
2016-04-21 |
2023-08-13 |
Not clear |